Articles tagged with Inflammatory Signaling
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Researchers discovered that Rac1 activates a cascade of reactions in nerve cells associated with inflammatory pain. Inhibiting Rac1 using NSC23766 reduced pain hypersensitivity in rats injected with bee venom. These findings suggest potential for new drugs to treat chronic inflammatory pain.
The Biophysical Society has announced the winners of its annual CPOW Travel Awards to increase women biophysicists' participation at the 2016 Annual Meeting. The recipients include Jana Broecker, Nabanita Das, and others presenting posters or oral presentations on various membrane proteins and calcium signaling.
A study published in Cellular and Molecular Gastroenterology and Hepatology found that modulating B lymphocyte function may help regulate T lymphocyte activity to treat immune-mediated disorders like IBD. Researchers discovered a pathway involving IL-10, IL-27, and regulatory T lymphocytes.
Duke researchers have identified the uhrf1 gene as a key regulator of tumor necrosis factor (TNF) levels, which are associated with inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The study found that loss of uhrf1 leads to increased TNF production, which can cause inflammation and damage to the digestive tract.
A new study suggests that reversing brain inflammation caused by a high-fat diet greatly improves symptoms related to obesity and type II diabetes. Administering butein to obese mice improved glucose tolerance and brain insulin signalling, even at lower doses compared to non-treated mice.
Researchers at Scripps Research Institute have identified key signaling proteins that contribute to the development of inflammatory diseases such as rheumatoid arthritis and psoriasis. By targeting these proteins, a new class of anti-inflammatory therapy may be developed.
Researchers at Ben-Gurion University of the Negev and Teva Pharmaceutical Industries Ltd. have developed a promising drug candidate to treat psoriasis. The engineered receptor effectively reduces inflammatory signals in mice models, showing potential for a viable treatment for severe psoriasis patients.
Researchers have mapped the 3D structure of CXCR1, a protein that detects inflammatory signals and triggers immune responses. The study's findings will enable the development of more precise drug targets and potentially lead to effective cancer treatments.
Researchers at Monash University have discovered a mechanism that shuts down the body's inflammatory response after injury. This finding has significant implications for treating inflammation and may lead to new treatments for conditions such as myeloperoxidase deficiency.
New research from the Trudeau Institute reveals a negative feedback loop regulating immune response to bacteria, preventing tissue damage while controlling bacterial growth. The study's findings have potential applications in improving prevention and treatment strategies for bacterial infections.
Researchers at the Salk Institute found that a molecular link between circadian rhythm disturbances and an increased inflammatory response can lead to chronic diseases. The absence of cryptochrome leads to the activation of a signaling system that elevates levels of inflammatory molecules, causing low-grade, chronic inflammation.
Two large meta-analyses found a genetic variation in the interleukin-6 receptor associated with lower levels of inflammatory biomarkers and reduced coronary heart disease risk. A single-nucleotide polymorphism was linked to effects consistent with known benefits of IL6R blockade in patients with rheumatoid arthritis.
Researchers discovered vitamin D's mechanism to inhibit inflammation by binding to DNA and activating the MKP-1 gene. Vitamin D levels above 30 ng/ml significantly reduced inflammatory responses.
Researchers discovered that caspase-8, an enzyme previously thought to only prevent inflammation through apoptosis, can also control inflammation by destroying a protein called RIP1. This new mechanism could lead to the development of effective therapies for inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease.
Researchers have identified a connection between DNA damage and the regulation of inflammatory responses in humans. The study found that an injury to chromosomes alters the expression of Toll-like receptors, leading to inflammation. This discovery may lead to new treatments for inflammatory diseases and cancer.
Researchers have identified a key inhibitory role for the IL-1 signaling pathway in the human innate immune system, revealing its impact on inflammatory bowel disease (IBD) and anti-inflammatory cytokine production. The study suggests that certain drugs used to treat conditions like rheumatoid arthritis may be harmful to IBD patients.
Researchers found that chokeberry extract reduced body weight, improved blood glucose regulation, and decreased inflammation in prediabetic rats. The study suggests that chokeberry's antioxidant properties may help modulate genes associated with adipose tissue growth and inflammatory pathways.
Researchers at Hospital for Special Surgery have discovered a new pathway involved in turning off inflammation that does not work properly in people with inflammatory arthritis. This finding could lead to the development of new therapeutic approaches to treating arthritis.
Researchers have defined a molecular mechanism underlying impaired inflammatory responses in mice lacking Hfe. Altering iron levels may provide a new approach to controlling inflammation, as seen in studies with drugs mimicking altered iron distribution.
Cells experiencing DNA damage send signals to neighboring cells, triggering an inflammatory response that can lead to cancer and accelerated aging. The discovery provides a new target for preventing these processes.
Researchers at Washington University School of Medicine have identified a rare immune cell, NK-22 cells, that can produce IL-22 to promote wound healing and prevent tissue damage. This discovery may lead to the development of new therapies for inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Researchers found that losing sleep for part of one night activates cellular pathways producing tissue-damaging inflammation, linked to increased risk of cardiovascular disease and autoimmune disorders. Good sleep habits may ease this risk.
Researchers at UC San Diego School of Medicine have uncovered a new signaling mechanism used to activate protein kinases involved in the body's inflammatory response. Smac mimic compounds may serve as prototypes for new anti-inflammatory therapy, potentially offering an alternative to expensive current treatments.
A study by the University of Washington researchers found that infections and toxins can activate caspase-1, an enzyme involved in both beneficial apoptosis and harmful pyroptosis. This activation leads to inflammation and can be detrimental to vital tissues, but also plays a role in resistance to infection.
Researchers have identified a key pathway involved in autoinflammatory diseases, including arthritis and certain types of cancer. Mutant forms of the PSTPIP1 protein can activate pyrin, leading to excessive IL-1 beta production and inflammation.
Researchers discovered a key gene, NALP1, associated with vitiligo and other autoimmune diseases. The gene controls the innate immune system and may help trigger these conditions.
A study by European Molecular Biology Laboratory researchers identifies NF-kB as a crucial signaling molecule in the development of chronic intestinal inflammation. The findings provide a new paradigm for understanding inflammatory bowel disease and may pave the way for novel therapeutic approaches.
Researchers found that tea extracts reduce inflammation and duration of radiation-induced skin damage by up to 10 days. Green tea extracts are more effective than black tea in some patients.
A new genetic link has been found for Crohn's disease, revealing a crucial target for drugs that might better manage the condition. The discovery of a specific gene variant confers significant protection against IBD, suggesting therapies targeting the IL-23 pathway may lead to more individualized treatments.
A recent study has identified a new genetic link to Crohn's disease, revealing that mutations in the IL-23 receptor gene are strongly associated with the condition. The researchers found that one type of mutation provides significant protection, paving the way for more individualized and effective treatments.
Scientists at Galileo Pharmaceuticals confirm a significant link between inflammation and glucose regulation in metabolic disease. The study demonstrates that administration of a proprietary dual 5- and 15-lipoxygenase inhibitor reduces resting glucose levels by approximately 20% without affecting insulin levels.
Research reveals NOD2 activation leads to modification of NEMO, a central component of the NF-kB signaling pathway controlling inflammatory responses. This discovery suggests a potential pharmacological target for Crohn's Disease treatment.
A20 is a critical regulator of inflammation in multiple tissues, protecting against damage by inhibiting TNF activation. The discovery suggests new ways to block inflammation and may lead to novel forms of therapy for conditions like ulcerative colitis and septic shock.
Researchers at Emory University Health Sciences Center discovered that non-pathogenic bacteria in the GI tract can block an immune system pathway called NF-KB, preventing cells from responding to potential threats. This mechanism may play a crucial role in the pathogenesis of inflammatory bowel disease and other intestinal diseases.
A study published in Molecular Psychiatry reveals that individuals with schizophrenia, bipolar disorder, and major depression have lower levels of a certain brain protein, leading to less 'plastic' brains. Researchers hope to improve current therapeutics by targeting the cascade of events responsible for phosphorylating this protein.
Researchers found Yersinia pestis uses a protein called YopJ to cut off cellular communication, disrupting immune response and killing the host. Understanding this mechanism could have important implications in medicine, particularly for cancer and immune-related diseases.