The cooperation aims to strengthen collaborative research and academic teaching, fostering a think tank for Jewish and non-Jewish perspectives on society's development. It seeks to address new research questions and perspectives from a transdisciplinary perspective.
The paper clarifies that academic freedom is not absolute and can be restricted in certain cases to protect fundamental rights. The university has set up new training courses to strengthen scientists' skills in dealing with criticism and arguments outside of scientific discourse.
A study from Goethe University Frankfurt reveals that venomous crustaceans, specifically remipede crabs in Mexican cenote caves, contain a variety of toxins with pharmacological potential. The xibalbines peptides effectively inhibit potassium channels and activate signaling pathways involved in pain sensitization.
A worldwide survey by Goethe University Frankfurt found that students in environmental studies are unaware of the main causes of biodiversity loss. The study identified eight response types with varying levels of understanding, with climate change being underestimated in many countries. The researchers suggest that this lack of knowled...
Researchers investigate four European regions experiencing demographic decline, exploring how relationships between generations and places change over time. The study uses participant observation and participatory action research methods to gather insights from families and local residents.
The 'Indigenous People of West Africa' project aims to examine the consequences of colonial era resettlements and promote indigenous governance. Climate change exacerbates agricultural problems and land use conflicts with semi-nomadic groups in West Africa.
The Goethe SDG Contest recognized three award-winning start-up teams: HOPES Energy, MySympto, and CERES FieldCheck. These innovative projects leverage AI and sustainable products to address pressing global challenges, including energy storage, healthcare efficiency, and environmental conservation.
Researchers at Goethe University Frankfurt have discovered thalidomide derivatives that target and degrade BCL-2, a protein essential for the survival of cancer cells. The derivatives bind to CRBN, reprogramming its binding surface to mark BCL-2 for degradation, ultimately leading to cell death.
A German-Chinese team at Goethe University Frankfurt has successfully visualized the temporal evolution of electron waves using the Kapitza-Dirac effect. The researchers measured the time-dependent interaction between free electrons and ultrashort laser pulses, opening up exciting applications in quantum physics.
Researchers analyze data from another series of observations to study Sgr A*, finding that strong and ordered magnetic fields are critical to how black holes interact with gas and matter around them. The discovery enhances theoretical models and simulations, refining our understanding of black hole dynamics near the event horizon.
Researchers have developed an innovative detection method using artificial glycocalyx to capture and identify specific bacteria. The sensor can detect intact bacteria, even in small quantities, and distinguish them from harmless bacteria.
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
A study models habitat suitability for medically relevant black flies in four German federal states, predicting an increase in their population due to climate change. The findings suggest that the warming temperatures and changing land use could promote the growth of species with a broad niche, leading to more frequent occurrences.
Scientists have discovered that the bat brainstem processes echolocation and communication calls differently, with a stronger response to less frequent calls due to better neural synchronization. The findings may also be relevant to medical applications in humans, such as understanding diseases like ADHD or schizophrenia.
Physicists at Goethe University Frankfurt have proposed a new solution to Einstein's field equations, describing the existence of 'nestars' - gravastars inside another gravastar. The 'nestar' has a thicker shell than previous theories, making it easier to imagine its existence.
A comprehensive study will examine how young caregivers balance educational responsibilities with care for older relatives, influencing academic performance and decision-making. The InterCare project aims to raise awareness about the challenges faced by this often-overlooked group, including feelings of shame and guilt.
Researchers developed an mRNA therapeutic that combats ovarian cancer by producing functional p53 protein, shrinking and killing tumors. The treatment is effective against metastases and has shown promise in preclinical studies.
A recent study by Goethe University Frankfurt has identified a mechanism that could be a suitable starting point for developing novel drugs against leukemia cells. The researchers discovered that the mutated NPM1 gene variant drives pro-autophagic activity, enabling cancer cells to recycle their structures and meet their needs.
Researchers examined venom genes in bees and other hymenopteran taxa using comparative genomics. They found that 12 'families' of peptides and proteins were present in all analyzed hymenopterans, indicating a common ancestor possessed these genes. This suggests that Hymenoptera insects are venomous as an entire group.
Researchers at Goethe University Frankfurt have identified a specific gene locus, MYNRL15, that is critical to the survival and replication of leukemia cells. Inhibiting this gene has been shown to deactivate genes necessary for AML cell survival, offering a new possibility for fighting leukemia.
Researchers analyzed whiteschist from the Dora Maira Massif to study rapid upward movements, revealing a sharp decrease in pressure or decompression. This suggests that UHP rocks may not have reached a depth of 120 kilometers before returning to the surface.
Acinetobacter baumannii bacteria can form special cells that survive for long periods in a dormant state, making antibiotic treatment challenging. The discovery could lead to new treatment concepts by targeting proteins involved in the transition to this slumber state.
A Phase IIIb study published in the New England Journal of Medicine found that esketamine nasal spray achieved higher remission rates (27.1%) compared to quetiapine extended-release (17.6%) in patients with treatment-resistant depression, indicating its potential as a targeted therapy for this population.
Research suggests that coral reefs in Belize are experiencing a decline in growth rates, with accretion rates decreasing over the past 9,000 years. This decline has significant implications for tropical island nations and the impact of climate change.
SARS-CoV-2's nucleocapsid protein (N) uses human body temperature to replicate, binding to RNA motifs at specific spatial folds. The study reveals new functions and potential targets for antiviral drugs.
A new study by Goethe University Frankfurt found that effluents from treated wastewater treatment plants alter invertebrate communities in Hesse's waters. Pollution-tolerant taxa like worms and crustaceans increase, while sensitive species like stonefly and caddisfly larvae decline.
Researchers find that Acinetobacter baumannii can achieve significant functional modifications in protein complexes over short evolutionary time spans, particularly in hair-like cell appendages. This diversity may affect the pathogen's interaction with its environment and inform personalized therapies.
A team of scientists has successfully elucidated the structure and function of LITE-1, a biomolecule used by Caenorhabditis elegans to detect danger. The researchers used artificial intelligence to predict the structure of LITE-1, which is a channel protein that forms a pore in the cell membrane allowing charged particles to pass through.
A team of researchers from Goethe University Frankfurt has discovered a central switch point in the mitochondrial signaling chain under misfolding stress. The mitochondria send two chemical signals to the cell when protein misfolding stress occurs, triggering a protective response that reduces misfolded proteins and stabilizes membranes.
Researchers have successfully visualized the three-dimensional structure of human tRNA splicing endonuclease TSEN, a crucial enzyme in tRNA maturation. The study reveals how TSEN recognizes and excises introns from precursor tRNAs, shedding light on its role in neurodegenerative disorders like pontocerebellar hypoplasia.
Researchers analyzed scientific literature from 1990 to 2021 and found that environmental pollution through chemicals is less studied than other causes of global biodiversity loss. The team calls for a stronger interdisciplinary focus to better understand and mitigate chemical impacts on biodiversity.
A team of scientists led by Professor Ivan Đikić and Christian Hübner identified the role of ubiquitin in regulating ER-phagy, a process involved in the degradation of the endoplasmic reticulum. This discovery sheds light on neurodegenerative diseases caused by defective FAM134B and ARL6IP1 proteins.
A research team from Germany, Austria, Canada, and the USA analyzed Troodon eggshells using a new method, revealing that they were produced at temperatures of 42°C and 30°C. The findings suggest that Troodon females laid eggs in communal nests, similar to modern ostriches.
Researchers at Goethe University Frankfurt have identified nitroxoline as a potential treatment alternative for mpox. The antibiotic demonstrates effectiveness against both the current mpox virus and a tecovirimat-resistant strain, offering a promising solution to combat the outbreak.
Children with Down syndrome are highly vulnerable to developing aggressive leukaemia due to a defect in the RUNX1 gene, which regulates blood cell formation. Researchers have identified a specific variant of the gene that promotes leukaemia development and discovered potential therapeutic approaches to correct this malfunction.
A new German Research Foundation-funded project investigates the possibility that a Roman land ditch was created in the Hessian Ried in the 1st century AD. The research aims to find the canal's original course and study its relationship with nearby Roman settlement sites.
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
A new game theory study by Professor Claudius Gros finds that unregulated competition can lead to catastrophic poverty for investors, with profits scaling as 1/N². Cooperation among investors can avoid this damage, resulting in a net profit corresponding to the number of investors.
Leif Ludwig's analytical method allows for easier disentanglement of blood cell trajectories, enabling identification of leukemia cell development or degenerative changes. This breakthrough opens up possibility for human medicine to conduct studies in clinical practice and derive therapeutic interventions.
Researchers analyzed ancient teeth from Homo erectus and great apes to reveal annual cycles in tooth enamel, providing insights into their diets and seasonal food supplies. The study shows that humans and great apes had distinct dietary patterns, with humans exhibiting less pronounced peaks and lower Sr/Ca values.
Researchers at Goethe University Frankfurt have found that jet engine lubrication oils are a significant source of ultrafine particles. These tiny particles can penetrate deep into the lungs and trigger inflammatory reactions, potentially contributing to cardiovascular diseases.
Researchers at Goethe University Frankfurt found that dying colon cancer cells release ATP to neighboring tumor cells, activating a survival signaling pathway. Interrupting this communication can significantly increase the effectiveness of chemotherapy against resistant tumors.
Physicists at Goethe University have developed over a million equations of state to model neutron star structure. These models reveal that 'light' neutron stars have a soft mantle and a stiff core, while 'heavy' stars have a stiff mantle and a soft core.
Researchers have developed a new model that combines nuclear physics and string theory to describe the transition to dense and hot quark matter in neutron star collisions. The model allows for the calculation of gravitational-wave signals, showing that both hot and cold quark matter can be produced.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
A meta-analysis by Goethe University Frankfurt found that individualized treatment combined with cognitive behavioral therapy (CBT) led to a significant increase in pain relief. The study showed an 84% higher success rate compared to standard exercise therapies, making this approach the most effective.
A team of researchers led by Goethe University Frankfurt analyzed a diamond from Botswana, revealing significant amounts of water stored in the transition zone. The discovery has far-reaching consequences for the dynamic situation inside the Earth, potentially altering global material circulation.
The analysis of particles from asteroid Ryugu has revealed a high carbon content, similar to the Sun, and the presence of rare earth metals in concentrations 100 times higher than elsewhere in the solar system. The findings suggest that Ryugu originated from a parent asteroid formed in the outer solar nebula.
Researchers captured first image of antigen-bound T-cell receptor complex with bound antigen at atomic resolution. The study reveals no significant structural changes in the receptor after antigen binding, sparking further investigation into the signaling pathway activation mechanism.