Articles tagged with Kidney
Rates for all types of kidney replacement therapy were consistently higher in men than women in European countries from 1965 to 2015. The male-to-female ratio increased with age and was particularly high for diabetic patients, suggesting that biological or access-related factors may be at play.
Researchers found that transplant centers accepted varying numbers of high-risk kidneys between 2010 and 2016, but differences were not fully explained by waitlist size or organ availability. The study suggests that accepting less-than-ideal organs can lead to shorter average wait times for patients.
A study found that prescription opioids are associated with a higher risk of death and hospitalization compared to other pain medications, especially at high doses. The risk is highest among individuals with lower kidney function, who may experience reduced clearance of the active compounds from their bodies.
A Johns Hopkins-led study of thousands of children with congenital heart disease found that cardiac surgery within 10 years of birth increases the risk of death and kidney failure. Children who had more complex surgeries were at higher risk for these outcomes.
Researchers found high rates of overall survival and kidney graft survival in recipients living with HIV who received kidney transplants from deceased donors with HIV. The study, published in the New England Journal of Medicine, showed that outcomes were comparable to those in a previous US study using kidneys from donors without HIV.
Researchers have created the first cell atlas of the human kidney's immune system, charting the communities of immune cells in different zones. The atlas shows how the immune system develops during early life and strengthens after birth, with implications for tackling kidney disease and transplant rejection.
A recent analysis reveals persistent disparities in preemptive kidney transplantation, with Black and Hispanic patients and those on Medicare facing reduced access. The 2014 Kidney Allocation System may have exacerbated some inequalities for these groups.
Researchers validate the hypothesis that IgG autoantibodies are crucial to IgA nephropathy's pathogenic immunodeposits. The study found co-localization of IgA1 and IgG in glomerular deposits, confirming their role in disease progression.
A new observational study published in JAMA sheds light on the use of metformin for patients with Type 2 diabetes and impaired kidney function. The study found that metformin is associated with a 20% decreased risk of major adverse cardiovascular events compared to sulfonylureas.
A healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease (CKD) and a 23% lower incidence of albuminuria, an early indicator of kidney damage. The findings suggest that maintaining a healthy diet may help prevent kidney disease.
Researchers developed a kidney transplant risk model combining data from kidney donor registries, statistics of probable genetic profiles, and immunological knowledge to improve predictions of donor-recipient match. The study suggests that incorporating partial antigen match data can further enhance the accuracy of the model.
Living kidney donation is linked with a higher risk of developing hypertension and kidney failure. Kidney function tends to improve after donation but plateaus if hypertension develops, highlighting the importance of preventing and managing hypertension in living donors.
This observational study compared major cardiovascular events among patients with diabetes and reduced kidney function treated with metformin or a sulfonylurea. The study found that metformin was associated with lower rates of cardiovascular events compared to sulfonylureas.
A potential treatment for polycystic kidney disease has shown a significant reduction in kidney size in afflicted mice, with no evidence of toxicity in animal or human cell tests. The drug is now in early clinical trials in humans, offering hope for a new option for survival beyond dialysis or transplant.
A new national study by Penn Medicine found that hepatitis C-infected kidneys can function comparably to uninfected kidneys in patients who do not already have the virus. The study showed a significant increase in the use of HCV-infected organs, but raised questions about why these organs are still assigned lower risk scores.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many US centers. These organs function just as well as uninfected kidneys throughout the first year after transplantation, providing strong evidence for their safe and effective use.
A study of nearly 1.5 million patients found that receiving dialysis at for-profit facilities was linked to lower likelihoods of being placed on the kidney waiting list and receiving a transplant. The authors suggest that more research is needed to understand this association.
Chronic kidney disease affects 37 million Americans, but primary care physicians lack sufficient knowledge and resources to effectively identify and manage patients. A focus group study found that PCPs need more training, resources, and clinical support tools to address the growing epidemic of CKD.
Russian researchers have shown an antioxidant compound called peroxiredoxin to be effective in treating kidney injury in mice by tripling survival rates. The compound may also offer prospects for longer kidney transplant storage and improved treatment options for ischemia-reperfusion syndrome.
Researchers used machine learning algorithms to classify kidney biopsy samples, achieving substantial agreement with pathologists' standard classifications. The methods may augment traditional diagnostics of kidney disease by automating and enhancing accuracy, potentially improving organ survival for transplant patients.
A new study found that nearly one-third of kidney transplant candidates die or are removed from the list without receiving a transplant, with many having had multiple organ offers declined. The research highlights concerns about the allocation system and suggests better communication between patients and transplant centers could improv...
A new study suggests transplanting Hepatitis C-infected kidneys to uninfected recipients is safe and can be implemented as a standard of care. This approach could greatly expand the number of available kidneys and reduce waiting times for donors, saving thousands of lives annually.
This observational study found that most donated kidneys (84%) were declined by transplant centers due to concerns over organ or donor quality. Patients who received a deceased donor kidney had significantly more offers (median of 17) than those who died on the waiting list (16) or were removed from the list (15).
A new study suggests that marathon runners are at risk of acute kidney injury (AKI) due to fluid and salt losses, rather than core body temperature. Researchers found that managing fluid volume and salt losses with a personalized regimen during training may help reduce the incidence of AKI.
A new study published in BMJ Open found that patients with gout are at increased risk of chronic kidney disease and kidney failure. The largest-ever study on the subject used data from over 620,000 patients in the UK health system and found a 29% higher risk of advanced CKD compared to those without gout.
A new study found that French transplant centers are more likely to accept lower-rated kidneys from older donors, which could benefit thousands of Americans on the waitlist. This approach could provide over 10,000 years of life with a functioning kidney transplant if adopted in the US.
A team of researchers has discovered a previously unrecognized mechanism that accelerates cystogenesis in polycystic kidney disease (PKD), leading to rapid cyst growth and kidney failure. The study suggests that increasing water intake and avoiding certain foods may slow the progression of ADPKD.
The study found a significant increase in pre-emptive kidney transplants covered by Medicaid in states that expanded the program, with a 66% rise compared to non-expansion states. Medicaid-covered living-donor kidney transplants also increased, particularly in expansion states.
Researchers grew 'miniature kidneys' in a lab from patient skin cells to better understand how kidney diseases develop and test potential treatments. The mini kidneys, or organoids, showed promise for personalized therapy approaches.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
Researchers at NUST MISIS have identified a mechanism for removing magnetic nanoparticles through the kidneys, allowing for safer drug delivery. The study used a combination of techniques to track nanoparticle transport, revealing that they can be excreted directly into the renal tubule, reducing the risk of liver accumulation.
Researchers at Children's Hospital Los Angeles create an in vitro model of the human kidney glomerulus that filters blood and removes toxins. The breakthrough could lead to better understanding of chronic kidney disease mechanisms and development of new treatments.
A new study from the University of Cincinnati found that Hispanic women have a higher likelihood of pregnancy than white women after receiving a kidney transplant. The study analyzed data from over 7,900 women and revealed a pregnancy rate of 21.4 per-thousand person years among Hispanic women.
A recent study published by Mount Sinai researchers found that fluoride exposure may contribute to complex changes in kidney and liver function among youth in the US. The findings suggest that adolescents with poorer kidney or liver function may absorb more fluoride, highlighting potential health concerns.
Researchers found that deregulated mTOR leads to decreased autophagy, causing accumulation of damaged organelles and promoting crystal-cell interactions. An mTOR inhibitor alleviates these effects, suggesting that targeting this pathway may prevent or treat kidney stones.
Researchers at KU Leuven have developed a non-invasive biomarker for detecting kidney transplant rejection symptoms after a transplant due to antibody-mediated rejection. The new blood test can identify patients with rejection symptoms earlier and more accurately than current methods, which often rely on invasive biopsies.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
A novel molecular mechanism has been discovered that underlies several genetic disorders, including MUC1 kidney disease, which results in a 'traffic jam' at the cellular shipping network. Researchers identified a compound called BRD4780 that can clear this traffic jam and prevent protein misfolding.
A recent analysis of US data over 20 years shows that children with kidney failure are being started on dialysis with higher levels of kidney function. Initiating dialysis at these higher levels is linked to lower patient survival, suggesting that asymptomatic children may benefit from delaying treatment.
A new AI/ML model developed at UC Davis Health can predict acute kidney injury in burn patients more accurately and quickly than traditional methods. The model achieved 90-100% accuracy for identifying AKI using just routine laboratory results, shortening diagnosis time by nearly a full day.
Researchers developed molecular imaging probes that can track changes in biological processes at the molecular level, detecting acute kidney failure up to 1.5 days earlier than current methods. The probes have high renal clearance efficiency and could be used as non-invasive test strips for urine samples.
Researchers have developed ultrasmall nanoclusters with antioxidative properties that can pass through the kidneys' filtration barrier to alleviate clinical symptoms of AKI. Selenium-doped carbon quantum dots also demonstrated effective treatment and prevention of AKI in mice by localizing in the kidneys and eliminating ROS.
A study found that older living kidney donors with hypertension had a higher risk of developing kidney failure within 15 years after donation. However, the absolute risk was relatively low. In contrast, hypertension was not linked to an increased risk of early death among older donors.
A restrictive approach to blood cell transfusions in heart surgery patients resulted in fewer transfusions without increasing the risk of acute kidney injury. The study found that reducing transfusions could prevent adverse effects and conserve the blood supply, while minimizing negative impacts on kidney health.
Researchers developed a new class of drugs to treat autosomal dominant polycystic kidney disease (ADPKD), a hereditary progressive disease causing cysts and kidney failure. The compound reduces levels of cyclic AMP, suppressing cyst growth and potentially controlling the disease.
Research supported by the Accelerating Medicines Partnership has provided new insights into tissue damage in rheumatoid arthritis and lupus. Novel molecular signatures have been identified in kidney cells and specific white blood cells may reflect their active role in disease process.
The VITALE study found that high-dose vitamin D supplementation significantly reduces fracture risk in kidney transplant recipients, with a lower incidence of fractures in the high-dose group compared to the low-dose group. The treatment was well-tolerated with no increased risks of adverse effects.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
A study found that one-fifth of US surgeons perform the less-recommended AV graft procedure too often, even when unnecessary. The research suggests that older, specialized surgeons are more likely to use this method.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
A large international clinical trial found that dulaglutide reduced cardiovascular events by 12% and kidney disease by 15% in people with Type 2 diabetes. The study, REWIND, followed over 9,900 participants for five years.
A new study published by University of Pittsburgh researchers found that removing excess fluid too quickly from critically ill patients with failing kidneys increases the likelihood of death. For every 0.5 milliliter increase in fluid removed per kilogram of patient weight per hour, risk of death increases.
UC researchers present findings from the Belatacept Early Steroid Withdrawal Trial (BEST), showing that belatacept can safely and effectively treat kidney transplant patients. The study demonstrates reduced side effects and cardiovascular risk reduction compared to traditional immunosuppressive regimens.
Researchers developed a gel-based delivery system to improve tissue regeneration in kidney injuries. The study found that the system could significantly enhance cell proliferation and survival, leading to rapid functional recovery.
Researchers have discovered that inhibiting two key proteins, ATM and ATR, can reduce BK polyomavirus levels in infected cells. This finding may provide an opportunity to use existing cancer drugs to combat the virus without reducing immunosuppressing drugs, which are needed to prevent transplant rejection.
Researchers at Wake Forest Institute for Regenerative Medicine have successfully engineered vascularized functional renal tissues using a novel biomimetic scaffold. The study's findings suggest that this approach may be a more feasible and practical treatment strategy for patients with chronic kidney disease.
A recent study by Drexel University researchers found that patients who lost significant weight before a kidney transplant had an 18% higher risk of death after the procedure. The study analyzed data from over 94,000 transplant recipients and found that even planned weight loss could be dangerous if not closely monitored.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
Researchers developed a new testing method using single-cell RNA sequencing to analyze individual cells in diseased organs, revealing genetic glitches that may allow for more effective treatment. The study found promising results in lupus patients and could potentially improve biopsy accuracy for other diseases.
Researchers have discovered a way to predict which patients with systemic lupus erythematosus (SLE) are most likely to respond to therapy by analyzing tissue samples from their kidneys and skin. This breakthrough could lead to personalized treatment plans for SLE patients.