Researchers at Hiroshima University have linked stomach (gastric) and prostate cancer to a specific type of DNA called T-UCRs. The study identifies a potential regulatory pathway of stomach (gastric) cancer, providing new insights into cancer genetics.
Researchers successfully experimented with chiral magnetic materials that show a unique magnetic twisting effect triggered by weak external magnetic fields. This leads to the development of new types of magnetic memories with unprecedented storage capacities, up to 10 million times larger than conventional magnetic storage memory devices.
Researchers have developed a terahertz transmitter that can transmit data at over 10 gigabits per second over multiple channels, exceeding 100 gigabits per second. The technology could revolutionize wireless communication with speeds ten times higher than current technology allows.
Researchers have revealed the mechanism behind the ferromagnetic properties of Cr-doped (Sb, Bi)2Te3 thin films, enabling electric current generation at room temperature without energy consumption. This breakthrough could lead to novel materials that operate efficiently in future devices.
A streamlined PITCh system enables efficient genome editing for inserting foreign DNA into targeted genomic loci. This method can aid rapid research progress in fields like drug screening and human disease modeling.
A multicenter clinical study found that pravastatin reduced the occurrence of strokes and specific vascular events, while no difference was observed for other stroke subtypes. The study's results contribute to the establishment of guidelines for statin use in preventing strokes caused by larger artery atherosclerosis.
Hiroshima University researchers develop a new technique to prevent 'springback' in press-forming high-strength steel, a common problem that causes defects and environmental concerns. By eliminating this issue, they enable the mass production of lightweight cars with reduced emissions.
Researchers at Hiroshima University have developed a new ultra-thin layered membrane that separates salt from seawater to produce fresh water through reverse osmosis. The membrane is heat-resistant and resistant to chlorine, making it suitable for desalination plants.
Researchers develop a better method for modelling panel data, offering rich opportunities for economists to apply analytical tools. The new approach improves upon existing techniques and can be used to analyze the effect of various factors such as job-training, clinical trials, and economic policies.
Researchers at Hiroshima University have discovered that fragments of cancer DNA circulating in the bloodstream can predict the recurrence and spread of liver cancer. This non-invasive method, known as circulating tumor DNA (ctDNA), provides valuable clinical information about the patient's disease progression.
Researchers at Hiroshima University developed a new animal model of hepatitis B using humanized mice and found that CTLA4Ig suppressed damage to liver cells infected with the virus. This model is useful for studying immunological reactions and viral clearance in hepatitis B virus infection.
Akinori Awazu's research reveals that active nuclear deformations play a significant role in determining intra-nuclear chromosome architectures. The study suggests that these dynamic changes contribute considerably to the segregation pattern formation of euchromatin and heterochromatin.
Researchers at Hiroshima University discovered that Sendai virus C protein inhibits STAT1 activation after interferon stimulation, enabling the virus to evade the host immune response. This finding opens up new avenues for developing anti-viral drugs to overcome damage caused by interferons.
A genetic polymorphism in the EPAS1 gene has been associated with poor prognosis and enhanced expression in patients with non-small cell lung cancer. The study found that individuals with the A allele had a significantly shorter overall survival time compared to those with the G allele.
Researchers discovered that antidepressant amitriptyline increases FGF2 mRNA expression in astrocytes through RTK activation. This signaling cascade could guide the development of novel antidepressants with new mechanisms. The study expands on previous findings, identifying EGR1 as a necessary protein for FGF2 expression.
Researchers discovered that coccoliths can modulate solar light, enhancing photosynthesis in microalgae. The study found that magnetically oriented coccoliths change light scattering, contributing to understanding how these structures control light.
Scientists from Hiroshima University have observed an unusual dispersion of the acoustic mode in liquid Bi using inelastic x-ray scattering (IXS). The results resolve previous disagreements and suggest a possible mechanism involving a long-range interatomic force, which is related to local structures.
A research group in Japan and Korea found that certain dipeptide species support CML stem cell activity. Pharmacological inhibition of nutrient uptake decreased CML stem cell activity in vivo, suggesting a potential therapeutic target for CML therapy. This discovery may provide concrete benefits to patients with CML.
International researchers found protein machines collectively induce fluctuating hydrodynamic flows, enhancing particle diffusive motions. The proteins supply power to the system by extracting energy from nonequilibrium effects.
The Mobile Bridge Version 4.0's viability was tested on a real river, showcasing its practical use with minimal personnel and no foundation work required. The bridge's scissor-like structure allows for efficient expansion and contraction while maintaining strength.
A research group at Hiroshima University found that downregulated spinal astrocyte connexin43 expression leads to sustained neuropathic pain following peripheral nerve injury. Restoring Cx43 function via adenovirus vector may reverse mechanical hypersensitivity and modulate glutamatergic neurotransmission.
Researchers identified bi-allelic mutations in RORC, essential for IL-17-producing T cells against Candida and IFN-γ-producing T cells against Mycobacterium. This study reveals a new understanding of genetic susceptibility to these infections.
Scientists at Hiroshima University successfully compounded ultra-thin all-inorganic molecular nanowires composed of Mo and Te, exhibiting high activity as an acid catalyst. The wires' diameters were only 1.2 nm, making them a promising material for heterogeneous catalysts, thermochromic materials, and semiconductors.
A new detection method has been developed to rapidly and accurately detect drug-resistant HCV mutants, including the Y93H mutation. The system achieved a high success rate of 98.9% in detecting this mutation in Japanese HCV genotype 1b patients.
Researchers at Hiroshima University found a correlation between telomere G-tail length and endothelial dysfunction, as well as stroke and dementia, in patients with chronic cerebrovascular disease. The study suggests that telomere G-tail length may be a useful biomarker for predicting cardiovascular risk.
Researchers developed a novel live-imaging system to study gene transcription and nuclear position, enabling simultaneous measurements of these processes. The technique shows high specificity and has potential applications in studying higher-order gene regulation and cell-to-cell heterogeneity.
Researchers at Hiroshima University have developed a next-generation illumination device using a silicon quantum dot-based hybrid light-emitting diode. The new LED exhibit higher current and optical power densities, and features an active area 40 times larger than traditional commercial LEDs.
Researchers at Hiroshima University found that long noncoding RNA CCDC26 controls receptor tyrosine kinase KIT expression in leukemia cells. This discovery provides new insights into leukemia recurrence and may help develop new therapies.
A new measurement method using droplet digital polymerase chain reaction (ddPCR) estimates the distribution of aquatic animals in water by quantifying target DNA copies. This technique offers higher accuracy than existing methods, especially at low environmental DNA concentrations.
Researchers at Hiroshima University developed a prototype called Sensorimotor Enhancing Suit (SEnS) to support human motion. SEnS reduces muscle load on the upper limbs, improving sensorimotor functions and enhancing the quality of life for both elderly individuals and healthy people working under extreme conditions.
Researchers discovered that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has anti-inflammatory effects. HYA alleviates intestinal inflammation in mice with colitis and improves epithelial barrier function.
Corals expel damaged symbiotic zooxanthellae under moderate thermal stress to avoid accumulation and maintain stable carbon concentration. However, prolonged exposure can lead to increased expulsion of photosynthetically damaged cells, which may not be enough to prevent coral deterioration.
A novel gene knock-in technique using PITCh enables accurate and efficient insertion of exogenous genes into human cells, silkworms, frogs, and other organisms. This method overcomes technical hurdles associated with homologous recombination in cultured cells and organisms.
Researchers established induced pluripotent stem (iPS) cells from Werner syndrome fibroblasts, which can be used for drug discovery and gene therapy. The iPS cells have recovered telomeric abnormalities and similar expression levels of aging-related genes as normal iPS cells.