A NYU Dentistry study found that a comprehensive cavity prevention program with primary and secondary prevention strategies significantly lowers the rate of new and untreated cavities compared to traditional molar sealant programs. Both school-based programs reduced the risk of untreated decay over time.
Researchers at the University of Basel have developed a method to generate stable cartilage tissue from adult human mesenchymal stem cells by inhibiting specific signaling pathways. This breakthrough has significant implications for the treatment of joint diseases and injuries.
The British Journal of Pharmacology has published updated guidance for authors on designing experiments, analyzing data, and presenting results. The editorials aim to improve reproducibility and transparency in preclinical research by providing approaches to data presentation and checklists for immunoblotting and immunohistochemistry.
Researchers have discovered a way to create superconducting materials that carry 'spin' currents, improving efficiency in high-performance computing. By aligning electron spins, they can generate pure spin supercurrents, which could use significantly less energy than current silicon-based electronics.
A new study found the Epstein-Barr virus is linked to seven serious diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), and type 1 diabetes. The virus affects nearly 8 million people in the US, highlighting a common cause of chronic illness.
The anthology explores dementia-associated apathy research, neural system effects on late-life depression, and adopting new models of care. It also proposes solutions to accelerate change in science, practice, training, and public policy.
A multicenter database study of adults undergoing spinal deformity surgery found that daily opioid users had longer ICU stays and more severe postop disability compared to non-opioid users. The study highlights the need for preoperative counseling and alternative pain management strategies for patients at risk of daily narcotic use.
A study found that tumors may overcome immunotherapy by increasing TIM3 and regulatory T cells, which inactivate immune killer T cells. Adding a TIM3 inhibitor to radiotherapy/immunotherapy increased response duration, but tumors still relapsed. Researchers also discovered that Tregs contribute to cancer regrowth.
Researchers at Indiana University have discovered a new and potentially toxic flame retardant, TTBP-TAX, in the environment. The chemical was found in dust and air samples from an electronic waste facility and 70% of household dust samples collected from homes in Bloomington, Indiana.
A systematic review of 49 randomized trials involving 23,098 participants found that various self-regulation interventions were effective in promoting emotional control, social skills, and learning. The review suggests that these programs can help maintain health and well-being throughout life.
Researchers found that combining anti-CTLA-4 and anti-PD-1 immunotherapies enhances response rates and generates more memory T cells, leading to better tumor control. This combination may help prevent relapse in patients with therapies targeting CTLA-4 and PD-1 checkpoints.
A study by Sina Esteky found that people at higher elevations are more willing to take financial risks and engage in sensory risks. This effect is subconscious and disappears when participants are informed or unable to see their floor level.
Research found that having an evening preference is linked to a higher BMI among people with Type 2 diabetes. Participants with late breakfast times had a BMI of 28.4 kg/m^2, compared to those who ate earlier, who had a lower BMI by 0.37 kg/m^2.
A recent study found that women are consistently less intensively treated with high-intensity statins after a heart attack, even when prescribed, and across various patient characteristics. This underutilization can lead to preventable vascular events, emphasizing the need for clinicians to communicate the benefits of these medications.
A new study from Stockholm University shows that prescribed burning in southern Ethiopia's tree heather heathlands maintains biodiversity and habitats for alpine plant species. The practice, which has been used for at least 2000 years, is recommended to be maintained but regulated to protect local ecosystems and societies.
A Portland State University research team published an interactive diagram and web-based presentation in Frontiers in Neurology, revealing the complex nature of mild traumatic brain injury (TBI). The causal-loop diagram shows how specific variables interact to influence concussion recovery.
Researchers at Lund University discovered a new approach to treat severe epilepsy by targeting a specific brain area, reducing seizure activity. This breakthrough method, using chemogenetics, may pave the way for improved treatment options for thousands of people in Sweden affected by the disease.
Researchers at the University of Copenhagen have identified a new protein shield called Shieldin that helps repair damaged DNA and affects resistance to PARP inhibitor drugs used for breast cancer treatment. This discovery may contribute to making decisions for treating cancer patients and understanding mechanisms of resistance.
Researchers at Duke University Medical Center have developed man-made aptamers that target prostate cancer cells, killing them while leaving healthy tissue unscathed. The findings suggest that these molecules could form the basis of new cancer therapies if further studies bear out.
Researchers used single-cell imaging to study how melanoma cells evade drug action and acquire resistance to BRAF-inhibitor dabrafenib. The study found that 10% of treated cells reactivated the MAPK signaling pathway within 2-3 days, allowing them to signal through the pathway even in the presence of BRAF inhibition.
Researchers found that organs from overdose deaths have noninferior outcomes to those from trauma or natural death, but may carry higher risks of HIV and hepatitis transmission. Optimizing their use could help address the organ shortage, but caution is needed due to small potential risks.
A novel computational method reveals that EBV protein EBNA2 activates human genes associated with increased risk for autoimmunity, including systemic lupus erythematosus and multiple sclerosis. Researchers propose potential therapies to interrupt this process.
Scientists at the University of Waterloo have developed a vaginal implant that decreases the number of cells targeted by the HIV virus, taking advantage of natural immunity. The implant, containing hydroxychloroquine, was tested in an animal model and showed significant reduction in T cell activation.
Two genetically modified broadly neutralizing antibodies protected rhesus macaques from an HIV-like virus, SHIV, with long-term protection of up to 37 weeks. The study demonstrated that genetic mutations increased durability and led to extended protection.
Researchers at Stockholm University have discovered a moss that can rapidly remove arsenic from contaminated water, making it safe for human consumption. The aquatic moss Warnstofia fluitans can absorb up to 80% of arsenic in just one hour.
A new study by The George Institute for Global Health found that women in the US are less likely to receive high-intensity statins after a heart attack, despite guidelines recommending them. The study of over 88,000 adults suggests that adherence to these guidelines may be needed to prevent deaths from heart disease and stroke.
The new guidelines would classify an extra 31 million Americans as having hypertension, but experts say this could lead to increased anxiety and depression, as well as serious treatment side effects. Doctors should only treat patients with high cardiovascular disease risk using reliable calculators.
A Johns Hopkins Medicine analysis shows that trauma patients are four times more likely to die from gunshot wounds and nearly nine times more likely to die from stab wounds before getting to a trauma center. The increased prehospital mortality suggests that violence is intensifying.
Researchers at Children's Hospital of Philadelphia have identified a brain pathway that, when stimulated, leads to 'antidepressive' behavior in animals. The study suggests that targeting this circuit could lead to a novel treatment for depression.
Michigan State University research reveals that millennials are driving a shift towards customized, experiential supply chains where customers have more control over the product. This change requires companies to deliver tailored offerings and prioritize greater visibility and social responsibility.
In a breakthrough study, NIH scientists identified distinct immune cell subsets that work together to repair the damaged meninges and blood vessels in mice. The research provides new insights into the recovery process after concussion and may lead to the development of targeted therapies to improve patient outcomes.
KTU has won EUR 2.4 million Horizon 2020 funding to attract top academics, boosting innovation economy and strengthening its competitiveness in the European Research Area. The project focuses on Industry 4.0's impact on management practices and economics.
Smoking has been linked to an increased risk of developing heart failure in African Americans, with hospitalizations for heart failure nearly three times more likely among current smokers. The study found that smoking a pack or more per day for 15 years was associated with twice the risk of heart failure compared to non-smokers.
Researchers discover urethane, a compound formed during beer and wine fermentation, is more effective at combating seizures caused by organophosphate nerve agents than the current recommended treatment. The study suggests urethane or its derivative may prevent seizures from developing into epilepsy.
A new study reveals that the origins of dinosaurs were triggered by a crisis mass extinction event 232 million years ago. The Carnian Pluvial Episode led to repeated extinctions and a surge in global warming, acid rain, and climate perturbations.
Researchers found that combining two approaches to reduce amyloid-beta improved spatial navigation and memory in a mouse model of Alzheimer's disease. The study suggests similar combination treatments may help patients with Alzheimer's disease in the future.
Researchers at Champalimaud Centre for the Unknown uncover exquisitely organized map of visual space in feedback connections, providing insights into visual perception. The study reveals that these connections encode information from further locations in visual space, giving lower structures contextual 'whole picture' information.
A new study found that higher levels of education during childhood significantly decrease the risk of dementia and Alzheimer's disease in older African Americans. This association is particularly strong for those who grew up in low-income rural areas.
Engineers at UC Berkeley developed a thin-film system that can convert low-quality waste heat into electricity, achieving unprecedented energy density and power density. The technology has potential applications in various industries, including electronics and manufacturing.
A randomized clinical trial found that smartphone app use improved self-reported medication adherence, but not systolic blood pressure, among participants with poorly controlled high blood pressure. The study used the Medisafe app and lasted 12 weeks.
Researchers isolated striosome neuron activity using optical neural imaging technology to shed light on their role in reinforcement learning. The study found that striosomal neurons fire more actively in response to odor cues associated with water rewards, indicating they are involved in anticipating the outcome of a stimulus.
A new method developed by researchers at USC Viterbi School of Engineering uses machine learning to measure key risk factor for cardiovascular diseases and arterial stiffness using just a smartphone. The method was validated with existing tonometry data and showed high correlation with actual tonometry measurements.
Emory University's Yerkes National Primate Research Center has received a five-year, $12.7 million NIMH grant to continue research on oxytocin, a brain chemical involved in social bonding. The goal is to understand its role in neural communication and social functioning.
Researchers found that pure conifer stands, particularly pine-dominated areas, were more susceptible to southern pine beetle infestations. The study's findings have important implications for forest management, suggesting that preventative treatments like thinning can be effective in newly-occupied northern ranges.
The U.S. Army Research Laboratory has developed an artificial intelligence technique that produces a visible face image from thermal images captured in low-light conditions. The technology leverages advanced domain adaptation techniques to enhance discriminability and recognition accuracy.
A recent study found that stereotactic radiosurgery (SRS) can improve overall survival and reduce cognitive side-effects in patients with brain metastases from small-cell lung cancer. The study compared outcomes of 5,752 patients who received whole-brain radiation therapy (WBRT) to those of 200 patients who received SRS.
A USC study found that individuals with a college education have a lower risk of developing dementia and living with it for longer periods. The research suggests that targeting chronic diseases like hypertension and diabetes may delay dementia onset but ultimately increase the number of people living with dementia at older ages.
Researchers found that species' phenology shifted four days earlier per decade after 1981, with increased synchrony between species pairs from 0.97 to 6.1 days per decade. However, the magnitude of shifts and correlations with temperature changes remain uncertain due to short time series and variations among species.
The Critical Path Institute has received a $10 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to identify unmet needs for biomarker development in Crohn's disease. The pre-consortium will focus on laying the groundwork for future regulatory endorsement and accelerate the development of new treatments.
A study identifies genetic variants related to consonant processing, dyslexia, and reading performance. Variations in the READ1 sequence are tied to modern human-specific changes acquired between 4 million and 550,000 years ago.
Researchers detect Bloch-Siegert shift in strongly coupled light and matter, a phenomenon previously speculated but never observed. The discovery could lead to a greater understanding of theoretical predictions in quantum phase transitions and the development of robust quantum bits for advanced computing.
Plants may have exerted greater influence on terrestrial ecosystems than megaherbivores that once roamed landscapes. Shrubs consistently predicted ecosystem change, with increasing shrub biomass reducing nitrogen availability and promoting tree growth.
A new BJS study found axillary ultrasound imaging to be less sensitive for detecting axillary metastatic lymph nodes in women with invasive lobular carcinoma compared to invasive ductal carcinoma. Women with invasive lobular carcinoma may benefit from axillary biopsies regardless of ultrasonographic appearance.
A team of UCSB physicists has created a device named DARKNESS, the first 10,000-pixel integral field spectrograph designed to overcome the limitations of traditional semiconductor detectors. This instrument enables direct imaging of planets around nearby stars and can detect fainter planets with higher contrast ratios.
A new study finds nearly one in four blood bank supplies contain malaria parasites, putting children and pregnant women at risk. The lack of sensitive diagnostic technology exacerbates the issue, highlighting the need for better vigilance and screening practices to keep blood banks safe.
Aalto University researchers have successfully created a new Bose-Einstein condensate that doesn't require cooling to near absolute zero. The condensate is made up of light and electrons in motion in gold nanorods, allowing for faster information processing and potentially enabling the creation of extremely small and fast light sources.
Researchers at UCLA have discovered Majorana particles, which are critical building blocks for quantum computers due to their resistance to external interference. The discovery could lead to the development of robust topological quantum computing and potentially improve situational awareness for the US Army.
A large cohort study found that nearly all mental health diagnoses were more common for transgender and gender-nonconforming youth than for cisgender youth, with depression and ADHD prevalence rates 4-7 times higher. The study aimed to raise awareness about the pressure young people may feel due to gender dysphoria and prejudice.
Researchers have determined the high-resolution structure of R2TP, a complex involved in key processes for cell survival. The study reveals that R2TP forms complexes with mTOR and other related kinases by interacting with HSP90.
Policies such as ecological restoration and improved crop residue management have contributed to increased carbon sequestration in China. China's distribution and magnitude of carbon pools vary in response to climate change and human activities.