Scientists developed a novel quantum sensor that can detect oxidative stress in organs during MRI scans, which could lead to early diagnosis of diseases like cancer and kidney dysfunction. The sensor uses a ring-shaped sugar-like compound and nitroxide derivatives to identify reduced cell/tissue capacity.
Tuberous sclerosis complex (TSC) affects millions worldwide, causing cysts and benign tumors to form in the kidney, leading to kidney failure. Researchers led by Dr. Manoocher Soleimani found that changes in cells lining the collecting ducts are responsible for cyst formation, offering new avenues for potential treatments.
A recent study published in Nature Communications has uncovered the biomedical basis of the Barker hypothesis, which suggests that infants with low birth weight are at increased risk of cardiovascular diseases and kidney disorders. The research team discovered that fetuin-A, a serum protein, plays a crucial role in fetal protective mec...
Researchers at Flinders University have discovered a new role for fibrinogen in reducing inflammation and protecting against disease. Fibrinogen's ability to neutralize harmful chemicals like hypochlorite could lead to new biomarkers and therapies for kidney, heart, and other diseases.
Research highlights subtle racist undertones in kidney function reporting, which may perpetuate biological basis for race. Physicians and scientists have a moral obligation to address historical practices rooted in racist ideology.
The study found that racial disparities in kidney transplantation persist despite advances in the field. Blacks are more likely to develop kidney failure but less likely to undergo transplantation, particularly from living donors.
A new study from researchers at the Geisel School of Medicine at Dartmouth has found that skin exposure to ultraviolet (UV) light can trigger inflammatory processes in the kidney, even in normal, healthy mice. This subclinical injury may lead to pathologic consequences in lupus patients and worsen their clinical symptoms.
A University of Houston researcher has identified the suPAR protein as a potential therapeutic target for treating focal segmental glomerulosclerosis (FSGS), a common form of kidney disease. High circulating levels of suPAR have been shown to induce oxidative stress in the kidneys, leading to cell damage and kidney failure.
A mutation in the gene KCTD1 leads to kidney defects that can cause metabolic bone disease. The study reveals KCTD1's critical role in regulating electrolyte balance in the distal nephron.
Researchers at the University of Birmingham have discovered a biological imbalance between free radicals and antioxidant cells that links gum disease to chronic kidney disease. A 10% increase in gum inflammation reduces kidney function by 3%, highlighting the importance of periodontal care for patients with chronic kidney disease.
Researchers found that stopping RAS inhibitors reduced the risk of requiring dialysis but increased the risk of cardiovascular events and death. The study suggests that doctors must carefully weigh the benefits and harms of these medications in patients with advanced CKD.
A virtual telehealth platform allows patients to undergo comprehensive evaluation for kidney transplantation from the comfort of their own homes. This innovative approach has enabled the Medical University of South Carolina's transplant program to maintain access to life-saving surgeries despite pandemic restrictions, with over 282 pat...
The ADQI consensus statement recommends using a combination of damage and functional biomarkers to manage Acute Kidney Injury (AKI). Proenkephalin penKid is proposed as a marker for assessing AKI progression and kidney recovery, with CE-IVD marked assay available for point-of-care usage.
A new study found that US kidney biopsies don't add value beyond standard donor and recipient characteristics in predicting survival. Many discarded kidneys would likely benefit US patients awaiting a transplant, with some matching transplantation outcomes in Europe.
A new study analyzing federal data reveals COVID-19 is associated with an increased need for ventilators, longer hospital stays and nearly five times the risk of death than the flu. The research also found COVID-19 can damage other organs, increasing the risk of complications such as kidney and liver damage.
A US study finds that many donor kidneys are discarded due to low-quality tissue, yet can function acceptably when transplanted. The study suggests that procurement biopsies add little value and may even reduce the supply of available kidneys.
A single-center retrospective study found that 1-year kidney transplant outcomes are similar for HCV-negative recipients from HCV-positive or negative donors. The results suggest that transplantation of kidneys from HCV-infected donors to HCV-negative recipients is a viable option.
Researchers developed a new model to predict kidney function in cancer patients, enabling more accurate chemotherapy dosing and minimizing harm. The model takes into account various factors like age, gender, and body mass index, providing clinicians with a valuable tool for guiding treatment decisions.
A clinical trial found that combining Verinurad and Febuxostat reduces albuminuria in Type 2 diabetes patients by 39.4%, a significant reduction in protein leakage through the kidney. The treatment combination also lowers uric acid levels by 57%.
A University of Houston team found that the new C-diff guidelines are fourfold more predictive in identifying patients likely to die during hospitalization. The revised severity assessment allows doctors to tailor treatment accordingly, improving patient outcomes.
A new study published in Science Advances found that a drug called phenylbutyrate can help cells clear herpes simplex 1 and 2 viruses. When used in combination with acyclovir, the drug combo is more effective and reduces side effects associated with long-term use of acyclovir.
A large prospective study found a link between kidney injuries and cognitive impairment in children with diabetic ketoacidosis. The study suggests that the presence of acute kidney injury is associated with lower IQ scores and subtle cognitive impairment.
A new study from Harvard Medical School forecasts the impact of eliminating race from kidney function formulas on Black patients with kidney disease. The analysis suggests that removing race-based adjustments may lead to earlier diagnoses and better access to care, but also restricts access to certain medications and treatments.
Researchers at Kumamoto University found that mild electrical stimulation with heat shock reduces inflammation and cell death in the kidneys, improving kidney function and preventing proteinuria. The treatment also inhibits apoptosis of kidney cells and activates survival pathways, offering a promising new approach for treating nephrot...
Researchers use single-cell RNA sequencing to analyze kidney cells' gene expression, enabling the reconstruction of their spatial arrangement and functional information. The algorithm succeeds in completing a 3D puzzle, providing new insights into kidney disease.
Australian researchers discovered a protein that protects kidney cells from 'bystander' damage caused by chemotherapy or radiotherapy. The study found that inhibiting BCL-XL could safely use in laboratory models alone or with other cancer therapies to prevent kidney damage, a common side effect of cancer treatments.
A recent analysis found that Accountable Care Organizations (ACOs) may reduce the cost of medical care for patients undergoing dialysis. The study discovered modest cost savings for Medicare beneficiaries in ACOs, especially those who received regular primary care physician visits.
Researchers have successfully bioprinted miniature human kidneys in a lab using cutting-edge technology. The study validates the use of 3D bioprinted human mini-kidneys for screening drug toxicity, paving the way for new treatments and potentially lab-grown transplants.
Acute kidney injury (AKI) is common among hospitalized US veterans with COVID-19, with nearly half not fully recovering their kidney function. The burden of death from AKI is disproportionately borne by Black veterans.
Patients with chronic kidney disease can proactively manage their health by receiving tailored guidance on diet and lifestyle. Effective communication with doctors and strong family support are also crucial in empowering patients to take a more active role in their care. This study highlights the importance of clearer information, bett...
A new study published in the American Journal of Transplantation shows that simultaneous robotic-assisted kidney transplant and weight loss surgery is safe for obese patients. The procedure resulted in a significant reduction in surgical complications and improved cardiac function, with all patients experiencing a substantial weight loss.
A new equation for estimating glomerular filtration rate (GFR) shows improved accuracy and precision compared to commonly used equations. The European Kidney Function Consortium's (EKFC) equation addresses limitations of existing methods and is suitable for a wide age range.
A unique biomarker combination predicts Acute Kidney Injury (AKI) in critically ill children, enabling early identification and potential pre-emptive therapy. The study found that a combination of clinical scores and urinary markers can accurately predict severe AKI in PICU admissions.
Combination therapy of verinurad and febuxostat significantly lowers urinary albumin excretion and uric acid levels in people with chronic kidney disease and type 2 diabetes. The treatment is generally well-tolerated, with minimal adverse events reported.
A six-month mass media campaign, Living Donation Storytelling Project, aims to capture 500 living donor kidney transplant (LDKT) stories, educating medical providers and patients about innovative resources. The project uses digital storytelling to supplement traditional education practices, allowing real people to share their experiences.
Social determinants like discrimination, depression, and mistrust predict patient-reported quality of life in kidney transplant patients. Lower medical mistrust leads to greater patient satisfaction with clinical services.
A study analyzing 60,229 patients found that Black patients are less likely to be referred for transplantation and more likely to receive a transplant after referral, but ultimately less likely to receive a transplant overall. Racial disparities in the transplant process emerge at listing stage and persist through organ allocation
A new AI-based algorithm can predict which hospitalized patients with COVID-19 are at risk of developing acute kidney injury (AKI) requiring dialysis. The model achieved high accuracy using data from over 3,000 patients and key features such as creatinine and potassium levels, age, and vital signs.
A new machine learning-based model predicts atrial fibrillation risk in chronic kidney disease patients, providing a potential tool for enhanced cardiovascular care and clinical trial selection.
Recent clinical trials have shown promising results for finerenone, which slows diabetic kidney disease progression and reduces cardiovascular events when added to standard care. Empagliflozin also demonstrated benefits in patients with heart failure and chronic kidney disease. These findings suggest new treatment options for patients ...
A study found that online peer mentoring for individuals with chronic kidney disease (CKD) improves patient activation, which is positively correlated with various aspects of quality of life. Improved patient activation correlates with improvements in physical symptoms and burdens of kidney disease but not mental aspects.
A new study examines the risk of acute kidney injury among Black individuals with sickle cell trait and disease, finding a higher risk for acute kidney injury and faster loss of kidney function. The study adds important information to sparse data on the risk of acute kidney injury in those carrying the sickle cell gene.
A new study found that Blacks and Hispanics experience higher rates of kidney failure compared to whites, driven by faster declines in kidney function after chronic kidney disease onset. This disparity can be addressed by slowing the progression of kidney disease in these populations.
A new study found that similar molecular processes are activated in diabetic kidney disease and COVID-19 patients, making them more susceptible to infection. The research suggests that diabetes primes kidney cells, which can lead to a severe immune response and kidney damage when combined with COVID-19.
ERA-EDTA has launched a series of e-seminars to apply recent trial findings to patient care. The e-seminars focus on topics like SGLT2 inhibitors and COVID-19, aiming to provide nephrology experts with insights into the benefits and risks of new treatments.
A new AI-based tool can help clinicians predict which hospitalized patients are at high risk of developing acute kidney injury, allowing for earlier treatment and potentially better outcomes. The Dascena algorithm outperformed the standard method in predicting AKI 72 hours prior to onset.
A research team discovered molecular processes in kidney cells that attract and feed COVID-19, making them a target for potential therapies. The study identified networks of molecules that result in higher levels of ACE2, a protein on the surface of kidney cells that aids in virus entry and activation.
A clinical trial published in the New England Journal of Medicine shows that finerenone significantly slows the progression of diabetic kidney disease by 18% compared to a placebo. The study also found a reduction in cardiovascular event rates, offering new treatment options for patients with chronic kidney disease and type 2 diabetes.
Glomerular diseases significantly increase the risk of cardiovascular disease, affecting blood cleaning units in the kidneys. A study analyzing 2000-2012 data found a 2.5-times higher risk compared to the general population.
Higher serum creatinine-to-cystatin C ratios are associated with lower mortality rates in patients initiating continuous renal replacement therapy for acute kidney injury. This simple tool may improve mortality risk assessment in critically ill patients developing AKI.
Researchers analyzed 1,347 nephrectomy specimens to understand kidney histopathological findings. They found that more scarring in glomerulus, tubules/interstitium, and vessels is associated with worse kidney function.
The MDI Biological Laboratory has received a grant to develop artificial kidney tissue to replace human kidney tissue lost due to disease or injury. The project aims to create a three-dimensional mini-organ called an organoid that can be transplanted into a host and potentially scaled to create an artificial human kidney.
Researchers found that patients with chronic kidney disease (CKD) or acute kidney injury (AKI) due to COVID-19 had significantly higher mortality rates in intensive care, with mortality rates ranging from 21% for those without kidney injury to 86% for patients with kidney transplants. The study highlights the need for calibration of IC...
Researchers found that using the race multiplier correction factor for Black patients with chronic kidney disease can lead to delayed referrals and critical conversations about dialysis. Removing this factor could reclassify up to one-third of Black patients to a more severe stage of CKD.
Dr. Adebiyi's research investigates newborn kidney functions and their alterations in acute and long-term disease, with a focus on growth-restricted infants. The new $3 million grant will explore the cellular mechanisms underlying progressive kidney insufficiency in these babies.
Researchers identify key risk factors for acute kidney injury (AKI) in patients with intracerebral hemorrhage (ICH), including higher baseline serum creatinine levels and higher doses of nicardipine, which increase the risk of AKI and death within three months
A Mayo Clinic study found that patients with large polycystic kidneys can have their diseased kidneys removed laparoscopically at the same time as a kidney transplant, without compromising kidney function. The dual surgery approach has been shown to be a safe and viable option for these patients.
A new study from Boston University School of Medicine found that an alpha adrenoceptor blocker may treat salt-sensitive hypertension by reducing a kidney mechanism that reabsorbs salt. This approach shows promise in treating high blood pressure associated with dietary salt intake.
A team of researchers from Osaka University has identified the crucial role of lipids, lysosomes, and autophagy in preventing kidney injury. By understanding how calcium, lipids, and lysosomal degradation interact, scientists can develop new treatments for kidney damage caused by crystal-induced injuries.
Researchers at UNSW Science discovered a new molecular pathway that controls Shiga toxin production in E. coli, which could lead to the development of drugs suppressing toxin production during infections. The study's findings provide a potential breakthrough for treating severe E. coli infections.