Articles tagged with Complementary Dna
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers discovered that languages from different continents and populations become more similar after contact, with rates of borrowing ranging from 4-9%. The team found that linguistic features are not consistently transferable, challenging long-held assumptions about language learning.
Researchers developed a chemical probe that binds to damaged mitochondrial DNA, blocking enzymatic processes that lead to its degradation. This approach lessens mtDNA loss, preserving energy production in vulnerable tissues. The new molecule successfully reduced inflammation and maintained functional DNA despite chemical tagging.
A new method for DNA detection uses heterogeneous probe particles and laser light to accelerate genetic analysis. This PCR-free technique offers greater sensitivity and speed than traditional methods, making it more accessible for medical, environmental, and personal health applications.
Researchers created optimized DNA hydrogels with fewer nucleic acids, achieving efficient and sustained drug release. The new hydrogel units showed prolonged persistence of at least 168 hours post-administration in mice, contributing to anti-tumor effects.
A recent study utilizing plant DNA metabarcoding identifies 186 terrestrial plant taxa on the Tibetan Plateau, surpassing traditional pollen analysis by 25%. The method provides a more detailed and localized perspective on vegetation monitoring and reconstruction.
A team of scientists captured a clear picture of the structural changes and intermediates that form during the initial stages of RNA polymerase binding to DNA. The findings provide new insights into the fundamental mechanisms of transcription and shed light on long-standing questions about the initiation mechanism.
Researchers at PNRI reveal how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. These complex rearrangements are caused by segments of DNA switching templates during the repair process, leading to disruptions in normal gene function and contributing to genetic disorders.
Scientists discovered a shift in gene regulation by enhancers during embryonic development, showing both 'instructive' and 'permissive' modes of regulation. The study found that developmental stage determines which mode is dominant, allowing for rapid gene expression changes and tissue-specific control systems.
Scientists develop novel synthetic strategy to create highly ordered colloidal crystals using DNA as the bonding element. The approach enables the synthesis of 10 new crystals with potential for designing metamaterials with unprecedented properties.
Scientists at the University of Vienna successfully created fluorescent duplexes that can generate any of 16 million colors, surpassing the previous limit of 256 colors. This breakthrough allows for accurate reproduction of digital images on a miniature surface with 24-bit color depth.
Researchers at WVU have developed a way to view synthetic DNA at the atomic level, enabling them to understand how to change its structure for enhanced scissor-like function. This breakthrough could lead to new technology for medical diagnoses and treatments, including potential therapies for diseases like retinal degeneration and cancer.
A new DNA biosensor developed by NIST, Brown University, and the French government-funded research institute CEA-Leti boasts accurate and inexpensive design. The modular device can measure biomarkers in a scalable and high-sensitivity manner.
Researchers at Northwestern University discovered that colloidal crystals with DNA can change shape in response to external stimuli, exhibiting a 'shape memory' effect. The crystals can break down but then revert to their original state when water is added, making them useful for sensing and optics applications.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
Researchers at Hokkaido University have developed a tuneable, elastic and temperature-sensitive gel by using complementary DNA strands to connect star-shaped polymer molecules together. The gel exhibits predictable behavior, self-healing properties and durability suitable for medical and engineering applications.
A new genosensor, developed by a Brazilian research team, can detect the genetic sequence of SARS-CoV-2 in saliva or other body fluids with high sensitivity. The device can analyze samples in 30 minutes for a cost of less than $1 per genosensor.
Researchers found that cube-shaped nanoparticles coated with single-stranded DNA chains assemble into an unusual 'zigzag' arrangement that maximizes attraction and minimizes repulsion. The discovery breaks the orientational symmetry of cubes relative to the vectors of the unit cell, allowing for a new type of nanoscale packing.
Researchers at Northwestern University develop a technique to create new classes of optical materials with precise control over particle architectures. The method combines DNA-programmed self-assembly with top-down lithography, resulting in optically active superlattices that can exhibit almost any color across the visible spectrum.
Researchers cloned an epidemic strain of Zika virus, creating a model to test strategies for stopping the pandemic. The clone is used for developing a live but attenuated vaccine to create long-term immunity.
Researchers developed a method to fabricate structured composite materials using directional bindings of shaped particles for predictable assembly. The approach uses linker molecules made of complementary strands of DNA to control the arrangement of particles, achieving long-range order in large-scale assemblies and clusters.
A Northwestern University research team successfully built near-perfect single crystals out of nanoparticles and DNA, transforming disordered materials into orderly crystal structures. The technique, developed by Chad Mirkin and Monica Olvera de la Cruz, holds promise for novel technologies and new industries.
The study reveals that DNA hybridization is sensitive to sequence composition, with certain sequences binding rapidly and others through a diffusive process. Understanding this process can aid researchers in designing technologies like gene chips more effectively.
Researchers at CU-Boulder and University of Milan found that short segments of DNA can assemble into liquid crystal phases with 'self-orient' properties, paving the way for a new scenario on the origin of life. The discovery was made by observing how short DNA segments could condense into droplets in which conditions are favorable for ...
Researchers create DNA shells to coat particles' surfaces, allowing for precise control over their structure and properties. The technique enables applications in efficient energy conversion, drug delivery, and environmental monitoring.
Direct observations of DNA are giving new insights into genetic material copying and repair processes, revealing how enzymes like RecA assemble into filaments. The findings have implications for understanding breast cancer risk and future studies on single enzymes at work unwinding DNA strands.
Two DNA repair proteins, XPB and XPD, can destroy HIV DNA, reducing viral replication and integration into host chromosomes. This finding may lead to new strategies for treating HIV infection and AIDS.
Researchers at the University of Illinois have developed a method to detect trace amounts of contaminants using single-walled carbon nanotubes coated with DNA. The technique allows for passive sensing of hybridization, enabling the detection of specific DNA sequences in living cells.
A comprehensive breast cancer protein library has been established, enabling researchers to study proteins' roles in cancer development. The library's vast collection of cDNAs covers a broad spectrum of breast cancer-related genes, offering new avenues for understanding and treating the disease.
Researchers at the University of Pittsburgh have developed a method using carbon nanotubes to detect single DNA base mutations. The technique produces sensor results comparable to state-of-the-art optical techniques and has several advantages over existing methods, including cost, time, and simplicity.
Scientists have successfully created a liquid form of DNA, which can be processed in various ways and may improve genetic engineering and microelectronic circuitry. The liquid DNA is also soluble in several solvents that ordinary DNA is not, enabling new scientific studies.
Researchers at Northwestern University have developed a novel DNA detection method that is more accurate, less expensive, and easier to use than conventional methods. The scanometric DNA array detection method uses gold nanoparticles and a flatbed scanner to detect target DNA with high sensitivity and selectivity.
Researchers have identified 15 M. tuberculosis genes expressed only when the bacteria are growing in macrophages, key disease-fighting cells. These genes play important roles in pathogen metabolism, propagation and self-protection, potentially leading to new drug targets or vaccines.
Researchers have identified a structural anomaly in the Taq DNA polymerase enzyme that hampers its performance in DNA sequencing. By modifying this anomaly, scientists created an improved version of the enzyme, which increases sequencing speed and reduces errors.
Researchers at New York University have developed a technique to assemble DNA molecules into two-dimensional crystals with precise topographic features. The method uses synthetic DNA double-crossover molecules and exploits the key chemical feature of DNA to achieve predictable self-assembly.
Scientists at the Technion-Israel Institute of Technology have successfully created a working electronic component using DNA to assemble a conducting wire. The wire, 100 nanometers wide, has potential properties that could be used to make computer memories, and its narrow size allows for potentially much faster computer chips.