Researchers identified a modified host protein as a potential risk factor for plasma cell dyscrasis. Individuals with high levels of SUMO-modified HSP90 are at increased risk of developing multiple myeloma and other related diseases.
A new technique has uncovered large sets of previously unknown pancreatic cancer genes by introducing DNA transposons into mouse genomes. The study found that the Foxp1 gene drives cancer progression and is highly expressed in human cancers that have metastasised.
A UT Arlington team developed a new model for snake venom evolution, suggesting that venom genes evolved independently in distinct lineages of reptiles. The study found similar expression levels of venom gene families in python oral glands and brain tissue, challenging the traditional view of a core venom system developing first.
Researchers discovered a protein called BAZ2A that influences epigenetic patterns in prostate cancer cells, leading to increased malignancy and tumor growth. High levels of BAZ2A expression were linked to more advanced tumors, metastases, and poor patient outcomes.
Researchers at Toyohashi University of Technology developed back-gated field-effect phototransistors made of MoSe2 crystals. The devices exhibited excellent performance, with a measured photoresponsivity of 97.1 AW-1 and a theoretical external quantum efficiency 280-fold higher than commercial Si and InGaAs photodiodes.
Researchers have developed a new sensor that can detect gaseous ammonia, hydrogen peroxide, and cyclohexanone wirelessly using a smartphone. The sensors, made from modified NFC tags, require almost no energy and can function at ambient temperatures.
Researchers used NASA wind tunnel to study threshold speeds for particle movement on Titan, finding higher speeds than predicted from Earth-based models. The findings can help understand atmospheric forces on icy moons and planets with thin or thick atmospheres.
Experts recommend reducing air pollution exposure and decreasing fossil fuel use to combat cardiovascular risk. People with heart disease are urged to follow these guidelines to minimize harm from air pollution.
Researchers from North Carolina State University have developed a new lithography technique that uses nanoscale spheres to create three-dimensional structures. The new method reduces the cost of nanolithography and allows for the creation of complex nanostructures without expensive equipment.
Researchers found an unexpected connection between titanium-oxypnictide superconductors and familiar cuprates and iron-pnictides, providing a new family of materials to explore. The discovery sheds light on the mysteries of high-temperature superconductivity.
A new study by University at Buffalo Research Institute on Addictions found that smoking is associated with difficulties in alcohol treatment. Tobacco smokers had shorter treatment durations and were less likely to achieve their alcohol-related goals compared to non-smokers.
A Dartmouth study found that hookah smoking increased the probability of trying cigarette smoking over two years by 19%. Hookah and snus use are associated with later cigarette smoking in non-cigarette smoking adolescents and young adults. The study highlights the need for FDA regulation to restrict manufacturers' ability to flavor, pa...
New research reveals RSV mortality rates are significantly lower than previously estimated, affecting mostly premature babies and those with preexisting conditions. Most hospitalizations due to RSV can be managed with minimal complications.
Research suggests that P53 gene mutations accumulate in blood stem cells as people age, increasing the risk of therapy-related AML. The study found nearly 50% of healthy individuals over 68 had P53 mutations, and these mutations can contribute to chemotherapy resistance.
Researchers at Dana-Farber Cancer Institute have discovered an effective treatment for small cell lung cancer using the compound THZ1, which targets tumor cells' basic survival machinery. Clinical trials are underway to test its safety and efficacy in human patients.
A large study found that mothers of children with autism were over twice as likely to have had preeclampsia pregnancies. Children with autism and developmental delay also showed greater cognitive impairment when their mothers experienced preeclampsia. The study suggests a potential link between preeclampsia and autism development.
Postpartum anxiety and depression are prevalent in new mothers, affecting both maternal well-being and infant health. Animal research provides valuable insights into the causes of these conditions, which may lead to better treatment options and earlier diagnosis.
Scientists at CAMH have discovered a novel drug target that could lead to better antipsychotic medications for schizophrenia patients. The discovery, led by Dr. Fang Liu, identifies a protein combination that disrupts symptoms without side-effects.
Researchers found a significant warming trend in air and water temperatures over 51 years, with impacts on water quality, eutrophication, and aquatic life. Rising temperatures will lead to increased nutrient runoff and shifts in plant and animal distributions in the bay's freshwater rivers and streams.
Researchers found that HSP90 inhibition increases the ability of anti-estrogen agents to block cell cycle progression, thereby thwarting replication of tumor cells. The study provides a strong rationale for combining HSP90 inhibitors with hormonal therapy in ER+ breast cancer treatment.
A collaborative project between UK researchers will focus on developing formal verification techniques for autonomous systems. The goal is to ensure robots make decisions that are safe, ethical, and follow legislation, with applications in industries such as automotive and manufacturing.
A team at Recursion Pharmaceuticals aims to accelerate the development of therapies for rare diseases by leveraging custom-designed software and human cellular models. The approach has already led to the identification of potential treatments for cerebral cavernous malformation, a rare hereditary vascular disease.
Activation of glucokinase in the arcuate nucleus of rodents increased food intake and body mass, as well as preference for glucose. Inhibition of glucokinase decreased food consumption and glucose intake, indicating that glucokinase dysfunction may underlie glucose cravings.
The FOXSI mission will observe high-energy X-rays from the Sun, helping scientists understand solar flares and the sun's atmosphere. By detecting these faint events, researchers aim to confirm the existence of nanoflares, which are thought to occur constantly but are difficult to detect.
A recent article collection in BMC Medicine examines the safety of e-cigarettes, with two experts offering differing views on their impact. Peter Hajek argues that e-cigarettes are orders of magnitude safer than conventional cigarettes, while Charlotta Pisinger believes they can be less harmful but still pose health risks.
Researchers have successfully treated patients with advanced CD19-positive hematologic malignancies using CAR T cells, achieving complete remission in some cases. The study used the Sleeping Beauty non-viral transduction system to modify T cells, demonstrating further promise in treating lymphoid malignancies.
New nanopore DNA sequencing technology has been shown to revolutionize genomic sequencing of drug-resistant bacteria, enabling rapid diagnosis and identification. The technology, called MinION, is small, affordable and accessible, and can produce accurate results in just 18 hours.
Researchers discovered that punishing children for lying can have the opposite effect, making them less likely to tell the truth. Children are more likely to lie if they're afraid of punishment than if they believe it's the right thing to do.
A study found that testing for antibiotic-resistant Escherichia coli before prostate biopsy can reduce post-biopsy infections by nearly 40%. Patients with pre-existing, drug-resistant E. coli on rectal swab cultures had lower infection rates and shorter hospitalizations.
Researchers at Trinity College Dublin and the University of York used genetic sequencing techniques to analyze DNA from parchment samples, revealing insights into livestock breeding history. The study sheds light on how agricultural development shaped animal genetics across centuries.
A recent study published in Cancer journal reveals that older breast cancer patients continue to receive radiation therapy despite evidence suggesting limited benefits. The study analyzed data from a national health database and found that only about one-third of eligible women no longer receive radiation therapy.
A recent study found that cell division in endothelial cells leads to the formation of large, ordered eddies in tissue, which may help widen blocked blood vessels and aid healing. The researchers used phase-contrast microscopy to observe the movement of new cells and found characteristic turbulence patterns.
A study found unheated high tunnels to be an effective method for finishing cold-tolerant annuals, reducing plant mortality and delays in days to flower. The use of high tunnels also led to improvements in measures of plant quality, such as shorter, more compact plants.
Researchers identified a critical pathway that enables cancer cells to survive despite DNA errors, relying on the PKCƐ signal pathway. Disrupting this pathway could trigger cancer cells to self-destruct, offering a new strategy to beat the disease.
A study at MD Anderson Cancer Center found PRM-151 to be well-tolerated in patients with advanced myelofibrosis, showing encouraging trends in clinical and histologic aspects of the disease. The therapy demonstrated reduced bone marrow fibrosis and improved hematologic parameters, suggesting potential for further development.
A survey of primary care physicians suggests a decrease in opioid prescriptions, with 58% reporting reduced prescribing habits. The study highlights the growing concern among doctors about the risks of prescription opioid use, including addiction and death by overdose.
New research finds nearly half of all children in the US are exposed to at least one traumatic experience, increasing risk of negative long-term health consequences. Training parents and communities to help children cope with trauma may soften the blows and lead to later success.
A novel biochip has been developed to evaluate red blood cell properties in sickle cell patients, providing a potential tool for monitoring and managing the disease. The research aims to identify and predict flare-ups, allowing for earlier treatment and prevention of complications.
The new Science Across Virtual Institutes project will create a shared platform for broader research at the nation's 10 CZO locations and international counterparts. This will enable scientists to establish common experiments and measurements, providing training for graduate students and post-doctoral fellows.
Researchers at UMass Amherst produce a new model of the Coachella Valley faults, capturing more geometric complexity than previous models. The study yields an estimated 10% increase in shaking overall for the Coachella segment, but decreased shaking for towns to the west of the fault.
A new study found that Caribbean gorgonian corals can calcify and grow under elevated CO2 concentrations, suggesting they may be more resistant to ocean acidification. The research also challenges the idea that all high-magnesium calcite-secretors are susceptible to ocean acidification.
A study found that cancer's gene-control system is disordered, allowing tumors to adapt and evade therapy. The disorder in methylation patterns - a process controlling gene expression - contributes to cancer progression and heterogeneity.
A UT Arlington civil engineering team has installed a new mix of lime and fly ash on a section of U.S. 82 to reduce soil sulfate heaving and extend the life of the highway. The project aims to increase road longevity and reduce deterioration, with the potential to benefit motorists' vehicles.
A new study identifies a neural mechanism for translating unpleasant experiences into fear memories by changing amygdala connections. The findings suggest that Hebbian plasticity is partially correct but requires concurrent activation of noradrenaline to form memories.
A study by Ohio State University researchers found that patients treated at highly-experienced radiation oncology centers had better survival rates and fewer cancer recurrences compared to those treated at less experienced centers. The study analyzed data from 470 patients treated with radiation therapy between 2002-2005.
Researchers have developed injectable 3D vaccines using programmable biomaterials that can induce an immune response to fight cancer and infectious diseases like HIV. The vaccines recruit dendritic cells, which then trigger an immune response to attack harmful cells.
The global spread of asbestos is a pressing concern, with over 50 countries banning the substance due to its deadly health risks. India and the US remain among the largest producers and importers of asbestos, contributing to the ongoing challenge to global health.
Researchers have successfully designed a substance combining three metabolically active hormone components (GLP-1, GIP, and glucagon) to fight metabolic diseases. The triple hormone reduces body weight by around 30 percent while improving insulin sensitivity, essentially curing obesity and diabetes in animal models.
A new study has found early warning signals of a reorganisation of the Atlantic Ocean's circulation, which could impact the global climate system. The researchers used a complex model to analyze the Atlantic Meridional Overturning Circulation (AMOC), finding that these signs are present up to 250 years before it collapses.
Scientists have developed a method to transmute living cells into more permanent materials that defy rot and can endure high-powered probes. This technique is widening research opportunities for biologists developing cancer treatments and materials scientists creating commercially useful shapes.
A recent study published in the Canadian Medical Association Journal has found that HPV vaccination does not lead to increased risky sexual behavior in young girls. The study followed 260,493 girls and found no significant increase in pregnancies or sexually transmitted infections among those who received the vaccine.
University of British Columbia researchers found that hummingbirds lose positional stability when exposed to moving visual patterns, even with prolonged exposure or combination of moving and stationary stimuli. This discovery highlights the complex relationship between a hummingbird's visual field and its ability to hover in place.
A study found that seasonal flu vaccines can induce strong immune responses against multiple flu virus subtypes, including some not included in vaccine formulations. This could provide protection against emerging pandemic strains from avian populations.
The new journal aims to bridge the gap in publication options for the mechanics community, featuring short articles on cutting-edge research in various disciplines. It is edited by three distinguished scientists and offers immediate publication of papers without waiting for other articles.
A team of researchers has discovered a way to make triple-negative breast cancer cells susceptible to chemotherapy by inhibiting the HIF protein network. The study found that HIF inhibitors can decrease tumor size and prevent relapse in mice, offering new hope for treatment-resistant patients.
Researchers at UBC found that hummingbirds struggle to control their hovering when faced with visual stimuli like moving images. This phenomenon was observed in virtual reality experiments where birds were unable to adapt to dynamic visual input.
A new study published in Annals of Internal Medicine found that breast density notification laws substantially increase costs and save relatively few lives. The study suggests that these laws would result in limited health gains and substantially increased expenses.
A new study in The Lancet has found that combining insecticide spraying with bed nets offers no additional protection against malaria. In fact, the researchers suggest that investing more resources into providing bed nets may be a more effective solution to tackle malaria, as it is a low-cost and cost-effective method.
Scientists discovered ancient engravings from human ancestors on a 400,000 year old fossilised shell from Java. The discovery is the earliest known example of ancient humans deliberately creating pattern.
Researchers found that weight loss surgery in obese individuals can reduce lower urinary tract symptoms, including increased frequency and urgency. The improvement is linked to improved insulin sensitivity, indicating a reduced risk of developing type 2 diabetes.