Articles tagged with Senescence
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Scripps Research Institute scientists have identified key triggers of an important cancer-blocking mechanism in cells, known as oncogene-induced senescence. The study reveals a cascading interaction of three enzymes necessary to initiate this response.
Researchers found a strong association between spinal posture and dependency in activities of daily living (ADL), with those in the highest quartiles having 3.47 times higher risk of dependence. Spinal measurements were taken using a computer-assisted noninvasive device, and data from 804 participants aged 65+ were analyzed.
Researchers discovered that oncogene-induced senescence can suppress cancer development by depriving cells of nucleotides, the building blocks of DNA. By targeting the RRM2 enzyme, which produces these nucleotides, scientists may be able to stabilize senescence and improve the effectiveness of chemotherapy or targeted drugs.
A study found that healthy menopausal women with an Alzheimer's risk factor showed accelerated biological aging, but hormone therapy reversed this effect. The research used telomere length as a measure of biological aging and found that estrogen therapy protected against this aging process.
Researchers discovered a class of p53 target genes and regulatory molecules that regulate metabolism and senescence in cells. Malic enzymes, identified as novel pharmaceutical targets for anticancer therapy, may also play a role in the normal process of cellular aging.
Researchers found that male toads storing sperm during the breeding season produced sperm with higher motility than those kept under natural conditions without females. Frequent mating also appeared to slow down sperm senescence, a process affecting sperm quality with age.
Researchers at the University of East Anglia found that individuals with shorter telomeres have an increased risk of death, and that longer telomeres are associated with a longer lifespan. The study, published in Molecular Ecology, measured telomere lengths in a wild population of Seychelles Warblers over 20 years.
Researchers will directly examine biological aging in schizophrenia using psychiatric and medical interviews, as well as laboratory techniques. The study aims to unravel biological mechanisms underlying faster aging in patients with schizophrenia.
Researchers activated a gene called PGC-1, which increases mitochondrial activity, and found it significantly extends the lifespan of fruit flies' digestive tracts. The study's implications for human aging suggest targeting the intestine as a vital tissue type for healthy aging.
Research reveals age-related degradation of bone's intrinsic and extrinsic toughness. Biological aging increases collagen cross-linking, osteonal density, and micro cracking, compromising fracture resistance.
Research reveals that male houbara bustards who perform the most elaborate sexual displays suffer from premature biological aging. This study finds that these males pass their reproductive prime earlier than less extravagant rivals, highlighting an early-life cost to later-life declines.
Researchers identified a gene regulatory link between early brain development and aging, suggesting 'runaway' development may be detrimental. This process is observed in both humans and macaques, with the latter experiencing accelerated rates, potentially limiting their lifespan to one-third that of humans.
Researchers from the University of Illinois at Chicago have discovered a cellular response that breaks down and inhibits excess scar tissue in wound healing. Fibroblasts recruited to the wound site enter a state of reproductive dormancy called senescence, which accelerates collagen breakdown and limits scar tissue formation.
Researchers found liver transplant recipients develop premature immune senescence due to chronic immune stress. The study suggests that accelerated T-cell aging contributes to increased morbidity and mortality in established liver graft recipients.
Researchers have discovered that two cell protection programs work together to prevent tumors, with the Myc oncogene triggering apoptosis and senescence. The findings suggest a new approach to treating cancer by inducing senescence through chemotherapy.
A study published in JAMA found that higher omega-3 fatty acid blood levels were associated with a lower rate of telomere shortening, a marker of biological aging, in patients with coronary heart disease. Patients with the highest levels of omega-3 fatty acids experienced the slowest rate of telomere shortening over 5 years.
Four leading biologists will present their research on the biological causes of aging, revealing that complex molecules become dysfunctional over time. The symposium aims to advance our understanding of aging and its relationship with age-associated diseases.
Regular aerobic exercise can slow or reverse the decline of maximal aerobic power, delaying biological aging and maintaining functional independence. By conserving maximal oxygen intake, individuals may retain their physical abilities longer, reducing the risk of serious disease and improving overall health.
A recent study published in the Archives of Internal Medicine found that individuals with sedentary lifestyles exhibit shorter telomeres, indicating an accelerated aging process. Regular exercise, however, has been shown to reduce oxidative stress and inflammation, which may help mitigate this effect.
A new study published in PLOS ONE found that bears' selective feeding habits on salmon with less signs of senescence accelerates the aging process in these fish. The research suggests that predation pressure is a primary driver of senescence, rather than the physical characteristics of the prey.
A study in mice shows that switching off a single malfunctioning gene can halt the growth of tumor cells and turn them back to their normal life cycle. The researchers found that cancer cells retained the ability to undergo senescence, a natural mechanism that causes cells to die when they become old or dysfunctional.
A new study found that breeding Zambian mole-rats lived up to 20 years and twice as long as non-breeding individuals. The researchers suggest this could be due to the species' eusocial lifestyle and pair-bonding habits, making it a valuable model organism for studying aging mechanisms.
A new study confirms that evolution selectively influences life history traits affecting fitness, such as age at reproduction and senescence. Guppy populations show no postreproductive lifespan variation, contrary to expectations, suggesting this aspect of life history may be randomly determined.
The study found that suppressing SIRT1 increases the ability of cells to divide indefinitely without senescence. This discovery has potential applications in generating normal cells for research and could be used in techniques to produce large numbers of cells.
A study by UC Riverside researchers has found that fish living in high-predator environments challenge classical evolutionary theories on aging. They have been shown to live longer, exhibit lower mortality rates, and maintain higher levels of fertility compared to those from low-predator environments.
Researchers found that naked mole-rats, living up to 20 years in the wild, outlive other similar-sized rodents by a factor of 10 due to reduced extrinsic mortality. Their remarkable longevity is linked to their subterranean lifestyle and cooperative defense against predators.
Aging cells retire when their telomeres become too short to function, according to a new Rockefeller University study. The researchers found that protein TRF2 helps critically short telomeres function better, allowing old cells to live longer.