A new strategy for single-cell spatial proteomics has been developed using an ordered colloidal crystal chromatographic column, improving analytical throughput while maintaining deep proteome coverage. This approach enables the identification of up to 2,304 proteins from a single hepatocyte slice within 5 minutes.
Wiley has expanded its spectral libraries with major updates to IR, Raman, and LC-MS collections, delivering researchers enhanced capabilities for faster and more confident compound identification. The expansion brings over 9.5 million high-quality spectra, including 1 million IR spectra and 161,000 Raman spectra.
Researchers developed a reliable and affordable purification technique for chromatography using calcium chloride, applying to organic compounds like amines and peptides. The technique has shown promising results in purifying APIs with high accuracy.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
The ARRAKIS project team aims to understand how microbial life thrives in extreme environments by studying the Great Kobuk Sand Dunes in Alaska. Researchers will use Raman spectroscopy and gas chromatography/mass spectrometry to identify and quantify organic compounds and measure ATP and total DNA.
A total of 105 compounds are identified from the SQ extract, with organic acids and amino acids dominating in the bloodstream. Pharmacokinetic profiles show dynamic changes in compound absorption and levels over time.
The study identified 105 compounds in Shenqi Fuzheng extract, with organic acids and amino acids showing higher concentrations in the bloodstream. Compounds such as Astragalosides promptly enter the bloodstream within 5 minutes after administration.
A new study published in Clinical Chemistry and Laboratory Medicine reveals that smartphone swabs can successfully detect drugs on phone surfaces. The method, which uses dry swabs, identified MDMA, cocaine, and THC as the most common substances, with other drugs including ketamine, LSD, and heroin also detected.
SourceDe Gruyter·JournalClinical Chemistry and Laboratory Medicine (CCLM)·TypeExperimental study·DateApr 22, 2024
Researchers at Hokkaido University identified 341 different molecular species of lipids in four types of herbal tea, which may contribute to the teas' health benefits. The study reveals significant variations in lipids among the teas, with some containing novel short-chain fatty acid esters and polyunsaturated fatty acids.
Researchers at the University of Texas at Arlington have developed a method to determine the clinical potency of psilocybin and psilocin in Psilocybe cubensis mushrooms. This technique uses liquid chromatography with tandem mass spectrometry, allowing for accurate extraction and measurement of the strength of the mushrooms.
Researchers at UTA discovered that using carbonated water in chromatography reduces the technique's Analytical Method Greenness Score (AMGS) making it safer for the environment. The study also showed that carbonated liquids are just as fast and efficient as other liquids used in chromatography.
A team of Japanese researchers has successfully developed a recycling photoreactor that enables the synthesis of optically pure compounds with high yields, achieving an optical purity of 98-99%. The system uses a two-step rapid photoracemization process and can produce enantiomerically pure chiral sulfoxides in yields higher than 80%.
Dr. Vesna Najdanovic from Aston University won a $25,000 grant to develop greener analytical methods using ethyl lactate as a solvent for liquid chromatography. This environmentally friendly alternative reduces carbon footprint and pollution in the pharmaceutical industry.
Acylceramides and protein-bound ceramides play a vital role in forming the oral barrier, similar to their function in the skin. Researchers found that these molecules protect against pathogens, chemicals, and allergens in mice.
Scientists have detected uracil and nicotinic acid in asteroid Ryugu samples collected by the Hayabusa2 spacecraft. The discovery suggests that important building blocks for life were created in space and delivered to Earth via meteorites, supporting current theories on the source of nucleobases.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
Researchers developed a new method to quantify the structure and quality of messenger RNA (mRNA) medicines using liquid chromatography, mass spectrometry, and software analysis. The platform can analyze all three key components of mRNA medicines simultaneously, providing unparalleled efficiency in checking for quality.
A team of Brown researchers has developed a new, highly accurate method for detecting antidepressants in patients using liquid chromatography tandem mass spectrometry. The technique requires minimal biological samples and can be fully automated using liquid-handling robots.
Researchers at Hokkaido University identified over 1,300 types of ceramides in the top layer of human skin, including their chain lengths and fatty acid compositions. The discovery could improve understanding of skin barrier function and disease pathology.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
Researchers used wastewater samples from 25 treatment plants across 10 countries to track the popularity of new synthetic drugs. Synthetic cathinones, including eutylone and 3-MMC, were found to have high per capita levels in wastewater, with increased international presence reported between 2020-2021 New Year periods.
Archaeologists found a 1,000-year-old bundle in the Bolivian Andes with traces of ayahuasca fixings, including dimethyltryptamine and harmine. Researchers believe ancient South Americans combined different medicinal plants to produce powerful hallucinations.