Researchers at Emory University Health Sciences Center have identified a new tumor suppressor gene, ATBF1, which inhibits cell proliferation. This finding suggests that ATBF1 may play a role in the development of prostate cancer and potentially other types of cancers.
The introduction of the pneumococcal conjugate vaccine led to significant reductions in invasive pneumonia rates, with a 71% decrease in children aged 2-4 years and an 82% decrease in those under 2. The vaccine also showed herd immunity effects, reducing antibiotic resistance in adults who did not receive the vaccine.
A recent Emory University study found that HIV infection is not an independent risk factor for severe heart disease in patients who undergo cardiac catheterization. Lifestyle and traditional cardiac risk factors, such as hypertension and high cholesterol levels, play a larger role in the development of CAD.
A study by Emory University researchers found that patients with hypersensitivity reactions to drug-eluting stents had a higher risk of cardiovascular complications, including heart attacks. The research suggests that careful monitoring and timely treatment are essential for patients at risk.
A study by Emory University Health Sciences Center found that drug eluting stents are at least equivalent to vascular brachytherapy in preventing restenosis. SES treatment had a lower incidence of heart attacks and major adverse cardiovascular events compared to conventional VB treatment.
In a randomized clinical trial, researchers found that combining three anti-platelet drugs did not increase the risk of bleeding, and treatment adherence was high. The combination of cilostazol, clopidogrel, and aspirin was tested in patients who had undergone successful angioplasty and stent implantation.
Researchers at Emory University found that infected monarch butterflies flew slower, were tired faster, and had reduced flight ability compared to healthy ones. The study suggests parasite burdens are lower in migratory populations, which may have implications for conservation efforts.
A new study found that genetic amplification (NAAT) testing detects HIV more effectively than standard antibody testing in urban settings. The test identified four individuals with acute HIV infections who had previously tested negative, highlighting its potential to prevent transmission and improve early detection.
A new investigational transplant drug called LEA29Y has been shown to selectively block the co-stimulatory signal that triggers an immune response, thereby preventing organ rejection and preserving kidney function. This approach avoids the toxic side effects associated with current immunosuppressant medications like cyclosporine.
Researchers found that leg growth occurs primarily when lambs are at rest, potentially explaining growing pains in children. The study provides valuable new data on bone growth spurts and suggests that pressure on growth plates may be eased during rest, allowing bones to elongate.
Researchers found that older male nonhuman primates' spatial memory declines at a greater rate than females, suggesting sex differences in age-related cognitive decline. The study aims to investigate factors contributing to these differences and potentially inform the development of sex-specific therapies.
A study by Emory University researchers found that a sex hormone metabolite, allopregnanolone, reduces stress and anxiety in female rats. The findings suggest that progesterone may inhibit the effect of CRF on the acoustic startle response.
Researchers find chimpanzees' responses to unfair situations depend on the strength of their social connections. In a study, chimpanzees in long-term groups were less likely to react negatively to unfair situations compared to those in short-term groups.
Vaccinating 70% of school children, ages 6 to 18, can reduce community-wide transmission to very low levels. This strategy is more effective than vaccinating only high-risk groups.
A recent study by Emory University Health Sciences Center found that patients with depression are less likely to clear the hepatitis C virus from their blood after six months of treatment. Only 34% of those experiencing a significant increase in depression were able to clear the virus, compared to 59-69% of those with milder increases
Researchers found mitochondrial DNA mutations in 12% of prostate cancer samples and 7.8% of general population controls, with increased tumor growth and oxygen radical production in mutant cells. These findings suggest a causal link between mtDNA mutations and prostate cancer development, particularly in African men.
Researchers at Emory University reveal a new pathway for formaldehyde decomposition that bypasses the traditional transition state, providing evidence for alternative mechanisms in chemical reactions. The study's findings have implications for our understanding of transition-state theory and its applications in chemistry and biochemistry.
Dr. Keith Wilkinson's Nobel Prize-winning research on ubiquitin has provided detailed information about cell survival and death, shedding light on the ubiquitin system's role in regulating protein turnover rates. The discoveries present opportunities to develop highly selective drugs targeting various aspects of the ubiquitin pathway.
Researchers found asymmetries in KNOB and language brain region correspond to right- and left-handedness, challenging previous theory of human-chimpanzee brain differences. The Yerkes National Primate Research Center is a leader in biomedical and behavioral studies involving nonhuman primates.
Researchers at Emory University have successfully created a unique metallic molecule, breaking the record for stable metal-oxo species. The breakthrough enables new insights into improving existing technology, particularly in automobile catalytic converters and fuel cells.
Research found that neonatal infections in low-birth-weight infants are associated with impaired neurodevelopmental outcomes, including cerebral palsy, vision impairment, and cognitive delays. Infected infants also had impaired head growth, a predictor of poor neurodevelopmental outcome.
Research by Emory University scientists found that chronic viral infections fail to develop long-term immune memory cells due to poor cytokine response. The study suggests that rest from antigen exposure is crucial for developing these memory cells.
A study of 28 individuals with acrophobia found that combining D-cycloserine (DCS) with virtual reality exposure therapy significantly reduced fear of heights, with effects lasting at least three months. The treatment works by facilitating 'fear extinction' in the brain, a process previously used to treat phobias and post-traumatic str...
Researchers found that estrogen deficiency triggers the expression of interferon gamma, which stimulates T cell activation and TNF production. Estrogen treatment increases TGFb levels in bone marrow, leading to bone preservation.
Yerkes researchers are presenting a variety of new data at the Society for Neuroscience Meeting, demonstrating advances in understanding brain function and behavior. Key findings include insights into how evolution has shaped human cellular systems, stress response mechanisms, and the role of vasopressin in social recognition.
Researchers have described the pattern of brain evolution in dolphins for the first time, revealing a significant increase in brain size relative to body size over 47 million years. This change is believed to be linked to changes in social ecology and the emergence of echolocation abilities.
A study by Emory University researchers found that brief reductions in blood oxygen levels during critical brain development can lead to long-lasting deficiencies in dopamine release and hyperactivity in juvenile rats. This discovery may help explain the development of ADHD and provide insights into potential treatments.
Researchers couple bacterial life with theophylline production, which breaks down caffeine slowly in plants. The goal is to create coffee plants low in caffeine using these engineered bacteria.
A new partnership aims to develop nanotechnology tools for linking molecular signatures to cancer behavior and clinical outcome. Researchers will create nanoparticles for molecular profiling of cancer, as well as imaging microscopes and software integrated with nanotechnology discoveries.
Emory researchers create three-dimensional, atomic-scale images of epothilone A binding site with key protein controlling cell division. The study's results pave the way for creating new compounds and a clinical tool for pharmacogenetic profiling.
The Emory University Health Sciences Center, AABB, and Red Cross will work together to reduce HIV transmission in developing countries by improving blood supply systems, testing for HIV, and creating safe transfusion centers.
Scientists successfully designed and tested nanoparticles to both target and visualize prostate tumors in mice, offering potential for early cancer detection and treatment. The breakthrough uses a unique coating to protect the particles from degradation and enhance their targeting capabilities.
The study found that LR11 plays a crucial role in regulating beta amyloid levels, suggesting its potential as a therapeutic target for Alzheimer's disease. The Emory researchers used lentiviruses to selectively reduce and enhance LR11 expression in mouse brains and cultured cells.
A study by Emory University researchers found that patients with mild cognitive impairment (MCI) show compromised ability to perform instrumental activities of daily living (IADLs), a trend also observed in Alzheimer's disease. Early detection and treatment can help maintain independence for individuals with MCI.
Researchers are using primate behavioral memory tasks and infrared eye-tracking technology to identify patients with mild cognitive impairment. The study aims to detect impaired memory in humans before major brain damage occurs.
A randomized, controlled clinical trial found that a targeted HIV prevention intervention significantly reduced consistent condom use and risky sexual behaviors in high-risk African-American adolescent girls. The intervention emphasized ethnic and gender pride, HIV knowledge, communication, and healthy relationships.
The Emory Vaccine Center's Hope Clinic will conduct clinical trials for topical vaginal microbicide gels to prevent HIV transmission, particularly among women in Atlanta and worldwide. The trials aim to test the safety and acceptability of two different gel formulations on healthy and high-risk individuals.
By transferring vasopressin receptor genes into meadow voles, scientists observed a strong preference for current partners, mirroring the behavior of prairie voles. This study provides evidence that changes in a single gene can profoundly impact social behavior in animals.
Researchers found that estrogen combined with MPA caused increased aggression and anxiety, reduced sexual activity, and altered brain chemistry. The study provides insight into the behavioral effects of HRT and its potential links to depression, anxiety disorders, and premenstrual mood changes.
Yerkes researchers found a combination of dopamine transporter inhibition and serotonin transporter inhibition effective in limiting cocaine use in rhesus macaques. The therapy shows promise as a potential treatment for cocaine addiction.
A Phase II study found LEA29Y effective in preventing acute rejection, but showed significant improvements in kidney function, blood pressure, and cholesterol levels compared to cyclosporine therapy.
A recent Emory University study found that adults with better mental health have a lower risk of cardiovascular disease. Only 17% of the sample met full mental health criteria, highlighting the need for healthcare professionals to consider mental well-being in treating patients with heart conditions.
Researchers used fMRI to study brain activity in response to rewards, finding that reward centers were activated when participants actively received the reward. Active participation was found to be more salient and arousing than passive receipt, highlighting its importance for brain function.
The Emory research team will model disease outbreaks in hypothetical American communities to find the best methods of controlling epidemics. They will also investigate the interaction of microorganisms with the immune system and its relation to disease spread.
Researchers studied 87 women with epilepsy and found that nearly 40% experience catamential patterns where seizures fluctuate with menstrual cycles. Progesterone lozenges may help reduce seizure frequency and severity during monthly hormonal changes.
Researchers at Emory University Health Sciences Center have identified a genetic sequence for the anti-bacterial protein Escapin found in sea slugs. The protein prevents bacteria from growing on surfaces, making it a potential solution for preventing biofilm formation and associated problems.
A five-year study found that four commonly prescribed antiepileptic drugs were associated with varying levels of birth defects, developmental disabilities, and death in children. The study revealed that lamotrigine may cause less harm compared to other medications, while valproate posed the highest risk.
Patients with uncontrolled epilepsy have significantly lower levels of DHA in their red blood cell membranes compared to healthy individuals. This deficiency may contribute to seizure severity and inform potential treatment strategies involving DHA supplementation.
A novel mutation in the SCN1A gene has been discovered in a family with generalized epilepsy with febrile seizures plus (GEFS+), a condition characterized by unusual brain activity. This finding may lead to improved diagnoses, treatments, and genetic counseling for affected individuals.
A recent study found that male and female brains react uniquely to sexual cues, with males showing higher activation in the amygdala. This discovery may have implications for understanding human behavior and developing treatments for sexual dysfunctions.