Articles tagged with Kidney
A study found that women with a history of recovered acute kidney injury had an increased rate of preeclampsia and delivered infants earlier than those with normal kidney function. Infants born to these women were also at higher risk for small-for-gestational-age births.
A study by Massachusetts General Hospital found that women with a history of acute kidney injury have a higher risk of adverse outcomes during pregnancy, including preeclampsia and preterm delivery. Despite normal kidney function before pregnancy, these women were more likely to develop complications.
Children whose mothers smoked during pregnancy are more likely to show signs of kidney damage. Maternal smoking is linked to an increased risk of childhood proteinuria, a sign of reduced kidney function that can lead to chronic kidney disease and end-stage renal disease in adulthood.
A new study found that urinary epidermal growth factor levels provided improved ability to distinguish between patients with kidney involvement and those without. The biomarker was also associated with overall lupus damage, suggesting its potential role in monitoring disease progression.
Rates of dementia and Alzheimer's disease are higher among older kidney transplant recipients than in the general population. Older patients with kidney failure who receive a kidney transplant are at increased risk of developing these conditions, which can threaten both their transplanted organ and survival.
A study found that patient and kidney survival rates are comparable among donor age groups, including those over 80. Kidneys from octogenarian donors have a higher discard rate, but the difference is not significant. The results support using extended criteria donors, including older adults.
A meta-analysis published in Neurology found that people with protein in their urine are 35% more likely to develop cognitive impairment or dementia. Chronic kidney disease shares many risk factors with dementia, including high blood pressure, diabetes, and high cholesterol.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
Researchers developed low-cost 3D printed organ models of varying size and shape to aid in determining optimal dosing for individual patients. The study demonstrates the potential of 3D printing technology for clinical prototyping, particularly in quantitative SPECT/CT imaging.
Researchers have discovered an experimental molecule that inhibits kidney function in mosquitoes, preventing resistance to conventional insecticides. The new compound, VU041, targets blood-feeding female mosquitoes and does not harm honeybees.
A new review of 55 kidney stone studies suggests alpha blockers may be useful in facilitating stone passage, particularly for patients with larger stones. The findings indicate a 57% higher risk of stone passage for larger stones with an alpha blocker, but no benefit for smaller stones.
The Journal of X-Ray Science and Technology has added embedded 3D image videos to its articles, enhancing the value of five papers on kidney injuries, tumor diagnoses, and dental medicine. The videos allow readers to examine rotating 3D images in detail, gaining a deeper understanding of diagnoses, prognoses, and treatments.
A recent study found that low-fat diets and regular exercise can reduce liver inflammation and scarring in patients with non-alcoholic steatohepatitis. Additionally, improved liver health was associated with enhanced kidney function in these individuals, independent of other factors such as diabetes or weight loss.
Research found that short and poor quality sleep were associated with a lower risk of developing kidney failure, while higher sleep fragmentation increased the risk. Patients who experienced daytime sleepiness also had a higher risk of death during follow-up.
Researchers have developed a living membrane using conditionally immortalized human renal proximal tubular epithelial cells on polyethersulfone-based hollow fiber membranes. This breakthrough brings the development of a bioartificial kidney closer to reality, offering hope for millions of patients with kidney failure.
A study by Eugene Lin and colleagues found that multi-disciplinary care is a cost-effective intervention, costing $24,613 per quality-adjusted life year (QALY), compared to dialysis which costs $129,090 per QALY. This approach can improve the health of patients with kidney disease while reducing medical costs.
Researchers found that diabetes patients with all three risk factors (AKI, proteinuria, and poor blood sugar control) lose renal function at nearly 5% annually, accelerating dialysis need to within 12 years. Patients with two or one of these risk factors still face accelerated loss of renal function.
Recent studies have yielded promising results for patients with type 2 diabetes, including a 21% reduced risk of kidney dysfunction or death. Remote ischemic preconditioning has also shown sustained improvement in kidney function after transplantation. Meanwhile, trials examining dialysate sodium levels and voclosporin treatment have o...
A study found that intensive systolic blood pressure lowering can prolong life compared to standard levels, preventing approximately 107,500 deaths per year. Additionally, this approach is projected to save around 32,800 lives annually among adults with stage 3-4 chronic kidney disease.
A simple saliva test for salivary urea nitrogen showed high accuracy in diagnosing kidney disease in adults in Malawi. The test also predicted patients' risk of early death, highlighting its potential to improve treatment outcomes.
The ASN Foundation is launching a Securing the Future Campaign to raise critical funding for the Career Development Grants Program. The program aims to provide support for early career investigators in kidney research. With the campaign, the organization hopes to guarantee funding and attract top talent to the field.
Amit X. Garg, a renowned nephrologist, is being honored by the American Society of Nephrology for his groundbreaking research on living kidney donation and kidney health analytics. His work has led to improved understanding and treatment of kidney diseases, including E. coli O157:H7 poisoning and acute kidney injury.
Studies found that proton pump inhibitors and histamine receptor-2 blockers increase the risk of developing kidney stones and chronic kidney disease. Long-term use of these medications was associated with a higher risk of kidney stone formation, particularly those made of calcium oxalate.
A multinational study found that nearly one-fourth of children admitted to pediatric intensive care units worldwide develop acute kidney injury (AKI), which increases the risk of death. The study also revealed that severe AKI is associated with an increased need for mechanical ventilation and renal replacement therapy, highlighting the...
Boston University researchers discovered a novel molecular pathway needed to regulate kidney podocytes, critical in maintaining normal kidney function. This finding may help identify a new drug target for chronic kidney diseases associated with podocyte loss.
A new program, Live Donor Champion, has been shown to increase knowledge of live donation and comfort approaching others about live donation. The program boosted live donor referrals, with a 5.5-fold increase in having at least one donor referral compared to matched controls on the waiting list.
A study found that cigarette smoking blocked the benefits of medications taken by patients with early chronic kidney disease. Nonsmokers and quitters had slower worsening of kidney function compared to those who continued to smoke, highlighting the importance of quitting smoking for kidney health.
A telemedicine program in partnership with a national dialysis provider and a rural hospital in Kentucky has successfully treated over a dozen patients with more than 20 dialysis treatments, achieving 67% success rate. The program also provides 24/7 nephrology care for patients with kidney and electrolyte disorders.
A new study found that reducing sodium intake significantly reduced albuminuria and blood pressure in patients with chronic kidney disease. The combination of paricalcitol and a low sodium diet resulted in the lowest albuminuria levels in patients, indicating a strong reduction in kidney function decline and heart benefits.
Scientists have developed a method to create functional kidney units from patient cells, allowing for the study of human kidney diseases and potential therapeutic agents. The research enables in vitro studies of kidney pathophysiology and nephrotoxicity, with the ultimate goal of developing bioengineered kidneys for regenerative medicine.
Research links kidney damage to impaired cognitive function, including memory and attention, as well as structural brain changes. Higher albumin in urine, indicative of poor kidney function, was associated with worse cognitive performance.
Research found no association between allopurinol use and increased risk of chronic kidney disease (CKD) Stage 3 or higher in gout patients with normal kidney function. Allopurinol may be beneficial for preventing renal decline, suggesting its safe use in managing gout symptoms.
A retrospective cohort study found that chronic kidney disease patients who achieve target urate levels show improvement in kidney function. The study suggests that urate-lowering therapy may help stabilize or improve kidney function in patients with significantly elevated serum uric acid and moderate kidney failure.
Researchers have discovered a link between constipation and poor kidney health, suggesting that diagnosis and management of constipation may help prevent or treat kidney disease. Individuals with constipation had a 13% higher likelihood of developing chronic kidney disease and a 9% higher likelihood of developing kidney failure compare...
New research suggests a novel mechanism by which HIV-1 may infect kidney epithelial cells lacking the major CD4 receptor. Transmembrane TNF-alpha is identified as a key player in this process, potentially facilitating the transmission of HIV-1 from mother to fetus.
A study published in Mayo Clinic Proceedings found a persistent decline in kidney function after an individual's first case of kidney stones. This decline was linked to higher levels of cystatin C and urine protein, both associated with increased risk of chronic kidney disease.
A clinical trial found that patients with large kidney stones passed them more often when treated with the prostate drug Tamsulosin, offering potential relief from painful conditions. The treatment may also allow patients to be treated closer to home, improving care and reducing costs.
The US FDA has awarded Critical Path Institute three grants to develop data standards for HIV treatment, Clostridium difficile-associated diarrhea, and improved animal efficacy studies. C-Path will collaborate with CDISC to create therapeutic area data standards to accelerate clinical research and medical product development.
Researchers at Cedars-Sinai discovered that cutting nerves to the kidneys dramatically improves liver sensitivity to insulin, effectively curing insulin resistance in laboratory animals. The study reveals a previously unknown communication pathway between the kidneys and liver to regulate blood sugar levels.
A study found that most pediatric ICU physicians do not use current guidelines to diagnose acute kidney injury (AKI) in critically ill children. The prevalence of AKI among patients in pediatric intensive care units is rising, highlighting the need for improved diagnosis and treatment.
Researchers found no association between sex and risk of kidney damage when analyzing studies that took patient characteristics into account. Women are more likely to develop kidney damage following cardiovascular surgery, but this link is disputed when adjusting for comorbidities.
An educational and outreach program increased rates of referral for kidney transplant evaluation, especially among African American patients. The program reduced racial disparities in referral, with a significant increase in African Americans referred for transplant from 10% to 16%.
Researchers discovered factors secreted by gut bacteria, Oxalobacter formigenes, can stimulate oxalate transport and reduce urinary excretion in mice by 32.5%, potentially aiding in preventing or treating kidney stones.
A new polymer designed to detect acute kidney injury can identify the condition in its initial stages, allowing for simple treatment and good prognosis. The polymer selectively captures lipocalin-2, a protein biomarker for acute kidney injury.
Researchers at the Wyss Institute have successfully bioprinted a functional 3D renal architecture that recapitulates key functions of the kidney, including nutrient reabsorption. The printed tissue is composed of living human epithelial cells and has been sustained for over two months in vitro.
Researchers at MUSC discovered novel biomarkers that significantly improve the prediction of therapeutic efficacy in lupus nephritis. A targeted panel of urinary biomarkers, combined with machine learning modeling, provides an early decision-support tool for predicting outcomes.
Research on NKT cells reveals a crucial balance between type I and II subtypes in regulating inflammation. NKT cell activation can induce anergy in type I NKT cells, maintaining physiological inflammatory response. Regulation of NKT cells through membrane receptors and drugs like rapamycin may alleviate acute kidney injury
A new 6-part series on core curriculum for kidney specialists has been released by the Canadian Journal of Kidney Health and Disease, covering treatments for kidney failure and management of related complications. The series aims to enhance education and practice among nephrologists, students, and educators.
A newly developed compound inhibits high blood sugar's deleterious effects on kidney cells and slows kidney disease progression in diabetic mice. It protects kidneys in early and advanced phases of diabetes, improves function, and reduces inflammation.
A unique health survey of Finnish cats has identified common health issues such as mouth, skin, and kidney problems, as well as nearly 60 breed-specific illnesses. The study provides valuable information for preventing disease and developing breeding programs, highlighting the importance of genetic research and improving cat welfare.
A new study found that some living kidney donors are not given prompt access to transplantation when they need a transplant. The study examined data from the Organ Procurement and Transplantation Network (OPTN) and found that only 40-50 prior living donors are added to the kidney waiting list each year.
Dr. Hirofumi Kai's research focuses on inhibiting Alport syndrome progression, a progressive genetic kidney disease with high risk for kidney failure. The Alport Syndrome Foundation awarded $50,000 per year for two years to support his project on modeling AS in mice and humans.
Salk Institute scientists have discovered a method to create unlimited numbers of precursor kidney cells using a three-dimensional culture and new supporting molecules. These early-stage kidney cells could be used to grow replacement kidney tissue for studying and treating diseases.
After major trauma, debris from damaged cell powerhouses triggers an immune response in the kidneys, leading to permanent damage or destruction. Researchers aim to prevent this by understanding how formyl peptide receptors activate the immune system.
A recent study found that canagliflozin slows the progression of kidney function decline to a greater extent than glimepiride, while having similar blood sugar-lowering effects. The findings suggest that potential kidney protective effects of canagliflozin may be unrelated to glycemic control.
A new study from Ohio State University found that patients who experience anxiety after a kidney transplant are more likely to be readmitted within 30 days. The research suggests that standardized post-transplant care and training caregivers to convey empathy can reduce anxiety and prevent readmissions.
A study of US adults with diabetes found that overall diabetic kidney disease prevalence remained stable from 1988 to 2014, while albuminuria declined and reduced estimated glomerular filtration rate (eGFR) increased. The prevalence of reduced eGFR was higher among younger and non-Hispanic white populations.
A study by University of Washington researchers found that the prevalence of diabetic kidney disease has remained relatively stable over 30 years, but its clinical manifestations have changed significantly. Albuminuria rates decreased, while reduced glomerular filtration rate increased.
Researchers found a natural fruit extract, hydroxycitrate (HCA), dissolves calcium oxalate crystals, the most common component of human kidney stones. The study suggests HCA is an effective inhibitor and may be preferred over existing treatments.
Robotic partial nephrectomy (RPN) has shown excellent patient outcomes compared to traditional open partial nephrectomy (OPN) for endophytic kidney tumors. The study found shorter hospital stays, lower blood loss, and fewer blood transfusions in RPN patients.