A study of Italian women with breast cancer found that most cases were diagnosed in people over 50 and had not spread to lymph nodes. The disease was hormone-receptor positive and HER2-negative, indicating a classical endocrine-responsive type. Treatment choices were influenced by tumor stage rather than biological factors.
Researchers discovered that the North American comb jellyfish generates a hydrodynamically silent feeding current using microscopic cilia. This allows it to approach and capture copepod plankton with ease, despite their acute escape response.
Researchers at the University of Gothenburg have discovered how sunscreens break down in sunlight, leading to an increase in contact allergy. The study has led to the development of a new test for photocontact allergy, which could help patients avoid substances that cause allergic reactions.
Researchers watched a fundamental process of cellular organization in living plant cells, where protein complexes create the microtubule cytoskeleton. They observed that these complexes are distributed at the cell membrane and interact with other microtubules to organize the cell shape and structure.
A new meta-analysis shows that continuing chemotherapy after bringing cancer under control can increase survival time and reduce disease progression in metastatic breast cancer patients. The analysis found a 34% reduction in disease progression and a 9% reduction in death rates for patients who received longer chemotherapy durations.
The final phase-II results show that iniparib plus chemotherapy significantly improves overall survival from 7.7 to 12.3 months, offering a promising new treatment option for metastatic triple-negative breast cancer patients. Over half of patients experience clinical benefit, and there is little increase in adverse events.
Researchers have found that cancer cells are accompanied by growth-enabling stromal cells when they travel to new sites in the body. This discovery challenges current understanding of metastasis and has implications for effective treatments.
A new definition of Alzheimer's disease has been proposed to diagnose the condition earlier and select patients for trials of disease-modifying treatments. The revised definition includes biomarkers as a key diagnostic feature, enabling diagnosis at an earlier stage, and allows for more precise selection of patients for clinical trials.
Physicists at Rutgers University have discovered new properties in a material that could result in efficient and inexpensive plastic solar cells. The discovery reveals that energy-carrying particles generated by packets of light can travel much farther in organic semiconductors, increasing the practicality of solar-generated electricity.
Research finds that tsunamis can be triggered by moderate earthquakes on strike-slip faults, posing a significant threat to coastal cities. In Haiti's case, three-quarters of tsunamis are generated by submarine landslides, unlike the previously estimated 3% globally.
A study presented at the ESMO Congress found that a patient's overall survival time is linked to the time to treatment failure for each line of chemotherapy. Analyzing data from 980 women with metastatic breast cancer, researchers identified this key factor as the most significant determinant of overall survival.
UK scientists have reported direct evidence that taking up smoking results in epigenetic changes associated with cancer. A study funded by Cancer Research UK found women who started smoking had a higher risk of acquiring p16 methylation, a type of epigenetic change linked to tumor suppressor genes.
Researchers have identified a natural substance in a fungus that infects a common weed, showing potential as the first stinkbug repellent. The substance repelled up to 90% of stinkbugs and was almost twice as effective as naphthalene, a gold-standard for measuring insect repellents.
Research reveals that budgetary constraints have led to a less rigorous FDA inspection process, failing to provide necessary oversight and guidance to the pharmaceutical manufacturing industry. This can result in manufacturers taking advantage of the system and prioritizing complaints over addressing actual safety issues.
Researchers report a new surgical technique, balloon kyphoplasty, offers quick pain relief and improves quality of life for patients with vertebral compression fractures. The procedure, which involves inflation and injection of bone cement, shows sustained improvements in disability and mobility.
Erlotinib has been shown to improve progression-free survival in patients with advanced lung cancer carrying EGFR activating mutations. The OPTIMAL trial found that erlotinib nearly tripled progression-free survival compared to a standard chemotherapy combination. Safety analyses also showed lower rates of adverse events with erlotinib.
A new drug targeting the MET receptor added benefit to erlotinib in patients with advanced lung cancer who express MET, improving overall survival and progression-free survival
Two clinical trials show that intensive lifestyle interventions with diet, physical activity, and behavioral support can result in significant weight loss and improvements in cardiometabolic risk factors. The studies found that weight loss was more pronounced in the first six months, but similar at 12 months, with reductions in waist c...
A randomized controlled trial found that a structured weight loss program with free prepared meals, combined with one-to-one counseling, resulted in significant weight loss (up to 16 pounds) for participants. The program was maintained at two-year follow-up, suggesting long-term effectiveness.
Researchers found that individuals who dine at establishments labeled as healthy tend to underestimate their actual caloric consumption and subsequently indulge in high-calorie treats. To combat this effect, experts suggest doubling estimated calorie counts for meals served at these restaurants.
A Phase II clinical trial of MLN8237, a selective Aurora A kinase inhibitor, demonstrates single-agent activity with durable disease control in some patients with ovarian cancer resistant to platinum-based chemotherapy. The study found encouraging responses in several patients, suggesting potential for future combination therapies.
The Lancet Series on Critical Care assesses the future of intensive care services amid increasing demand. Authors highlight the need for improved productivity, prevention efforts, and better-designed studies to address challenges in rationing care.
Scientists at the University of Illinois Chicago have found a gene expression mechanism that contributes to drug resistance in aggressive ER-positive breast tumors. The study reveals how estrogen and inflammatory proteins work together to drive cancer progression.
A GSU professor received a $225,000 USDA grant to explore the dynamics of childhood obesity from childhood to adolescence. The research aims to identify causal effects of prior weight gains on future weight outcomes and assess the impact of food assistance programs.
A Texas Tech University biologist has identified a possible cause of the sudden death of bee colonies across North America: a combination of an insect virus and a fungus. The researchers' study published in PLOS ONE found an association between the two pathogens and high mortality rates among bees.
Researchers at Karolinska Institutet have discovered how stem cells and other cells repair damaged spinal cord tissue in mice. The study identified ependymal cells as a key player in this process, which is crucial for developing therapies for spinal cord injury.
Researchers found that certain neurons represent accumulation of evidence to a threshold and others represent evidence itself, driving decision-making. The study offers potential insights into psychological disorders, such as ADHD, where impairments in decision-making occur.
University of Missouri researchers create a National Botanical Research Center to investigate the safety and efficacy of botanical dietary supplements, focusing on five key plants that may aid in preventing strokes, prostate cancer, and infectious diseases.
The University of New Hampshire has been awarded a $487,000 grant from NASA to develop high school climate change curriculum. The project will utilize data from NASA and other federal agencies to create classroom-friendly materials, aiming to provide teachers with a scientifically sound means of teaching climate change issues.
Researchers at UT Southwestern Medical Center have created an experimental vaccine that stimulates more than 10 times as many antibodies against beta-amyloid as similar DNA vaccines. The new approach shows promise in generating enough antibodies to be useful clinically in treating patients.
The device uses piezoelectric material and carbon nanotube films to harness light and thermal energy, allowing small electronic devices to operate autonomously. The technology has the potential to impact wireless sensory networks and enable perpetual micro/nano devices.
A new study found significant inconsistencies in bloodstream infection surveillance methods across hospitals, making it challenging to compare performance. The variations have implications for pay-for-performance and reimbursement, as well as the accuracy of publicly reported data.
Researchers found that alienation increases aggression in children who feel like outcasts after being rejected by peers. The study recruited students aged 10-13 and found they were more aggressive when receiving negative feedback.
Cassel is honored for his sustained technical contributions to missile systems, including hypersonic flight regimes and navigation systems. He developed innovative solutions such as jet interaction in hypersonic flight, aerodynamic control configurations, and optical sensors.
The European Society for Medical Oncology launches OncologyPRO, a unique scientific portal providing instant access to high-quality scientific knowledge. The platform offers a range of services tailored to the specific needs of cancer specialists, improving their efficiency and patient outcomes.
The Sample Analysis at Mars (SAM) instrument suite is nearly ready for a December delivery to the Curiosity rover on NASA's Jet Propulsion Laboratory. Once deployed, SAM will become an automated laboratory, assessing whether Mars ever supported microbial life.
Researchers discover that CD4+ T cells release interleukin-21, instructing B cells to produce antibodies targeting helminth-derived products. This signaling pathway is specific to worm infections and may hold key to treating diseases like asthma and allergies.
A new study by Northwestern University researchers uses complex systems and computer modeling to better understand educational policies. The approach, which treats education as a complex system, has been applied to school choice and student tracking, revealing promising results in understanding policy implications.
A UCSF study confirms that a woman's race/ethnicity and socioeconomic status impact whether healthcare providers recommend the most effective form of contraception. The interaction between these factors also plays a role in clinicians' decisions.
A study published in PNAS reveals that large predatory fish and vascular plants emerged around 400 million years ago, coinciding with a significant increase in oxygen levels. This finding suggests that animals evolved under lower oxygen conditions than previously thought.
A study by researchers at the University of Missouri has found that students' spatial abilities are crucial for success in sonography. Students with greater spatial abilities were more likely to score high on scanning proficiency tests over two semesters.
New research evidence reveals gold nanoclusters can break the O-O bond by forming a novel one-dimensional gold-oxide phase. This mechanism is predicted to dominate at ambient conditions, enabling catalysts to use ambient oxygen in reaction processes.
A consensus statement from The Endocrine Society and the US Centers for Disease Control and Prevention calls for improved testosterone testing standards. The recommendations aim to increase accuracy, reliability, and comparability of measurements over time.
The UK aims to reduce carbon emissions by 80% by 2050 with a focus on community-based initiatives. Seven projects have received funding to address energy demand and promote sustainable practices in communities across the country.
The Chronic Disease Alliance, a coalition of 10 European health organizations, has been recognized for its efforts to improve the prevention of chronic diseases at the European level. The alliance has produced a policy paper that identifies central causes of chronic diseases and furnishes action proposals on how to combat their spread.
Neil Chi, a UCSD cardiologist, has been awarded a $2.3 million NIH New Innovator Award to investigate the remarkable ability of zebrafish to regenerate their hearts. His goal is to develop regenerative therapy for humans using this process.
Researchers found that androgen deprivation therapy is associated with structural decay of cortical and trabecular bone in men with prostate cancer. The study used virtual bone biopsies to assess bone microarchitecture and found a link between testosterone deficiency and increased fracture risk.
The La Jolla Institute will host research projects throughout the San Diego biomedical community, exploring genetic triggers of disease and developing new therapies for cancer and other diseases. The Center is expected to propel immunology research and catalyze a broad base of basic and clinical investigations.
The European Board of Intensive Care Medicine aims to increase recognition of intensive care medicine within European legislation. The ESICM launches the 'Linking Intensive Care to Family Experience' (LIFE) campaign to improve quality by including patient and family views.
Otto intensified into the Atlantic Ocean's 8th hurricane on October 8, bringing heavy rainfall to the northern Leeward Islands and Puerto Rico. The storm is expected to strengthen due to light wind shear and warm waters but may weaken when it encounters cooler waters.
The University of Miami School of Nursing and Health Studies has received a $704,000 grant to support its Family Nurse Practitioner Program. The program will provide tuition support to students enrolled in the 12-month program, preparing advanced practice nurses for primary care services.
The article discusses the variations in end-of-life care in intensive care units (ICUs) and the need for clinicians to be aware of subtle institutional pressures and adapt their approach to individual patients. Key findings include differences in family involvement, communication styles, and attitudes toward withdrawing life support ac...
Menssana Research Inc. has been awarded a $4.2 million contract by the US government to develop a breath test for detecting radiation exposure. The test aims to identify biomarkers of radiation exposure in patients receiving radiation therapy, with the goal of creating a rapid and reliable diagnostic tool.
A new study by Duke University researchers estimates the total value of lost job productivity due to health problems among U.S. full-time employees with obesity, which exceeds medical expenditures. The per capita cost of obesity is as high as $16,900 for obese women and $15,500 for obese men.
The conference focuses on managing global health security during mass gatherings, such as the Hajj pilgrimage. It covers various areas including communicable disease alert and response systems, water and sanitation management, and bioterrorism management.
Ongoing studies by the US Department of Agriculture (USDA) are investigating the health benefits of omega-3 fatty acids found in fish oil. Research has shown that DHA and EPA, two essential fatty acids, can help protect against chronic diseases such as insulin resistance and non-alcoholic fatty liver disease.
A Queen's University study found autistic children are prone to telling white lies to avoid hurting others' feelings. In a test, most nodded or said yes instead of expressing disappointment with a soap gift.
The James Webb Space Telescope's sunshield has successfully completed launch depressurization tests, validating its flight design. The tests, conducted in vacuum chambers, simulated the rapid change in air pressure during launch and proved that the stowed sunshield will retain its shape and allow trapped air to escape safely.
Temporary combativeness in anesthetized children may be prevented by reducing epinephrine production with specific drugs, according to a medical expert. This can improve post-surgery experience for both children and their families.
A new report by the Commonwealth Fund predicts that up to 12.1 million young adults will gain subsidized insurance under the Affordable Care Act, while 7.2 million will gain Medicaid coverage and 4.9 million private coverage through new exchanges. The law aims to reduce the uninsured rate among young adults from nearly 15 million in 2009.