Articles tagged with Lipids
Researchers at the University of Edinburgh discovered that invadolysin, a protein present in all cells, is linked to lipid droplets used for fat storage. Lower levels of invadolysin were found to be associated with reduced fat deposits, suggesting its potential role in obesity and related complications.
For the first time, researchers have induced antibodies that neutralize HIV-1 and simultaneously recognize both HIV-1 envelope protein and lipids. The study employed widely used, clinically acceptable, well-tolerated and relatively inexpensive generic antigen-adjuvant constituents.
Researchers at the University of Missouri have completed a comprehensive analysis of bioactive lipids in an inflammatory response triggered by Lyme disease. The study found correlations between eicosanoid levels and arthritis severity, paving the way for diagnostic tools, personalized therapies, and more effective treatments.
BA profiling in IBD patients showed decreased levels of certain BAs, while UC patients with liver and gallbladder diseases exhibited increased primary and secondary BAs. The study also found accelerated detoxification activity in IBD patients and a significant increase in primary and secondary BAs in UC patients with extraintestinal ma...
A new process controlling cell fat storage has been discovered, which could lead to novel drugs for metabolic syndrome and fatty liver disease. The study found that autophagy regulates lipid metabolism, and disrupting this process can contribute to diseases such as obesity and type 2 diabetes.
Spartin localizes to lipid droplets and binds to TIP47, regulating their turnover. Overexpressing or knocking down Spartin causes an increase in LD size and number.
Researchers at University at Buffalo link capsaicin's analgesic effects to PIP2 lipid in cell membranes. The receptor's adaptation property allows it to continuously respond to varying stimuli, providing a novel strategy for developing safe pain-relieving medications.
The presence of mineral oil in edible oils and foods exceeds recommended safety limits, raising concerns about human health. Analytical campaigns are underway to address this issue and provide toxicological data for improved safety evaluation.
Researchers identify COPI complex as a regulator of lipid homeostasis, finding it reduces PAT protein expression at the lipid droplet surface. This study reveals COPI's role in energy storage and shedding, with implications for treating obesity and metabolic disorders.
Researchers identified a new class of hormones called lipokines, which help regulate metabolism and improve insulin sensitivity in mice. The discovery could lead to new treatments for obesity-related conditions such as diabetes and fatty liver disease.
A UC San Diego scientist presents the first unified vision of 'the building blocks of life', revealing that only 68 molecules construct four fundamental cell components: nucleic acids, proteins, glycans, and lipids. This framework may hold the key to unlocking the origins of many serious diseases.
Scientists discover that glutathione peroxidase 4 senses and translates oxidative stress into a distinct signaling pathway leading to cell death, highlighting potential therapeutic targets for mitigating degenerative diseases. This discovery sheds new light on the molecular mechanisms of oxidative stress and its role in cellular damage.
Researchers at Gladstone Institutes have identified genes responsible for fat storage in cells, which may lead to new understanding and potential treatments for obesity, diabetes, and heart disease. The study found that ~1.5% of all genes function in lipid-droplet formation and regulation.
Researchers have uncovered the molecular mechanism behind chloroform's action as a general anaesthetic, revealing its potential to design new anesthetics with reduced harm. Chloroform inhibits TRPC5 calcium ion channels, a key player in pain transmission and brain function.
VIB researchers find certain brain lipids destabilize fibrils, leading to toxic protofibril formation and memory loss in mice. This discovery opens new avenues for medicines against Alzheimer's disease.
Researchers found that the northern portion of the Tibetan Plateau rose later than previously thought, revealing a complex timeline for the plateau's growth. This discovery can help climate models and understand ancient biological communities.
Researchers found that fats in the stomach reduce vitamin C's ability to protect against cancer-forming compounds. The presence of lipids overrides the antioxidant effect, allowing harmful nitrosating species to form.
Researchers have identified a new class of lipids in tears and oleamide, a previously unknown lipid, shedding light on the complex design of tears. The discovery may help scientists better understand eye-related disorders like dry eye disease, which affects millions Americans.
Researchers found that Akt1 is specifically required for lactating mice to synthesize sufficient milk. The protein kinase plays a critical role in glucose metabolism, which may have implications for cancer therapy. Studies suggest that the metabolic demands of lactation bear similarities to those of tumor cells.
Researchers at UC Davis and colleagues discovered that green plants contain a bacterial toxin called lipid A, which is also found in Gram-negative bacteria. The presence of this toxin in plants challenges current knowledge about plant biology and evolution.
Researchers from IDIBAPS and Queensland University discovered that caveolin-1 and lipid droplets are essential for liver regeneration. The protein allows hepatocytes to accumulate energetic reserves and start the genetic machinery for division. Without it, mice are unable to regenerate their liver tissue.
Case Western Reserve University researchers found a dart-like molecule, Carboxyethylpyrroles (CEPs), that adheres to proteins in the eye, triggering uncontrolled blood vessel growth. This contributes to the development of age-related macular degeneration, the leading cause of blindness over 65.
Researchers at the University of Illinois Chicago discovered a molecular motor that helps cells determine which way is up by transporting a key lipid. This process is essential for maintaining cell polarity and preventing cancerous metastasis. The study sheds light on the trafficking and disposition of polarity determinants.
Researchers at the Ludwig Institute for Cancer Research discovered that SREBP1 regulates both lipid synthesis and cell cycle progression. Disrupting SREBP1 activity can prevent lipid production, which is essential for new cell wall construction.
A 30-year study published in the journal Diabetes found that type 1 diabetics showed improved mortality and morbidity rates for certain complications, but cardiovascular disease rates remained unchanged. The study suggests that focusing solely on blood-glucose control is insufficient to prevent long-term complications of type 1 diabetes.
A study published in the American Physiological Society found that pine nut oil stimulated two well-known appetite-suppressing peptide hormones, CCK and GLP1, increasing their levels by 60% and 25%, respectively. This effect lasted for up to four hours, reducing desire to eat and prospective food intake scores.
Scientists at the University of California, Santa Barbara, have created a new lipid molecule that delivers therapeutic genes directly to cells, potentially helping inherited diseases and cancers. The novel molecule has a tree-shaped headgroup and displays superior DNA-delivery properties.
Researchers at the University of Illinois have developed a method to stabilize lipids and create biocompatible capsules. These capsules can be used for drug delivery, enzyme-catalyzed reactions, and biosensors, offering new possibilities for health and agricultural applications.
Research reveals that offspring of type 2 diabetic parents have reduced mitochondrial content and impaired muscle glucose uptake, increasing their risk of developing insulin resistance and type 2 diabetes. Reduced mitochondrial function can lead to lipid accumulation in muscle cells, further exacerbating the condition.
A study identifies CD36 as a multifunctional glycoprotein that detects fat in the mouth, influencing behavior and digestive physiology. Altering this system may increase obesity risk through feeding dysregulation.
A retrospective analysis of patients with invasive aspergillosis showed that those who initially received Pfizer's antifungal agent VFEND had better survival rates and were less likely to need salvage therapy than those on amphotericin B. The study found that patients who started on VFEND also had higher success rates in switching to o...
Research reveals significant decreases in myelin lipid synthesis in mice with Canavan disease, suggesting a link between acetate deficiency and the disorder. The findings support the potential of acetate supplementation as a therapy for this devastating congenital disease.
The Lipid Metabolites and Pathways Strategy (LIPID MAPS) consortium has proposed a new comprehensive classification system for lipids, dividing them into eight primary categories with further subdivisions. The system includes a nomenclature system and a unique identifier for each lipid molecule.
Researchers at UC Santa Barbara have engineered over 300 new chemical penetration enhancers (CPEs) to improve the safety and efficacy of topical drug delivery. The new CPEs were designed using computer-aided modeling, allowing for the prediction of skin penetrability and potential irritation.
Researchers identified a new class of aspirin-triggered bioactive lipids called resolvins, which inhibit inflammatory cell migration and activation. Omega-3 fatty acid consumption may reduce inflammation by promoting the production of these anti-inflammatory compounds.
A new study found that green tea extract (GTE) supplementation improves swimming endurance by 8-24% over 10 weeks, with benefits attributed to increased fat oxidation and lower respiratory quotients. The study also suggests that long-term GTE consumption may be beneficial for improving exercise performance and overall health.
A sugary lipid called iGb3 from a marine sponge plays a key role in regulating natural killer T cells, a component of the immune system. Activating NKT cells may be particularly valuable for preventing or treating cancers that spread to the liver.
Researchers at NIST have developed a new method for producing uniform, self-assembled nanocells using micrometer-size channels. These nanocells can be controlled to specific sizes and are ideal for encapsulating medicine, leading to more accurate drug delivery.
Scientists have discovered a key role for lipid metabolism in the regulation of the immune system. The study reveals that natural killer T cells can recognize lipids on the surface of bacteria, triggering an immune response. By understanding this process, researchers hope to develop new treatments for autoimmune diseases and cancer.
Kansas State University has received $4.2 million from the National Science Foundation to support new science initiatives, including a project in ecological genomics that aims to understand how organisms respond to environmental changes caused by human activities. The project will use the tools of molecular genetics with ecology to inv...
Researchers will create fluorescent dyes to bind to DNA, lipids, carbohydrates, and proteins in Martian soil to detect life forms. The system aims to be versatile enough to couple with different types of rovers used in planetary expeditions.
A study by Purdue University scientists found that dogs on fatty diets exhibited reduced growth, bone formation, and immune function. The research suggests that oxidized fats in the diet can contribute to aging and disease development in humans, particularly children during critical stages of growth.
USC researchers propose lipid peroxidation as a mechanism for renal cell carcinoma, uniting known risk factors such as obesity and high blood pressure. The process creates DNA damage that can lead to cancer mutations, increasing kidney cancer risk.
Research reveals that peroxynitrite damages endothelial NO synthase (eNOS), promoting uncoupled catalysis and oxidative stress in vascular tissues. This damage can propagate to other susceptible enzymes, exacerbating inflammation and oxidative stress.
Scientists at Duke University have discovered a new enzyme that attaches aminoarabinose to the outer coat of gram-negative bacteria, reducing the ability of positively charged antibiotics to attach and kill them. This discovery offers a potential approach to overcoming antibiotic resistance.
Researchers from the Howard Hughes Medical Institute identified a crucial lipid molecule produced by M. tuberculosis to infect lung tissue. The discovery could lead to improved vaccines and treatments for tuberculosis, which kills more people than AIDS or malaria.
Daily consumption of a tomato-based juice supplemented with vitamin C, vitamin E, and beta-carotene significantly decreased breath pentane excretion and improved LDL oxidation resistance. Increased plasma lycopene concentrations were also found to be correlated with antioxidant defenses.