Articles tagged with Kidney
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers used cryo-electron microscopy to visualize the structure of the TRPV5 protein, which serves as a passageway for calcium across kidney cell membranes. The study reveals how inhibitor molecules attach to and close the channel, leaving calcium stranded in the urine where it can form kidney stones.
Researchers found that racial and ethnic disparities in live donor kidney transplantation have persisted over the past two decades, with Black and Hispanic patients less likely to receive a transplant than white patients. The study's findings highlight the need to revisit existing strategies aimed at reducing these disparities.
A Japanese research group develops a method to induce ureteric buds from pluripotent stem cells and successfully reproduces the higher-order structure of the kidney. This achievement is a significant step towards regenerating functional kidneys, which could potentially treat millions of patients with chronic kidney disease.
Survival rates for individuals with kidney failure have improved significantly over the past 22 years, with decreases observed across all age groups. Improvements in dialysis care, organ transplantation, and clinical practice guidelines may be contributing factors to these advancements.
Researchers have discovered that extracellular vesicles isolated from amniotic fluid stem cells can slow the progression of kidney damage in mice with Alport syndrome. The findings provide new insights into the mechanisms of kidney disease and point to a potential new approach for improved treatments.
A randomized clinical trial of bortezomib in late antibody-mediated kidney transplant rejection found no improvement in transplanted kidney function or prevention of immunologic tissue injury. The treatment was also linked with adverse effects, ruling out its potential as a therapeutic option for this condition.
Researchers at Max Delbrück Center find GRHL2 protein crucial for concentrating urine and maintaining salt levels in the kidneys. Genetically modified mice lacking GRHL2 produce more diluted urine, highlighting its importance for regulating body fluids.
A new study from Washington University School of Medicine in St. Louis suggests that kidney dysfunction increases the risk of diabetes. Elevated urea levels, which can be lowered through medication and diet, are a likely cause of this relationship.
Researchers at the University of Konstanz have successfully prevented chronic antibody-mediated organ rejection in a rat model using immunoproteasome inhibition with the selective inhibitor ONX 0914. This approach reduces activated plasma cells producing allo-antibodies and leads to improved renal function.
A team of researchers from the Broad Institute of MIT and Harvard has developed a new compound that can protect kidney cells from death and restore kidney function in multiple animal models of progressive kidney disease. The compound, called AC1903, works by blocking a damaging feedback loop involving the protein TRPC5.
A study found that many discarded kidneys from deceased donors could have potentially been transplanted with good outcomes. The majority of discarded kidneys had traits considered unappealing, but their partner kidneys performed well after being used for transplantation.
Researchers have discovered that macrophages form a barrier around kidneys and that dendritic cells communicate with each other to control the magnitude of the immune response. This complex mechanism challenges previous ideas about how the kidney reacts to injury, and may lead to new strategies for protecting individuals' kidney health.
A new study found that normothermic machine perfusion can evaluate kidney quality and suitability for transplantation. Four out of five kidneys assessed by the technique functioned immediately after transplantation.
A new study from Columbia University Medical Center suggests that DNA sequencing may offer real clinical value in diagnosing and managing patients with chronic kidney disease. The researchers analyzed 92 adults with kidney disease, yielding a diagnosis in 22 participants, including 13 individuals whose cause of kidney failure was unknown.
Researchers found genes associated with B cell receptor signaling and activation in tolerant kidney transplant recipients, suggesting an active immune regulation of B cells. The study provides insights into the mechanisms behind tolerance induction in renal transplantation, potentially leading to minimization of immunosuppression.
Researchers discovered vasopressin's role in stimulating red blood cell production, with implications for treating anemia after traumatic injuries or chemotherapy. The hormone's effectiveness was demonstrated in mouse models and clinical data from patients with central diabetes insipidus.
Researchers found that non-vitamin K antagonist oral anticoagulants are associated with reduced risk of adverse kidney outcomes in patients with atrial fibrillation. The study, published in the Journal of the American College of Cardiology, showed that about 1 in 4 patients taking these medications experienced significant kidney functi...
A study by Indiana University researchers found that expanding the geographic range of donated kidneys could save lives and increase kidney transplants. The analysis showed an expected annual increase in procured organs ranging from 58 to 174, depending on regional sharing.
Researchers at Massachusetts General Hospital have developed a potential alternative to gadolinium-based contrast agents for magnetic resonance imaging (MRI). The new manganese-based agent Mn-PyC3A produced comparable image enhancement to the standard of care with rapid clearance and less likelihood of toxicity. The study used a baboon...
A comprehensive study of heart-spleen and heart-kidney networks reveals the interconnectedness of organ damage after a heart attack. Researchers found histological and cellular changes in the spleen and kidney, as well as bimodal inflammatory responses and irreversible dysregulation in the cardiosplenic and cardiorenal networks.
A study suggests that expanding geographic sharing of donor kidneys could add 58 to 174 additional kidney transplants per year, helping more patients get off dialysis treatments. Organ quality varies from donor to donor and is concentrated in less populous regions, where patients are more willing to accept lower-quality organs.
Scientists at Duke-NUS and National Heart Centre Singapore have made a major breakthrough discovering that interleukin 11 is responsible for fibrosis and causes widespread organ damage. This finding has the potential to transform treatment of millions worldwide, as inhibiting IL11 can prevent heart and kidney fibrosis.
A new nuclear medicine test can identify kidney transplant infection in non-invasive procedures, using positron emission tomography/magnetic resonance imaging (PET/MRI). The test has the potential to refine characterization of infectious and inflammatory kidney diseases.
Research highlights the need for better nutritional management in chronic kidney disease, where high protein diets may have deleterious impacts on kidney health. A low protein, low salt diet may slow progression and help patients defer dialysis initiation.
The global burden of chronic kidney disease attributable to air pollution is estimated to be over 10.7 million cases per year, with varying impacts by geography. Air pollution may contribute to the rising incidence of CKD worldwide, particularly in Central America and South Asia.
A study of 3725 participants with chronic kidney disease found that depressive symptoms were associated with a higher risk of early death in white individuals, but not in black individuals. Treatment of depressive symptoms may help lower this risk.
A recent analysis has linked proton pump inhibitors (PPIs) to a 33% increased relative risk of chronic kidney disease or kidney failure. The study, published at ASN Kidney Week 2017, suggests that providers should consider the potential risks of PPI therapy in patients.
New treatments for kidney disease, such as tolvaptan for autosomal dominant polycystic kidney disease (ADPKD), have shown promising results in slowing kidney function decline. Bardoxolone methyl has also improved renal function in patients with diabetic kidney disease. Meanwhile, QPI-1002 has reduced the incidence and severity of acute...
A study found VA patients had significantly lower rates of kidney transplantation compared to those with private insurance, Medicare, or Medicaid. The researchers suggest that distance from transplant centers and other factors may contribute to these disparities.
A history of kidney stones may increase the risk of metabolic and hypertensive complications during pregnancy. Research found that women with pre-existing kidney stones were more likely to experience gestational diabetes and hypertension.
A phase 3 trial found tolvaptan slows the rate of decline in kidney function in patients with autosomal dominant polycystic kidney disease. The condition affects millions in the US and has no cure. The drug targets a mechanism contributing to cyst growth, potentially delaying transplant or dialysis need.
New research suggests that greater reductions in mean blood pressure may harm the kidneys, rather than benefiting them. In hypertensive patients, intensive blood pressure treatment was found to be associated with an increased risk of kidney function decline.
A dose-dependent inverse association was found between caffeine consumption and early death in patients with chronic kidney disease. The study, presented at ASN Kidney Week 2017, suggests that advising patients to drink more caffeine may reduce mortality.
A recent study found that African American patients were less likely to be wait-listed for a kidney transplant than White patients. Non-medical factors such as comorbidities, socio-economic status and social support played a significant role in the disparities.
A recent study found that children with high blood pressure at night experienced a faster time to kidney failure than those with normal blood pressure. The study also showed that patients with high blood pressure during both day and night had an even more rapid decline, highlighting the importance of nighttime blood pressure control in...
A study of over 900,000 US veterans found chronic insomnia to be associated with increased risks of early death, rapid kidney function decline, and kidney failure. The study suggests that attention to proper management of chronic insomnia could have long-ranging positive effects on overall health.
A new computer program has been developed to help doctors detect acute kidney injury earlier, reducing its severity and improving survival rates. The program, which was tested in over half a million patients, showed a significant reduction in hospital mortality, length of stay, and dialysis rates.
Longtime advocates Paul T. Conway and Richard Knight received the ASN's President's Medal for their significant contributions to the fight against kidney diseases, including improving access to treatment and increasing funding for research and treatment innovations.
A particular protein, DNAJB9, is found in abundance in the kidneys of patients with fibrillary glomerulonephritis, an aggressive kidney disease. The discovery may improve diagnosis and treatment options for this disease, which affects nearly half of patients who become dependent on dialysis.
The US Renal Data System report highlights the high burden of kidney disease in the US, with over 30 million adults affected, and a significant cost to healthcare. However, there is low awareness about the condition among patients, especially those with early stages of CKD.
A recent analysis found that kidney transplant recipients lived longer than those who stayed on dialysis for at least 10 years. The benefit was observed after 657 days post-transplant, with a 40% lower risk of death compared to patients on dialysis.
A study published in The Clinical Journal of the American Society of Nephrology found that left ventricular assist device (LVAD) therapy can affect kidney function, particularly in patients with chronic kidney disease. Researchers identified interventions to improve outcomes, including nephrologist involvement and enhanced dialysis tra...
A team of engineers is creating a smartphone-based test kit to detect kidney inflammation in patients with Systemic Lupus Erythematosus. The test uses glow-in-the-dark nanoparticles to measure protein levels in urine, offering a non-invasive and quantitative solution for patients.
Researchers found that robot-assisted laparoscopic surgery for kidney removal had comparable patient outcomes but higher costs, with a 46.3% chance of prolonged operative time compared to traditional procedures.
A study found that young adults with kidney failure have lower quality of life, worse employment prospects, and are less likely to be married or have a partner. Higher education, alcohol abstinence, and smoking status did not differ significantly between those on dialysis and transplantation.
Scientists have discovered a key protein controlling ferroptosis, a highly regulated cell death process that plays a role in health and disease. The research links ferroptosis to diseases such as asthma, kidney injury, and brain trauma, suggesting potential drug targets for treatment.
A new study found that acute kidney injury (AKI) is associated with significant healthcare costs, with the mildest forms of AKI resulting in 1.2 to 1.3 times greater costs than patients without AKI. The study estimates the incremental cost of AKI in Canada to be over $200 million per year.
A team of researchers has identified a region of the genome that regulates vitamin D activation in the kidneys, which could lead to new treatments for diseases involving vitamin D. The discovery also sheds light on the role of calcitriol in inflammatory diseases and its potential use as a treatment.
A study found that Canadian nephrologists generally recommend follow-up kidney evaluations for most patients with acute kidney injury but only a minority receive these evaluations. The disparity between recommendations and actual practices may be attributed to various factors, including patient age and pre-existing conditions.
A study found that many discarded kidney organs can be suitable for transplantation if certain steps are taken to limit damage following donation. The use of these organs could be increased by limiting cold ischemia times.
Researchers at UW Medicine have developed mini-kidney organoids that can track the early stages of polycystic kidney disease. By manipulating the micro-environment, they found that cyst formation can be increased or decreased.
A new $5 million NIH grant will investigate the effects of a genetic variation on kidney transplant outcomes in African American donors. The study aims to improve matching of donor kidneys with recipients and extend post-transplant kidney function.
Researchers found that adding healthy bacteria like Lactobacillus can reduce disease symptoms in female mice with lupus. The study suggests that a 'leaky gut' condition may contribute to the disease, and testosterone suppression may affect probiotic effects.
A study found a linear relationship between air pollution levels and the risk of experiencing kidney function decline and developing kidney disease or failure. The results suggest that particulate matter above the EPA's recommended limit is associated with new cases of chronic kidney disease (CKD) and end-stage renal disease (ESRD).
A new study from Washington University School of Medicine and VA St. Louis Health Care System found that breathing dirty air may harm kidneys. The research analyzed data on nearly 2.5 million people over 8.5 years, concluding that high levels of particulate matter increase the risk of chronic kidney disease and failure.
The UCLA-led study highlights the success of the kidney voucher program, which enables individuals to donate a kidney now and prioritize family members for future transplants. The program has led to 25 lifesaving transplants across the US, thanks to the altruistic donations of living donors.
Researchers discovered the GREB1L gene associated with renal agenesis, a hereditary condition causing one or no kidneys. The finding enables early detection of the disorder, providing relief to families.
A study found that individuals with chronic kidney disease who experienced high sleep fragmentation were at elevated risk of developing kidney failure. Higher sleep fragmentation and shorter sleep duration were also linked to steeper declines in kidney function over time. Subjectively measured daytime sleepiness was associated with an ...
A new research network, led by CHOP and Penn Medicine, aims to identify strategies to prevent kidney stone recurrence. The PUSH study tests personalized fluid goals, financial incentives, and health coaching to reduce stone recurrence over a two-year period.
A new study finds that sofosbuvir-based direct-acting antiviral therapy is safe and effective in patients with chronic kidney disease (CKD) and Hepatitis C virus (HCV) infection. The treatment improved kidney function in stage 3 patients after cure, suggesting a potential therapeutic option for CKD patients with HCV.