Articles tagged with Senescence
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
A large-scale study has linked accelerated biological aging to an increased risk of depression and anxiety in older adults. Adults with more advanced biological age were found to be more likely to develop depression and anxiety over time compared to peers who were biologically younger.
A study found that biological age in humans and mice increases rapidly in response to diverse forms of stress, only to reverse after recovery. The researchers used DNA methylation clocks to measure changes in biological age, revealing transient changes in response to stressful stimuli.
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
Researchers found that senescent cells promote regeneration by secreting factors that stimulate nearby muscle tissue to produce new muscle cells. The presence of these cells enhances the regeneration process, allowing salamanders to grow lost limbs in a matter of weeks.
Researchers at the University of Minnesota Medical School found that genetic background and social rank are critical contextual modifiers of aging and lifespan in animal models. They discovered that low social status corresponds to a shorter lifespan, but with varying effects depending on the individual's genetic predisposition.
A study found that regular exercise increases mitochondrial fusion, benefiting muscle cells and maintaining physical fitness even in old age. Daily sessions of exercise throughout life delay the accumulation of dysfunctional mitochondria and decline in physical fitness.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Researchers explore cellular senescence's complex relationship with growth stimulation and cell cycle arrest, revealing potential anti-aging drug targets. Understanding these mechanisms is crucial for developing new treatments for age-related diseases.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
A new study finds epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV. Participants showed accelerated biological age and different brain activity patterns compared to controls, suggesting a link between biological aging and neural function in PWH.
Adults with higher serum sodium levels were more likely to develop chronic conditions, show signs of advanced biological aging, and die at a younger age. Optimal hydration may be associated with slower aging and reduced risk of chronic diseases.
A 16-year longitudinal study found associations between DNA methylation-based measures and neuropsychologically-validated cognitive decline in midlife. The results suggest that these measures may serve as biomarkers for a molecular aging mechanism, potentially identifying individuals at risk of cognitive impairment and dementia.
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
A team of researchers identified senescent cells as a major obstacle to muscle regeneration, which can be overcome genetically or pharmacologically. Neutralizing these cells improves tissue repair in both young and elderly individuals.
A study published in Aging-US reveals changes in gene expression associated with age-related muscle loss and frailty. Researchers identified unique cellular subpopulations in aged and sarcopenic skeletal muscle, which may facilitate the development of new treatments for age-related frailty.
A new study found that obeticholic acid can reverse cognitive impairment in patients with cholestatic liver disease, improving short-term memory and restoring brain function. The study used a rodent model of bile duct ligation-induced cholestasis and found that the drug significantly improved cognitive deficits.
The German Research Foundation renewed CRC 1361 for an additional four years to explore mechanisms of DNA repair and genome stability. The consortium aims to elucidate how cells safeguard genetic information and promote human health by understanding DNA damage signaling pathways.
Johannes Gutenberg University Mainz has been awarded funding for three Collaborative Research Centers in the life sciences, including CRC 1551 and CRC/Transregio 355. The centers will focus on investigating polymer concepts in cellular function and heterogeneity of regulatory T cells in distinct microenvironments.
Researchers found that glutaminase inhibitor BPTES selectively eliminates senescent dermal fibroblasts, improving skin aging phenotype by increasing collagen density and cell proliferation. The study suggests BPTES as a potential therapeutic agent for skin aging, offering new treatment options.
Researchers discovered that krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Krill oil increases neuronal resilience, promoting anti-oxidative stress and anti-inflammation, and abrogating multiple aging hallmarks.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
Researchers discovered that a lipid called prostaglandin E2 weakens lung immune cells with age. This increased PGE2 production impairs alveolar macrophage health and leads to a suppressed immune response, making older people more vulnerable to flu infections.
Researchers at IRB Barcelona found that senescent cells stimulate the immune system to attack tumors more effectively than dead cells. Vaccinating healthy mice with senescent cells reduced tumor growth and improved immune response in animal models of melanoma and pancreatic cancer.
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
Researchers at the University of Minnesota Medical School have received $19.3 million in NIH grants to map senescent cells and develop senolytic drugs. The project aims to create a 4D atlas of human senescent cells and advance knowledge on how to use senolytics to improve human health.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
Peter Adams and Bing Ren will map senescent cells in five tissues using state-of-the-art technologies to analyze gene expression and chromatin structures. The project seeks to reveal how and where aging cells accumulate, ultimately generating an atlas that can help develop strategies to prevent and treat age-related diseases.
Researchers discovered that liver cancer cells modify their metabolism to leave them susceptible to disruptions in arginine supply, a key molecule. A three-pronged approach targeting tumor metabolism, blocking survival-promoting responses, and starving tumors of arginine can induce senescence, making cancer cells killable.
A new study by researchers at the University of Oxford found that ageing female wild red deer on the Isle of Rum in Scotland tend to adopt a life of solitude as they grow older. They interact with fewer other individuals within their home ranges and shift to less populated areas of their habitat.
Researchers analyzed stored blood samples from infected men and found significant age acceleration in DNA epigenetic measures and telomere shortening. The study demonstrates HIV's substantial impact on the body's aging processes within two to three years of infection.
A new study reveals that oxidative damage to telomeres can trigger cellular senescence, leading to the development of 'zombie cells'. Researchers found that damage at telomeres disrupts DNA replication and induces stress signaling pathways, contributing to age-related diseases.
A new study in Science found that many species of turtles and tortoises have slowed or switched off senescence, challenging evolutionary theories. Out of 52 species, 75% show extremely slow senescence, and 80% have slower senescence than modern humans.
A new study found a clear link between brisk walking and longer telomere length, indicating slower biological aging. Researchers estimate that a lifetime of brisk walking could lead to the equivalent of 16 years younger biological age by midlife.
Children of exceptionally long-lived parents and their spouses experience lower risk of type II diabetes compared to the general population. The study found that low BMI, high HDL cholesterol, and certain hormones in the blood protect against developing diabetes II.
A new technique called Operational Genomic Units (OGU) allows for improved resolution and simplicity in analyzing microbiome samples. By using individual genomes as basic units, researchers can pinpoint biologically relevant characteristics such as age and sex with greater accuracy.
Researchers developed tools to measure biological aging of various organ systems using biomarkers, statistical modeling, and machine learning. They found diverse correlations between different bodily systems, with some unexpected findings such as a link between gut microbiota diversity and kidney aging.
Researchers from Osaka University discovered that MondoA protein delays cellular senescence by activating autophagy, promoting longevity. Activation of MondoA also maintains mitochondrial stability, preventing senescence in tissues like the kidney.
A study published by Arizona State University found that survivors of Hurricane Maria experienced accelerated aging in their immune systems, with molecular changes indicating a 7-8 year acceleration in human lifespan. The research used rhesus macaques as a model to explore the effects of extreme weather events on biological aging.
Research finds a strong association between retinal age and real age, with large gaps associated with increased mortality risk. The 'retinal age gap' could be used as a screening tool to predict mortality risk, particularly for non-cardiovascular causes.
Researchers discovered that genome-wide disruptions in Down syndrome cells share similarities with cellular aging or senescence. Anti-senolytic drugs were found to correct these disruptions, improving gene accessibility and cell function in cell cultures.
A new research framework is needed to fully understand plant biology, integrating multiple approaches and levels of organization. By incorporating spatiotemporal context, scientists can better comprehend the complexities of plant life and develop more effective solutions for conservation and sustainability.
A research team at the University of Montreal Hospital Research Centre has found that cellular aging is caused by irreversible damage to the genome, not just telomere erosion. This discovery challenges the long-held scientific model and opens up new research opportunities for preventing cellular aging and genomic instability.
Researchers create maps of senescence in heart and lung cells, comparing different types of senescent cells across the lifespan. The goal is to understand how senescent cells contribute to age-related diseases and develop therapies called senolytics.
Researchers have identified a new method for clearing senescent cells using an antibody treatment, which could transform treatments for ageing and related conditions. The treatment targets specific membrane markers on senescent cells, effectively eliminating them and slowing age-related degeneration.
A study of roundworms found that older parents can produce larger, faster-developing offspring with better reproductive success, challenging the notion that old parental age is detrimental. The research showed that older parents invest more nutrients in eggs, resulting in larger offspring.
Researchers at University College London discovered that worm mothers secrete a milk-like fluid to support their offspring's growth. This unique selfless act helps explain mysteries about the biology of ageing in nematode worms, which could have far-reaching implications for understanding human ageing.
Scientists at UEA have identified a way to determine the age of lobsters using DNA. The method is based on quantifying DNA changes that accumulate with age within a lobster. This breakthrough could help manage lobster fisheries more sustainably by providing accurate estimates of lobster ages.
A recent study published in Cell Metabolism found that reducing naturally occurring errors in protein synthesis improves both health and lifespan. By engineering a mutation in ribosomes, researchers observed fewer protein mistakes and improved heat resistance, leading to longer lifespans in yeast, worms, and fruit flies.
A Brazilian-UK study found that older individuals with both abdominal fat and muscle weakness experience a significant loss of gait speed over eight years. This decline can lead to difficulty walking and increased risk of falls, impacting independence. Researchers urge health workers to measure abdominal fat and muscle strength to pred...
A new study finds that early-life exposure to tobacco smoke is associated with accelerated biological ageing in children. The analysis of over 1,000 children in six European countries revealed that maternal tobacco smoke during pregnancy and indoor exposure to black carbon are linked to an acceleration in epigenetic ageing.
Researchers from Gero and Roswell Park Comprehensive Cancer Center discovered that biological age is changing over time, leading to reduced resilience. As people age, it takes longer to recover from stresses, and chronic diseases are linked to loss of resilience.
Researchers found that a significant gap between numerical age and biological age, as predicted by AI-enabled EKGs, is associated with increased risk of death from heart disease. The study validated the use of AI-aged EKGs in predicting mortality rates.
A new mathematical model provides unique insights into the multiscale biological alterations in the elderly and neurodegenerative brain, linking genetic changes to cognitive decline. The study identified genes contributing to healthy aging and Alzheimer's disease progression, with implications for future treatment targets.
Researchers found that premature boys age more quickly than their normal weight counterparts, with a biological age gap of 4.6 years by age 30-35. This accelerated aging may be influenced by prenatal stress and hospital care after birth, emphasizing the need for monitoring and healthy aging strategies.
High levels of RANK protein trigger senescence in early stages of tumors, delaying their onset, but promote stem cell accumulation and tumour growth in advanced stages. This discovery sheds light on the complex mechanisms underlying breast cancer development and progression.
GeroSense AI tracks biological age and resilience via smartphone sensor data, providing personalized health recommendations. The technology predicts biological age acceleration and stability, enabling timely detection of lifestyle or health status changes.