A study led by University of Pennsylvania scientists reveals how tumor-derived factors stimulate trogocytosis, a process that can help cancer cells evade detection and grow unchecked. Blocking this process improved the effectiveness of CAR T cell therapy in mice.
A team of researchers found microplastics in water trapped in plant leaf axils, a first-time discovery that highlights the global risk of contamination. The study, conducted in Slovakia, used teasel phytotelmata, small aquatic ecosystems formed by plants, to detect the presence of microplastics.
Researchers from MSU and Berkeley Lab have developed a high-resolution image of the cyanobacterial light-harvesting antenna, providing insights into how light energy is captured and converted. The study reveals new discoveries, including a small protein acting as a surge protector for the massive antenna.
Researchers developed a novel, single-dose, intranasal treatment that reduces symptoms and viral shedding of multiple SARS-CoV-2 variants. The therapeutic interfering particle (TIP) treatment effectively blocks COVID-19 transmission in animal models.
A new neural network model developed by Aalto University researchers can accurately predict the occurrence of fires in peatlands. The model identified a suite of interventions that would reduce fire incidence by 50-76%.
A new study published in Frontiers in Medicine found that around 30% of people with long COVID experience a decreased sense of smell, with 29.9% reporting persistent anosmia after 12 weeks. Researchers also discovered an elevated prevalence of blurred vision and hearing-related symptoms after three months.
The U.S. Department of Energy has renewed funding for a research center studying molten salts, which have potential applications in improving the safety and efficiency of nuclear power. The center, led by Brookhaven National Laboratory, will receive $13.3 million over four years to advance our understanding of molten salt properties.
A research team analyzed germ cells in chickens using RNA-sequencing to predict the mechanism that determines sex. The study reveals a mix of cell-autonomous and somatic-cell regulation, with sex determination occurring earlier in females than males.
Researchers have discovered that L-cryptochrome, a molecule in marine animals, can interpret moonlight to entrain the monthly clock for sexual maturation and reproduction. This ability helps organisms adjust their behavior and physiology by light.
A randomized phase III trial found that combination hormonal therapy, delivered for a finite treatment interval of 12 months, more durably suppresses PSA levels compared to hormone injections alone. The treatment approach improved disease progression in patients with high-risk biochemically relapsed prostate cancer.
A new study from the Strategic Management Journal found that budgeting flexibility is crucial for financial security in higher education. Universities that can reallocate resources more regularly are more likely to run larger budget surpluses, with high governance arrangements actually weakening resource allocation flexibility.
Researchers discovered that tetrapods had more complex connections between skull bones than fish, limiting their evolution for millions of years. This complexity resulted in a single, consolidated skull unit, whereas fish ancestors had multiple distinct sections.
The Center for Leadership in Environmental Awareness and Research (CLEAR) will investigate toxic mechanisms, exposure pathways, biomarkers, and strategies to prevent exposures. It aims to reduce toxic exposures and improve health outcomes through innovative methods such as phytoscreening and Internet of Things technology.
A new study by UC Berkeley neuroscientists simulated food insecurity in juvenile mice, finding lasting changes in learning, decision-making, and dopamine neurons. The stability of the food supply during young age affects cognitive flexibility in adulthood.
Researchers at the University of Zurich found that compound concurrent hot day and night extremes are projected to increase by up to 7.8-fold in frequency and 5.3-fold in duration in all cities in Switzerland by the end of the century. Lugano and Geneva will be most affected.
The study found that pregnant individuals younger than 25 years, non-Hispanic Black individuals, unmarried individuals, and those with obesity before pregnancy experienced higher gestational weight gain. The pandemic also led to a higher risk of excessive gestational weight gain among these groups.
A new study published in Cell Metabolism found that eating a larger meal in the morning does not impact energy metabolism but may help with appetite control and satiety. Healthy subjects who followed a morning-loaded diet reported feeling less hungry later in the day.
A new analysis found that increased Medicaid dental payment policies were associated with modest improvements in children's dental visits. The study also showed a link between the payment rates and better oral health outcomes for kids.
The NIH will fund a program to establish partnerships between universities and allow undergraduate students from diverse backgrounds to conduct genomics research and receive career development training. The goal is to strengthen the pathway for undergraduate students to pursue graduate education in genomics.
The NEUROCOV project seeks to understand the interplay between SARS-CoV-2 infection and the nervous system, with a focus on immune response and neuronal functions. The research aims to predict risk for neurological symptoms and develop effective treatments.
A new study by St. Edward’s University, University of Mississippi, and University of Texas at Austin finds that female executives focus on customer relationships to a greater degree than their male counterparts, leading to more customer-oriented discussions in the C-suite. The researchers examine 389 Fortune 500 firms over six years an...
Researchers at Stockholm University solved the mystery of the supergene responsible for distylous flowers with differing lengths of male and female sexual organs. The study reveals that the supergene itself varied in length, with a dominant form containing about 260,000 base pairs of DNA.
The study reveals a new pathway to develop lead-free ferroelectric materials with strong piezoelectric properties. The novel hybrid improper ferroelectric material combines rotation and tilting of oxygen octahedra to produce polarization, enabling the creation of powerful piezoelectric systems.
Three pre-Columbian South American mummies found evidence of lethal trauma, with two males dying from extreme intentional violence. The study used 3D CT scans to examine the mummies and provide new insights into the rate of trauma and violent deaths in prehistoric human societies.
A new study led by the University of Miami Rosenstiel School found that artificially cooling oceans to weaken hurricanes is a futile solution due to its high energy requirements and minimal benefits. The research suggests focusing on adaptation strategies such as reinforcing infrastructure and improving evacuation procedures instead.
Scientists have discovered a slowing of continental plate movement was the critical event that enabled magma to rise to the surface and deliver devastating knock-on impacts. This fundamental process controlled the evolution of climate and life on Earth throughout its history.
Late-breaking results at ESMO Congress 2022 reveal a strong association between air pollution and non-small cell lung cancer, with exposure to particulate matter linked to increased risk. The research underscores the need for environmental sustainability in oncology, particularly in cancer prevention and early detection.
The study reveals that donkeys were first domesticated in Africa 5,000 years ago, with a previously unknown genetic lineage discovered in the Levant. This discovery has significant implications for understanding the history of trade between Europe and North Africa.
Researchers at University of Illinois Chicago developed a method to convert 100% of captured carbon dioxide into ethylene, producing hydrocarbons with high purity. The process uses electrolysis and can recycle almost all carbon dioxide captured, making it carbon negative when powered by renewable energy.
Researchers have developed a new safety system for CAR-T cells, called VIPER CAR-T cells, that can be turned on or off. This allows doctors to target cancer more aggressively while minimizing side effects. The new system uses an FDA-approved antiviral drug to control the cell's activity.
Researchers at Princeton University have discovered a biosynthetic pathway that incorporates selenium into microbial small molecules, marking the first time such atoms have been uncovered in natural products. This breakthrough suggests that selenium may have a more important biological role in bacteria than previously assumed.
A new study found that Americans support multilateral military interventions and prioritize peaceful conflict resolution, with a strong preference for protecting civilians. The research also revealed concerns about the legitimacy of US intervention were more important than cost and success.
Researchers from Hiroshima University have identified two types of genes that are upregulated in both rice and thale cress when exposed to oxygen deprivation. The study suggests distinct molecular mechanisms under hypoxia in plants and animals, with potential applications for creating flood-tolerant crops.
A study of 2.4 million Medicare beneficiaries found that those enrolled in Medicare Advantage had lower rates of low-value care, including unnecessary tests and treatments. This study highlights the potential benefits of Medicare Advantage plans in reducing waste in healthcare.
A study by researchers at MSU, Northwestern, Notre Dame and NYU found that gender-balanced teams produced significantly more novel and impactful scientific work compared to unbalanced teams. Teams with an equal number of men and women had the highest likelihood of novel and impactful results.
Researchers developed a predictive test to assess asthma risk in babies, allowing for preventive treatments and potentially bypassing disease development. The test identifies a network controlled by the IRF1 gene that drives an exaggerated inflammatory response in children who develop asthma.
A new simulation suggests that gravitational interactions, not over-eating, are responsible for the Milky Way Galaxy's peanut-shaped and nuclear bulges. The study reveals a clear break in star ages between the two types of bulges, indicating when the bar formed.
Researchers found climate models are less accurate in projecting how tropical cyclones will affect individual coral reefs, highlighting the importance of targeted conservation efforts. The study urges caution when using climate models to identify vulnerable reef communities to storm damage.
A new study compares the proteomes of skin cells from 11 mammals, revealing protein variation that drives biological diversity and may explain cancer resistance. The researchers found that some proteins are more variable between species than within, suggesting they play key roles in mammalian evolution.
A Phase 3 clinical trial is enrolling adults and children with monkeypox infection in the US to evaluate the efficacy and safety of tecovirimat (TPOXX). The trial aims to gather data on lesion healing, pain scores, disease progression, and safety.
Researchers found avian neurons consume three times less glucose than mammalian neurons due to smaller size and efficient energy usage. This surprising finding sheds light on the evolution of intelligent bird brains.
The National Multiple Sclerosis Society awards Kessler Foundation a five-year grant to continue the long-running MS Fellowship in Neuropsychological Rehabilitation program. The grant provides funding for postdoctoral fellows to work on rehabilitation research projects.
The study found that pandemic federal programs, including grab-and-go school meals and the Pandemic EBT (P-EBT) program, reached over 30 million children and provided nearly 1.5 billion meals in 2020. The programs helped low-income families access nutritious food during a critical time when schools were closed due to COVID-19.
A new study from the University of Kansas found that racial and ethnic minority populations in the US faced unique challenges while seeking COVID-19 information online, including misinformation, harassment, and hostility. Younger and healthier individuals were more resistant to vaccination due to lower perceived risk and benefit.
Researchers propose using precision data from upcoming experiments to test the cosmological collider effect and unravel the mystery of matter's origin. They suggest that leptogenesis, a well-known mechanism, could be used to explain the imbalance between matter and antimatter in the early universe.
Researchers analyzed the knowledge of chemical space between 1800 and 1869 to discover how well the periodic table corresponds to the chemical data at its formulation. They found that the periodic table's basic structure was already encoded in space by the 1840s, two decades before its creation.
A study by Kyoto University and BonBon Inc found that complex games like Potion can measure distinct cognitive skills such as stealth behavior and abstract thinking in young players. However, older players did not exhibit the same level of engagement, challenging existing beliefs about gaming's impact on cognition.
A new analysis reveals that mandatory prescription drug monitoring programs (PDMPs) do not significantly impact retail opioid sales across eight commonly prescribed opioids. The findings suggest that PDMP implementation is best considered as part of a broader policy response to the opioid crisis.
Researchers found two distinct populations of the invasive American bullfrog in Brazil, one descended from 1935 introductions and another from the 1970s. The study highlights the need for law enforcement to prevent escape from frog farms.
Researchers have made significant progress in designing and controlling continuum robots, which can be used for targeted therapy and precise control. However, challenges remain, including miniaturization, perception accuracy, and stable simulation engines.
A large international study of 156,000 people from 21 countries found that women have lower CVD risk than men, especially at younger ages. However, diet was more strongly associated with CVD risk in women than men, while high cholesterol and depression were more common risk factors for men.
A new study published in Earth Science Frontiers elucidates the role of nanopores in accumulating shale oil in the Gulong-Qingshankou reservoir in China. The research found that well-developed nanopores and nanofissures play a crucial role in storing shale oil, leading to a high source-reservoir ratio.
A new randomized, controlled trial demonstrates that Medasense's NOL monitoring during major abdominal surgery can reduce postoperative pain by 30% compared to standard care. The study found that personalized fentanyl dosing with NOL guidance leads to lower sympathetic activation and surgical stress, resulting in reduced PACU pain scores.
Research suggests that COVID-19 patients can transmit viruses with multiple genetic sequences simultaneously, which may impact the development of new variants. This complex sequence diversity highlights the need for continued research into the evolution and transmission of SARS-CoV-2.
A new study suggests that green hydrogen will likely supply less than 1% of global energy by 2035 due to supply bottlenecks. However, historic analogues indicate that emergency-like policy measures can drive unprecedented growth rates in energy technologies.
Financial literacy decreased in the US, with fewer people knowing objective financial knowledge, yet more believing they excel. This decline contradicts increasing overconfidence in financial abilities.
A new study found that individuals with low confidence in the importance of vaccination are five times more likely to remain unvaccinated. Rural areas and those with lower socioeconomic status also had higher prevalence of non-vaccination across all regions.
A team of researchers has designed in silico molecular probes to track the progress of a misbehaving protein linked to neurodegenerative diseases like ALS and FTD. The probes can detect TDP-43 aggregates at high resolution, paving the way for early diagnosis.
A new analysis reveals that the world is already at risk of passing five dangerous climate tipping points, even at current levels of global heating. The study synthesizes evidence from over 200 papers and identifies 16 major biophysical systems with potential to cross tipping points.
Researchers found that modern human brains produce more neurons than Neandertal brains, particularly in the frontal lobe, due to a single amino acid substitution in the TKTL1 protein. This increase is attributed to changes in metabolism and membrane lipid synthesis.