Researchers at Osaka Metropolitan University developed a cold perfusion method to isolate hepatic stellate cells (HSCs) from both murine and human fatty liver-associated tumors with high yield and purity. This breakthrough could provide new tools for investigating the role of HSCs in NASH-associated liver cancer progression.
Researchers at Imperial College London discovered a 'silent' mutation in bacteria that helps them evade antibiotics. The mutation alters the structure of an mRNA intermediate, preventing ribosomes from producing protein, and has arisen independently several times globally.
Researchers at Michigan State University discovered that increased carbon dioxide levels decrease phosphorus levels in plants, making them less nutritious. The team found that plants avoid overloading their chloroplasts with phosphorus as an adaptive response to elevated CO2 levels.
A study led by Arizona State University Professor Gabriel Shaibi found that a community-based program combining education and exercise significantly improves the health of Latino children at risk for diabetes. The program, which included 117 families from around the Valley, provided culturally focused lessons on healthy eating and phys...
The study found that colloidal membranes transition from flat disc-like shapes to saddle-like shapes as the fraction of short rods increases. The saddles then merge into more complex structures like catenoids and four-noids, exhibiting properties similar to biological membranes.
A phase 2 study found that combining nivolumab and ipilimumab showed a high response rate with durable results for patients with advanced Merkel cell carcinoma. The addition of stereotactic body radiation therapy did not improve efficacy in this dual checkpoint inhibitor therapy.
A new combination immunotherapy regimen shows remarkable activity in metastatic colorectal cancer patients without liver metastases, achieving a response rate of 40% and median overall survival exceeding 20 months. The study's findings confirm the importance of the tumor microenvironment in shaping the response to immunotherapy.
A study from Linköping University shows that individuals with type 1 diabetes should keep their mean long-term sugar level below 53 mmol/mol (7.0%) to avoid serious damage. The risk of eye- and kidney complications increases as the level increases.
A University of Houston engineer has developed a sprayable ice-shedding material that is 100 times stronger than any others. The new durable coating material controls interfacial fractures and can accelerate crack formation and growth.
A systematic review and meta-analysis found that training programs for community supervision improve outcomes for both probation officers and their clients. The programs enhance the selection of topics to discuss and intervention strategies during client contact sessions.
In a Phase I/II trial, selpercatinib demonstrated a 44% objective response rate across multiple tumor types, including pancreatic and colorectal cancers. The study found responses regardless of cancer type or prior treatment history, confirming RET fusions as a tissue-agnostic target.
Scientists defined the structure of a substrate-bound iron enzyme and found it uses cations to drive desaturation during catalysis. The work could lead to the creation of valuable molecules like vinyl isonitriles with antibiotic properties.
Researchers found that vaccine companies, such as Moderna and Pfizer, experience significant price movements when one company performs well or poorly. Sinopharm is found to be the most affected by market volatility, while AstraZeneca has the greatest influence on Moderna's stock price.
Researchers found that lettuce takes up nanoplastics from soil and transfers them into the food chain, with particles detected in insects and fish. The study highlights potential health risks to herbivores and humans due to tiny plastic particles in soil.
In an international clinical trial, 63.3% of patients with stage II-IV cutaneous squamous cell carcinoma saw their tumors nearly or completely disappear when treated with immunotherapy before surgery. The anti-PD1 therapy cemiplimab was well-tolerated and met its primary endpoint with a pathologic complete response rate of 50.6%.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
A new study suggests that massive volcanic eruptions were the primary cause of mass extinctions, including the one that wiped out the dinosaurs. The research found a strong temporal connection between flood basalt eruptions and significant climatic events.
A new study by NC State University found that total formulation impacts surface sanitizer efficacy against norovirus, with only alcohol-based products showing significant reduction. Additionally, paper towels used to clean up messes can be a source of cross-contamination.
The AI model, trained with end-to-end and multi-task manners, achieves best drivability in a standard simulation environment, outperforming recent models. It extracts useful information from a single RGBD camera and uses sensor fusion techniques to enhance performance.
Researchers found that dark matter halos in ultra-diffuse galaxies have lower concentrations than expected, raising questions about their formation and evolution. The study's surprising results indicate these galaxies may be younger and contain more gas than normal galaxies.
Researchers used a computer model to identify potential candidates for treating ASD, including loperamide, which has shown promise in restoring social behaviors in genetically engineered mice. The study suggests that repurposing existing drugs like loperamide could provide a new treatment option for core autism symptoms.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
A new study challenges traditional stereotypes by revealing that subordinate men are most likely to engage in social sexual behavior for personal gain. The research found that these men use unwanted flirtation and harassment to appear more powerful and masculine in the workplace.
Scientists have developed a thin device that can produce complex webs of entangled photons, enabling new information processing schemes and advanced encryption methods. The device uses a metasurface to control the phenomenon of quantum entanglement, paving the way for more compact and powerful computing and sensing technologies.
Researchers have successfully inserted nanotubes into bacteria, allowing for the creation of
A new software application predicts the likelihood that a case of dilated cardiomyopathy has a genetic mutation. The Madrid Genotype Score identifies patients most likely to have inherited the disease, facilitating genetic screening and tailored treatment adjustments.
Researchers from Johns Hopkins Medicine and Dana Farber Cancer Institute found that irisin reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.
Researchers discovered lonsdaleite in ancient dwarf planet meteorites, confirming its existence and potential industrial applications. The unusual structure of lonsdaleite could help inform new manufacturing techniques for ultra-hard materials.
A study published in Animal Behaviour found that female Kinda baboons with strong social connections and higher ranks have babies that mature faster. This allows mothers to redirect their energy towards reproduction sooner.
A new study finds that older children are more likely to effectively test surprising claims made by adults, suggesting an increase in skepticism and intentional exploration. As a result, their exploration becomes more targeted and efficient.
Researchers found that starting pembrolizumab before surgery significantly improves the outlook for patients with stage III-IV melanoma. The study showed a 42% lower event rate in patients receiving neoadjuvant therapy compared to those receiving adjuvant therapy.
Weekly injections of semaglutide reduce type 2 diabetes risk by over 60%, mirroring significant weight loss. Sustained treatment is necessary to maintain the benefit.
A new blood test has shown promising results for detecting multiple types of cancer from tumor DNA in the blood, enabling early detection and potentially changing cancer screening practices. The test's accuracy and effectiveness have been demonstrated in a recent study, with high sensitivity and specificity rates.
A new study by Emory University researchers suggests that antibiotics can accelerate the growth of malignant melanoma in mice by depleting their intestinal flora and weakening their immune response. This depletion leads to a higher tumor burden in infected mice compared to those with intact gut microbiomes.
Researchers at Tokyo Metropolitan University discovered that a protein excreted by type I muscle fibers can differentiate surrounding myoblasts into type I fibers, upending the notion that fiber ratios are fixed at birth. This finding has significant implications for treating conditions such as type 2 diabetes and aging populations.
Scientists have discovered a link between air pollution and lung cancer in people who have never smoked. Exposure to particulate matter (PM2.5) has been shown to promote cancerous changes in airway cells with EGFR and KRAS gene mutations, driving them towards a cancer stem cell-like state.
A phase 3 study shows that tumour-infiltrating lymphocytes (TIL) therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma. The treatment reduces disease progression or death by 50% in patients treated with TILs.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
A new study reveals a widening gap in diabetes-related mortality between urban and rural areas in the USA, with significant disparities seen in male and younger patients. The study found that reductions in mortality rates in urban areas were mainly limited to female and older patients, while outcomes worsened for male and younger indiv...
Researchers developed bioresponsive polymers for targeted delivery and controlled release of therapeutic agents. However, achieving exclusive selectivity remains a challenge due to complex biology.
Researchers found that blocking FNDC5, the precursor of irisin, prevents severe muscle atrophy and weakness in cancer-induced cachexia. Mice lacking FNDC5 showed improved body weight and skeletal muscle mass compared to control mice with tumors.
A recent study finds that fungal infections during the pandemic are a significant public health problem with limited treatment options. The interaction between pathogen and host may be different in people with compromised immunity, leading to increased mortality rates among severe COVID-19 patients.
Researchers warn that climate change will increase uncertainty in international law governing maritime zones, affecting small island states. Technologies like GPS and satellite bathmetry may help solidify claims, but more data is needed to accurately delineate existing boundaries.
A study by Helmholtz Centre for Environmental Research - UFZ found that climate-induced deforestation can lead to a significant increase in dissolved phosphorus concentration and nitrogen levels in reservoirs. This can result in an overgrowth of diatoms and green algae, compromising water quality.
A new study predicts a sharp increase in hip fractures globally, with men and the oldest old facing particularly high risks. The study's findings highlight the urgent need for improved prevention and care strategies to address this growing public health concern.
A new study found that COVID-19 treatments like remdesivir and dexamethasone persist in wastewater treatment plants and may harm aquatic life. The research highlights the utility of wastewater surveillance in monitoring human health impacts on water quality and ecosystem health.
A new study suggests that Earth's habitability could increase if Jupiter's orbit becomes more eccentric, leading to parts of the surface warming up and becoming habitable for multiple life forms. The researchers also found that this change in Jupiter's orbit could have implications for the search for habitable planets around other stars.
The Healthy-Day-App assesses time use patterns in children and predicts outcomes on body fat percentages, wellbeing, and academic performance. Shifting screen time to physical activity results in improved health outcomes, including 4.2% lower body fat and 2.5% better wellbeing.
Researchers discovered a link between increased drought and increased wood formation in plant stems on islands. The study found over three times as many insular woody species as previously known, with over 175 independent transitions. This research offers promising avenues for agriculture to increase drought tolerance and food production.
Researchers emphasize the importance of understanding climate tipping points, which can occur abruptly in response to anthropogenic greenhouse gas emissions. They recommend a special report on tipping points by the IPCC and improved monitoring of critical chokepoints, such as ice sheets and tropical systems.
Researchers found that a 2% reduction in atomic distance on the surface leads to a significant decrease in hydrogen ion conductivity, reducing fuel cell performance. Developing methods to mitigate this strain is crucial for improving high-performance fuel cells for clean energy production.
Oregon State University is leading a five-year national polar education and arts program, Polar STEAM, funded by the National Science Foundation. The program engages educators, artists, and writers in polar science activities to increase visibility and impact of scientific work in the Arctic and Antarctic.
The research team at the University of Würzburg has reported the first structures of UBA6 in complex with either ATP or FAT10, shedding light on its dual recognition capability. The study also identified UBA6 variants that selectively abolish the activation of either ubiquitin or FAT10.
Elite sports schools offer a balance between academic work and sports development, while regular sports-friendly schools pose more challenges. Students who attend elite sports programs have an easier schedule and better development opportunities.
A study by OIST researchers found that a well-known gene called Tob plays an important role in reducing depression, fear, and anxiety. The presence of the Tob gene helps with stress-resilience, while its removal leads to increased symptoms.
Researchers at Washington University in St. Louis have invented a technique to generate Airy beams in water using 3D-printed binary acoustic metasurfaces, enabling broad applications in biomedical imaging and therapy.
Researchers analyzed genomic data from 30,000 patients and found a highly diverse patient population with ancestries from virtually all continents. This study aims to leverage genetic diversity for discovery in personalized healthcare, especially for underrepresented populations.
West Virginia University has been selected as a partner institution for the National Science Foundation's Innovation Corps Hub: Interior Northeast Region. The university will receive nearly $1 million to support entrepreneurship training for STEM researchers with deep tech innovations. The I-Corps program aims to expand innovation ecos...
Researchers found virus-specific T cells in the noses of people who received vaccines and later became infected with SARS-CoV-2, providing an additional layer of protection. These cells persisted for at least 20 weeks and could recognize various viral proteins, including those from the Omicron variant.
Researchers discovered a protein LYSET that enables cancer cells to digest extracellular proteins as an alternative food source under nutrient starvation conditions. This finding provides insight into the molecular pathways underlying cancer cell adaptation and could lead to new therapeutic strategies.