Researchers at CSIC-UMH have identified dozens of new regulatory proteins involved in guiding neural axons to their targets, a key process during nervous system development. These findings provide new avenues for understanding brain function and congenital defects.
A new study published in the Journal of Policing, Intelligence & Counter-Terrorism found that most posts in extremist online forums are made by a clique of highly committed members. The research, led by Professor Stephane Baele and Dr Lewys Brace, analyzed over 12 million unique posts across eight far-right, seven Salafi-jihadist, and ...
A team from the University of Tsukuba has developed a mouse model carrying a disease-associated mitochondrial mutation, which reveals that faulty RNA processing is responsible for metabolic disorders. The study provides new avenues for scientific discovery in understanding mitochondria and multiple diseases.
A team of researchers has developed a method to derive the magnetopause position from wide field-of-view soft X-ray imager simulation. The Tangent Fitting Approach (TFA) enables reconstruction of the 3D magnetopause from a single X-ray image, providing clearer views of the Earth's magnetosphere.
The proposed CODE-EHR best practice framework aims to standardize the use of structured electronic healthcare records in clinical research. The framework focuses on identifying and addressing data quality issues, ensuring interoperability between systems, and promoting transparency and trust.
Young people with 22q11.2 Deletion Syndrome show distinct brain activity patterns during sleep, which may influence psychiatric symptoms. These differences are associated with altered connections within and between brain areas.
A recent study found that poor management is the biggest risk factor for workplace bullying, with a new evidence-based screening tool developed to address the problem. The tool identifies nine major risk areas in day-to-day practices, highlighting the need for organisations to proactively assess and mitigate underlying risk factors.
Researchers have successfully visualized α-synuclein aggregates in the brains of patients with multiple system atrophy (MSA) using a new positron emission tomography (PET) imaging agent. The agent, 18F-SPAL-T-06, shows high specificity and potential for MSA diagnosis.
Researchers at the Max Planck Institute have successfully generated up to 14 entangled photons using a single atom, enabling efficient creation of quantum computer building blocks. This breakthrough could facilitate scalable measurement-based quantum computing and enable secure data transmission over greater distances.
Researchers create textile-based pneumatic computers capable of digital logic, onboard memory, and user interaction. The technology aims to assist people with functional limitations in daily tasks without electricity.
Seed system-oriented interventions have shown positive impacts on food security, household resilience, dietary quality, and nutrition status. The review highlights the importance of seed system research for improving diets and nutrition in vulnerable populations.
Archaeoecology examines the past 60,000 years of human-ecosystem interactions, revealing how humans impacted nature and ecosystems shaped human culture. By integrating data from archaeology, ecology, and palaeoecology, this emerging field can provide crucial insights to solve today's environmental challenges.
Diatoms in aquatic ecosystems have a previously unknown ability to store and use nitrate as a nutrient. They can replace oxygen with nitrate, allowing them to thrive in deep sediments and at night.
Researchers developed a method to identify valve dysfunction using complex network analysis that is accurate, simple to use, and low-cost. The diagnostic tool works by analyzing the sounds produced by the heart, creating a graph of connected points, and identifying correlations between nodes.
A new federal grant will develop training for thousands of future faculty in evidence-based teaching practices, aiming to foster interest and support all STEM students. The project, led by PSU Associate Professor Erin Shortlidge, has the potential to increase student success and close the opportunity gap for marginalized students.
A new music intervention called Musical Bridges to Memory sparks an emotional connection between patients with dementia and their caregivers. The program enhances social engagement and reduces neuropsychiatric symptoms in both patients and caregivers.
The study found that a booster shot's effectiveness is the primary factor influencing people's willingness to receive it. Those who believe in vaccine efficacy are more likely to accept the booster shot, especially if it is made by Moderna or Pfizer. A partisan divide persists, with Democrats more willing and Republicans less willing.
A population-based retrospective cohort study found that COVID-19 vaccination during pregnancy is not associated with an increased risk of preterm birth, small for gestational age at birth, or stillbirth. The study concluded that COVID-19 vaccination during pregnancy can inform evidence-based decision-making about its safety.
Researchers have used state-of-the-art technology to study the prehistoric Trilophosuchus rackhami, a tiny crocodile found in north-west Queensland. The analysis reveals distinctive ridges on its skull and brain cavity similarities with distantly related terrestrial extinct crocs from Africa and South America.
Researchers developed a novel way to visualize densely packed molecules using expansion microscopy, allowing for the first time their imaging. The technique enables visualization of nanostructures found in neurons and Alzheimer's-linked amyloid beta plaques.
A study published in Cell found that a Western-style diet high in sugar alters the gut microbiome, leading to metabolic disease, pre-diabetes, and weight gain. Eliminating sugar from the diet restored the protective effects of Th17 immune cells, which were depleted by the sugar.
Researchers developed a light-based therapy, photodynamic therapy (aPDT), to combat antibiotic-resistant bacteria. The treatment showed promise in weakening bacteria, allowing lower doses of current antibiotics to effectively eliminate them.
Researchers designed a centered error entropy-based sigma-point Kalman Filter to enhance the filtering algorithm's robustness in spacecraft attitude determination. The proposed CEEUKF outperformed classical methods and other robust algorithms in simulating non-Gaussian noise, achieving higher accuracy and faster convergence rates.
A prospective cohort study found that drinking two or more cups of black tea per day is associated with a moderately lower mortality risk. The findings suggest that tea can be part of a healthy diet.
A new method for generating realistic images in driving simulations uses machine learning to improve visual fidelity. This enables better testing of driverless cars and study of driver distraction, ultimately enhancing safety and interaction between humans and AI on the road.
Researchers at Arizona State University have developed a machine learning model to predict melting temperatures for any compound. The model enables faster and more accurate calculations of melting points, which is critical for designing high-performance materials in various industries.
Researchers at Institute of Physics, Chinese Academy of Sciences have discovered new hafnium polyhydrides exhibiting superconductivity above 80K, a temperature threshold previously unattained by any 5d transition metal hydride. The study reveals these compounds display high critical fields and Ginzburg-Landau superconducting coherent l...
A novel mutation in the Kcnc3 gene causes learning deficits in mice, specifically in spatial learning and memory. The study uses a forward genetics approach to identify the causal mutation, providing new insights into the genetic basis of learning and memory.
The Chang'E-4 mission has provided the first in-situ temperature measurement of lunar regolith on the far side, revealing a particle size of ~15 μm and thermal conductivity values. The study's findings will aid in designing future in-situ temperature probes and provide crucial 'ground truth' for global temperature observations.
The study found that ultra rapid lispro (URLi) provided superior control of postprandial glucose excursions compared to insulin lispro. URLi showed non-inferiority for HbA1c reduction and improved PPG excursion control in adults with type 2 diabetes.
A study published in Circulation found that moderate or vigorous physical activity can lower the risk of developing heart failure. The research, which analyzed data from over 94,000 adults, suggests that increasing physical activity duration and intensity may provide greater protection against heart failure.
Researchers at UT Southwestern Medical Center found a significant link between early onset of Type 2 diabetes and hypertension and the development of primary open-angle glaucoma. The study suggests that these conditions may predispose individuals to POAG, highlighting the importance of early detection and screening protocols.
Research in the American Journal of Preventive Medicine reveals a significant association between paid sick leave requirements and reduced mortality among US adult workers. The study found that state preemption laws hindering local mandates contribute to increased workforce mortality.
Scientists create a novel dual-metal precursors method to grow non-layered 2D transition metal chalcogenides (TMCs) with controlled thickness and unique properties. The method enables the growth of various TMCs, including Fe1-xS, Co1-xS, Cr1-xS, and V1-xS, with ordered cation vacancies.
A recent study found that 38 Chinese cities have achieved emission peak, reducing emissions significantly for at least five years while economy and population increased. The cities' decoupling of emissions and social development indexes was a key factor in this achievement.
A massive landslide in Nevada's Red Rock Canyon National Conservation Area flattened an area larger than downtown Cincinnati, covering over 7 square miles. Geologists studied the landslide to better understand its dynamics and predict future landslides, which are a growing concern in areas with significant topography.
A pilot clinical trial found that implanted brain-stimulating devices dramatically reduced bingeing episodes and helped patients lose weight in two patients with loss-of-control binge eating disorder. The study used a device to monitor activity in the nucleus accumbens, a brain region involved in processing pleasure and reward.
Researchers found that integrated membrane system (IMS) technology can remove up to 98% of microplastics from wastewater, preventing their entry into coastal waters. This breakthrough could help reduce ocean pollution and solve water resource shortages.
Rice University's ROBE Array algorithm slashes the size of DLRM memory structures, allowing training on 100 megabytes of memory and a single GPU. The method matches state-of-the-art DLRM training methods with improved inference efficiency.
Physician-scientists at Beth Israel Deaconess Medical Center found that despite FDA deauthorization, a large number of doses of ineffective COVID-19 treatments were administered to patients in 2022, with wide variability by state. The study highlights the need for improved transparency and regulation of COVID-19 therapies.
A new study reveals that partner-drug resistance facilitates artemisinin resistance in malaria parasites. The research collaboration found a 10-fold increase in partner-drug resistant genotypes led to earlier artemisinin resistance establishment among these parasites, resulting in significant treatment failures globally.
A national collaboration will focus on creating durable and scalable soft semiconductor technologies for low-cost, highly efficient solar fuel production. Organic polymers offer 'exquisite control' over material properties, allowing for tunability and dynamic adjustment to maintain equilibrium.
A recent study by K-State researchers found that reintroducing bison to grasslands can significantly increase plant diversity. The study revealed that the return of bison led to long-running and resilient increases in grassland biodiversity.
New research from the University of Ottawa finds that climate change is waking bumblebees earlier from winter hibernation, putting the species at risk. The study found that this early emergence timing puts bees out of sync with their food sources, leading to smaller colonies and lower survival rates.
A new study suggests that the nuclear receptor TLX can inhibit the growth and progression of triple-negative breast cancer. TLX+ cells showed lower tumor growth, migration, and invasion rates compared to those without TLX expression.
The study developed a high-throughput method for screening non-photochemical quenching rates in field-grown plants using pulse amplitude modulated chlorophyll fluorescence analysis. This approach enables testing hundreds of genotypes within a day, paving the way for genome-wide association studies.
The Institute for Basic Science (IBS) collaborated with the National Institutes of Health (NIH) and St. Jude’s Children’s Research Hospital to increase virus research capacity and respond to infectious disease outbreaks. IBS and NIAID discussed potential research cooperation opportunities, including joint symposia and resource sharing.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers have discovered that viruses modify the host's translation machinery to optimize protein production. The chikungunya virus genome is enriched in non-optimal triplets, yet it expresses viral proteins efficiently. Viral infection induces a change of language in the cell, enabling efficient expression of viral proteins.
A team led by Jianxi Gao developed equations to measure and compare distances to tipping points across various mutualistic systems, allowing for the triage of declining ecosystems. This method enables the identification of areas that need intervention most urgently, providing a critical sense of urgency to mobilize resources.
A clinical trial has shown that full-dose anticoagulation therapy is more effective than standard-dose prophylactic anticoagulation in preventing blood clotting complications in COVID-19 patients. The study found a significant reduction in venous or arterial clotting complications among patients who received full-dose treatment.
A 21% relative risk reduction in reported high-risk HIV behavior was found for single mothers with a State-level Earned Income Tax Credit (SEITC) of 10% or above the Federal EITC. A 10 percentage-point increase in SEITC was also linked to a 38% relative reduction in high-risk behavior.
A recent study has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease. The research highlights the causal role of mesenchymal cells in intestinal inflammation, shedding light on the genetic roots of inflammatory bowel disease.
A new preclinical model of thymic cancer reveals how a common mutation sparks tumor formation and identifies potential targets for therapy. The model, developed by Weill Cornell Medicine researchers, shares molecular characteristics with human thymic tumors, paving the way for new treatments.
Researchers at the Florida Museum of Natural History found that frog forelimbs are not just for jumping, but also for fighting and grasping mates during reproduction. The fused radius and ulna bones provide strength and weight reduction, while also increasing stress on the tendon connecting to the bone.
Kaunas University of Technology researchers collaborated with citizens to create a sustainable takeaway food package made from cardboard. The innovative design features heat-resistant materials, adjustable inserts, and clear recycling instructions, reducing plastic waste and promoting environmental responsibility.
Researchers discovered that a naturally insulating material, lanthanide-doped upconversion nanoparticle (UCNP), emits bursts of superfluorescence at room temperature and regular intervals. This property is valuable for quantum optical applications, such as faster microchips or neurosensors.
Research from the University of Georgia found that physically active high school students were 23% more likely to use e-cigarettes than their less active peers. The study linked physical activity levels to risk of e-cigarette use among American adolescents.
A team of researchers from Florida Atlantic University and Tel Aviv University are investigating the connection between neuroimmune serotonergic interactions and Alzheimer's-related mood disorders. By studying mice with AD-linked mutations, they aim to determine if immune-serotonin crosstalk plays a role in depressive traits.
Researchers found that brief rapamycin exposure in early adulthood can prevent age-related decline and extend lifespan. The study used fruit flies and mice to test the effects of short-term drug administration, showing protection against intestinal pathology and increased health span.