Articles tagged with Kidney
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The University of Maryland School of Medicine has been awarded a $6.5M grant to develop a treatment for alcoholic liver disease-associated kidney dysfunction. The Institute of Human Virology and MitoPower will conduct clinical trials to test the safety and efficacy of MP-04, a lead compound in treating HRS.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
Children in UK and Ireland diagnosed with larger kidney cancers, leading to late diagnosis and potential poorer outcomes. A call for frontline healthcare workers to be trained in paediatric medicine has been made to improve early detection.
Researchers created novel frog models to replicate polycystic kidney disease, allowing for real-time observation of disease processes. AI analysis enabled rapid assessment of disease in the tiny animals.
A new study examines why people object to bodily markets, revealing that both liberals and conservatives consider these markets morally wrong due to different reasons. Liberals believe commercialization can be exploitative, while conservatives view it as violating the sanctity of the human body.
New research identifies coffee metabolites that may affect kidney disease risk, with some associated with higher risks of chronic kidney disease. The study found 3 metabolites linked to increased CKD risk: glycochenodeoxycholate, O-methylcatechol sulfate, and 3-methyl catechol sulfate.
Researchers discovered that spiny mice can regenerate severely damaged kidneys without scarring, a process triggered by unique transcriptional programs in their genome. This finding offers new hope for treatments of end-stage kidney disease and fibrotic diseases.
A new study improves AI diagnoses by penalizing algorithms for false negatives, which can be more urgent than accuracy. Researchers achieved significant improvements in precision and recall for chronic kidney disease and other conditions using cost sensitivity techniques.
Researchers found that certain urinary biomarkers, including neutrophil gelatinase-associated lipocalin and kidney injury molecule-1, were associated with increased risk of severe acute kidney injury or death in patients hospitalized with COVID-19. These biomarkers may help identify patients at high risk for adverse kidney outcomes.
A targeted drug, cabozantinib, has shown activity against brain metastases from kidney cancer, achieving a 50% response rate. The drug's ability to reach the brain through the blood-brain barrier offers a promising systemic option for patients with poor life expectancy and intervention tolerability.
A new four-year study identifies appropriate ethical and policy guidance for translational xenotransplantation kidney clinical trials. The research team will develop recommendations and decision aids for transplant candidates, clinicians, and institutional review boards reviewing xenotransplantation protocols.
A team led by NYU Langone's Robert Montgomery successfully transplanted a genetically engineered pig kidney into a human body, marking a major step forward in xenotransplantation. The procedure, performed on September 25, 2021, used a GalSafeTM pig with the alpha-gal biomolecule removed to avoid rejection.
A research team from the University of Zurich has identified a common genetic variant in the AQP1 gene that affects treatment efficacy and patient survival on peritoneal dialysis. Patients carrying this variant have a higher risk of death, but researchers found a way to circumvent the problem using colloid osmotic agents.
A new study found that racial and ethnic disparities in pediatric kidney transplantation decreased significantly after the implementation of the Kidney Allocation System in 2014. The study showed no racial disparities in waitlist time until transplantation before or after the policy change, but disparities remained for time on dialysis...
A new study published in Mayo Clinic Proceedings found that patients with acute kidney injury who receive continuous renal replacement therapy (CRRT) have a high incidence of needing CRRT reinstitution after removal. This contributes to poor 90-day outcomes. Successful CRRT liberation is marginally associated with fewer major adverse k...
Researchers found that females rely more heavily on aldosterone to regulate blood pressure, whereas males primarily use angiotensin II. This discovery could lead to targeted treatments for female hypertensive patients, improving treatment outcomes and reducing the risk of heart disease and stroke.
A new protocol combining patient monitoring and monoclonal antibody therapy reduced hospitalizations by half and deaths to zero for eligible patients. The study, conducted at Keck Medicine of USC, shows improved outcomes among liver and kidney transplant recipients with COVID-19.
A new study found that the COVID-19 pandemic led to a 30% decline in patients seeking treatment for kidney failure, with Black patients experiencing significantly worse kidney function. The decline was attributed to changes in healthcare delivery and may reflect delays in treatment due to fear of infection or logistical barriers.
A plasma biomarker panel identified a combination of sTNFR1, sTNFR2, cystatin C, and eGFR that discriminated between patients with worsening or low risk of chronic kidney disease after three years. This combination was particularly effective at identifying those with very low risk of subsequent kidney dysfunction.
A national review of nocardia infection in kidney transplant patients found that those with compromised immune responses are more vulnerable to the opportunistic agent. Nocardiosis can lead to pneumonia and brain abscess, and screening is crucial, especially in combination with pneumonia symptoms.
A survey of US transplant centers found a consensus to remove race-based adjustments from kidney function calculations, but also acknowledged potential harms of dropping the adjustment. The study aims to reduce healthcare disparities and improve patient care.
An analysis of Medicare's Comprehensive ESRD Care Initiative found that factors like leaner operations, organizational experience, and community resources contribute to successful performance. The study aims to inform healthcare providers and policymakers in developing value-based payment models for kidney care.
The National Kidney Foundation has released a research roadmap to accelerate innovations in treatment and increase understanding of kidney disease. The report calls for increased funding in preclinical science, genetics, health equity, and implementation science to tackle the most vexing challenges in kidney disease.
A new patient decision aid developed by Duke-NUS Medical School's experts empowers patients with ESKD to choose care strategies consistent with their values and goals. The tool provides a balanced overview of dialysis, kidney supportive care, and other treatment options.
Researchers at Medical University of Vienna discovered that lithium chloride can reduce peritoneal thickening, fibrosis markers, and αB-crystalline expression in mesothelial cells. This innovative solution aims to preserve the peritoneum for longer, allowing patients to live a normal life or wait for a transplant.
Research provides insights on immune responses of kidney transplant recipients following SARS-CoV-2 infection. The study found that production of IgG antibodies against the virus was delayed in these individuals, but their IgM and IgA responses were similar to those observed in non-transplant individuals.
The study reveals that SARS-CoV-2 damages the kidneys by interacting with ACE2, leading to an imbalance in blood pressure regulation and inflammation. This can result in impaired kidney function, reduced glomerular filtration rate, and increased risk of acute renal injury.
A recent analysis found a large increase in deaths among susceptible individuals, including minorities, due to COVID-19. The study highlights the vulnerability of kidney transplant recipients and those with kidney failure to severe illness from the virus.
A team of researchers has developed a low-cost and low-waste device that uses Tootsie Roll candy as an electrode to monitor ovulation status or kidney health. The sensor works by detecting changes in salt levels in saliva, with preliminary tests showing promising results.
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
A national task force endorses a new diagnostic equation for measuring kidney function, which removes racial data to increase access to transplantation for Black patients. The recommendation is supported by Penn Medicine research and aims to reduce disparities in healthcare.
A study by Brigham and Women's Hospital researchers found that higher-rated dialysis centers have a 47% higher likelihood of patients being listed for kidney transplantation. The integration of waitlisting rates into quality metrics aims to incentivize greater referral rates and improve facility quality.
A BfR study confirms that perfluorobutanoic acid (PFBA) does not accumulate excessively in human lung and kidney tissue. Only one sample contained a measurable PFBA value, supporting the conclusion that PFBA is unlikely to cause health problems.
Researchers at Kaiser Permanente identified a blood cystatin C test as an alternative to estimate kidney function, eliminating the need for racial considerations. The study showed that this approach produces similarly accurate results and may promote equity for people of all racial and ethnic backgrounds.
Researchers propose reinstating waiting time for recipients experiencing early post-transplant allograft failure within an expanded timeframe to boost transplant numbers. This policy change could potentially reduce the perceived patient-level risk of transplanting marginal organs and improve organ utilization.
A serum biomarker, polyubiquitinated phosphatase and tensin homolog (PTEN), was associated with a four-fold higher risk of kidney function decline. This modified form of PTEN was linked to severity of lesions in kidney structure, indicating early manifestations of diabetic kidney disease.
Sandrine V. Pierre, a Marshall University researcher, has received a $1.36 million NIH grant to study the regulatory mechanism of salt handling by the kidney and its impact on cardiovascular function.
Research reveals a significant decline in kidney function among COVID-19 long-haulers and even those with mild infections. The study highlights the critical need for paying attention to kidney function and disease in caring for patients who have had COVID-19, as kidney problems can be silent and untreated until it's too late.
A new global study found a significant decline in solid organ transplants performed during the first wave of Covid-19 in 2020, with over 48,000 years of patient life lost. Kidney transplantation showed the largest reduction across nearly all countries.
A study of 20,304 kidney transplants found that black recipients and patients receiving kidneys from Asian donors had a higher risk of graft failure within seven years. The study suggests that improved access to organ donation among ethnic minority groups can improve long-term outcomes for all recipients.
A new approach called an immunobiological algorithm provides a comprehensive assessment of how a patient's immune system will react to tissue from each potential living donor. This method outperforms current HLA testing in identifying the best potential living donor, which could lead to improved organ transplant outcomes.
Referral guidelines for nephrology care are shifting towards identifying patients at higher risk of kidney failure. A study using Veterans Health Administration data found that referring patients with a two-year risk of kidney failure above 1% would identify those at highest median risk.
A recent study found that introducing new airline routes leads to a 7.3% increase in kidneys sent to transplant centers across the US, while also reducing the discard rate of kidneys. This improved transportation infrastructure facilitates broader organ sharing and can help match supply and demand.
A USC-led study has mapped the developmental blueprint of human kidneys, shedding light on how cells interact to form filtering units. The research provides a foundation for creating synthetic mini kidneys and could lead to new treatments for kidney diseases.
A large study found that people with hypertension or diabetes often lack a simple urine test for protein in the urine, despite being at high risk of chronic kidney disease. The researchers suggest widening albuminuria testing to detect early chronic kidney diseases and emphasize the importance of treatment.
Ongoing acute kidney injury in deceased donor kidneys is linked to lower long-term graft survival. Notably, abnormal serum creatinine values during procurement also negatively impact graft outcomes.
Researchers at the University of Pennsylvania School of Medicine have identified 182 genes likely responsible for kidney function and 88 genes for hypertension. The study provides a clearer picture of the genetic underpinnings of chronic kidney disease, paving the way for potential treatments.
Research finds that immunocompromised dialysis patients who received the Pfizer-BioNTech mRNA vaccine have higher levels of neutralising antibodies against SARS-CoV-2 variants, including Delta. A third dose of an mRNA vaccine is recommended to protect this vulnerable group.
A pooled analysis of three clinical trials found that roxadustat boosts hemoglobin levels and reduces the need for red blood cell transfusions. The treatment also showed no increased risks of mortality, heart attacks, or strokes.
A recent clinical trial found that vitamin D supplementation had no significant effects on kidney outcomes in adults with pre-diabetes. However, among those not taking any vitamin D, the supplement was associated with a lower amount of urine protein over time, suggesting potential benefits for kidney health.
A recent study published in Transplant Infectious Disease found that COVID-19 vaccination provides strong protection against the virus for solid organ transplant recipients, with an almost 80% reduction in symptomatic cases. The study examined data from over 2,150 transplant patients and showed that nearly 70% of vaccinated patients re...
Researchers compared various race-free equations and found that removing race adjustments increases eGFR values for Black patients, leading to more chronic kidney disease stage reclassifications. Blending or direct removal of race coefficients resulted in decreased eGFR estimates.
A study of 924 kidney transplantations reveals that natural killer cells play a major role in organ rejection, leading to improved risk assessment and potential new treatments for kidney transplant rejection. The findings suggest genotyping donors and recipients for MHC and KIR proteins can help predict rejection.
Researchers found five aspects underlie feelings of repugnance: moral outrage, regulation desire, monetary value translation, exploitation concern, and seller risk exposure. Transactions triggering strong repugnance often require policy interventions to protect vulnerable individuals or address unknown risks.
The new allocation system could result in reduced access to kidney transplants and longer wait times for patients in South Carolina. Researchers argue that the current system unintentionally worsens inequities and recommend improving access to transplant care.
Researchers at Mayo Clinic have found that COVID-19 can induce a strong immune response in patients, contributing to kidney injury. Mitochondrial dysfunction is also commonly found in kidney injury related to COVID-19, suggesting it may be a potential target for therapies.
A scoping review found that 80% of studies on acute kidney injury did not define recovery of kidney function, highlighting the need for clear application of standard definitions. Researchers recommend transparent reporting of how the Kidney Disease Improving Global Outcomes (KDIGO) definition is applied.
Researchers at Georgia State University have developed an oral prodrug that delivers carbon monoxide via artificial sweeteners, showing promise in treating acute kidney injury. The study demonstrates the protective effects of CO against organ damage and suggests potential applications for transplantation and other conditions.
The DAPA-CKD trial found that dapagliflozin significantly reduced kidney function decline, cardiovascular events, and mortality rates in patients with stage 4 chronic kidney disease. The study also showed similar safety profiles for dapagliflozin and placebo in this patient population.
The US physician-scientist workforce doing kidney research is shifting towards more women and international medical graduates. However, this trend is accompanied by an increasing age of the workforce, a decline in relative numbers, and a shift away from basic science research.