Articles tagged with Kidney
The American College of Physicians (ACP) recommends less intensive blood sugar control targets for most patients with type 2 diabetes, aiming for an A1C range of 7-8% rather than 6.5-7%. This approach prioritizes symptom management over intensive treatment to balance benefits and harms.
In a groundbreaking study, doctors at Johns Hopkins successfully transplanted hepatitis C-infected kidneys into patients without the virus. The recipients remained hepatitis C-free, and their kidneys functioned well, paving the way for more organs to be used in transplants.
Two landmark studies by Vanderbilt researchers show significant improvement in patient outcomes using balanced fluids instead of saline for intravenous therapy, leading to a decline in saline use at the hospital. The studies found a 1 percent lower incidence of serious kidney problems or death in patients receiving balanced fluids, res...
A new study by Queen Mary University of London aims to develop a 'beetroot pill' that could reduce the risk of kidney failure in patients undergoing coronary angiography. The research seeks to harness the antioxidant properties of dietary nitrate found in beetroot to prevent contrast-induced nephropathy, a common complication of the pr...
Research found that resolvin D-1 limits heart attack-induced kidney inflammation and promotes reparative macrophage change. This suggests potential application to clinical settings for treating cardiorenal syndrome.
Researchers created an open-source data atlas of human kidney development, providing detailed molecular and cellular information. The dataset will accelerate stem cell-based technologies for kidney replacement and regeneration therapies.
Recent studies have compared human and mouse kidney development, revealing deep conservation of certain processes but also significant differences in gene expression and cell structures. The findings provide new insights into the processes directing cells to form functional kidney structures and may help guide emerging stem cell techno...
A Mayo Clinic study found a steady increase in kidney stone formers, particularly among women aged 18-39. Improved imaging technology allowed for better diagnosis and classification of stones, leading to more symptomatic cases being detected.
Scientists at the University of Manchester successfully produced human kidney tissue within a living organism that is able to produce urine. The new structures contain most of the constituent parts present in human nephrons, including proximal tubules and Bowman's capsule, and have been linked to the vasculature of mice.
Researchers have successfully palliated kidney disease in mice by removing protein tyrosine phosphatase 1B from renal podocytes. Mice with this modification displayed improved glucose tolerance and insulin sensitivity, alleviating some consequences of diabetes.
A study published in Pediatric Transplantation found that detecting and treating dnDSA early can decrease antibody levels by 76% and prevent graft failure. However, the treatment came at a price: increased hospitalization rates for infection.
A landmark study has identified a small stretch of DNA that best predicts long-term kidney transplant success. The HLA locus genetic match between donor and recipient is crucial for predicting transplant survival and potential personalized treatments.
Researchers from ColoradoSPH identified new risk factors for a mysterious kidney illness affecting farm workers worldwide. The study found that access to water, rest, and shade reduces the rates of kidney disease onset and injury severity.
A systematic review found that living kidney donors have higher diastolic blood pressure, poorer renal function, and increased risk of end-stage renal disease. Female donors are at increased risk for preeclampsia and pregnancy-related complications.
Researchers at Westmead Institute for Medical Research are conducting a new clinical trial using water to treat polycystic kidney disease. The PREVENT-ADPKD trial aims to investigate whether drinking the right amount of water can prevent adult polycystic kidney disease (ADPKD) from progressing to kidney failure.
Researchers found a link between renal cysts and an increased risk of stroke, independent of other factors. The study suggests that renal cysts may be an early sign of kidney damage, highlighting the importance of monitoring for this condition.
Despite policies to increase diversity, racial/ethnic minority patients are less likely to receive live donor kidney transplants. The study found that disparities worsened over the last two decades, with black patients receiving only a quarter of the number of live donor transplants as white patients.
A team of scientists developed a novel platform to study lumen formation in epithelial tubes, which can lead to diseases like atherosclerosis and kidney failure. The 3D microtube setup allows cells to form tubes under different physical constraints, revealing the importance of mechanical forces in tissue development.
A new AI model based on convolutional neural networks (CNN) significantly improves the analysis of kidney biopsy images, enabling accurate quantification of kidney damage and prediction of life remaining in the kidney. This technology has the potential to act as a surrogate nephropathologist, particularly in resource-limited settings.
Researchers used cryo-electron microscopy to visualize the structure of the TRPV5 protein, which serves as a passageway for calcium across kidney cell membranes. The study reveals how inhibitor molecules attach to and close the channel, leaving calcium stranded in the urine where it can form kidney stones.
Researchers found that racial and ethnic disparities in live donor kidney transplantation have persisted over the past two decades, with Black and Hispanic patients less likely to receive a transplant than white patients. The study's findings highlight the need to revisit existing strategies aimed at reducing these disparities.
A Japanese research group develops a method to induce ureteric buds from pluripotent stem cells and successfully reproduces the higher-order structure of the kidney. This achievement is a significant step towards regenerating functional kidneys, which could potentially treat millions of patients with chronic kidney disease.
Survival rates for individuals with kidney failure have improved significantly over the past 22 years, with decreases observed across all age groups. Improvements in dialysis care, organ transplantation, and clinical practice guidelines may be contributing factors to these advancements.
Researchers have discovered that extracellular vesicles isolated from amniotic fluid stem cells can slow the progression of kidney damage in mice with Alport syndrome. The findings provide new insights into the mechanisms of kidney disease and point to a potential new approach for improved treatments.
A randomized clinical trial of bortezomib in late antibody-mediated kidney transplant rejection found no improvement in transplanted kidney function or prevention of immunologic tissue injury. The treatment was also linked with adverse effects, ruling out its potential as a therapeutic option for this condition.
Researchers at Max Delbrück Center find GRHL2 protein crucial for concentrating urine and maintaining salt levels in the kidneys. Genetically modified mice lacking GRHL2 produce more diluted urine, highlighting its importance for regulating body fluids.
A new study from Washington University School of Medicine in St. Louis suggests that kidney dysfunction increases the risk of diabetes. Elevated urea levels, which can be lowered through medication and diet, are a likely cause of this relationship.
Researchers at the University of Konstanz have successfully prevented chronic antibody-mediated organ rejection in a rat model using immunoproteasome inhibition with the selective inhibitor ONX 0914. This approach reduces activated plasma cells producing allo-antibodies and leads to improved renal function.
A team of researchers from the Broad Institute of MIT and Harvard has developed a new compound that can protect kidney cells from death and restore kidney function in multiple animal models of progressive kidney disease. The compound, called AC1903, works by blocking a damaging feedback loop involving the protein TRPC5.
A study found that many discarded kidneys from deceased donors could have potentially been transplanted with good outcomes. The majority of discarded kidneys had traits considered unappealing, but their partner kidneys performed well after being used for transplantation.
Researchers have discovered that macrophages form a barrier around kidneys and that dendritic cells communicate with each other to control the magnitude of the immune response. This complex mechanism challenges previous ideas about how the kidney reacts to injury, and may lead to new strategies for protecting individuals' kidney health.
A new study found that normothermic machine perfusion can evaluate kidney quality and suitability for transplantation. Four out of five kidneys assessed by the technique functioned immediately after transplantation.
A new study from Columbia University Medical Center suggests that DNA sequencing may offer real clinical value in diagnosing and managing patients with chronic kidney disease. The researchers analyzed 92 adults with kidney disease, yielding a diagnosis in 22 participants, including 13 individuals whose cause of kidney failure was unknown.
Researchers found genes associated with B cell receptor signaling and activation in tolerant kidney transplant recipients, suggesting an active immune regulation of B cells. The study provides insights into the mechanisms behind tolerance induction in renal transplantation, potentially leading to minimization of immunosuppression.
Researchers discovered vasopressin's role in stimulating red blood cell production, with implications for treating anemia after traumatic injuries or chemotherapy. The hormone's effectiveness was demonstrated in mouse models and clinical data from patients with central diabetes insipidus.
Researchers found that non-vitamin K antagonist oral anticoagulants are associated with reduced risk of adverse kidney outcomes in patients with atrial fibrillation. The study, published in the Journal of the American College of Cardiology, showed that about 1 in 4 patients taking these medications experienced significant kidney functi...
A study by Indiana University researchers found that expanding the geographic range of donated kidneys could save lives and increase kidney transplants. The analysis showed an expected annual increase in procured organs ranging from 58 to 174, depending on regional sharing.
Researchers at Massachusetts General Hospital have developed a potential alternative to gadolinium-based contrast agents for magnetic resonance imaging (MRI). The new manganese-based agent Mn-PyC3A produced comparable image enhancement to the standard of care with rapid clearance and less likelihood of toxicity. The study used a baboon...
A comprehensive study of heart-spleen and heart-kidney networks reveals the interconnectedness of organ damage after a heart attack. Researchers found histological and cellular changes in the spleen and kidney, as well as bimodal inflammatory responses and irreversible dysregulation in the cardiosplenic and cardiorenal networks.
A study suggests that expanding geographic sharing of donor kidneys could add 58 to 174 additional kidney transplants per year, helping more patients get off dialysis treatments. Organ quality varies from donor to donor and is concentrated in less populous regions, where patients are more willing to accept lower-quality organs.
Scientists at Duke-NUS and National Heart Centre Singapore have made a major breakthrough discovering that interleukin 11 is responsible for fibrosis and causes widespread organ damage. This finding has the potential to transform treatment of millions worldwide, as inhibiting IL11 can prevent heart and kidney fibrosis.
A new nuclear medicine test can identify kidney transplant infection in non-invasive procedures, using positron emission tomography/magnetic resonance imaging (PET/MRI). The test has the potential to refine characterization of infectious and inflammatory kidney diseases.
Research highlights the need for better nutritional management in chronic kidney disease, where high protein diets may have deleterious impacts on kidney health. A low protein, low salt diet may slow progression and help patients defer dialysis initiation.
A history of kidney stones may increase the risk of metabolic and hypertensive complications during pregnancy. Research found that women with pre-existing kidney stones were more likely to experience gestational diabetes and hypertension.
A phase 3 trial found tolvaptan slows the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease. The condition affects millions in the US and has no cure. The drug targets a mechanism contributing to cyst growth, potentially delaying transplant or dialysis need.
The global burden of chronic kidney disease attributable to air pollution is estimated to be over 10.7 million cases per year, with varying impacts by geography. Air pollution may contribute to the rising incidence of CKD worldwide, particularly in Central America and South Asia.
A study of 3725 participants with chronic kidney disease found that depressive symptoms were associated with a higher risk of early death in white individuals, but not in black individuals. Treatment of depressive symptoms may help lower this risk.
A recent analysis has linked proton pump inhibitors (PPIs) to a 33% increased relative risk of chronic kidney disease or kidney failure. The study, published at ASN Kidney Week 2017, suggests that providers should consider the potential risks of PPI therapy in patients.
New treatments for kidney disease, such as tolvaptan for autosomal dominant polycystic kidney disease (ADPKD), have shown promising results in slowing kidney function decline. Bardoxolone methyl has also improved renal function in patients with diabetic kidney disease. Meanwhile, QPI-1002 has reduced the incidence and severity of acute...
A study found VA patients had significantly lower rates of kidney transplantation compared to those with private insurance, Medicare, or Medicaid. The researchers suggest that distance from transplant centers and other factors may contribute to these disparities.
A study of over 900,000 US veterans found chronic insomnia to be associated with increased risks of early death, rapid kidney function decline, and kidney failure. The study suggests that attention to proper management of chronic insomnia could have long-ranging positive effects on overall health.
New research suggests that greater reductions in mean blood pressure may harm the kidneys, rather than benefiting them. In hypertensive patients, intensive blood pressure treatment was found to be associated with an increased risk of kidney function decline.
A dose-dependent inverse association was found between caffeine consumption and early death in patients with chronic kidney disease. The study, presented at ASN Kidney Week 2017, suggests that advising patients to drink more caffeine may reduce mortality.
A recent study found that African American patients were less likely to be wait-listed for a kidney transplant than White patients. Non-medical factors such as comorbidities, socio-economic status and social support played a significant role in the disparities.
A recent study found that children with high blood pressure at night experienced a faster time to kidney failure than those with normal blood pressure. The study also showed that patients with high blood pressure during both day and night had an even more rapid decline, highlighting the importance of nighttime blood pressure control in...
A new computer program has been developed to help doctors detect acute kidney injury earlier, reducing its severity and improving survival rates. The program, which was tested in over half a million patients, showed a significant reduction in hospital mortality, length of stay, and dialysis rates.
Longtime advocates Paul T. Conway and Richard Knight received the ASN's President's Medal for their significant contributions to the fight against kidney diseases, including improving access to treatment and increasing funding for research and treatment innovations.
A particular protein, DNAJB9, is found in abundance in the kidneys of patients with fibrillary glomerulonephritis, an aggressive kidney disease. The discovery may improve diagnosis and treatment options for this disease, which affects nearly half of patients who become dependent on dialysis.
The US Renal Data System report highlights the high burden of kidney disease in the US, with over 30 million adults affected, and a significant cost to healthcare. However, there is low awareness about the condition among patients, especially those with early stages of CKD.
A recent analysis found that kidney transplant recipients lived longer than those who stayed on dialysis for at least 10 years. The benefit was observed after 657 days post-transplant, with a 40% lower risk of death compared to patients on dialysis.