Scientists have identified four microRNAs that can aid in the differential diagnosis of malignant pleural mesothelioma (MPM) from non-cancerous pleural tissue. The biomarkers, miR-126, miR-143, miR-145, and miR-652, were found to classify tissue samples with high accuracy.
Researchers found that microRNA-155 is responsible for cleaving epithelial cells, creating microscopic gaps that allow toxins to reach the brain. This discovery helps explain diseases like multiple sclerosis and opens a new path for developing therapies that can penetrate the blood-brain barrier.
Researchers found that calorie restriction decreased microRNA production, which promotes the extracellular matrix and prevents cancer cells from spreading. The study aims to test whether calorie restriction can improve outcomes for women with breast cancer in a clinical trial.
Researchers at UT Southwestern Medical Center discovered a critical role for microRNA cluster miR-143 and miR-145 in regulating wound healing in the intestine, which may lead to potential treatments for chronic digestive diseases like ulcerative colitis and Crohn's disease.
Researchers have identified a new microRNA, hsa-miR-765, that suppresses expression of HMGA1 in prostate cancer cells, offering potential as a targeted therapy. The microRNA is activated by an FDA-approved anti-estrogen drug, fulvestrant.
Researchers have found that graphene's thermal conductivity increases with the number of layers, but still falls short of idealized values. The team is exploring novel ways to support graphene, including three-dimensional interconnected foam structures and hexagonal boron nitride.
Researchers at Ohio State University found that microRNA-3151 promotes AML-cell growth and survival by blocking tumor-suppressor gene TP53. High expression of miR-3151 is associated with a bad prognosis, while inhibition with the drug bortezomib offers a possible therapy.
Researchers discovered that microRNA-135b (miR-135b) is overexpressed in both mouse and human colorectal tumors, associated with poor clinical outcomes. The study suggests that miR-135b could be a valuable target for colorectal cancer treatment and a biomarker of tumor progression.
Researchers have gained new understanding of how brain cells are formed and controlled by a key molecule miR-9, which is linked to brain development and function. This study could help explain what happens when cell production goes out of control in diseases like cancer.
UCSF researchers found that breast tissue stiffening in cancer development leads to tumor progression, triggering the production of a molecule associated with worse clinical outcomes. The discovery may lead to more accurate prognosis and new treatment strategies targeting structural changes in breast cancers.
Researchers have discovered a feedback loop between IL-6 and microRNA-34a that promotes tumor cell mobility and metastasis. The loop involves the activation of STAT3, which represses miR-34a production and leads to increased tumor-promoting proteins.
A genetic variant in SCN10A modifies cardiac expression of SCN5A, essential for conduction. An inflammatory feedback loop activates STAT3, repressing miR-34a and promoting EMT in colorectal cancer cells. Insulin resistance in bone disrupts glucose homeostasis through decreased active osteocalcin.
Lung cancer cells use high levels of TGF-β to suppress NK cell activity, leading to reduced DAP12 expression and impaired cytotoxic pathways. The researchers identified a critical role for miR-183 in this process, providing new insight into the exploitation of immune evasion mechanisms by cancer cells.
Researchers found that MicroRNA-34 can suppress prostate cancer when paired with p53, but not individually. The study used mice models and found that combined silencing of miR-34 and p53 led to uncontrolled stem cell growth and high levels of cancer.
Researchers at Sanford-Burnham and Icahn School of Medicine at Mount Sinai have discovered a key cellular process leading to heart failure, which can be halted with a therapeutic approach. Blocking the effects of miR-25 has improved cardiac function and survival in mice.
A team of researchers at New York University and the University of Texas at Austin has discovered that carbohydrates serve as unique identifiers for cancer cells. By analyzing the role of microRNA in regulating carbohydrate structures, the study reveals a new way to detect cancer using sugar-based biomarkers.
Researchers at CNIO have identified two novel treatments for psoriasis, one targeting S100A9 and the other inhibiting miR-21, which show promise in reducing side effects. These discoveries offer new hope for patients suffering from this chronic disease.
Researchers at Scripps Research Institute create Inforna, a technique to identify potent compounds targeting cancer-causing microRNAs. The method enables unprecedented targeting of disease-associated RNAs, offering a promising approach to designing novel anti-cancer drugs.
Researchers at Case Comprehensive Cancer Center have identified a microRNA biomarker, miR-181a, that predicts treatment response in ovarian cancer. Elevated levels of miR-181a are associated with chemotherapy resistance and disease progression.
New research shows microRNA-128 controls complex functions in the adult brain by adjusting a neuronal signaling pathway. Reducing miR-128 expression led to increased motor activity and fatal epilepsy in mice, while overexpression decreased motor activity and reduced seizure susceptibility.
Researchers at Massachusetts General Hospital have developed an approach to increase beneficial HDL cholesterol levels in non-human primates by targeting shared nucleotide sequences that inhibit microRNAs. This strategy showed a nearly 40% increase in HDL levels, outperforming current therapies.
Millimeter-wave imaging technology helps scientists understand and manage plasma instabilities in fusion plasmas. By imaging waves and density fluctuations, researchers can develop strategies to maintain plasma stability and accelerate progress towards a viable new energy source.
Researchers have found that miR-137 is downregulated in the brains and peripheral blood of post-stroke depression patients. Injection of a miR-137 antagonist into the brain ventricles of post-stroke depression rats improved behavioral changes, suggesting that miR-137 suppresses Grin2A protein expression through binding to its mRNA.
Researchers at Boston University School of Medicine have discovered a regulatory molecule, miR-4423, that is less abundant in people with lung cancer and inhibits lung cancer cell growth. This molecule may aid in diagnosing lung cancer in earlier stages and treating the disease when at healthy levels.
A new study from LSUHSC has identified two microRNAs regulating FOXP2, a gene linked to speech and language impairments and autism disorders. The study found that social context governs the function of these miRNAs in vocal learning, providing insights into human speech-language development.
A new LSUHSC study identified two microRNAs regulating FOXP2 levels in zebra finch brains, showing that social context influences their function. The findings provide insights into speech and language impairments and autism disorders.
Researchers at Ohio State University have discovered that high levels of microRNA-31 in primary tumor cells predict lymph node metastasis and poor survival in patients with non-small cell lung cancer. Low expression levels were associated with excellent survival.
Researchers at the University of Copenhagen discovered that mir-79, a tiny molecule, plays a crucial role in regulating neural development in roundworms. By controlling the addition of specific sugars to signaling molecules, mir-79 guides nerve cell migration and ensures proper nervous system function. This finding has important implic...
Researchers developed a test that can clearly distinguish early liver cancer cells from normal liver cells by giving them a distinctive red-brown hue. The test uses a probe to detect and stain a microRNA called mir-21, which is found in liver cancer but not healthy liver cells.
A new study found that microRNA-486 (miR-486) is a potent tumor-suppressor molecule in lung cancer. It regulates the proliferation and migration of lung-cancer cells and induces programmed cell death.
Researchers found that high levels of miR-200 expression boost survival rates for patients with lung, ovarian, renal, and triple-negative breast cancers. MicroRNAs regulate gene activation and expression, and targeting IL-8 and CXCL1 can inhibit angiogenesis and cancer progression.
Researchers at UTHealth discovered a novel signaling axis that promotes pancreatic cancer growth by activating a transcription factor CREB and an oncogenic miR-373, while suppressing tumor suppressor genes. The findings provide potential mechanistic insights into how a zinc transporter functions in cancer cells.
A Scripps Research Institute study found that overproduction of a specific cluster of microRNAs can trigger lymphomas. The research identified key biological pathways involved in cancer growth and offers new potential therapy targets.
Researchers at Ohio State University Comprehensive Cancer Center discovered that the tumor-suppressor gene A20 is silenced due to the loss of microRNA-29, leading to increased levels of NF-kB and tumor progression. This finding could guide the development of more effective therapies for soft-tissue sarcomas.
Researchers have identified microRNA-22 as a driver of both cancer onset and metastasis, particularly in breast cancer and blood cancers. The study suggests that inhibiting miR-22 through a 'decoy' method could offer a novel therapeutic option for treating these diseases.
Researchers at Johns Hopkins Bloomberg School of Public Health found that NRF2 signaling plays a role in regulating cell metabolism, leading to increased energy production and tumor cell proliferation. The study demonstrates the importance of targeting Nrf2 with small molecule inhibitors to intervene in therapeutic resistance.
A team of scientists at Scripps Research Institute identified a family of tiny RNA molecules that work as powerful regulators of the immune response in mammals. These RNA molecules enable the differentiation of T cells into follicular helper T cells, which assist B cells in producing antibodies.
A team of Caltech biologists found that microRNA-146a acts as a critical regulator and protector of blood-forming stem cells during chronic inflammation. Mice lacking miR-146a showed a decline in HSCs, while normal mice maintained their levels despite long-term inflammation.
A new study identifies microRNA-155 as a potential treatment target and prognostic marker for patients with cytogenetically normal acute myeloid leukemia. High levels of miR-155 expression are associated with poorer patient outcomes, including lower complete remission rates and shorter overall survival.
Researchers at the University of Liege discovered a molecule, miR-146a, that can serve as a biomarker for peripartum cardiomyopathy. Elevated serum miR-146a levels were found in pregnant women who developed PPCM, suggesting its potential use to predict disease risk.
A new study reveals that microRNAs regulate the size of bald patches on fruit fly legs, driving natural variation in morphology. The findings suggest a novel mechanism for evolutionary adaptation involving small RNA molecules.
Researcher Peter Vekilov will test his theories on crystal formation in space, studying how liquids transform into crystals. His work could lead to more efficient large-scale production methods.
Research at the University of Colorado Anschutz Medical Campus reveals that hsa-miR-146a is overexpressed in most metastatic bladder cancer tumors. This tiny miRNA molecule plays a crucial role in making bladder cancer more aggressive.
Researchers at Moffitt Cancer Center found that microRNA-155 overexpression promotes new blood vessel growth, tumor inflammation, and metastasis in breast cancer. Controlling miR-155 expression could inhibit malignant growth, providing a new avenue of treatment.
Researchers at Henry Ford Hospital have discovered a novel approach for treating malignant brain tumors using microvesicles generated from mesenchymal bone marrow cells. The treatment significantly reduced tumor volume in living lab rats, suggesting a potential new therapy for glioma, a common and aggressive type of brain cancer.
A team of medical researchers has identified a specific microRNA, miR-342-5p, that plays a key role in promoting inflammation in atherosclerosis. Inhibiting this microRNA has been shown to retard the progression of the disease in animal models.
Researchers found high activity levels of miR-93 in fat cells of women with PCOS and insulin resistance, contributing to glucose impairment. This study provides a new molecular mechanism for PCOS and insulin resistance, pointing towards targeted therapies.
A tiny piece of RNA, mir-125a-5p, plays a crucial role in regulating cyclical gene activity that defines the timing of tissue segment formation. This regulation is essential for proper embryonic tissue development and has implications for treating human conditions affected by embryonic development.
Researchers identified a molecular 'switch' controlling skin cell migration necessary for wound closure and healing. The discovery may hold the key to developing therapeutics that reduce or prevent chronic wounds.
Researchers identified microRNA expression signatures that define the progression of Barrett's esophagus into esophageal adenocarcinoma. A small number of microRNAs, including miR-375 and the miR-17-92 family, may differentiate Barrett's esophagus from esophageal adenocarcinoma.
Researchers found that cigarette smoke-induced miRNA alterations promote lung carcinogenesis by repressing miR-487b. Additionally, high levels of ox-CaMKII are linked to increased risk of sudden death after heart attack in diabetic patients, suggesting a potential mechanism for increased mortality.
A recent study reveals that cigarette smoke-induced miRNA expression alterations, specifically the repression of miR-487b, play a crucial role in lung carcinogenesis. Loss of miR-487b increases oncogene expression and enhances tumor proliferation, invasion, and metastasis in both normal and cancer cells.
Researchers found a potential therapeutic candidate, miR-506, which blocks epithelial-to-mesenchymal transition and inhibits mesenchymal markers in ovarian cancer cells. Higher miR-506 expression is associated with longer overall survival.
Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. The study found that miR-27b is sensitive to high triglycerides and is involved in lipid metabolism.
Researchers have discovered a trigger that turns muscle stem cells into brown fat, a form of good fat associated with less obesity. The discovery, published in Cell Metabolism, provides hope for a potential obesity treatment using adult skeletal muscle stem cells.
Researchers identified miR-7 as a metastasis suppressor that suppressed cancer stem-like cells' ability to metastasize to the brain. The miR-7/KLF4 axis played a critical role in cancer stem-like cell brain metastasis, suggesting its potential as a diagnostic or therapeutic target for predicting or treating brain metastases.
A new study by Scripps Research Institute scientists confirms a critical role for microRNA-182 in the development of emotional memory in the amygdala. MicroRNA-182 was found to promote local protein synthesis and support synapse-specificity of memories.
Researchers at LSUHSC have identified a new therapeutic target to block the function of Her2, a gene that promotes breast cancer progression and spread. The study also found that a novel protein called Nischarin regulates breast cancer cell migration and movement.
The hepatitis B virus X protein (HBx) represses microRNA-148a, leading to increased levels of the oncogenic protein HPIP and subsequent oncogenic transformation in liver cancer. This study demonstrates a cancer-associated virus promoting carcinogenesis through direct manipulation of a microRNA.
A Weill Cornell study reveals that a specific miRNA, miR-708, acts as a metastatic tumor inhibitor and can be restored to stop the spread of aggressive breast cancer. Synthetic miR-708 delivery has blocked metastatic outgrowth in mice, making it a promising therapeutic target.