Articles tagged with Lipids
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Research reveals that offspring of type 2 diabetic parents have reduced mitochondrial content and impaired muscle glucose uptake, increasing their risk of developing insulin resistance and type 2 diabetes. Reduced mitochondrial function can lead to lipid accumulation in muscle cells, further exacerbating the condition.
A study identifies CD36 as a multifunctional glycoprotein that detects fat in the mouth, influencing behavior and digestive physiology. Altering this system may increase obesity risk through feeding dysregulation.
A retrospective analysis of patients with invasive aspergillosis showed that those who initially received Pfizer's antifungal agent VFEND had better survival rates and were less likely to need salvage therapy than those on amphotericin B. The study found that patients who started on VFEND also had higher success rates in switching to o...
Research reveals significant decreases in myelin lipid synthesis in mice with Canavan disease, suggesting a link between acetate deficiency and the disorder. The findings support the potential of acetate supplementation as a therapy for this devastating congenital disease.
The Lipid Metabolites and Pathways Strategy (LIPID MAPS) consortium has proposed a new comprehensive classification system for lipids, dividing them into eight primary categories with further subdivisions. The system includes a nomenclature system and a unique identifier for each lipid molecule.
Researchers at UC Santa Barbara have engineered over 300 new chemical penetration enhancers (CPEs) to improve the safety and efficacy of topical drug delivery. The new CPEs were designed using computer-aided modeling, allowing for the prediction of skin penetrability and potential irritation.
Researchers identified a new class of aspirin-triggered bioactive lipids called resolvins, which inhibit inflammatory cell migration and activation. Omega-3 fatty acid consumption may reduce inflammation by promoting the production of these anti-inflammatory compounds.
A new study found that green tea extract (GTE) supplementation improves swimming endurance by 8-24% over 10 weeks, with benefits attributed to increased fat oxidation and lower respiratory quotients. The study also suggests that long-term GTE consumption may be beneficial for improving exercise performance and overall health.
A sugary lipid called iGb3 from a marine sponge plays a key role in regulating natural killer T cells, a component of the immune system. Activating NKT cells may be particularly valuable for preventing or treating cancers that spread to the liver.
Researchers at NIST have developed a new method for producing uniform, self-assembled nanocells using micrometer-size channels. These nanocells can be controlled to specific sizes and are ideal for encapsulating medicine, leading to more accurate drug delivery.
Scientists have discovered a key role for lipid metabolism in the regulation of the immune system. The study reveals that natural killer T cells can recognize lipids on the surface of bacteria, triggering an immune response. By understanding this process, researchers hope to develop new treatments for autoimmune diseases and cancer.
Kansas State University has received $4.2 million from the National Science Foundation to support new science initiatives, including a project in ecological genomics that aims to understand how organisms respond to environmental changes caused by human activities. The project will use the tools of molecular genetics with ecology to inv...
Researchers will create fluorescent dyes to bind to DNA, lipids, carbohydrates, and proteins in Martian soil to detect life forms. The system aims to be versatile enough to couple with different types of rovers used in planetary expeditions.
A study by Purdue University scientists found that dogs on fatty diets exhibited reduced growth, bone formation, and immune function. The research suggests that oxidized fats in the diet can contribute to aging and disease development in humans, particularly children during critical stages of growth.
USC researchers propose lipid peroxidation as a mechanism for renal cell carcinoma, uniting known risk factors such as obesity and high blood pressure. The process creates DNA damage that can lead to cancer mutations, increasing kidney cancer risk.
Research reveals that peroxynitrite damages endothelial NO synthase (eNOS), promoting uncoupled catalysis and oxidative stress in vascular tissues. This damage can propagate to other susceptible enzymes, exacerbating inflammation and oxidative stress.
Scientists at Duke University have discovered a new enzyme that attaches aminoarabinose to the outer coat of gram-negative bacteria, reducing the ability of positively charged antibiotics to attach and kill them. This discovery offers a potential approach to overcoming antibiotic resistance.
Researchers from the Howard Hughes Medical Institute identified a crucial lipid molecule produced by M. tuberculosis to infect lung tissue. The discovery could lead to improved vaccines and treatments for tuberculosis, which kills more people than AIDS or malaria.
Daily consumption of a tomato-based juice supplemented with vitamin C, vitamin E, and beta-carotene significantly decreased breath pentane excretion and improved LDL oxidation resistance. Increased plasma lycopene concentrations were also found to be correlated with antioxidant defenses.