Articles tagged with Kidney
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The penKid biomarker accurately predicted acute kidney injury (AKI), multiorgan failure, and mortality in unselected sepsis patients at presentation to the emergency department. Increasing penKid levels indicated worsening kidney function, enabling timely treatment decisions that improve outcomes.
A recent study found that a significant proportion of children with chronic kidney disease (CKD) are prescribed medications that may be toxic to their kidneys. Among the studied population, 71% of those with CKD and 50% without received at least one potentially nephrotoxic medication over an average follow-up period of 3.3 years.
A new study reports high patient satisfaction with a minimally invasive approach to creating vascular access for kidney patients requiring hemodialysis. The Ellipsys Vascular Access System showed nearly all dialysis access sites remained functional after two years, significantly improving upon surgically created fistulas.
Researchers identified patches of normal-looking kidney tissue carrying DNA changes that cause Wilms' tumour, promising improved treatment and prevention strategies. The study found epigenetic changes associated with cancer in normal kidney tissue, enabling cells to grow rapidly into pre-cancerous patches.
The 2020 Edith and Peter O'Donnell Awards recognize Texas researchers making groundbreaking discoveries in Alzheimer's disease treatment, malaria treatment, kidney stone research, and star merger processes. The awards celebrate innovative work that advances science and improves lives.
Dr. Jeffrey Rimer's groundbreaking research using crystals has led to the development of new materials and treatments for malaria and kidney stones. His work enables visualization of complex mechanisms, improving catalysis in petrochemical processes.
Researchers will evaluate how sleep-disordered breathing impacts chronic kidney disease progression, recruiting 2,200 adults from the CRIC study. They hypothesize that sleep apnea is associated with increased risk of chronic kidney disease progression due to its effects on blood pressure, insulin resistance, and organ damage.
Researchers have identified a combination of two drugs that can relax the walls of the ureter, reducing contractions that cause pain when passing a kidney stone. The treatment, which delivers muscle relaxants directly to the ureter, has shown promising results in reducing the frequency and length of contractions.
Researchers at MUSC found that primary cilia generate approximately 60% of small EVs produced by renal tubule cells, with manipulation of cilium length affecting EV production. The protein content of EVs varies depending on cilia length, suggesting a significant role for cilia in intercellular communication.
The study evaluates the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, demonstrating lack of oncogenic properties and tumorigenic capacity. These cells show promise for clinical application as cell-based renal replacement therapy.
A Yale-led group developed a new mathematical model to predict acute kidney injury (AKI) risk in patients undergoing percutaneous coronary intervention. The model accounts for individual differences and complex associations between contrast levels and AKI risk, providing more accurate estimates.
Researchers at the University of Illinois Chicago report that robotic kidney transplants produce similar one- and three-year patient survival rates as those seen among nonobese patients. The study included over 230 robotic-assisted kidney transplants in patients with obesity, achieving dramatic reductions in post-surgery wound infections.
A high-protein diet may boost chronic kidney disease and increase the risk of de novo kidney diseases, says a new study. Experts warn that patients with diabetes or obesity who follow a high-protein diet may be at risk of severe kidney damage.
A new study found that genetic variants influence the benefits of broccoli on kidney health, suggesting tailored dietary interventions. Individuals with a specific gene variant (GSTM1) who consume cruciferous vegetables may experience improved kidney function.
Recent advancements in wearable and implantable hemodialysis devices have the potential to revolutionize treatment for patients with kidney failure. These devices aim to provide a more patient-friendly alternative to traditional hemodialysis, allowing patients to lead healthier lives.
The Singapore Diabetes Study in Nephropathy and other Microvascular Complications (DYNAMO) aims to reduce DKD prevalence in Singapore by 30% over five years. The study, led by Professor Thomas Coffman, uses a multi-pronged approach to better understand the disease biology and risk factors behind DKD.
A combined test of Renal Angina Index (RAI) and urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) can predict severe acute kidney injury risk in critically ill children, according to a recent study. This early identification allows for targeted interventions to reduce morbidity and hospital stay duration.
A recent analysis found increasing rates of acute kidney injury in pregnant women, especially those with diabetes. The study revealed a significant increase in the rate of hospitalizations involving acute kidney injury from 0.04% in 2006 to 0.12% in 2015.
A study of 4,567 hemodialysis patients found that those in residential areas with a high percentage of Black residents had significantly higher hospitalization rates. The association remained after adjusting for individual and community factors, suggesting unidentified health determinants at play.
A new study published in JAMA found that patients with kidney dysfunction who were prescribed high doses of the muscle relaxant baclofen were more likely to experience cognitive-related symptoms such as severe confusion. The research team analyzed data from over 16,000 patients and found a significantly higher risk of hospitalization a...
The American Society of Nephrology has honored five individuals for their outstanding contributions to kidney disease research, education, and clinical practice. Mitchell Rosner received the Robert G. Narins Award for his work in education and teaching, while Toshiro Fujita was recognized for his groundbreaking research on hypertension.
Researchers tested an Automated Wearable Artificial Kidney (AWAK) device for effective toxin removal in patients with kidney failure. The study found no serious adverse events, improving portability and flexibility of treatment.
A multi-institutional study found that adolescents with Type 2 diabetes experienced improved hyperfiltration and reduced elevated urine albumin-to-creatinine ratio after gastric bypass surgery compared to adults. In contrast, adults with pre-existing diabetes did not show significant improvements until five years post-surgery.
Several high-impact clinical trials have yielded promising results, including the ATHENA trial showing azathioprine to be as effective as mycophenolate mofetil in preventing chronic kidney rejection, and the NOBILITY trial demonstrating that obinutuzumab improves kidney health in patients with lupus nephritis. Additionally, a phase 3 s...
A new risk calculator tool predicts accurate five-year risk of chronic kidney disease based on variables like age, hypertension, and diabetes status. The tool enables healthcare providers to identify patients at high risk and benefit from preventive interventions.
A three-year clinical study found that reducing uric acid levels with the generic drug allopurinol did not slow diabetic kidney disease progression in type 1 diabetes patients. The study's conclusions provided a clear answer to an important scientific question, while suggesting further research may be needed.
A large clinical trial found that vitamin D and omega-3 fatty acid supplements did not slow the decline of kidney function in adults with Type 2 diabetes. The study involved over 1,300 participants and measured their kidney function over five years.
A study suggests that extending lifelong Medicare coverage of transplant medications would reduce healthcare costs and improve quality of life for kidney transplant recipients. This policy change could benefit patients who are currently left without coverage after 36 months.
Patients who transition to home dialysis after an unplanned start experience a higher risk of death compared to those who never made the switch. However, researchers found that younger patients and those with private insurance were more likely to make the transition to peritoneal dialysis.
A recent analysis found that home remote monitoring can benefit patients on peritoneal dialysis by preventing hospitalizations and extending treatment time. The successful implementation of the program requires effective communication, technical support, and patient engagement.
Community house hem dialysis allows patients to perform treatment independently in a shared community space, reducing burden on family and promoting flexibility. The study found that this approach supports extended-hour dialysis and fosters social connections among patients of Maori and Pacific ethnicity.
Researchers at UCSF have successfully implanted a bioreactor containing human kidney cells into pigs without triggering an immune reaction or blood clots. The device, similar to the size of a deck of cards, maintained healthy kidney function and demonstrated progress towards eliminating dialysis for patients with end-stage renal disease.
A machine learning model identified patients at risk of requiring kidney replacement therapy, leading to a significant improvement in dialysis initiation rates. The system calculates weekly risk scores and alerts clinicians to optimize treatment decisions, resulting in better patient outcomes.
A study examining clinical trial data found that sleep problems and fatigue significantly impact the cognitive function and behavior of children with chronic kidney disease. The research highlights the importance of assessing sleep problems and fatigue in these children to improve their emotional-behavioral and neurocognitive outcomes.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Researchers studying spherical exosomes, tiny cargo-filled spheres that arrive at the scene of acute kidney injury, aim to learn more about their role in repair and restore function. They suspect these exosomes can be controlled to better treat injuries and prevent permanent damage.
Researchers found that identical twin kidney transplants have high success rates, but patients often require immunosuppressive drugs due to misidentification. The study proposes genetic testing and management guidelines for identical twin transplants to minimize side effects.
Researchers have discovered that surface waves can spread on water-glass boundaries, creating a phenomenon that could be used to pulverize kidney stones. The study uses an experimental system to visualize stress created by such waves.
Researchers have discovered significant differences in gene expression between male and female mouse kidneys, shedding light on the organ's complex physiology and potential impact on human kidney disease. The study's findings may help clinicians better understand genetic programs linked to disease and improve treatment outcomes.
A new study finds that acute kidney injury affects 17% of patients taking immunotherapy medications for cancer, while proton pump inhibitors increase the risk of sustained AKI. Nephrologists and oncologists must recognize these factors to diagnose and treat patients effectively.
Rates for all types of kidney replacement therapy were consistently higher in men than women in European countries from 1965 to 2015. The male-to-female ratio increased with age and was particularly high for diabetic patients, suggesting that biological or access-related factors may be at play.
A new study found that less than 20% of Canadian patients with chronic kidney disease received a critical urine test within six months of diagnosis, highlighting a significant gap in care. The test is crucial for assessing the severity of kidney disease and guiding treatment.
Researchers found that transplant centers accepted varying numbers of high-risk kidneys between 2010 and 2016, but differences were not fully explained by waitlist size or organ availability. The study suggests that accepting less-than-ideal organs can lead to shorter average wait times for patients.
A Johns Hopkins-led study of thousands of children with congenital heart disease found that cardiac surgery within 10 years of birth increases the risk of death and kidney failure. Children who had more complex surgeries were at higher risk for these outcomes.
A study found that prescription opioids are associated with a higher risk of death and hospitalization compared to other pain medications, especially at high doses. The risk is highest among individuals with lower kidney function, who may experience reduced clearance of the active compounds from their bodies.
Researchers found high rates of overall survival and kidney graft survival in recipients living with HIV who received kidney transplants from deceased donors with HIV. The study, published in the New England Journal of Medicine, showed that outcomes were comparable to those in a previous US study using kidneys from donors without HIV.
Researchers have created the first cell atlas of the human kidney's immune system, charting the communities of immune cells in different zones. The atlas shows how the immune system develops during early life and strengthens after birth, with implications for tackling kidney disease and transplant rejection.
A recent analysis reveals persistent disparities in preemptive kidney transplantation, with Black and Hispanic patients and those on Medicare facing reduced access. The 2014 Kidney Allocation System may have exacerbated some inequalities for these groups.
A new observational study published in JAMA sheds light on the use of metformin for patients with Type 2 diabetes and impaired kidney function. The study found that metformin is associated with a 20% decreased risk of major adverse cardiovascular events compared to sulfonylureas.
A healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease (CKD) and a 23% lower incidence of albuminuria, an early indicator of kidney damage. The findings suggest that maintaining a healthy diet may help prevent kidney disease.
Researchers validate the hypothesis that IgG autoantibodies are crucial to IgA nephropathy's pathogenic immunodeposits. The study found co-localization of IgA1 and IgG in glomerular deposits, confirming their role in disease progression.
Researchers developed a kidney transplant risk model combining data from kidney donor registries, statistics of probable genetic profiles, and immunological knowledge to improve predictions of donor-recipient match. The study suggests that incorporating partial antigen match data can further enhance the accuracy of the model.
This observational study compared major cardiovascular events among patients with diabetes and reduced kidney function treated with metformin or a sulfonylurea. The study found that metformin was associated with lower rates of cardiovascular events compared to sulfonylureas.
Living kidney donation is linked with a higher risk of developing hypertension and kidney failure. Kidney function tends to improve after donation but plateaus if hypertension develops, highlighting the importance of preventing and managing hypertension in living donors.
A new national study by Penn Medicine found that hepatitis C-infected kidneys can function comparably to uninfected kidneys in patients who do not already have the virus. The study showed a significant increase in the use of HCV-infected organs, but raised questions about why these organs are still assigned lower risk scores.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many US centers. These organs function just as well as uninfected kidneys throughout the first year after transplantation, providing strong evidence for their safe and effective use.
A potential treatment for polycystic kidney disease has shown a significant reduction in kidney size in afflicted mice, with no evidence of toxicity in animal or human cell tests. The drug is now in early clinical trials in humans, offering hope for a new option for survival beyond dialysis or transplant.
A study of nearly 1.5 million patients found that receiving dialysis at for-profit facilities was linked to lower likelihoods of being placed on the kidney waiting list and receiving a transplant. The authors suggest that more research is needed to understand this association.
Russian researchers have shown an antioxidant compound called peroxiredoxin to be effective in treating kidney injury in mice by tripling survival rates. The compound may also offer prospects for longer kidney transplant storage and improved treatment options for ischemia-reperfusion syndrome.
Chronic kidney disease affects 37 million Americans, but primary care physicians lack sufficient knowledge and resources to effectively identify and manage patients. A focus group study found that PCPs need more training, resources, and clinical support tools to address the growing epidemic of CKD.