Articles tagged with Kidney
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A recent study found that SARS-CoV-2 can induce kidney injury in patients, particularly those with high blood pressure and APOL1 gene variants. The virus triggers an inflammatory reaction, leading to collapsing glomerulopathy and tubular damage, even in the absence of direct viral infection.
A recent study found that hospitalized NYC COVID-19 patients had higher rates of kidney complications and needed mechanical ventilation more frequently than other patient groups. The study analyzed data from over 1,000 patients treated at NewYork-Presbyterian/Columbia University Irving Medical Center between March and April 2020.
A study found that SARS-CoV-2 infection led to renal Fanconi syndrome in 75% of hospitalized COVID-19 patients, characterized by proteinuria, phosphate loss, and increased uric acid excretion. The condition often preceded severe acute kidney injury, and intensive care patients were more frequently affected.
Researchers analyzed EMPA-REG OUTCOME trial data to investigate impact of initial 'eGFR dip' on kidney outcomes. Diuretic use and higher KDIGO risk category were predictive factors for 'eGFR dip', but no significant impact on risk reduction
Focal segmental glomerulosclerosis is a common cause of steroid-resistant nephrotic syndrome, which may progress to end-stage renal disease. Researchers found that the protein MafB plays a protective role in FSGS, with increased levels of MafB reducing kidney damage and nephrotic syndrome.
A recent study found that COVID-19 patients with kidney disease have a poor prognosis and increased risk of in-hospital death. The study also showed that the kidneys are a target organ for the virus, with viral load detected in renal tubules and glomerular cells.
A recent analysis found that kidney transplant patients are at a higher risk of death from COVID-19, with advanced age being the most significant factor. The study, conducted on ERACODA database, showed that 21% of kidney transplant recipients died within 28 days, compared to 25% of dialysis patients.
A new study found that patients with lower socioeconomic status and additional illnesses are less likely to be put on transplant waiting lists in the UK, despite universal healthcare. The study suggests that patient factors, such as age and health literacy, play a significant role in determining access to transplantation.
A unique microscope, called DIVER, uses phasor approach to fluorescence lifetime imaging (FLIM) to examine kidney tissue samples. The device can quickly analyze scarring in damaged kidneys, providing valuable insights for treatment decisions.
A novel technology that simulates human kidney functions could transform treatment options for those in the final stage of renal disease. The device, developed by University of Arkansas researchers, can filter blood and control chemistry using an electric field.
A new urine-testing system inspired by nature can identify metabolites that cause kidney stones to form, enabling patients to receive results within 30 minutes. The test is more cost-effective and simpler than current methods, making it a promising solution for managing urinary stone disease.
Researchers from University Hospital of Toulouse treated a severely ill patient with COVID-19 using tocilizumab, a biological agent targeting inflammatory cytokines. The patient showed dramatic improvement in respiratory outcomes, suggesting potential benefits for patients with the most severe forms of COVID-19.
A study examining factors affecting racial disparities before kidney transplantation found that socioeconomic status and comorbidities explain up to 58% of the disparity in listing. Black patients with kidney failure are more likely to be waitlisted than white patients, despite similar rates of transplant receipt.
Researchers have identified ROBO2 as a potential therapeutic target for treating kidney diseases, including glomerular diseases and chronic kidney disease. High ROBO2 protein levels are found in injured kidney models and can lead to reduced podocyte adhesion, making it a promising area of investigation.
Researchers have developed a non-invasive method to visualize damage in donor kidneys using photoacoustic imaging. This technique allows for accurate assessment of kidney scarring and can potentially revolutionize transplantation protocol by matching organs with patient life expectancy, reducing costs and improving outcomes.
A study of patients with glomerular disease and their caregivers reveals that they highly value kidney function, mortality, and need for dialysis or transplant. They also stress the importance of addressing factors related to life participation, fatigue, anxiety, and family impact.
Researchers at Rush University Medical Center found that high plasma suPAR levels are associated with worse lung outcomes and increased risk of intubation. The study suggests that measuring suPAR could help identify patients who may need ventilatory support, enabling earlier intervention and potentially improving outcomes.
Researchers developed a CRISPR-based diagnostic test that screens for cytomegalovirus, BK polyomavirus, and CXCL9 mRNA in urine samples to monitor kidney transplant patients. The assay is highly accurate even at low target concentrations, offering a promising alternative to traditional blood tests and biopsies.
A Yale-led study found that a cancer therapy drug can slow T cell infiltration and reverse damage in kidney tissue damaged by lupus. The findings suggest the therapy might be beneficial for patients with lupus nephritis.
A study from Kumamoto University predicts Alport syndrome severity by examining the causative protein genotype, providing a new tool for precision medicine. The researchers developed a system to analyze type IV collagen trimer formation and secretion, which helps identify pathogenic mutations and predict disease severity.
A study found housing insecurity is associated with a 3.2-fold higher odds of albuminuria, a sign of kidney disease, but not rapid kidney function decline. Housing insecurity was linked to delayed healthcare visits and compromised health in urban-dwelling adults.
A study of Southeastern US patients found that living far from a transplant center did not affect referral and evaluation initiation. Key findings indicate that other factors like travel time or transportation options may have a larger impact.
Kidney stone disease is associated with impaired lipid metabolism and downregulation of fatty acid-binding protein 4 (FABP) 4. FABP4 plays a key role in kidney stone formation and may be a therapeutic target for prevention.
A new study found that hospitalized pregnant women have a significantly higher risk of acute kidney injury (AKI), with black and Native American women at increased risk. The study also suggests that awareness and detection of AKI may be contributing to the rising rates of kidney damage in pregnant women.
A new study aims to identify molecular fingerprints of progressive kidney failure in patients with diabetes, while also exploring the development of targeted therapies. The Transformative Research in Diabetic Nephrology (TRIDENT) study is a $5 million collaboration between Penn Medicine and over 20 institutions nationwide.
A newly discovered blood marker has been linked to a patient's subsequent risk of kidney transplant failure in a study of 284 kidney transplant recipients. The composition of immune cells called CD8+ memory T cells 1 year after kidney transplantation was found to be a critical factor in predicting organ rejection.
Researchers found that young, first-time sugarcane workers with even slightly lower than average kidney function were at a greater risk for rapid onset of kidney injury. The study highlights the importance of routine blood pressure and renal function screenings for workers in high-risk occupations.
A recent study found that exposure to fine particulate matter is associated with a higher degree of albuminuria and a higher risk of developing chronic kidney disease. The study suggests that efforts to improve air quality may yield health benefits, including reducing rates of chronic kidney disease.
A new study published in NDT found that elderly patients (older than 75 years) who received kidney transplants from similarly aged donors remained dialysis-free for the rest of their lives. The study's results suggest that transplantation is beneficial for this age group, with excellent graft survival rates.
Researchers at SKI Vascular Center in Arizona have pioneered a minimally invasive procedure, Ellipsys, which provides easier access to a patient's bloodstream for dialysis treatments. The new technology shows promise in reducing complications and improving quality of life for patients with kidney failure.
Two studies demonstrate that penKid is the most accurate surrogate for assessing true GFR and predicting AKI in critically ill patients with severe burns. It can complement current diagnostic standard methods to provide timely diagnosis of impaired renal function.
Using HCV-infected donor kidneys can reduce average wait time for dialysis patients from four years to 1.56 years and improve quality of life. Patients receiving transplants with HCV-infected kidneys gain nearly 10 months in quality-adjusted life expectancy compared to those who waited longer.
Survival rates have improved significantly for children who received kidney transplants, with a 72% lower mortality risk among those transplanted later than earlier periods. This improvement is primarily attributed to reduced deaths from cardiovascular causes and infections.
A comprehensive evaluation of existing quality metrics for kidney disease reveals that less than half are highly valid, with nearly half related to dialysis management. The study proposes refinements and new metrics to better reflect the spectrum of kidney care delivery, aiming to improve the accuracy of quality measurement.
A study by Brigham and Women's Hospital researchers found that more than half of existing kidney disease quality metrics are of middle or low quality, which hampers efforts to improve patient care. The team advocates for shifting focus to metrics that matter most to patients and accurately reflect kidney health or disease progression.
Researchers at the University of Cincinnati are using APOL1 genotyping to identify high-risk African American donors and reduce their chances of developing kidney disease. The study aims to optimize the health of organ donors by protecting them from genetic factors that increase their risk of kidney disease.
Researchers find that free radicals produced by immune cells in the kidneys contribute to salt-sensitive hypertension. By targeting these ROS-producing immune cells, effective therapies may be developed to alleviate blood pressure and kidney damage.
Researchers at Case Western Reserve University have developed a new method to preserve donated kidneys using a drug that generates S-nitrosothiols, restoring flow-through and reducing resistance. This could extend the number and quality of kidneys available for transplant, saving more people with end-stage renal disease.
A recent analysis estimates that kidney transplant failure incurs significant medical costs of $78,079 per patient and a loss of 1.66 quality-adjusted life years. The total incremental lifetime costs are $1.38 billion, highlighting the urgent need for reducing graft failure rates.
Researchers have identified a new treatment target for preventing acute kidney injury, which affects up to 10% of hospitalized patients. High levels of soluble urokinase plasminogen activator receptor (suPAR) are linked to the risk of acute kidney injury, and reducing suPAR levels may help prevent damage to healthy kidneys.
Researchers have successfully isolated kidney stem cells from urine, expressing markers similar to bone marrow-derived mesenchymal stem cells and renal stem cell markers. The isolated cells can differentiate into various kidney cell types, including proximal- and distal-tubules and podocytes.
Scientists at the University of Freiburg created nanoparticles with polysaccharides, which allow them to pass through the kidneys and be excreted in urine. This breakthrough enables the combination of tumor accumulation and kidney clearance in a single nanoparticle, paving the way for safer nanomedicine administration.
Researchers have identified C4BP as a promising therapeutic agent for autoimmune kidney disease, showing improved symptomatology in mice with lupus nephritis. The study demonstrates the immunomodulatory capacity of C4BP, transforming proinflammatory activity into anti-inflammatory and tolerogenic effects.
The technique reduces waiting time for compatibility testing, improving transplant surgery scheduling and alleviating patient stress. Virtual crossmatching resulted in a 2.4-hour decrease in cold ischemia time and a 26% decline in delayed graft function.
A new study in 50 patients found that persistent mixed chimerism can reduce the reliance on immunosuppressive drugs after a kidney transplant. The treatment achieved immune tolerance and reduced rejection episodes, allowing some patients to survive with their donated kidneys for over eight years.
A new study found that high levels of soluble urokinase plasminogen activator receptor (suPAR) in the blood predict patients at increased risk of acute kidney injury. The protein may be a promising target for future therapies or interventions to prevent or treat AKI.
Recipients of kidney paired donation experience equivalent outcomes to those receiving kidneys from other living donors, with similar rates of organ failure and mortality. The study demonstrates the safety and effectiveness of national kidney paired donation programs in treating patients with incompatible living donors.
A study by University of Limerick researchers found that patients treated with PD had similar survival rates to those on in-centre HD, regardless of diabetes status or country of origin. The findings suggest that PD may be a more cost-effective and better quality-of-life option for patients approaching kidney failure.
High levels of protein in urine shortly after an episode of acute kidney injury are associated with increased risk of kidney disease progression. The study suggests that measuring urine protein levels can help identify patients at highest risk and guide appropriate referrals to reduce adverse health outcomes.
A low-cost test screening for excess protein in the urine accurately identifies patients at higher risk for progressive kidney disease after being hospitalized for acute kidney injury. Targeting treatment to these high-risk patients could reduce future need for dialysis or kidney transplants and save billions of dollars.
Research found subtle structural features of donated kidneys, such as scarring and hardening of vessels, are associated with shorter kidney lifespan after transplantation. These findings may help clinicians evaluate organ quality at time of donation and identify potential predictors of transplant failure.
Mayo Clinic researchers discovered subtle structural features in living donor kidneys that can predict transplant failure in recipients. These features include minimal scarring, hardening of vessels, and enlarged nephrons.
Biopsies from donated kidneys often show different results than initial readings, casting doubt on decision-making based on these findings. However, a second biopsy performed in standard conditions provided useful information about organ function after transplantation.
New statements from ACR and NKF clarify risk of contrast-induced acute kidney injury and provide recommendations for use of intravenous contrast media in patients with varying degrees of impaired kidney function. The authors emphasize the need for prospective controlled data to further understand the risk.
InDepth Pharmaceuticals has executed an option agreement to evaluate a novel diagnostic technique that can predict kidney transplant success in patients with focal segmental glomerulosclerosis (FSGS). The company aims to serve all 1 million FSGS patients worldwide and develop new therapeutics for other forms of kidney disease.
Researchers identified four ageotypes: metabolic, immune, hepatic, and nephrotic, which determine biological pathways in the body. The study also found that lifestyle changes can slow aging rates in some individuals.
Hemodialysis patients who used an online patient portal were more likely to receive a donor kidney transplant and reduce wait times compared to non-users. The study found that active users logged into the portal at least once every two months had shorter wait times for transplantation.
Hundreds of discarded deceased donor kidneys with acute kidney injury (AKI) can be successfully used for transplantation. This finding challenges current medical criteria and has the potential to significantly increase the organ donor pool, helping to address the growing shortage of available kidneys for transplant.
A new study found that higher adherence to the Mediterranean diet is associated with a lower risk of kidney function decline and failure in transplant recipients. Those with higher Mediterranean Diet Scores experienced 29% less risk of function loss and 32% less risk of failure.
Researchers at Mayo Clinic tested a new injection method for delivering gene therapy vectors directly into the kidney, outperforming traditional intravenous injections. The study found that direct injections were superior to intravenous injections and had fewer off-target effects.