Researchers aim to improve treatment response in patients with clear cell renal cell carcinoma by reprogramming tumor cells into immune cells that recognize and kill cancer cells. This approach combines checkpoint inhibitors to enhance the immune response.
A new study from the University of Missouri-Columbia found that socioeconomic status and education level are associated with lower odds of children receiving CPR and surviving after experiencing a cardiac arrest. The study analyzed 21,137 data entries across 54 states and territories in the United States.
Researchers have discovered a new approach to treating fentanyl overdoses using naloxone methiodide, which blocks peripheral opioid receptors. This therapy reverses fentanyl-induced respiratory depression without causing withdrawal symptoms.
A study of 9,000 US-based participants reveals that they prioritize efficiency over fairness when choosing between human and algorithmic decision-makers. Notably, Republicans prefer humans more than Democrats, yet most claim fairness is a top priority.
A new study by Kaunas University of Technology found that NGOs' financial adaptations during the COVID-19 pandemic were crucial for their success. Key factors contributing to financial success included working with governments, virtual fundraising, and publicity.
Researchers from Bar-Ilan University discover that classifying objects together through Multi-Label Classification can yield better results than detecting individual objects. This new method allows networks to learn correlations between object combinations, making them more recognizable in real-life applications such as autonomous vehi...
Annals of Thoracic Surgery Short Reports has been accepted for indexing in PubMed Central, enhancing its reach and impact within the global medical community. The journal is on pace for 750 submissions in 2024, with over 400 articles published across eight electronic issues, attracting more than 240,000 page views or downloads.
The study found a significant increase in late-stage breast cancer diagnoses among U.S. women, with annual percentage increases of up to 2.9% between 2004 and 2021. The researchers attribute the trend to factors such as lack of national screening programs, inconsistent guidelines, and increasing obesity rates.
A new study comparing early restrictive vs liberal oxygen for trauma patients found no significant reduction in death and/or major respiratory complications within 30 days. The study suggests that the choice of oxygen strategy may not be as critical in trauma care.
Renowned researcher Iain Couzin has received the 2024 Fyssen International Prize for his groundbreaking work on collective behaviour across species. His research, which explores how coordinated patterns emerge from individual behaviours in diverse animal systems, significantly advances our understanding of group dynamics.
Racially and ethnically minoritized US children experience disparities in mean levels and variability of sleep compared to white peers. These findings emphasize the importance of addressing multiple sleep dimensions across diverse racial and ethnic groups to achieve equitable pediatric sleep health.
A new portable MRI machine, augmented with machine learning tools, matches conventional MRI in measuring brain characteristics relevant to Alzheimer's disease. The study has the potential to expand neuroimaging in settings with limited MRI access and streamline care for AD patients.
A new study finds that heavy rains deliver the greatest amounts of fertilizer-derived nitrogen through creeks and rivers into the northern Gulf of Mexico. The research can be used to develop policies to protect the gulf from nutrient overloading, harmful algal blooms, and oxygen-depleted 'dead zones'.
A new multi-target quantum compilation algorithm developed by Tohoku University's Dr. Le Bin Ho improves the flexibility and performance of quantum computers. This allows for efficient handling of complex systems and tasks involving multiple variables in quantum machine learning.
Researchers at NYU Tandon School of Engineering have discovered new growth-directed graphene stacking domains that can be self-assembled without manual twisting or alignment. These domains are well-suited for enabling unconventional quantum Hall effects, superconductivity, and charge density waves.
A new hepatitis B vaccine, Heplisav-B, has been shown to be more effective than an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination. The study found that up to 99.4% of subjects received the new vaccine showed protective levels of antibodies.
A recent study highlights the importance of deep soil health in improving crop productivity on low-yielding farmland. Researchers found that improving surface soil health can increase wheat yield, while a complex microbial network is essential for maintaining soil health and crop productivity.
Insilico Medicine has nominated ISM8969, an orally available NLRP3 inhibitor, as a potential treatment for various inflammatory diseases. The compound has shown promising results in preclinical evaluation studies, including balanced druggability and efficacy against inflammation.
A new study highlights the devastating impact of illegal ritualistic hunts in West Bengal, India, where over 5,000 animals are estimated to be killed annually. The research reveals that these large-scale events target more than 90 species, including those at risk of extinction.
Researchers analyzed financial and environmental data from 8,547 companies across 34 countries, revealing that stronger environmental engagement leads to better financial outcomes. Companies with superior environmental performance demonstrate better financial results and attract greater interest from investors.
Researchers trained an AI system to predict future warming based on climate model simulations and historical temperature data. The study suggests that even in the best-case scenario, global warming will likely exceed 2 degrees Celsius, with severe impacts expected in regions such as South Asia and Central Europe.
Researchers suggest a scientific framework to operate the Nile's mega dams during droughts, balancing sustainable hydropower generation with minimizing downstream water deficit. The framework aims to increase resilience for over 300 million inhabitants in the Eastern Nile Basin living under uncertain climatic projections.
The Study of Tecovirimat for Mpox (STOMP) trial found that tecovirimat was safe but did not improve mpox resolution or pain in adults with mild to moderate clade II mpox. The study recommended stopping further enrollment due to the lack of efficacy signal.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
A study found that wild hedgehogs in the same area have varying hibernation patterns, with some starting as early as mid-September and others not entering until December. This flexibility could help them adapt to changing environmental conditions.
GLP-1RAs improve liver histology, reduce liver fat, and enhance metabolic parameters in MASLD patients. However, challenges remain in assessing long-term liver benefits and clarifying the effects on liver fibrosis.
Researchers found significant increases in anxiety, stress, and cortisol among emergency responders during training, highlighting the importance of recovery time. The study's results shine a spotlight on burnout affecting over 50% of healthcare professionals.
Recent studies suggest HBV infection is associated with liver cancer stem cells, but the exact mechanisms are unclear. This study investigates the role of HBV infection in regulating the stemness of HCCs and its link to drug resistance.
Adults who stutter experience underemployment and lower job satisfaction compared to non-stutterers. They are also less likely to earn higher salaries, with a notable decrease at the $100,000 annual threshold.
The introduction of high-speed rail between 1998 and 2010 spread green technologies and reduced industrial pollution across lagging regions, particularly in central inland provinces and northeastern areas. This led to a 0.49%–1.70% reduction in national industrial pollution and increased patent filings for green technology patents.
A majority of US adults (72%) hope to avoid discussing politics with family over the holidays, citing stress and disagreements. Younger adults are more likely to avoid family gatherings altogether, while many value meaningful relationships over political discussions.
Researchers found structural and functional alterations in specific brain regions of individuals with opioid use disorder, including increased global connectivity. Women in the group had smaller medial prefrontal cortex volume compared to men.
A new study reveals that medical schools are not teaching doctors to care for the incarcerated or formerly incarcerated population, who face significant chronic health issues. Approximately 95% of those incarcerated will return to the community, but medical providers are not prepared to serve them.
A recent study by the University of Surrey found that organisations are reluctant to adopt blockchain technology due to its high expectations and low deliverables. The research revealed that adoption drivers and barriers often conflict, creating a mismatch that slows organisational decision-making.
The rose prickle's curved tapering shape and microstructural density enable supreme damage resistance capabilities. Researchers propose that these features could be used to develop ultra-small anchoring tools for diverse applications.
A new study reveals woodburning contributes significantly to fine particulate matter (PM2.5) levels in the region, accounting for 25% of total PM2.5 mass. The experts recommend targeted measures to mitigate health risks associated with woodburning activities, including raising public awareness and promoting cleaner alternatives.
Researchers introduce a framework to classify biodiversity credits, highlighting the challenges of representing biodiversity in a single unit. The study demonstrates the risks of relying on 'offsetting' and emphasizes the need for genuine nature recovery funding.
Endothelial cells lining pulmonary veins contribute to blood vessel repair and angiogenesis after lung injury. The study found that these cells proliferate into the adjacent capillary bed, differentiating into capillary cells, which can help regenerate damaged tissues.
A study found that ADAMTS13 regulates VWF expression and reduces hepatic platelet accumulation in PA-ILI patients and mice. Systemic administration of recombinant ADAMTS13 decreased platelet accumulation and mitigated liver necrosis.
Researchers at UC Santa Barbara discovered that the orbitofrontal cortex and hippocampus collaborate to understand context-dependent stimuli. Rats learned to associate auditory cues with rewards in specific contexts, demonstrating the brain's ability to adapt and learn from experience.
Scientists at Lund University and Hokkaido University have successfully synthesized 2D gold monolayers with remarkable thermal stability and potential catalytic utility. The team used a novel bottom-up approach combined with high-performance computations to create macroscopically large gold monolayers with unique nanostructured patterns.
Researchers found variation in practice patterns of sarcoidosis treatment, particularly in the use of nonsteroidal immunosuppressive medications and sequence of administration. The study highlights the need for future randomized trials and comparative effectiveness studies to ascertain optimal treatment algorithms.
A new method developed by Penn researchers uses a chemical-separation technique to extract cobalt from 'junk' materials, increasing the capacity for purified cobalt production with minimal environmental harm. The process avoids harsh chemicals and generates lower costs than traditional methods.
Fast-growing tree species are dominating Brazilian forests in regions with high levels of deforestation, threatening ecosystem services and biodiversity. The study highlights the urgent need to conserve and restore tropical forests to preserve these vital ecosystems.
Researchers and teachers in Swedish academia face high levels of threats and harassment, with 47% of humanities staff reporting threats or harassment. The study highlights the need for institutions to prevent such incidents and ensure support for those affected.
Researchers at USF and TGH Cancer Institute found a potential link between the Western diet and chronic inflammation that drives tumor growth. Chronic inflammation fueled by poor dietary choices plays a vital role in colorectal cancer growth and progression.
Researchers found a 28% decline in social acceptability of drinking sugar-sweetened beverages, with attitudes changing after tax increases and media attention. The shift in social norms has major implications for public health efforts.
The American Society for Nutrition (ASN) applauds the release of the Scientific Report of the 2025 Dietary Guidelines Advisory Committee, developed by 19 ASN members. The report provides evidence-based advice on best dietary patterns and habits to prevent chronic diseases.
Researchers at Penn State and Columbia University have observed a type of quasiparticle called a semi-Dirac fermion that has mass when moving in one direction but not in the other. The discovery, made using a technique called magneto-optical spectroscopy, could lead to advances in emerging technologies such as batteries and sensors.
The collaboration aims to evaluate the potential of AMB-066 as a first-in-class treatment option for patients with colorectal cancer and minimal residual disease. MD Anderson researchers have identified a potential opportunity for AMB-066 to effectively treat MRD-positive CRC, based on robust preclinical data.
A new system, EXPLINGO, enables AI models to generate readable narratives explaining their predictions, helping users make better decisions. The system, developed by MIT researchers, uses large language models to transform complex explanations into plain language and automatically evaluate their quality.
A team of Rice University scientists has developed a coating that suppresses thermal emissions from hot windows while remaining transparent enough to capture thermal radiation from objects behind the window. This breakthrough enables clear thermal imaging at high temperatures, with potential applications in industries such as chemical ...
Charles Shoemaker, a Tufts University professor, has been named Fellow of the National Academy of Inventors for his work on developing immunotherapeutics. His research focuses on creating antibody-based agents that can prevent and cure diseases, including those caused by viruses and bacteria.
PLOS has been awarded a $3.3 million grant from the Bill & Melinda Gates Foundation to transition towards APC-free publishing and promote open access options for authors without funding. The grant will also support improvements in funding metadata capture and peer review transparency.
Research suggests that T-cell receptor repertoire analysis can inform treatment responses and predict efficacy in combination therapies for HCC. Advances in sequencing technologies are refining our understanding of tumor-immune interactions and adaptive immune mechanisms.
Omid Veiseh, a Rice University bioengineer, has been elected as a National Academy of Inventors Fellow for his significant contributions to innovation and society's welfare. He holds over 5,000 issued US patents and has demonstrated leadership in biotechnology.
A study from Tulane University found that a low-protein diet in one generation can lead to lower birthweights and smaller kidneys in offspring across multiple generations. The findings suggest that food scarcity or malnutrition may result in decades of adverse health outcomes.
A recent review examines how SARS-CoV-2 variants impact long COVID symptoms, revealing key differences in clinical manifestations and vaccination effectiveness. The study suggests that vaccinations significantly reduce both acute and long-term symptoms, making a critical contribution to managing the condition.
High-flow nasal oxygen was found to be more effective than noninvasive ventilation in preventing endotracheal intubation or death within 7 days in four of five patient groups with acute respiratory failure. However, the results were sensitive to analysis models and may require further study in specific patient populations.
A new study using AI-powered climate modeling predicts that most land regions will reach the critical 1.5°C threshold by 2040 or earlier, while several regions are expected to exceed the 3.0°C threshold by 2060. This could compound risks for vulnerable ecosystems and communities.