Articles tagged with Kidney
Researchers found a link between the two diseases, with mutations in HNF-1a protein interfering with PKHD1 gene transcription. This discovery may lead to similar therapeutic approaches for both MODY5 and polycystic kidney disease.
A $3.3 million NIH grant-funded study will compare six-times-per-week overnight home hemodialysis to standard three-times-a-week hemodialysis at dialysis centers. The research aims to determine if the higher dose of dialysis improves patient outcomes, including hospitalization rates and quality of life.
Researchers have developed a novel technique that allows them to visualize three genes at once in embryos, body tissues, or even single cells. This improved FISH method combines existing technologies to illuminate gene activity, enabling scientists to study embryonic development and birth defects in greater detail.
A study found that both hemodialysis and peritoneal dialysis improved general functioning and well-being, but with different outcomes. Peritoneal dialysis patients showed improvements in finances, while hemodialysis patients had better sleep.
Patients who develop diabetes after kidney transplant experience poorer outcomes, including higher rates of infection and recurrent infections. Tight control of glucose levels is crucial for these patients to remain healthy.
A study by Johns Hopkins researchers found that patients on peritoneal dialysis rate their care as excellent, citing independence, access to staff, and quality of treatment. In contrast, hemodialysis patients report lower satisfaction rates, with many citing inadequate information and economic factors as barriers.
Scientists give mice with damaged kidneys injections of BMP-7 to prevent adynamic bone disorder, a condition causing weakening and distortion of bones. The treatment is shown to be effective in normalizing bone cell counts and structures.
Screening for proteinuria is not recommended for the general population due to high costs and false positive/negative test results. However, targeted screening for hypertensive patients aged 30+ and adults 60+, or less frequent screenings every 10 years, can be cost-effective.
Researchers found no survival benefit from solitary pancreas transplantation for patients with diabetes, but may justify procedure for quality of life benefits. The study suggests weighing potential benefits against increased mortality risk, particularly in the early posttransplant period.
A new CT scan technique called multi-detector CT urography (MDCTU) has been shown to detect various urinary system problems, including bladder cancer, kidney stones, and cysts. The technique is more accurate than traditional methods and may be beneficial for high-risk patients.
The demand for kidney transplants is soaring due to type 2 diabetes and hypertension, but the number of available donors is low. Experts at the American Society of Nephrology conference discuss the pros and cons of paid donations, weighing the need to increase the transplant pool against ethical concerns.
Non-directed kidney donations have the potential to save thousands of lives, but raise important ethical considerations. Transplant centers are developing policies to evaluate and allocate these kidneys, addressing issues like allocation and donor expenses.
Research finds that heavy use of analgesics for at least nine years prior to irreversible kidney failure is associated with anatomic changes of SICK. Over 7% of dialysis patients had SICK, with 33% having overused analgesics preceding dialysis start.
Scientists discover that linking sugars to aquaporin-2 is essential for water channel transport in the kidneys. This process enables the body to conserve water and prevent dehydration. The study also identifies a new protein, AQP2-BP, that plays a crucial role in aquaporin-2 production.
Researchers found increased COX-2 protein expression and changes in TXA2 and PGE2 levels in the Obese Zucker rat, which led to kidney damage. The study suggests that COX-2 inhibitors may be beneficial for preventing renal damage in obesity-related type II diabetes.
Researchers found that adolescents with impaired stress-induced pressure natriuresis showed increased urinary creatine levels and higher blood pressure after stress, indicating excessive kidney workload. This response pattern may lead to early development of renal disease.
Researchers have identified a novel treatment for polycystic kidney disease (PKD) by targeting a specific receptor responsible for cyst development. The treatment, OPC31260, shows promise as a potential therapy for conditions like heart and liver failure.
The Notch molecule is found to be crucial for kidney development, particularly in the formation of podocytes. The study reveals that Notch signaling tells some cells to become podocytes from non-specialized epithelial cells. After a certain amount of time without Notch signaling, cells can recover and form podocytes again.
Scientists have discovered that cells can adapt to survive without oxygen, a key finding that could lead to new treatments for cancer, heart attack, and stroke. Researchers are tracing the signaling pathways for cell injury and death, with hopes of identifying therapeutic tools to switch cellular behavior.
A study found that organ-transplant patients are particularly vulnerable to measles due to their compromised immune systems. Low MMR vaccine uptake in southeast London poses a significant threat to these individuals, highlighting the need for increased awareness and vigilance.
Researchers found that moderate blood dilution can cause measurable kidney damage in patients undergoing coronary artery bypass surgery. The risk increases with patient body weight, and transfusions may also contribute to kidney injury.
A new study found that 16.5% of non-kidney transplant recipients develop chronic kidney failure, with older age, being a woman, and pre-transplant hepatitis C infection increasing the risk. The risk is higher for those whose kidneys fail after transplant, highlighting the need for better treatment regimens.
The Mayo Clinic team has successfully transplanted kidneys into 29 high-risk patients, achieving an 80% success rate. By filtering out antibodies from the patient's blood, they can create a less hostile environment for the donor kidney to adapt. This approach may change the fate of thousands of patients waiting for a transplant.
Researchers at the Mayo Clinic have identified a key finding about how donor kidneys adapt to new bodies. By analyzing gene expression patterns, the study found that donor kidneys can develop protective processes that shield them from the recipient's immune system, potentially reducing rejection rates and improving transplant outcomes.
Researchers identified a new gene, inversin, associated with nephronophthisis type 2, a deadly kidney disease in children. The discovery may lead to treatments and connections between the childhood disease and adult polycystic kidney disease.
A new study by Stanford Medicine researchers found that B cells play a significant role in acute kidney rejection, and targeting them may lead to more effective treatment. The study identified three distinct subgroups of acute rejection based on gene-expression profiles, which could help physicians tailor their treatment approaches.
A new nanotech strategy creates a precise architectural framework for liver or kidney cells to sustain viability for at least one week. Experiments show 96% of kidney cells and 95% of liver cells survived with the device, paving the way for whole, functional organs
A new study reveals that bone morphogenic protein-7 (BMP-7) can reverse chronic kidney injury by reducing scar tissue and repairing damaged areas. This breakthrough could lead to a cost-effective treatment alternative for patients currently undergoing dialysis, significantly improving their quality of life.
New data from the Roche Organ Transplantation Research Fund challenge the idea that potent immunosuppressants increase cancer risk. People receiving CellCept are less likely to develop lymphoma or post-transplant lymphoproliferative disease, with a lower risk of malignant lymphoma compared to conventional immunosuppressive treatment.
A major study of over 7,000 living donor kidney transplant patients found that Neoral significantly improves three-year graft survival rates and prolongs the estimated graft half-life compared to tacrolimus. This suggests a clear advantage for Neoral in reducing the risk of transplant failure.
African-American kidney dialysis patients know about live donor transplants but may not discuss their wishes with healthcare providers, a Johns Hopkins study shows. Machine-preserving cadaveric kidneys improves early function after transplant and increases survival rates.
A study published in Science suggests that proteins normally pass into the kidneys and that kidney disease may result from an inability to draw them back out. Researchers identified at least two patients with kidney disease who lack one copy of CD2AP, a protein critical for kidney function.
A recent study found that linezolid significantly improves the survival rate of patients with hospital-acquired MRSA pneumonia compared to vancomycin. The analysis of two earlier studies showed that patients who received linezolid were more than twice as likely to survive.
Multidetector CT (MDCT) accurately identified 66 out of 71 total cancers found after additional tests and surgery, including small cancers under 5mm in diameter. MDCT offers a more comfortable and time-efficient alternative to excretory urography for detecting urinary tract abnormalities.
Researchers report successful treatment of 50 out of 51 renal tumors using radiofrequency ablation. The therapy is particularly effective for tumors on the outer surface of the kidney due to surrounding fat insulation.
Researchers investigate how income, race, and Medicaid regulations affect kidney transplant outcomes for low-income individuals. The study aims to provide guidance for policymakers on immunosuppression coverage duration.
Scientists in Japan and UCSD have discovered a novel regulatory role for pseudogenes, which stabilizes a protein-coding gene on another chromosome. The study found that disabling the pseudogene led to abnormal kidneys and bones in laboratory mice, while re-introducing it resulted in normal development.
A recent study has found a direct link between cilia assembly proteins and polycystic kidney disease (PKD), a condition affecting one in every 500 people. The research suggests that stopping cilia formation can cause PKD, providing new insights into the disease's mechanisms.
A high-meat protein diet may accelerate loss of kidney function in women with mild chronic kidney disease, according to data from the Nurses Health Study. Meanwhile, implantable cardioverter defibrillators have been shown to significantly reduce sudden cardiac death and deaths from all causes in many patients.
Researchers at Indiana University School of Medicine have localized the original mineral deposit site for most common stone formers and determined the composition of calcium phosphate crystals. This discovery refutes current theories on kidney stone formation, shedding new light on the disease's complex physiology.
A man with kidney disease experienced severe abdominal pain after using a whirlpool in a Jacuzzi, highlighting potential health risks. The case study suggests that whirlpooling may cause mechanical injury to the kidneys, particularly under conditions like hypertension or anticoagulation.
Researchers successfully treated 42 individual kidney tumors using minimally invasive RFA, with all surface tumors completely destroyed. Patients with limited kidney function maintained good kidney function and had no local recurrence of the treated tumor.
A new study by UF researchers has shown that mycophenolate mofetil significantly decreases the risk of late acute rejection and increases kidney survival after transplantation. The drug also appears to prevent the severe scarring of the kidney, a common cause of organ malfunction or failure.
Researchers estimate 8 million people in the US have less than half of normal kidney function, a treatable condition. Chronic kidney disease is strongly associated with older age and non-Hispanic whites, raising concerns about minority populations' higher risk of kidney failure
Scientists have successfully transplanted human and porcine 'kidney precursor cells' into mice, resulting in functional kidneys that produce urine. The optimal time for transplantation is between 7-8 weeks (human) and 4 weeks (porcine), reducing the risk of immune rejection.
A recent study published in The New England Journal of Medicine found that higher doses of hemodialysis and more permeable artificial kidneys did not improve survival rates for all patients with end-stage kidney disease. However, selected subgroups, such as women and those treated with a more permeable membrane, showed significant impr...
Researchers at Ohio State University successfully tested micro-sized gelatin particles that may deliver therapeutic genes to the glomerulus in the kidneys. The biodegradable particles dissolved quickly enough to pass through the glomerulus within 10 hours, suggesting they could be useful in transferring genes to tissues.
Researchers at Wake Forest have identified a gene responsible for two rare kidney diseases, familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2. The discovery may lead to early detection and improved treatment options for affected individuals.
A study published in JAMA found that ICU patients treated with diuretics have a 68% increase in mortality and 77% non-recovery of kidney function. The researchers suggest reassessing diuretic use, particularly for those not responding to treatment, as delays can lead to adverse outcomes.
UF researchers found that patients who wait longer for a kidney transplant are more likely to experience poorer outcomes. The study showed that even those who receive kidneys from living donors may not reap the full benefits if they have been on dialysis for too long.
A new non-calcium phosphate binder, lanthanum carbonate (Fosrenol), has shown a reduction in mortality and cardiac death among kidney patients on hemodialysis compared to conventional phosphate binders. The study involved 647 patients who received Fosrenol therapy for two years.
Researchers suggest using rapamycin to improve renal function and reduce ischemia-reperfusion injury in marginal kidney transplants. The study found that kidneys treated with cyclosporine fared worse than those treated with rapamycin, leading to restricted blood flow and poorer filtration.
A study in southern India found that selling a kidney led to a decline in economic and health status for the seller, with only 14% experiencing no negative effects. The findings contradict arguments in favor of financial incentives, suggesting they may deter organ donations instead.
Researchers from CU-Boulder will conduct cell biology experiments in microgravity, mimicking normal functioning kidney cells and studying molecular responses to infections. Plant growth experiments will also explore the role of gravity on plant development, with potential applications in timber and pharmaceutical industries.
Drs. Gerald DiBona and John Hall have overturned the medical community's long-held understanding of kidney function, revealing that increased nerve activity leads to high blood pressure. Their research shows that abnormal kidney function causes salt and water excretion to decrease, resulting in hypertension.
Researchers found that knocking out enzymes adds fucose to proteins, protecting the kidney from damage and inflammation. Developing drugs targeting these enzymes could lead to new therapies for conditions like heart attacks and strokes.
A new study shows that CellCept substitution of cyclosporine reverses renal toxicity, improving the life span of transplanted kidneys. 58% of patients on CellCept therapy had a reversal or stabilisation of their kidney function compared to 32% on cyclosporine.
Pittsburgh researchers report a new clinical approach that radically reduces and eventually weans patients off all immunosuppression after small intestine transplants. Results show many patients can take minimal doses of a single anti-rejection drug, with some remaining drug-free for up to 38 years.
A clinical trial at Massachusetts General Hospital has shown that combined kidney and bone marrow transplantation can induce long-lasting tolerance in patients with multiple myeloma. The treatment, called non-myeloablative bone marrow transplantation, reduces the need for anti-rejection drugs.
Researchers at Johns Hopkins Medicine developed a new technique using plasmapheresis and immunosuppressive medication to prevent antibody production against donor organs. The treatment resulted in an average of 13-month-long protection against organ rejection, significantly reducing long-term complications.