Articles tagged with Kidney
Researchers developed a two-pronged approach targeting cancer progression and cell destruction, leveraging cathepsin S and p21 BAX proteins to treat kidney cancer. The novel peptide CS-PEP1 inhibits these proteins, encouraging cancer cell death and overcoming molecular resistance found in conventional chemotherapy treatment.
Researchers found that a chemical modification of RNA, influenced by diet, plays a key role in polycystic kidney disease. Limiting methionine in the diet may partially control cyst formation, and identifying chemicals that stem Mettl3 activity may lead to new drug treatments.
The ASN and NKF publish an interim report assessing alternative methods to diagnosing kidney diseases, highlighting the need for a standardized approach. The task force recommends replacing existing equations with a new method that is accurate, representative, and unbiased.
Patients with kidney failure who cycled during dialysis showed improved heart health, including reduced scarring and stiffness of major blood vessels. The study found significant savings in healthcare costs, potentially benefiting the NHS.
The study reveals that COVID-19 hospitalizations peaked between March 22 and April 25, with rates 40 times higher than in the general population. Patients undergoing dialysis had a 17% increase in death rates compared to 2017-2019 rates.
A new study from USC reveals the importance of β-catenin in striking a balance between stem cell self-renewal and differentiation into kidney cells. High levels of β-catenin trigger a switch that directs progenitor cells to differentiate into specialized kidney cells.
Researchers developed a new tool to capture patients' opinions on home dialysis care, highlighting the importance of communication and care coordination. The Home Dialysis Care Experience instrument will be valuable for future research, clinical care, and quality improvement initiatives among home dialysis facilities.
A study found that nearly 20% of patients with antibiotic-loaded spacers and IV antibiotics developed acute kidney injury, with those with preexisting chronic kidney disease at highest risk. The study identified several risk factors for AKI, including high doses of antibiotics and certain heart rhythm disorders.
The Acute Kidney Injury Project aims to develop improved predictive and detection tools for kidney injury, addressing a global public health concern. The project will focus on developing prognostic tools to identify drug-induced kidney injury, with the goal of improving patient safety during clinical trials and advancing drug development.
A team of researchers led by Professor Alexander Meyer has created an early warning system for intensive care units (ICUs) using big data and artificial intelligence. The system predicts postoperative bleeding and acute kidney injury with high accuracy, allowing timely interventions to save lives.
Only 3% of patients with high blood pressure who are at risk for primary aldosteronism receive screening, a condition that can lead to heart and kidney complications. Researchers emphasize the importance of initiatives to encourage screening to prevent cardiovascular and kidney disease.
Renal fibrosis, a leading cause of kidney failure, has been linked to telomere shortening. Researchers found that short telomeres exacerbate epithelial-to-mesenchymal transition, promoting pathological scarring of kidney tissue. They propose treating renal fibrosis by lengthening telomeres and restoring normal gene expression.
Researchers investigate using a cell-signaling chemokine from cats to treat human kidney fibrosis and slow disease progression. The study suggests that intra-renal injection of CXCL12 may be a potential therapy for early kidney disease, offering new hope for millions with the condition.
Patients recovering from COVID-19-associated acute kidney injury require long-term monitoring of kidney function post-discharge. The study highlights the importance of tracking kidney function to prevent future complications and ensure optimal recovery.
Clinical algorithms that adjust for race can cause harm to patients by delaying access to additional tests and treatments, according to a new article. The authors argue that the medical community must step up to achieve consensus on paths forward to address racial inequities in health care.
Researchers at Brigham and Women's Hospital have developed a novel urine test to diagnose human kidney transplant rejection. The study, published in the Journal of the American Society of Nephrology, demonstrates that exosomes isolated from urine samples can serve as a viable biomarker for kidney transplant rejection.
A study published in Environment International found that overweight children exposed to lead in utero and during their first weeks of life are at risk for poorer kidney function in adulthood. The research measured blood levels of lead during pregnancy and eGFR levels in children between 8-12 years old.
Measures of kidney function, such as the urinary albumin-to-creatinine ratio and estimated glomerular filtration rate, may improve estimates of future cardiovascular disease risk. The addition of these non-traditional risk factors could refine stratification and predict cardiovascular disease more accurately.
Researchers analyzed nationwide data to find a strong correlation between kidney stones and osteoporosis or bone fracture diagnoses. The study suggests that bone density screening may be necessary for individuals with kidney stones, particularly middle-aged and older men at risk of osteoporosis or fracture.
A study by researchers at Johns Hopkins Medicine found that proteins in urine can be used as biomarkers to predict the likelihood of progression to chronic kidney disease and death after acute kidney injury. The three protein biomarkers, MCP-1, UMOD, and YKL-40, showed promise in predicting patient outcomes.
The article highlights the importance of pediatric nephrologists' involvement in caring for children with cancer, from diagnosis to treatment and beyond. Key findings include the increasing need for onco-nephrology expertise due to rising childhood cancer rates and advances in therapy protocols.
Researchers tested CER-001 on a human patient with familial LCAT deficiency, showing improved kidney function and stable vision for up to 11 months. The treatment was well-tolerated, but further studies are warranted to prevent kidney progression.
A study found associations between urinary miRNAs and cardiorenal outcomes, including blood pressure and eGFR levels, in Mexican children. The researchers identified several miRNAs associated with kidney function, blood pressure, and electrolyte biomarkers.
A randomized clinical trial found that patients who received corticosteroids after kidney transplantation had similar survival rates compared to those who did not receive them. Corticosteroid use was associated with increased risk of side effects, including acne and bone disease.
Researchers identified a biomarker that predicts kidney transplant rejection risk by analyzing immune molecule ratios. Monitoring this ratio may help clinicians identify high-risk patients and intervene with new treatments to prevent long-term organ rejection.
Researchers discovered a blood biomarker that predicts kidney transplant rejection with a lead time of about eight months. The biomarker suggests using an existing medication to right the course of long-term recovery and prevent permanent damage.
A recent study found that enrolling Black patients on the waitlist with slightly better kidney function could reduce racial disparities in transplant access. This approach aims to bridge the gap between Black and white patients' wait times before kidney failure, ultimately promoting greater equality in transplantation.
Scientists developed a rodent model to understand and identify young pregnant women who have previously suffered kidney injuries, which can lead to complications such as preeclampsia and low birthweight. The model suggests that even years after the injury, some women may still experience renal insufficiency during pregnancy.
A study found that veterans receiving all post-kidney transplant care within the VA have a lower risk of death compared to those receiving care through Medicare. The study suggests that high-quality care within the VA may contribute to better outcomes.
Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, which could lead to a revolutionary new genetic approach to treating kidney disease. The study found that important genes change when a scar forms on the interstitium, a previously undercharacterized part o...
Despite policies and interventions aimed at improving access to kidney transplantation, a new study found no overall improvement in rates of wait list placement and transplantation over two decades. The researchers also identified striking disparities in access to transplantation, highlighting the need for more effective strategies to ...
Research using magnetic resonance spectroscopy reveals that SGLT2 inhibitors trigger a balance between glucose loss and new production in the liver, affecting metabolism in several organs. The study provides insight into the acute impact of these drugs on lipid and energy metabolism.
Tuberous sclerosis complex (TSC) affects millions worldwide, causing cysts and benign tumors to form in the kidney, leading to kidney failure. Researchers led by Dr. Manoocher Soleimani found that changes in cells lining the collecting ducts are responsible for cyst formation, offering new avenues for potential treatments.
A study by Mayo Clinic researchers found that certain biomarkers can help diagnose acute kidney inflammation in cancer patients treated with immune checkpoint inhibitors. These biomarkers, such as serum creatinine and C-reactive protein, may aid in distinguishing treatment-associated kidney injury from other causes.
Scientists developed a novel quantum sensor that can detect oxidative stress in organs during MRI scans, which could lead to early diagnosis of diseases like cancer and kidney dysfunction. The sensor uses a ring-shaped sugar-like compound and nitroxide derivatives to identify reduced cell/tissue capacity.
A recent study published in Nature Communications has uncovered the biomedical basis of the Barker hypothesis, which suggests that infants with low birth weight are at increased risk of cardiovascular diseases and kidney disorders. The research team discovered that fetuin-A, a serum protein, plays a crucial role in fetal protective mec...
Researchers at Flinders University have discovered a new role for fibrinogen in reducing inflammation and protecting against disease. Fibrinogen's ability to neutralize harmful chemicals like hypochlorite could lead to new biomarkers and therapies for kidney, heart, and other diseases.
Research highlights subtle racist undertones in kidney function reporting, which may perpetuate biological basis for race. Physicians and scientists have a moral obligation to address historical practices rooted in racist ideology.
The study found that racial disparities in kidney transplantation persist despite advances in the field. Blacks are more likely to develop kidney failure but less likely to undergo transplantation, particularly from living donors.
A new study from researchers at the Geisel School of Medicine at Dartmouth has found that skin exposure to ultraviolet (UV) light can trigger inflammatory processes in the kidney, even in normal, healthy mice. This subclinical injury may lead to pathologic consequences in lupus patients and worsen their clinical symptoms.
A University of Houston researcher has identified the suPAR protein as a potential therapeutic target for treating focal segmental glomerulosclerosis (FSGS), a common form of kidney disease. High circulating levels of suPAR have been shown to induce oxidative stress in the kidneys, leading to cell damage and kidney failure.
A mutation in the gene KCTD1 leads to kidney defects that can cause metabolic bone disease. The study reveals KCTD1's critical role in regulating electrolyte balance in the distal nephron.
Researchers at the University of Birmingham have discovered a biological imbalance between free radicals and antioxidant cells that links gum disease to chronic kidney disease. A 10% increase in gum inflammation reduces kidney function by 3%, highlighting the importance of periodontal care for patients with chronic kidney disease.
Researchers found that stopping RAS inhibitors reduced the risk of requiring dialysis but increased the risk of cardiovascular events and death. The study suggests that doctors must carefully weigh the benefits and harms of these medications in patients with advanced CKD.
A virtual telehealth platform allows patients to undergo comprehensive evaluation for kidney transplantation from the comfort of their own homes. This innovative approach has enabled the Medical University of South Carolina's transplant program to maintain access to life-saving surgeries despite pandemic restrictions, with over 282 pat...
The ADQI consensus statement recommends using a combination of damage and functional biomarkers to manage Acute Kidney Injury (AKI). Proenkephalin penKid is proposed as a marker for assessing AKI progression and kidney recovery, with CE-IVD marked assay available for point-of-care usage.
A new study analyzing federal data reveals COVID-19 is associated with an increased need for ventilators, longer hospital stays and nearly five times the risk of death than the flu. The research also found COVID-19 can damage other organs, increasing the risk of complications such as kidney and liver damage.
A US study finds that many donor kidneys are discarded due to low-quality tissue, yet can function acceptably when transplanted. The study suggests that procurement biopsies add little value and may even reduce the supply of available kidneys.
A new study found that US kidney biopsies don't add value beyond standard donor and recipient characteristics in predicting survival. Many discarded kidneys would likely benefit US patients awaiting a transplant, with some matching transplantation outcomes in Europe.
A single-center retrospective study found that 1-year kidney transplant outcomes are similar for HCV-negative recipients from HCV-positive or negative donors. The results suggest that transplantation of kidneys from HCV-infected donors to HCV-negative recipients is a viable option.
Researchers developed a new model to predict kidney function in cancer patients, enabling more accurate chemotherapy dosing and minimizing harm. The model takes into account various factors like age, gender, and body mass index, providing clinicians with a valuable tool for guiding treatment decisions.
A University of Houston team found that the new C-diff guidelines are fourfold more predictive in identifying patients likely to die during hospitalization. The revised severity assessment allows doctors to tailor treatment accordingly, improving patient outcomes.
A clinical trial found that combining Verinurad and Febuxostat reduces albuminuria in Type 2 diabetes patients by 39.4%, a significant reduction in protein leakage through the kidney. The treatment combination also lowers uric acid levels by 57%.
A new study published in Science Advances found that a drug called phenylbutyrate can help cells clear herpes simplex 1 and 2 viruses. When used in combination with acyclovir, the drug combo is more effective and reduces side effects associated with long-term use of acyclovir.
A large prospective study found a link between kidney injuries and cognitive impairment in children with diabetic ketoacidosis. The study suggests that the presence of acute kidney injury is associated with lower IQ scores and subtle cognitive impairment.
A new study from Harvard Medical School forecasts the impact of eliminating race from kidney function formulas on Black patients with kidney disease. The analysis suggests that removing race-based adjustments may lead to earlier diagnoses and better access to care, but also restricts access to certain medications and treatments.
Researchers at Kumamoto University found that mild electrical stimulation with heat shock reduces inflammation and cell death in the kidneys, improving kidney function and preventing proteinuria. The treatment also inhibits apoptosis of kidney cells and activates survival pathways, offering a promising new approach for treating nephrot...
Researchers use single-cell RNA sequencing to analyze kidney cells' gene expression, enabling the reconstruction of their spatial arrangement and functional information. The algorithm succeeds in completing a 3D puzzle, providing new insights into kidney disease.
Australian researchers discovered a protein that protects kidney cells from 'bystander' damage caused by chemotherapy or radiotherapy. The study found that inhibiting BCL-XL could safely use in laboratory models alone or with other cancer therapies to prevent kidney damage, a common side effect of cancer treatments.
A recent analysis found that Accountable Care Organizations (ACOs) may reduce the cost of medical care for patients undergoing dialysis. The study discovered modest cost savings for Medicare beneficiaries in ACOs, especially those who received regular primary care physician visits.