Articles tagged with Kidney
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Researchers used machine learning algorithms to classify kidney biopsy samples, achieving substantial agreement with pathologists' standard classifications. The methods may augment traditional diagnostics of kidney disease by automating and enhancing accuracy, potentially improving organ survival for transplant patients.
A new study suggests transplanting Hepatitis C-infected kidneys to uninfected recipients is safe and can be implemented as a standard of care. This approach could greatly expand the number of available kidneys and reduce waiting times for donors, saving thousands of lives annually.
This observational study found that most donated kidneys (84%) were declined by transplant centers due to concerns over organ or donor quality. Patients who received a deceased donor kidney had significantly more offers (median of 17) than those who died on the waiting list (16) or were removed from the list (15).
A new study found that nearly one-third of kidney transplant candidates die or are removed from the list without receiving a transplant, with many having had multiple organ offers declined. The research highlights concerns about the allocation system and suggests better communication between patients and transplant centers could improv...
A new study suggests that marathon runners are at risk of acute kidney injury (AKI) due to fluid and salt losses, rather than core body temperature. Researchers found that managing fluid volume and salt losses with a personalized regimen during training may help reduce the incidence of AKI.
A new study published in BMJ Open found that patients with gout are at increased risk of chronic kidney disease and kidney failure. The largest-ever study on the subject used data from over 620,000 patients in the UK health system and found a 29% higher risk of advanced CKD compared to those without gout.
A team of researchers has discovered a previously unrecognized mechanism that accelerates cystogenesis in polycystic kidney disease (PKD), leading to rapid cyst growth and kidney failure. The study suggests that increasing water intake and avoiding certain foods may slow the progression of ADPKD.
A new study found that French transplant centers are more likely to accept lower-rated kidneys from older donors, which could benefit thousands of Americans on the waitlist. This approach could provide over 10,000 years of life with a functioning kidney transplant if adopted in the US.
The study found a significant increase in pre-emptive kidney transplants covered by Medicaid in states that expanded the program, with a 66% rise compared to non-expansion states. Medicaid-covered living-donor kidney transplants also increased, particularly in expansion states.
Researchers grew 'miniature kidneys' in a lab from patient skin cells to better understand how kidney diseases develop and test potential treatments. The mini kidneys, or organoids, showed promise for personalized therapy approaches.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
Researchers at NUST MISIS have identified a mechanism for removing magnetic nanoparticles through the kidneys, allowing for safer drug delivery. The study used a combination of techniques to track nanoparticle transport, revealing that they can be excreted directly into the renal tubule, reducing the risk of liver accumulation.
Researchers at Children's Hospital Los Angeles create an in vitro model of the human kidney glomerulus that filters blood and removes toxins. The breakthrough could lead to better understanding of chronic kidney disease mechanisms and development of new treatments.
A new study from the University of Cincinnati found that Hispanic women have a higher likelihood of pregnancy than white women after receiving a kidney transplant. The study analyzed data from over 7,900 women and revealed a pregnancy rate of 21.4 per-thousand person years among Hispanic women.
A recent study published by Mount Sinai researchers found that fluoride exposure may contribute to complex changes in kidney and liver function among youth in the US. The findings suggest that adolescents with poorer kidney or liver function may absorb more fluoride, highlighting potential health concerns.
Researchers found that deregulated mTOR leads to decreased autophagy, causing accumulation of damaged organelles and promoting crystal-cell interactions. An mTOR inhibitor alleviates these effects, suggesting that targeting this pathway may prevent or treat kidney stones.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
A novel molecular mechanism has been discovered that underlies several genetic disorders, including MUC1 kidney disease, which results in a 'traffic jam' at the cellular shipping network. Researchers identified a compound called BRD4780 that can clear this traffic jam and prevent protein misfolding.
A recent analysis of US data over 20 years shows that children with kidney failure are being started on dialysis with higher levels of kidney function. Initiating dialysis at these higher levels is linked to lower patient survival, suggesting that asymptomatic children may benefit from delaying treatment.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
A study found that older living kidney donors with hypertension had a higher risk of developing kidney failure within 15 years after donation. However, the absolute risk was relatively low. In contrast, hypertension was not linked to an increased risk of early death among older donors.
Researchers have developed ultrasmall nanoclusters with antioxidative properties that can pass through the kidneys' filtration barrier to alleviate clinical symptoms of AKI. Selenium-doped carbon quantum dots also demonstrated effective treatment and prevention of AKI in mice by localizing in the kidneys and eliminating ROS.
A restrictive approach to blood cell transfusions in heart surgery patients resulted in fewer transfusions without increasing the risk of acute kidney injury. The study found that reducing transfusions could prevent adverse effects and conserve the blood supply, while minimizing negative impacts on kidney health.
Researchers developed a new class of drugs to treat autosomal dominant polycystic kidney disease (ADPKD), a hereditary progressive disease causing cysts and kidney failure. The compound reduces levels of cyclic AMP, suppressing cyst growth and potentially controlling the disease.
Research supported by the Accelerating Medicines Partnership has provided new insights into tissue damage in rheumatoid arthritis and lupus. Novel molecular signatures have been identified in kidney cells and specific white blood cells may reflect their active role in disease process.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
The VITALE study found that high-dose vitamin D supplementation significantly reduces fracture risk in kidney transplant recipients, with a lower incidence of fractures in the high-dose group compared to the low-dose group. The treatment was well-tolerated with no increased risks of adverse effects.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
A study found that one-fifth of US surgeons perform the less-recommended AV graft procedure too often, even when unnecessary. The research suggests that older, specialized surgeons are more likely to use this method.
A large international clinical trial found that dulaglutide reduced cardiovascular events by 12% and kidney disease by 15% in people with Type 2 diabetes. The study, REWIND, followed over 9,900 participants for five years.
A new study published by University of Pittsburgh researchers found that removing excess fluid too quickly from critically ill patients with failing kidneys increases the likelihood of death. For every 0.5 milliliter increase in fluid removed per kilogram of patient weight per hour, risk of death increases.
UC researchers present findings from the Belatacept Early Steroid Withdrawal Trial (BEST), showing that belatacept can safely and effectively treat kidney transplant patients. The study demonstrates reduced side effects and cardiovascular risk reduction compared to traditional immunosuppressive regimens.
Researchers developed a gel-based delivery system to improve tissue regeneration in kidney injuries. The study found that the system could significantly enhance cell proliferation and survival, leading to rapid functional recovery.
Researchers have discovered that inhibiting two key proteins, ATM and ATR, can reduce BK polyomavirus levels in infected cells. This finding may provide an opportunity to use existing cancer drugs to combat the virus without reducing immunosuppressing drugs, which are needed to prevent transplant rejection.
Researchers at Wake Forest Institute for Regenerative Medicine have successfully engineered vascularized functional renal tissues using a novel biomimetic scaffold. The study's findings suggest that this approach may be a more feasible and practical treatment strategy for patients with chronic kidney disease.
A recent study by Drexel University researchers found that patients who lost significant weight before a kidney transplant had an 18% higher risk of death after the procedure. The study analyzed data from over 94,000 transplant recipients and found that even planned weight loss could be dangerous if not closely monitored.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
Researchers have discovered a way to predict which patients with systemic lupus erythematosus (SLE) are most likely to respond to therapy by analyzing tissue samples from their kidneys and skin. This breakthrough could lead to personalized treatment plans for SLE patients.
Researchers developed a new testing method using single-cell RNA sequencing to analyze individual cells in diseased organs, revealing genetic glitches that may allow for more effective treatment. The study found promising results in lupus patients and could potentially improve biopsy accuracy for other diseases.
A genomic collision may explain why many kidney transplants fail due to genetic incompatibility between donor and recipient. The study found that recipients with two copies of a deletion near the LIMS1 gene had a significantly higher risk of rejection when the donor kidney had at least one full-sized version of the same gene.
A new study published in Mayo Clinic Proceedings found that renal infarction is associated with acute kidney injury in patients with cardiac amyloidosis. The study revealed a relatively high prevalence of renal infarction among these patients, suggesting it as a potential cause of acute kidney injury in this context.
Children who receive kidney transplants have impaired quality of life with higher mental health difficulties and disrupted sleep patterns. Parents' reports often differ from children's self-reports, indicating more difficulties in emotional functioning and social domains.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Dr. Bradley Yoder receives the prestigious prize for his significant research on polycystic kidney disease, recognizing his work on primary cilium function and its role in cyst development. The award aims to stimulate research towards a treatment and cure for PKD.
A new study found that consuming a nutrient-rich plant-based diet may help protect against chronic kidney disease (CKD) development. Participants with the highest adherence to a healthy plant-based diet had a lower risk of developing CKD compared to those with low adherence.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Kidney transplant patients face a higher risk of cardiovascular complications and mortality due to existing damage and immunosuppressive drug side effects. The current post-transplantation care is fragmented, leading to undertreatment of modifiable cardiovascular risk factors.
Researchers have discovered a potential new treatment for renal fibrosis by selectively activating AT1 receptors on T cells, which may help limit scar formation in the kidney. The study found that activating these receptors mitigates renal fibrogenesis by inhibiting Th1 differentiation and renal accumulation of pro-fibrotic macrophages.
A large-scale genome-wide association study has identified 14 new variants associated with the development of kidney stones, including four linked to obesity and high blood uric acid levels. The findings may be useful for predicting individuals' risk of developing kidney stones and identifying new targets for prevention and treatment.
The Kidney Health Atlas reveals that 14.5 million people will have end-stage kidney disease by 2030, yet only 5.4 million will receive treatment due to economic and social factors. The atlas highlights significant gaps in kidney care globally, particularly in low-income countries.
A study by UCSF researchers found that nearly one in seven kidney donors experience potentially adverse events related to their donation. Long-term systematic renal monitoring and routine checkups for living kidney donors are recommended to prevent renal failure and cardiovascular issues.
A case study reveals that taking high doses of vitamin D can lead to kidney damage and malfunction. Patients should be better informed about the risks of using excessive amounts of vitamin D, particularly in low-risk individuals.
A new global study, Global Kidney Health Atlas (GKHA), is released on April 12 at the World Congress of Nephrology, detailing country and region breakdowns of global kidney health. The study highlights disparities in treatment access due to social, economic, and political factors, resulting in over 2 million deaths annually worldwide.
Racial disparities in access to kidney transplants continue, with patients from underserved groups more likely to be listed as inactive and less likely to receive transplants than white patients. A new study analyzing data from 2014-2016 found significant inequities despite a system aimed at increasing access for vulnerable populations.
A new study analyzed nearly 43,000 patients on a kidney transplant wait-list after implementation of the new system in 2014. The research found racial disparities in patient status on the list and sensitivity levels, which can affect transplantation likelihood.
A multidisciplinary team from Johns Hopkins Medicine has completed the first living donor HIV-to-HIV kidney transplant in the US. Nina Martinez, a 35-year-old living with HIV, donated her kidney to an anonymous recipient after undergoing rigorous evaluation and testing.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
A synthetic peptide has been found to directly disrupt destructive inflammation in the kidneys, enabling better recovery and maintaining important functions. The peptide reduced immune cell movement, resolved inflammation, and improved kidney function without increasing blood pressure.