Research on kidney function and disease. Covers kidney-failure prevention, gestational diabetes links, environmental risks, and gum-kidney connections.
A three-year clinical study found that reducing uric acid levels with the generic drug allopurinol did not slow diabetic kidney disease progression in type 1 diabetes patients. The study's conclusions provided a clear answer to an important scientific question, while suggesting further research may be needed.
A large clinical trial found that vitamin D and omega-3 fatty acid supplements did not slow the decline of kidney function in adults with Type 2 diabetes. The study involved over 1,300 participants and measured their kidney function over five years.
Researchers tested an Automated Wearable Artificial Kidney (AWAK) device for effective toxin removal in patients with kidney failure. The study found no serious adverse events, improving portability and flexibility of treatment.
A multi-institutional study found that adolescents with Type 2 diabetes experienced improved hyperfiltration and reduced elevated urine albumin-to-creatinine ratio after gastric bypass surgery compared to adults. In contrast, adults with pre-existing diabetes did not show significant improvements until five years post-surgery.
A recent analysis found that home remote monitoring can benefit patients on peritoneal dialysis by preventing hospitalizations and extending treatment time. The successful implementation of the program requires effective communication, technical support, and patient engagement.
Community house hem dialysis allows patients to perform treatment independently in a shared community space, reducing burden on family and promoting flexibility. The study found that this approach supports extended-hour dialysis and fosters social connections among patients of Maori and Pacific ethnicity.
Researchers at UCSF have successfully implanted a bioreactor containing human kidney cells into pigs without triggering an immune reaction or blood clots. The device, similar to the size of a deck of cards, maintained healthy kidney function and demonstrated progress towards eliminating dialysis for patients with end-stage renal disease.
A machine learning model identified patients at risk of requiring kidney replacement therapy, leading to a significant improvement in dialysis initiation rates. The system calculates weekly risk scores and alerts clinicians to optimize treatment decisions, resulting in better patient outcomes.
A study examining clinical trial data found that sleep problems and fatigue significantly impact the cognitive function and behavior of children with chronic kidney disease. The research highlights the importance of assessing sleep problems and fatigue in these children to improve their emotional-behavioral and neurocognitive outcomes.
A study suggests that extending lifelong Medicare coverage of transplant medications would reduce healthcare costs and improve quality of life for kidney transplant recipients. This policy change could benefit patients who are currently left without coverage after 36 months.
Patients who transition to home dialysis after an unplanned start experience a higher risk of death compared to those who never made the switch. However, researchers found that younger patients and those with private insurance were more likely to make the transition to peritoneal dialysis.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Researchers studying spherical exosomes, tiny cargo-filled spheres that arrive at the scene of acute kidney injury, aim to learn more about their role in repair and restore function. They suspect these exosomes can be controlled to better treat injuries and prevent permanent damage.
Researchers found that identical twin kidney transplants have high success rates, but patients often require immunosuppressive drugs due to misidentification. The study proposes genetic testing and management guidelines for identical twin transplants to minimize side effects.
Researchers have discovered that surface waves can spread on water-glass boundaries, creating a phenomenon that could be used to pulverize kidney stones. The study uses an experimental system to visualize stress created by such waves.
Researchers have discovered significant differences in gene expression between male and female mouse kidneys, shedding light on the organ's complex physiology and potential impact on human kidney disease. The study's findings may help clinicians better understand genetic programs linked to disease and improve treatment outcomes.
A new study finds that acute kidney injury affects 17% of patients taking immunotherapy medications for cancer, while proton pump inhibitors increase the risk of sustained AKI. Nephrologists and oncologists must recognize these factors to diagnose and treat patients effectively.
Rates for all types of kidney replacement therapy were consistently higher in men than women in European countries from 1965 to 2015. The male-to-female ratio increased with age and was particularly high for diabetic patients, suggesting that biological or access-related factors may be at play.
A new study found that less than 20% of Canadian patients with chronic kidney disease received a critical urine test within six months of diagnosis, highlighting a significant gap in care. The test is crucial for assessing the severity of kidney disease and guiding treatment.
Researchers found that transplant centers accepted varying numbers of high-risk kidneys between 2010 and 2016, but differences were not fully explained by waitlist size or organ availability. The study suggests that accepting less-than-ideal organs can lead to shorter average wait times for patients.
A Johns Hopkins-led study of thousands of children with congenital heart disease found that cardiac surgery within 10 years of birth increases the risk of death and kidney failure. Children who had more complex surgeries were at higher risk for these outcomes.
A study found that prescription opioids are associated with a higher risk of death and hospitalization compared to other pain medications, especially at high doses. The risk is highest among individuals with lower kidney function, who may experience reduced clearance of the active compounds from their bodies.
Researchers found high rates of overall survival and kidney graft survival in recipients living with HIV who received kidney transplants from deceased donors with HIV. The study, published in the New England Journal of Medicine, showed that outcomes were comparable to those in a previous US study using kidneys from donors without HIV.
A recent analysis reveals persistent disparities in preemptive kidney transplantation, with Black and Hispanic patients and those on Medicare facing reduced access. The 2014 Kidney Allocation System may have exacerbated some inequalities for these groups.
Researchers have created the first cell atlas of the human kidney's immune system, charting the communities of immune cells in different zones. The atlas shows how the immune system develops during early life and strengthens after birth, with implications for tackling kidney disease and transplant rejection.
A healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease (CKD) and a 23% lower incidence of albuminuria, an early indicator of kidney damage. The findings suggest that maintaining a healthy diet may help prevent kidney disease.
Researchers validate the hypothesis that IgG autoantibodies are crucial to IgA nephropathy's pathogenic immunodeposits. The study found co-localization of IgA1 and IgG in glomerular deposits, confirming their role in disease progression.
A new observational study published in JAMA sheds light on the use of metformin for patients with Type 2 diabetes and impaired kidney function. The study found that metformin is associated with a 20% decreased risk of major adverse cardiovascular events compared to sulfonylureas.
Researchers developed a kidney transplant risk model combining data from kidney donor registries, statistics of probable genetic profiles, and immunological knowledge to improve predictions of donor-recipient match. The study suggests that incorporating partial antigen match data can further enhance the accuracy of the model.
Living kidney donation is linked with a higher risk of developing hypertension and kidney failure. Kidney function tends to improve after donation but plateaus if hypertension develops, highlighting the importance of preventing and managing hypertension in living donors.
This observational study compared major cardiovascular events among patients with diabetes and reduced kidney function treated with metformin or a sulfonylurea. The study found that metformin was associated with lower rates of cardiovascular events compared to sulfonylureas.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many US centers. These organs function just as well as uninfected kidneys throughout the first year after transplantation, providing strong evidence for their safe and effective use.
A potential treatment for polycystic kidney disease has shown a significant reduction in kidney size in afflicted mice, with no evidence of toxicity in animal or human cell tests. The drug is now in early clinical trials in humans, offering hope for a new option for survival beyond dialysis or transplant.
A new national study by Penn Medicine found that hepatitis C-infected kidneys can function comparably to uninfected kidneys in patients who do not already have the virus. The study showed a significant increase in the use of HCV-infected organs, but raised questions about why these organs are still assigned lower risk scores.
A study of nearly 1.5 million patients found that receiving dialysis at for-profit facilities was linked to lower likelihoods of being placed on the kidney waiting list and receiving a transplant. The authors suggest that more research is needed to understand this association.
Chronic kidney disease affects 37 million Americans, but primary care physicians lack sufficient knowledge and resources to effectively identify and manage patients. A focus group study found that PCPs need more training, resources, and clinical support tools to address the growing epidemic of CKD.
Russian researchers have shown an antioxidant compound called peroxiredoxin to be effective in treating kidney injury in mice by tripling survival rates. The compound may also offer prospects for longer kidney transplant storage and improved treatment options for ischemia-reperfusion syndrome.
Researchers used machine learning algorithms to classify kidney biopsy samples, achieving substantial agreement with pathologists' standard classifications. The methods may augment traditional diagnostics of kidney disease by automating and enhancing accuracy, potentially improving organ survival for transplant patients.
This observational study found that most donated kidneys (84%) were declined by transplant centers due to concerns over organ or donor quality. Patients who received a deceased donor kidney had significantly more offers (median of 17) than those who died on the waiting list (16) or were removed from the list (15).
A new study found that nearly one-third of kidney transplant candidates die or are removed from the list without receiving a transplant, with many having had multiple organ offers declined. The research highlights concerns about the allocation system and suggests better communication between patients and transplant centers could improv...
A new study suggests transplanting Hepatitis C-infected kidneys to uninfected recipients is safe and can be implemented as a standard of care. This approach could greatly expand the number of available kidneys and reduce waiting times for donors, saving thousands of lives annually.
A new study suggests that marathon runners are at risk of acute kidney injury (AKI) due to fluid and salt losses, rather than core body temperature. Researchers found that managing fluid volume and salt losses with a personalized regimen during training may help reduce the incidence of AKI.
A new study published in BMJ Open found that patients with gout are at increased risk of chronic kidney disease and kidney failure. The largest-ever study on the subject used data from over 620,000 patients in the UK health system and found a 29% higher risk of advanced CKD compared to those without gout.
A team of researchers has discovered a previously unrecognized mechanism that accelerates cystogenesis in polycystic kidney disease (PKD), leading to rapid cyst growth and kidney failure. The study suggests that increasing water intake and avoiding certain foods may slow the progression of ADPKD.
A new study found that French transplant centers are more likely to accept lower-rated kidneys from older donors, which could benefit thousands of Americans on the waitlist. This approach could provide over 10,000 years of life with a functioning kidney transplant if adopted in the US.
The study found a significant increase in pre-emptive kidney transplants covered by Medicaid in states that expanded the program, with a 66% rise compared to non-expansion states. Medicaid-covered living-donor kidney transplants also increased, particularly in expansion states.
Researchers grew 'miniature kidneys' in a lab from patient skin cells to better understand how kidney diseases develop and test potential treatments. The mini kidneys, or organoids, showed promise for personalized therapy approaches.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
Researchers at NUST MISIS have identified a mechanism for removing magnetic nanoparticles through the kidneys, allowing for safer drug delivery. The study used a combination of techniques to track nanoparticle transport, revealing that they can be excreted directly into the renal tubule, reducing the risk of liver accumulation.
Researchers at Children's Hospital Los Angeles create an in vitro model of the human kidney glomerulus that filters blood and removes toxins. The breakthrough could lead to better understanding of chronic kidney disease mechanisms and development of new treatments.
A new study from the University of Cincinnati found that Hispanic women have a higher likelihood of pregnancy than white women after receiving a kidney transplant. The study analyzed data from over 7,900 women and revealed a pregnancy rate of 21.4 per-thousand person years among Hispanic women.
A recent study published by Mount Sinai researchers found that fluoride exposure may contribute to complex changes in kidney and liver function among youth in the US. The findings suggest that adolescents with poorer kidney or liver function may absorb more fluoride, highlighting potential health concerns.
Researchers found that deregulated mTOR leads to decreased autophagy, causing accumulation of damaged organelles and promoting crystal-cell interactions. An mTOR inhibitor alleviates these effects, suggesting that targeting this pathway may prevent or treat kidney stones.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
A novel molecular mechanism has been discovered that underlies several genetic disorders, including MUC1 kidney disease, which results in a 'traffic jam' at the cellular shipping network. Researchers identified a compound called BRD4780 that can clear this traffic jam and prevent protein misfolding.
A recent analysis of US data over 20 years shows that children with kidney failure are being started on dialysis with higher levels of kidney function. Initiating dialysis at these higher levels is linked to lower patient survival, suggesting that asymptomatic children may benefit from delaying treatment.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
A study found that older living kidney donors with hypertension had a higher risk of developing kidney failure within 15 years after donation. However, the absolute risk was relatively low. In contrast, hypertension was not linked to an increased risk of early death among older donors.