Brain cells called OPCs (oligodendrocyte precursor cells) play a crucial role in shaping neural circuitry by pruning unnecessary synapses. This process is essential for the brain's functioning and has been linked to both glioma brain cancer and Alzheimer's disease.
Researchers found that plants use both DDM1 and RNAi to control chromosome division, providing a 'backup plan' when one molecule is lost. This discovery may lead to better treatments for human diseases such as ICF syndrome and cancer progression.
Researchers at Cold Spring Harbor Laboratory create a roadmap of how prostate cancer spreads throughout the body, showing that aggressive cells seed cancer's rare migrations to bones, liver, lungs, and lymph nodes. The new technology offers a clearer picture of cancer spread and could lead to more targeted therapeutics.
Researchers at Cold Spring Harbor Laboratory have discovered that innate-like T cells mature differently in humans than in mice, with age playing a critical role in their development. This finding has significant implications for the development of immunotherapeutics, highlighting the need to consider human-specific differences when te...
CREME, a new AI-powered virtual laboratory, allows scientists to run thousands of virtual experiments with the click of a button to identify key regions of the genome. This breakthrough may lead to discovering new therapeutic targets and giving scientists access to cutting-edge technology without a real laboratory.
A new algorithm, inspired by the nervous system's matchmaker, pairs drivers with riders in a way that maximizes everyone's happiness. The algorithm creates near-optimal pairings while preserving privacy, making it suitable for everyday applications.
Researchers at Cold Spring Harbor Laboratory have discovered a strategy to kill breast cancer cells and shrink tumors by depriving them of two vital nutrients: glutamine and its backup supply, alpha-ketoglutarate. This approach was successful in lab experiments and effective in treating tumors in mice.
Researchers have discovered a new approach to treating pancreatic ductal adenocarcinoma (PDAC), a rare type of pancreatic cancer. Folinic acid has been found to weaken the cancer's defenses by elevating levels of anti-cancer immune molecules, enabling a more effective immune response and slower tumor growth.
Researchers discover a gene drive system, Teosinte Pollen Drive (TPD), that enables the quick transfer of traits from teosinte to maize. This finding sheds light on corn's rapid adaptation to the highlands and has significant implications for agriculture.
A team of scientists has found that the same ancient gene family is responsible for prickles in multiple plants, including roses and eggplants. This discovery sheds light on convergent evolution and could have implications for understanding how similar traits emerge in different species.
Researchers have identified the critical step in NMDAR's routine where it rotates into an open formation, enabling electrical signals crucial for cognitive functions. This discovery may pave the way for drug compounds that can correct faulty NMDARs, potentially treating conditions like Alzheimer's and depression.
Researchers have found that blocking Interleukin-6 (IL-6) from binding to neurons in the area postrema prevents cachexia in mice. This breakthrough discovery could lead to the development of new drugs targeting these neurons, potentially treating cancer cachexia and improving patients' quality of life.
A study by Cold Spring Harbor Laboratory researchers has discovered a crucial receptor protein that regulates the timing of temporary neural connections in the developing brain. Without this protein, mice exhibit atypical behaviors, highlighting its potential role in shaping brain circuits and preventing neurodevelopmental disorders.
A new system named SQUID, a computational tool created by Cold Spring Harbor Laboratory scientists, helps interpret how AI models analyze the genome. It reduces background noise and leads to more accurate predictions about genetic mutations.
Researchers at Cold Spring Harbor Laboratory designed a new way for AI algorithms to move and process data more efficiently, inspired by the human brain. This design allows individual AI neurons to receive feedback and adjust on the fly, processing data in real-time.
Researchers have discovered that a protein called MED12 plays a critical role in pancreatic cancer's development, particularly in basal-like cells. The study builds on decades of research at Cold Spring Harbor Laboratory, which previously identified the importance of p63 for basal cell formation.
A study by Cold Spring Harbor Laboratory has discovered two regulator proteins that work together to keep the splicing process on track. The research, led by Professor Adrian Krainer, identifies SRSF1's interactions with other proteins, providing new insights into how this critical regulator works.
Researchers have used BARseq to map the brains of nine mice, tracing gene expression in the visual cortex. The results show that losing vision leads to changes in gene expression across neighboring cortical areas, highlighting the complex connections between brain regions.
A new AI model developed by Cold Spring Harbor Laboratory's Benjamin Cowley and team uses a 'population code' to predict fruit fly behavior, revealing that multiple neurons combine to sculpt actions. The breakthrough enables the AI to accurately predict how real flies will behave in response to visual stimuli.
Researchers found that UTIs can provoke structural changes in breast tissue in mice, which are reversible once the infections are resolved. The study suggests a possible link between UTIs and abnormal breast cell growth, highlighting the importance of considering everyday occurrences on women's well-being.
Cold Spring Harbor Laboratory researchers developed Accelerated SuFEx Click Chemistry to create over 150 new molecular compounds, including derivatives of complex natural molecules. These compounds show promise as leads for developing antibiotics and cancer therapies.
Researchers have developed a new tool to help clinics recruit patients from more communities by analyzing nearby hospitals serving diverse populations. The approach aims to increase accessibility and diversity in cancer trials, with the potential to improve patient outcomes.
Researchers have discovered why some RNA-splicing drugs work better than others, revealing a key factor that impacts treatment efficacy. By analyzing the interactions between drugs and RNA, they found that combining splice-modifying drugs targeting the same gene segment can lead to greater therapeutic effects.
Researchers at Cold Spring Harbor Laboratory discovered that different plant species use varying regulatory systems to control the same gene, leading to extreme genetic makeovers over millions of years. This finding highlights the importance of understanding genetic regulation in predicting crop genome engineering outcomes.
Researchers at Cold Spring Harbor Laboratory have uncovered a mechanism involved in pancreatic cancer transformation, discovering that low-grade pancreatic cancer cells depend on mucus to survive and thrive. This knowledge could help set the stage for future diagnostic or therapeutic strategies.
A recent study by Cold Spring Harbor Laboratory researchers reveals that chronic stress can increase cancer's ability to spread. By mimicking chronic stress in mice with cancer, the team discovered that stress causes neutrophils to form sticky web-like structures called NETs, making body tissues more susceptible to metastasis.
Researchers have found a new potential therapeutic target for autoimmune diseases such as lupus and multiple sclerosis by identifying an overlooked sequence in the IκBζ protein. This sequence, known as the OCA peptide, can activate key proteins in immune cells and may help reeling in immune cells gone haywire.
Scientists have discovered that pancreatic cancer hijacks the brain-building protein Engrailed-1, leading to faster and deadlier metastasis. By targeting this aberrant protein, researchers may be able to develop personalized therapies and slow cancer progression.
Researchers discovered the brain uses a process called temporal scaling to adjust processing of time, allowing for flexibility in behavior. This finding may have implications for understanding how our brains enable us to interact with the world.
Researchers have discovered that CAR T cells can be repurposed to target senescent cells, which accumulate with age and cause inflammation. This breakthrough offers a promising alternative to existing treatments, which often require repeated administration.
Researchers confirm that pancreatic cancer triggers a response in the immune system, but T cells struggle to infiltrate tumors. This finding could guide future treatment development for pancreatic ductal adenocarcinoma (PDAC), a deadly form of pancreatic cancer.
The Cold Spring Harbor Laboratory has developed the "Bicycle Principles" to tackle the shortcomings of short STEM training programs. The principles aim to make training effective, inclusive, and scalable, with a focus on setting clear objectives and making training adaptable for different institutions.
A team of scientists discovered two types of neurons in fruit flies and mice that enable them to identify distinct smells. With experience, these animals can learn to differentiate between very similar odors, a process that could improve machine-learning models and AI systems.
A new antibody created by Cold Spring Harbor Laboratory researchers may offer an effective treatment for some breast cancers. The antibody targets the PTPRD enzyme, which is overabundant in certain breast cancers and helps them spread.
Researchers found that certain combinations of gene mutations resulted in predictable effects on tomato size, while others yielded random outcomes. The study suggests the role of background mutations demands reassessment for genome editing applications. This new interpretation may help humanity adapt crops to meet evolving societal needs.
Researchers at Cold Spring Harbor Laboratory discovered that bat genomes contain unique adaptations to defend against infection and cancer. The study highlights the interconnectedness of immunity and cancer response, revealing potential new treatments for human diseases.
New research from Cold Spring Harbor Laboratory explores how adult brains adapt through critical periods of learning, such as caring for young. MECP2 dysfunction causes neurodevelopmental disorder Rett syndrome, but the study finds that brain circuits can be rapidly rewired in adults.
New research from Cold Spring Harbor Laboratory suggests that high tumor mutation burden does not guarantee an effective immune response in patients with mismatch repair deficiency. The study found that tumors with identical mutations across all cells responded to immunotherapy, while those with subclonal mutations did not.
A team of researchers has discovered that the worm C. elegans uses a unique system to regulate its development, with a quartet of molecules working in concert to control gene expression. This process shares similarities with human circadian clocks, and understanding how it operates could provide insights into developmental biology.
Researchers have discovered how plants pass along chemical markers that instruct cells on using DNA codes, a process known as epigenetic inheritance. The study reveals the role of protein DDM1 in making way for enzymes that add regulatory marks to new DNA strands, preserving genetic controls across generations.
Researchers at Cold Spring Harbor Laboratory have made a significant breakthrough in transforming rhabdomyosarcoma cells into regularly functioning muscle cells using differentiation therapy. This innovative approach has the potential to spare patients and their families from pain and suffering by offering a new treatment option.
A study by Cold Spring Harbor Laboratory researchers found that breast cancer cells trick the immune system using a molecule called MHC-II, allowing them to spread faster and evade treatment. Targeting this molecule may lead to new therapeutics and improve patient outcomes.
Researchers have captured never-before-seen images of the CALHM1 pore, which assembles into a circular channel with flexible arms resembling octopus tentacles. The discovery reveals how fatty molecules stabilize and regulate the channel, offering potential insights into its role in taste perception and Alzheimer's disease.
Researchers found that patients producing high levels of Cystatin C, a protein linked to immune system suppression, had worse survival rates and were less likely to benefit from immunotherapy. This suggests that Cystatin C may play a role in the failure of cancer immunotherapy.
A keto diet may help reduce body weight and slow tumor growth in cancer patients. However, research found that this diet can cause early-onset cachexia, a lethal wasting disease, in mice with pancreatic and colorectal cancer. Pairing keto with corticosteroids prevented cachexia in mice, allowing them to live longer.
Researchers at Cold Spring Harbor Laboratory have devised a chemical transformation called phosphorus fluoride exchange (PFEx), which efficiently assembles complex molecules. This click chemistry method uses phosphorous as a connector, inspired by biology's use of phosphorus in DNA and energy-storing molecules.
Scientists using popular computational tools to interpret AI predictions are picking up too much 'noise' when analyzing DNA. Researchers have found a way to fix this by applying a new line of code, leading to more reliable explanations and potentially unlocking the next breakthrough in health and medicine.
Scientists have found that siblings with autism spectrum disorder (ASD) share more of their father's genome than initially thought. In many cases, it is the father who may play a bigger genetic role in ASD. This discovery offers new potential sources for understanding and treating the disorder.
Researchers have developed a new method called EvoAug that uses artificial DNA sequences inspired by evolution to train deep neural networks for genome analysis. This approach enables the model to recognize regulatory motifs more accurately, leading to better performance and potential breakthroughs in understanding human health.
Researchers identify SRSF1 as a key player in promoting pancreatitis and pancreatic cancer growth. High levels of SRSF1 are associated with worse patient outcomes, highlighting its potential as a target for new therapies.