A new clinical trial found that burosumab significantly improves rickets and related outcomes in children with X-linked hypophosphatemia compared to conventional therapy. The study, which included 61 children, showed substantial healing of rickets in 72% of participants who received burosumab.
A study by researchers found that growth hormone insurance strategies reduced total and insurer costs, but patient savings were minimal. The cost of treatment decreased for insurers, while average copayments, deductibles, and patient financial burden increased.
A study presented at ENDO 2019 found that oxytocin weakens the connection between brain areas involved in food processing, potentially targeting overeating and obesity. Oxytocin modulates the brain's reward system during responses to highly palatable foods.
Researchers found statistically significant reductions in pain-rating scores and improvements in tendinosis and tear scores after transcatheter arterial embolization (TAE) treatment. The non-surgical procedure decreases abnormal blood flow to the injured area, alleviating inflammation and pain without invasive surgery or physical therapy.
A new study finds that immediate cognitive effects from exercise mirror long-term ones, suggesting a strong link between physical activity and brain health. Brain changes after a single workout can predict sustained gains in cognition and functional brain connectivity over time.
Researchers developed a device-sizing application for Google Home smart speakers to provide accurate medical information and recommendations during procedures. The technology aims to improve patient care by allowing physicians to concentrate on patient care while reducing device technicalities.
A study highlights the severe negative health consequences of low energy availability in female athletes, including hormonal imbalances and reproductive issues. Researchers emphasize the need for coaches, parents, and athletes to be aware of signs of low energy intakes and seek advice where needed.
A recent study published in the European Journal of Preventive Cardiology has found that paternal smoking and maternal passive smoking can significantly increase the risk of congenital heart defects in offspring. The analysis of 125 studies involving over 137,000 babies with congenital heart defects revealed a 74% increased risk for me...
Research suggests that exposure to chemical mixtures present in household dust may contribute to increased growth in children relative to their age and promote the development of fat cells. The study found that very low concentrations of dust extracts were able to promote precursor fat cell proliferation and fat cell development.
Researchers found that autoimmune diseases like Addison's and vitiligo often cluster together due to genetic links. In contrast, celiac disease tends to be less associated with other autoimmune conditions.
Researchers found that low-dose BPA exposure during gestation alters circadian rhythms, leading to increased activity and disrupted daily patterns in mice. This study suggests a potential contributing factor to hyperactivity observed in BPA-exposed mice.
A new study reveals that obesity in boys accelerates the start of puberty, with central and total obesity increasing the odds of early puberty. The study found that controlling obesity in children could help decrease risks of behavior problems and testicular cancer.
A team of scientists has developed a way to improve the tolerance of industrial oil-producing microalgae to high levels of CO2, allowing them to grow faster and more efficiently in flue gas environments. This breakthrough could have significant implications for carbon fixation, food production, and future space exploration.
Researchers found that a diet high in antioxidants from foods like citrus fruits, capsicum, and dark green vegetables can delay the onset of age-related cataracts. The study suggests that such a diet could halve the number of people requiring cataract surgery.
A recent study found that female mice on a ketogenic diet experienced impaired blood sugar control and no significant fat loss, unlike male mice. Removing the ovaries of female mice improved their weight loss outcomes, suggesting that estrogen may play a role in the differing response to the diet.
A new study reveals that patients and their families have borne an increased financial burden for growth hormone treatment since its FDA approval in 2003. The cost burden has risen by 234% due to increased copayments, deductibles, and insurance restrictions.
A nationwide survey of Brazilian teens found that excessive screen time and unhealthy snacking are associated with an increased risk of metabolic syndrome, a cluster of risk factors for heart disease and diabetes. The study suggests that limiting screen time and avoiding snacks in front of screens may help reduce this risk.
A new study by Dr. Keon West found that ethnic minorities and majorities experience similar decreases in happiness and life satisfaction after microaggressions. The researcher argues that the 'hypersensitivity hypothesis' has undermined the severity of microaggression effects, suggesting a shift towards eliminating these experiences.
A study in mice suggests that altering the gut microbiome via prebiotics or probiotics may be a potential treatment for PCOS. The research found improvements in testosterone levels, ovulation, weight, and insulin resistance in mice with PCOS, linked to changes in gut bacteria composition.
Research suggests that sperm DNA damage in male partners may cause recurrent pregnancy loss (RPL), with affected men having twice as much DNA damage as healthy counterparts. High levels of reactive oxygen species were also found, which can damage cells like sperm.
A new study reveals that long-term opioid users are at risk of hormone deficiencies, including hypogonadism and hypocortisolism. Up to 65% of men using opioids long term have low testosterone levels, leading to symptoms such as erectile dysfunction and infertility.
Researchers have identified new pathways controlling inflammation in the gut and explored diet-based interventions to prevent C. difficile infections. Prebiotics may also help mitigate gastrointestinal toxicity from radiation treatment.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
A large study published in The New England Journal of Medicine found that treating women with thyroid antibodies and normal thyroid function with Levothyroxine did not improve the chances of live birth. The study showed similar outcomes in both groups, with 56.6% and 58.3% becoming pregnant, respectively.
A large study led by the University of Birmingham found that treating women with normal thyroid function and thyroid peroxidase antibodies with Levothyroxine did not increase live-birth rates. The researchers suggested that previous recommendations to use Levothyroxine in these women may have been based on limited evidence.
A new study presented at ENDO 2019 found that the A1c test used to diagnose diabetes tends to underestimate its prevalence. The test missed detecting 73% of diabetes cases compared to the oral glucose tolerance test, highlighting its limitations.
A new study presented at the Endocrine Society's annual meeting suggests that eating later in the day is associated with a higher body mass index and greater body fat. The research used advanced technology to track participants' sleep, physical activity, and eating patterns over a week-long period.
Researchers found that older adults with type 1 diabetes spend more than an hour per day in the hypoglycemic range, increasing their risk of severe complications. This study highlights the need for interventions to reduce the risk of severe hypoglycemia in this age group.
A team of researchers from Tokyo Metropolitan University has demonstrated that the tunable hydrophobic nature of dense siloxane gels strongly correlates with their catalytic activity. The study shows that molecules with different hydrophobicity interact differently with surfaces, leading to increased or decreased catalytic activity.
A meta-analysis of 473 patients found that weight loss reduces headache frequency, pain intensity, and disability in obese migraine sufferers. Weight loss through bariatric surgery or behavioral intervention also shows significant improvements.
Transgender men undergoing testosterone therapy may retain their fertility potential even a year into treatment, according to researchers. The study found preserved ovarian function and unchanged hormone levels, suggesting well-preserved reproductive capabilities.
The Endocrine Society's Clinical Practice Guideline recommends simplifying medication regimens and tailoring glycemic targets to improve compliance and prevent complications in older adults with diabetes. The guideline prioritizes blood glucose targets over hemoglobin A1c tests, aiming to reduce cardiovascular disease outcomes.
Researchers at McMaster University have developed a method to create artificial tumours using magnetic 3D printing, enabling faster and more affordable testing of new treatments. The technique uses magnets to concentrate human cells in a predetermined area, forming 3D cell clusters that mimic human tissues.
A new study suggests that obesity may play a role in reproductive problems in women with type 1 diabetes. Menstrual irregularities were seen in 47% of those with the disease, and polycystic ovary syndrome (PCOS) was found in 14%, increasing the risk of miscarriages and stillbirths.
A study found that sleep quality decreases in the late luteal phase, just before menstruation, with less sleep efficiency, longer wake after sleep onset, and higher sleep fragmentation index. Caloric restriction also negatively affects sleep during this period.
Researchers have developed a new catalyst that can efficiently break down ammonia in the air, converting it into harmless nitrogen gas and water. The catalyst, made of gold nanoparticles on a metal oxide framework, is effective at room temperature and has been shown to reduce gases contaminated with ammonia to undetectable levels.
A new animal study suggests that exposure to dim light at night may contribute to the spread of breast cancer to bones. Researchers created a mouse model of bone metastatic breast cancer and found that mice exposed to a light/dim light cycle had larger tumors and increased bone damage compared to those in a standard light/dark cycle.
A study found that people with diabetes are at a higher risk of fractures, particularly among Caucasians and Hispanics. However, African Americans with diabetes showed little to no increased fracture risk compared to those without diabetes.
A new study by The Endocrine Society found that treating obstructive sleep apnea (OSA) with an overnight CPAP machine can result in more weight loss for adults with obesity who try to lose weight by restricting calories. Patients who received concurrent CPAP treatment lost an average of 5.7 pounds more than those who did not treat thei...
The study found that the percentage of younger women initiating bisphosphonate treatment decreased over the 12-year period, while older women and those with osteopenia or osteoporosis increased. The overall percentage of osteoporosis among white and Asian women also rose.
Researchers used correlated wavefunction theory to simulate the bulk hydrated electron, finding a persistent tetrahedral cavity made up of four water molecules. The model provided stronger theoretical evidence for the cavity model, dismissing non-cavity structures in stable and metastable states.
Researchers have found that modulating blood-forming stem cells' stiffness could help drive them out of the bone marrow and into the blood, but they need to be stiff to stay put. The study, published in Cell Stem Cell, suggests that altering cell biomechanics can improve mobilization regimens for stem cell-based therapy.
A PLOS Special Collection explores new steps in clinical research for optimal TB treatment, driven by WHO and IRD-France sponsorship. Experts outline best practices for future clinical trials to inform policy guidance.
Researchers used computer simulations to discover Jupiter was formed four times further from the sun than its current position and migrated over 700,000 years. The Trojan asteroids' asymmetry provided key evidence for this migration theory.
A study on Myxococcus xanthus reveals diverse social behaviors among cooperative bacteria, contradicting the assumption that groups are genetically homogeneous. The researchers attribute this diversity to evolutionary selection favoring specific 'social genes' that control behavior.
A new study explores the connection between poor sleep and Alzheimer's disease, revealing that sleep helps clear excess amyloid beta and tau proteins from the brain. Disruption of slow-wave sleep can cause a significant increase in these protein levels, suggesting that sleep plays a crucial role in preventing Alzheimer's development.
A new analysis tool developed by Florida State University scientists can help improve understanding of population genetics and combat pathogens. The f-coalescent model, which incorporates fractional calculus, offers a promising method for analyzing the spread and distribution of disease vectors.
Physicists at UMD developed a new method to detect radioactive material remotely using an infrared laser beam. The technique induces an electron avalanche breakdown near the material, allowing detection from a distance. With further development, it could be used to scan trucks and shipping containers at ports of entry.
The Ryerson-led research team developed a technique called F-Mode, which enables selective enhancement of features in biological structures based on size. This breakthrough has significant potential in ophthalmology, neurosurgery, and disease detection.
A study by SISSA neuroscientists reveals the existence of temporal maps in the brain's supplementary motor area (SMA) for decoding abstract features of time. The maps are represented via topography and duration tuning, with different portions responding to specific durations.
A study found that patients who stayed on phentermine longer experienced greater weight loss than those who took the drug for three months or less. Longer-term use was not associated with increased risk of heart attack, stroke, or death.
Researchers have discovered that tall ice-cliffs on glaciers can trigger massive calving events, which could lead to rapid sea-level rise. The study found that cliffs over 100 meters high are most susceptible to slumping, a process that accelerates calving without waiting for the melting of the front.
A new study from Stockholm University finds that climate changes are affecting weather forecasting accuracy, particularly with predicting summer rain volumes. Meanwhile, temperature and air pressure forecasts are expected to become more accurate.
The Cascades Arc is home to a string of volcanoes with radically different histories, sparking researchers to look beyond individual volcanoes. By analyzing heat flow, seismic wave speeds, and other data sources, scientists aim to understand why some volcanoes erupt differently than others.
Researchers developed a new technique combining optical tweezers with high-powered X-rays to position and manipulate crystals in solution. This allowed them to observe reactions as they occurred, revealing sub-nanometer scale defects and grain boundaries within the ZnO microcrystal.
Research on guppy fish reveals that genes in males are preserved over generations, allowing the evolution of bright colors. This genetic stability enables the conservation of characteristic traits, such as coloration, in males.
Researchers identified a new protocol to prioritize HCV treatment in US prisons, considering factors like liver health state, sentence length, and injection drug use. The approach aims to reduce hepatitis C-caused mortality and infections, both in prisons and the community.
A new sensor system can monitor wiring in buildings or ships to detect impending electrical failures, allowing for timely repairs. The system was tested on a Coast Guard cutter, pinpointing a motor with burnt-out wiring that could have led to a serious fire.
Researchers discovered how naturally occurring microbes like Rhodopseudomonas palustris use electrons from conductive substances to fix carbon dioxide. The process is connected to the microbe's ability to store and discharge electrons, similar to a rechargeable battery.
Researchers at the Salk Institute have identified a gene mutation that causes motor axon misrouting, leading to improper connection with muscles. The study reveals how p190 acts as a blinder to guide axons outside of the spinal cord, shedding light on the intricate mechanisms of cell signaling and development.