Articles tagged with Kidney
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Researchers found that new direct airline routes can significantly increase the number of kidneys shared between regions, with a potential increase of over 7%. The study also showed that this increase in kidney sharing does not come with a decrease in kidney quality.
A recent study published in CJASN found that patients with kidney failure did not report better experiences with care from more frequent face-to-face visits with kidney specialists. In fact, more frequent visits were linked to slightly lower patient-reported experiences with kidney-related care.
A new study found that intensive blood pressure-lowering therapy may harm patients with decreased kidney function after a stroke, whereas those with normal kidney function showed similar outcomes. The study suggests considering renal function when deciding optimal blood pressure ranges for each patient.
Researchers discovered 47 lipids significantly different between rapid and slow kidney function decliners, providing a platform for risk stratification. The study's findings also suggest the underlying mechanism of progressive kidney disease, which could be a future target for therapeutic intervention.
Researchers identified three proteins - FGF20, ANGPT1, and TNFSF12 - that offer protection against progressive kidney decline in diabetes patients. Elevated levels of these proteins were found to reduce the risk of end-stage renal disease.
A longitudinal study of 358 diabetics found that proteins ANGPT1, TNFSF12, and FGF20 are associated with slower kidney decline. These proteins may help identify individuals at higher risk of diabetic kidney disease, enabling earlier interventions and treatment.
Researchers at IU School of Medicine have made a breakthrough in treating and preventing kidney infections by utilizing the kidneys' own internal infection-fighting capabilities. The study found that intercalated cells can consume bacteria and secrete acid, offering a potential alternative to antibiotics.
Researchers examined family voucher-based kidney donations and found that timely kidney transplants are possible through voucher redemption. The study aims to provide a new option for individuals waiting for a transplant, improving outcomes for those in need.
Research led by University of Bristol scientists has shed light on the camel's kidneys, revealing a key role in helping it cope with dehydration and rapid rehydration stresses. The study suggests that cholesterol levels play a crucial role in water conservation, allowing camels to produce highly concentrated urine and minimize water loss.
Researchers found that damaged proximal tubule cells can promote disease progression by showing activity in genes that support survival and programmed cell death. These cells may contribute to the transition from acute to chronic kidney disease, affecting 9.1% of the world's population.
A new study highlights the high risk of kidney failure and cardiovascular complications in patients with primary nephrotic syndrome, particularly those with focal segmental glomerulosclerosis. Adults with this condition are 19.63 times more likely to develop kidney failure over a median follow-up period of 4.5 years.
Patients waiting for a kidney transplant who experienced various symptoms had a higher risk of dying while on the waitlist. However, those who underwent transplantation saw an improvement in symptoms, with overall 10% reduction and significant declines in fatigue and itchy skin.
A new study reveals that many patients with high-priority kidney transplants are not being placed on the transplant waiting list, despite having long expected post-transplant survival. African Americans, uninsured individuals, and those living in lower-income communities face significant barriers to expedited waitlist placement.
A study published in Hypertension reveals that vasopressin receptor stimulation leads to the short-term secretion of uromodulin into the urine in mice. Higher levels of uromodulin are associated with lower rates of urinary tract infections and kidney stones.
Scientists at USC have created rudimentary kidney structures, known as organoids, that resemble the collecting duct system. These organoids can be used to study kidney disease and test potential therapeutic drugs.
Researchers discovered that zinc slows down calcium oxalate crystal growth while also altering surfaces, creating defects for new crystals to form. The study offers a resolution to conflicting theories on zinc's role in kidney stone formation.
A study by National University of Ireland Galway found that nearly half of adults with diabetes attending a dedicated clinic have signs of established chronic kidney disease. The research suggests that careful medical management is not enough to prevent the development of kidney disease in people with diabetes.
Researchers found that COVID-19 virus can enter and replicate in human kidney cells, but does not typically cause cell death. However, infected cells with pre-existing injury are more susceptible to additional damage.
A new study reveals that COVID-19 vaccination leads to strong T cell responses against the virus in all patients on dialysis, and nearly 58% of kidney transplant recipients. However, low antibody responses were observed in kidney transplant recipients, raising concerns about their protection from COVID-19.
Researchers found dapagliflozin reduced the risk of progressive kidney disease by half in FSGS patients over a 2.4-year period, with good tolerability and safety. The medication stabilizes renal function and improves clinical outcomes in patients with type 2 diabetes and concomitant kidney damage.
Researchers found COVID-19 causes a wide range of organs, including the kidneys, resulting in acute kidney injury (AKI) with significant mortality rates. Studies showed viruses were directly detected in kidneys of deceased patients, correlating with age and comorbidities.
Studies have shown that COVID-19-associated nephritis can predict disease severity and mortality, while early signs of kidney involvement are associated with worse outcomes. Chronic kidney disease is a risk for some patients, particularly those who experience acute kidney injury (AKI), which may not recover fully.
Climate change is linked to environmental factors causing 24% of global deaths, including chronic kidney disease and acute kidney injury. The healthcare sector contributes to climate crisis, producing 4.4% of the global carbon footprint. Nephrologists play a crucial role in addressing climate change.
SGLT2 inhibitors like gliflozins reduce the risk of progressing to end-stage kidney disease in both diabetic and non-diabetic patients. The kidneys produce less erythropoietin as a result, which reduces anemia, resulting in reduced renal endpoint, cardiovascular events, and mortality
A recent study led by Kyushu University reveals that chronic kidney disease induces heart inflammation through dysfunctional white blood cells. The researchers found that elevated levels of vitamin A disrupt the circadian clock in these cells, leading to increased expression of a protein called GPR68.
A study of 4,763 individuals found that those with frequent depressive symptoms were more likely to experience rapid kidney function decline over a median follow-up period of 4 years. The study suggests that high depressive symptoms may be an important modifiable risk factor for chronic kidney disease.
Researchers map kidney stone formation from tiny to troublesome, revealing microspherules merge to form larger crystals, and stones undergo multiple cycles of partial dissolution and growth. The new classification scheme and GeoBioCell device aim to accelerate research, diagnostic testing, and individualized treatment targets.
A novel AI tool predicts the grade of interstitial fibrosis and tubular atrophy in kidney biopsies, a known structural correlate of progressive and chronic kidney disease. This technology has the potential to increase efficiency in clinical practices.
Scientists at Medical College of Georgia are working on a synthetic version of the HLA-G molecule to protect transplanted kidneys from rejection. They hope this therapy will enable dose reduction of standard immunosuppressive drugs, reducing the risk of infections and other medical problems.
Researchers at the Francis Crick Institute have discovered how lipid droplets in kidney cells help prevent damage from excess dietary fats. The study found that lipid droplets act as a safe haven for storing excess fats, and boosting the ATGL enzyme can repair damage caused by a high-fat diet.
Researchers found that finerenone reduced the risk of atrial fibrillation by 30% in patients with chronic kidney disease and Type 2 diabetes, regardless of their history with AFib. The study suggests that finerenone can delay the onset of heart rhythm disorder and protect the heart and kidneys from further damage.
Eliminating race-based adjustments in equations to estimate kidney function may lead to significant changes in medication prescribing practices for Black adults, according to a new study. The findings suggest that this change could result in lower eGFR values and potentially impact treatment outcomes for diabetic patients.
A new study led by Kotaro Sasaki elucidates the early biological processes involved in the development of ovaries and testes in human embryos. Researchers analyzed single-cell transcriptome data to understand gene expression at each developmental stage, providing insights into typical and atypical gonadal development.
Researchers found that people with reduced kidney function have an increased risk of developing dementia, with those with moderate chronic kidney disease having a 71% higher risk. The study highlights the importance of identifying and treating cases of kidney disease to reduce the risk of dementia.
A large observational study by Karolinska Institutet researchers found a clear link between poor kidney function and increased risk of dementia. The study of over 325,000 individuals suggested that an eGFR score of 30-59ml/min was associated with a 71% increased risk of dementia.
A recent study published in PLOS ONE found that low-protein intake during pregnancy can lead to a significant decrease in the number of nephrons in offspring, resulting in hypertensive effects and kidney damage. The researchers discovered this effect by analyzing microRNA expression in rat embryos fed with a low-protein diet during ges...
A team led by Iain Drummond, Ph.D. has identified the signaling mechanisms underlying podocyte formation, a crucial process in kidney function. The discovery could lead to new therapies to stimulate regeneration of these cells, vital for ridding the body of toxins and treating conditions like chronic kidney disease.
Researchers studied age-related changes in kidney function, combining protein analysis with gene transcription. They found that aging kidneys have increased immune cells, inflammation, and decreased mitochondrial energy production. This suggests that therapies promoting protein building or slowing breakdown may help treat age-related k...
Researchers at UniSA identified an enzyme, NEDD4-2, that regulates sodium reabsorption in kidneys. Low levels of the protein are linked to chronic kidney disease progression, even without high blood pressure.
A pharmacist-led smartphone app has been shown to significantly improve medication safety and reduce hospitalizations in kidney transplant recipients. The study found that participants who used the app were 61% less likely to experience medication errors and 45% less likely to experience serious side effects.
A simple device improved care after kidney transplantation by reducing swelling, hospital stays, and surgical site infections. Patients experienced a 31% reduction in swelling and a 60% decrease in wound infection rates.
A new algorithm developed by researchers at Columbia University can automatically scan electronic medical records for signs of chronic kidney disease, alerting physicians to patients in the earliest stages. The algorithm performs nearly as well as experienced nephrologists, correctly diagnosing kidney disease in 95% of identified cases.
A new study finds that prolonged exposure to extreme heat and humidity increases the risk of acute kidney injury. The risk was found to be highest when environmental conditions outpaced the body's ability to cool itself without access to cooling and hydration measures.
Researchers have discovered a compound found in some vegetables that may help reverse kidney problems associated with diabetes. Phenethyl isothiocyanate (PEITC) has been shown to target multiple pathways involved in diabetic nephropathy, including inflammation and oxidative status.
Researchers have found a link between certain blood types and increased risk of diseases such as kidney stones, pregnancy-induced hypertension, and bleeding conditions. A study scanning health data on over five million people revealed new connections and confirmed previously reported associations.
A study by Tokyo Medical and Dental University identified thick tubular basement membrane duplication as a diagnostic criterion for adult-onset NPH. The research also found that older patients are unlikely to have pathogenic mutations, providing a novel diagnostic pointer.
A recent study found that etelcalcetide slowed FGF23 levels and left ventricular mass growth by 6-8% in dialysis patients. The treatment could potentially reduce sudden cardiac death risk in this population with high cardiovascular risk.
A pilot trial found that the 'Sit Less, Interact, Move More' intervention decreased sedentary time, increased stepping time, and boosted step counts in patients with moderate-to-advanced CKD. However, these benefits were not sustained over 20 weeks. The study suggests that additional interventions may be needed to sustain long-term eff...
Researchers at Kumamoto University discovered that metformin prolongs survival of mice with non-diabetic chronic kidney disease by reducing kidney function and inflammation. The study suggests that a combination of metformin and losartan may be beneficial for patients with ND-CKD.
A Mayo Clinic study found that pregnancy significantly increases the risk of a first-time symptomatic kidney stone. The risk peaks close to delivery and improves by one year after delivery.
Researchers developed a two-pronged approach targeting cancer progression and cell destruction, leveraging cathepsin S and p21 BAX proteins to treat kidney cancer. The novel peptide CS-PEP1 inhibits these proteins, encouraging cancer cell death and overcoming molecular resistance found in conventional chemotherapy treatment.
Researchers found that a chemical modification of RNA, influenced by diet, plays a key role in polycystic kidney disease. Limiting methionine in the diet may partially control cyst formation, and identifying chemicals that stem Mettl3 activity may lead to new drug treatments.
The ASN and NKF publish an interim report assessing alternative methods to diagnosing kidney diseases, highlighting the need for a standardized approach. The task force recommends replacing existing equations with a new method that is accurate, representative, and unbiased.
The study reveals that COVID-19 hospitalizations peaked between March 22 and April 25, with rates 40 times higher than in the general population. Patients undergoing dialysis had a 17% increase in death rates compared to 2017-2019 rates.
Patients with kidney failure who cycled during dialysis showed improved heart health, including reduced scarring and stiffness of major blood vessels. The study found significant savings in healthcare costs, potentially benefiting the NHS.
A new study from USC reveals the importance of β-catenin in striking a balance between stem cell self-renewal and differentiation into kidney cells. High levels of β-catenin trigger a switch that directs progenitor cells to differentiate into specialized kidney cells.
Researchers developed a new tool to capture patients' opinions on home dialysis care, highlighting the importance of communication and care coordination. The Home Dialysis Care Experience instrument will be valuable for future research, clinical care, and quality improvement initiatives among home dialysis facilities.
A study found that nearly 20% of patients with antibiotic-loaded spacers and IV antibiotics developed acute kidney injury, with those with preexisting chronic kidney disease at highest risk. The study identified several risk factors for AKI, including high doses of antibiotics and certain heart rhythm disorders.
The Acute Kidney Injury Project aims to develop improved predictive and detection tools for kidney injury, addressing a global public health concern. The project will focus on developing prognostic tools to identify drug-induced kidney injury, with the goal of improving patient safety during clinical trials and advancing drug development.
A team of researchers led by Professor Alexander Meyer has created an early warning system for intensive care units (ICUs) using big data and artificial intelligence. The system predicts postoperative bleeding and acute kidney injury with high accuracy, allowing timely interventions to save lives.