A phase III clinical trial found that using a cardiac clot-busting drug to treat hemorrhagic strokes safely decreased the death rate by 10 percent. The study also showed that flushing unwanted blood from the brain was associated with better outcomes for many patients, with almost 50 percent living independently at 180 days.
Copper influx is crucial for brain cell development, allowing for the rapid transport of copper to activate enzymes and facilitate signaling between neurons. This study reveals how cells adjust copper allocation from energy production to enzyme activation as they mature.
Researchers use light to measure the 'big stretch' in spider silk proteins, shedding light on biological events such as cancer metastasis. The tool allows for real-time measurement of forces acting on proteins in live cells.
Researchers from Johns Hopkins Medicine have successfully controlled a prosthetic arm to move individual fingers using brain mapping technology. The study, published in the Journal of Neural Engineering, represents a potential advance in technologies to restore refined hand function to those who have lost arms to injury or disease.
Researchers from Johns Hopkins University School of Medicine presented new insights on the use of big data to discover personalized therapies for treating human illness. They also discussed the link between hearing loss and cognitive decline, as well as a new technique to predict outcomes in patients with neurodegenerative disorders.
A new study finds that only 9% of weight loss programs adhere to expert medical guidelines, leaving consumers unclear about their regimen. The majority of programs lack essential components like high-intensity interventions and moderate physical activity.
Researchers at Johns Hopkins University found a possible marker for recurring HPV-linked oropharyngeal cancers. The study suggests that an increase in E6 antibody levels after treatment may indicate a higher risk of cancer returning.
Research suggests that cancer cells rarely form metastatic tumors on their own but instead travel in groups for increased chances of survival. These traveling cells differ from those within primary tumors and may be intrinsically resistant to chemotherapy due to molecular programs that facilitate their movement.
Researchers found that individuals with higher MET scores (indicating higher physical fitness) had a 40% lower mortality rate after a first heart attack. The study, published in Mayo Clinic Proceedings, suggests that doctors should recommend exercise programs to patients at risk of cardiovascular disease.
Researchers developed a six-question online quiz to predict STIs in young women, with promising accuracy. The quiz assesses behaviors linked to STI risk and can encourage teenage girls and young women to get laboratory tests.
In a study, researchers found that making small modifications to a task during repeated practice sessions can lead to faster skill acquisition. This is due to the process of reconsolidation, which strengthens motor skills by recalling and modifying existing memories. By adjusting their performance despite unawareness of subtle changes,...
Researchers found that Hippo signaling pathway activates immune response to combat gram-positive bacteria, linked to organ growth control
Researchers at Johns Hopkins Medicine have discovered that cocaine triggers autophagy, a process that causes brain cells to digest themselves. A compound called CGP3466B has been shown to prevent this damage in mouse nerve cells.
Researchers found that fluoroquinolones interact with an enzyme in TB germs, but not as strongly as thought. They discovered a new way to make the drugs more potent by targeting broken DNA within the gyrase complex. This could lead to improved treatments for multidrug-resistant TB and other bacterial infections.
Researchers discovered a new type of antidepressant that acts quickly in mice, unlike current treatments which take weeks or months. The compound CGP3466B targets a new network of proteins and has fewer side effects than existing medications.
Studies show that inducing a second stroke nearby in the brains of mice can help them regain motor function to pre-stroke efficiency. This suggests that the optimal recovery window after a stroke may not be permanently closed and can reopen under certain conditions.
The new allocation system has boosted transplantation rates for black and Hispanic patients on waiting lists, reducing racial disparities. Younger adults have gained wider access to coveted organs, while older candidates have seen a decline in transplant rates.
Researchers found that high doses of vitamin D3 supplements reduced inflammation and disease activity in people with relapsing-remitting MS. The study suggests vitamin D may be a potential treatment option for managing MS symptoms.
Researchers at Johns Hopkins Medicine found that marmosets use auditory cues similar to humans to distinguish between low and high notes, shedding light on our evolutionary history.
Scientists found that brief exposure to 'asynchrony' using a pacemaker can reverse cellular damage, fix damaged motor proteins in the heart muscle, and boost the heart's response to hormones like adrenaline. The therapy uses alternating electrical shocks to push the heart into normal synchronization for part of each day.
A new Johns Hopkins study of over 930,000 patient records found that patients undergoing bariatric surgery during winter months fared worse than those in the summer due to lower vitamin D levels. The researchers also noticed a disproportionate number of complications occurred north of latitude 37 degrees.
Researchers found that vitamin A converts 'angry' immune cells into inflammation suppressors, reducing the severity of necrotizing enterocolitis in mice. This discovery adds to evidence of vitamin A's anti-inflammatory properties and could lead to new treatments for premature infants with severe bowel disease.
Academic medical centers that partner with community organizations to form accountable care organizations (ACOs) face various challenges, according to a recent study published in Academic Medicine. The authors report on the startup experience of Johns Hopkins Medicine Alliance for Patients (JMAP), an ACO formed after 22 months, and hig...
A nearly complete skeleton of a well-preserved early carnivorous mammal, Galecyon, has shed light on the ecology and evolutionary relationships of hyaenodontids. The fossil, dating back to the Eocene Epoch, suggests that these ancient animals were adaptable ground-dwelling creatures, unlike their tree-climbing or runner relatives.
A Johns Hopkins study suggests that individualized report cards improve VTE prevention efforts, increasing correct therapy use and resident performance. The approach also boosted trainee morale, with a significant spike in resident satisfaction scores.
A new study finds that minimally invasive hysterectomies for early uterine cancer are less accessible to poor and minority women, despite being linked to fewer postoperative complications. The procedures occurred only 23.6% of the time in low-volume hospitals, which performed fewer than 10 hysterectomies annually.
A new study identifies brain processes in mice that may help explain how weak sensory inputs are interpreted differently in the same brain. Activity in higher-level perception areas of the brain is shaped by lower-level sensory input, adding a cellular layer to our understanding of perception.
A new study by Johns Hopkins researchers finds no link between breast density and breast cancer risk, instead attributing increased cancer to age and body fat. The study suggests that women with dense breasts may be younger and leaner, reducing their risk of breast cancer.
Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, a type of nerve cell that transmits visual signals. The breakthrough could lead to the development of cell transplant therapies for glaucoma and multiple sclerosis patients.
Inner ear cells in newborn rodents practice processing sounds through a self-stimulation process involving chloride ion channels. This process helps establish and refine connections between the ear and brain, enabling proper hearing from an early age.
Researchers discovered that Mipp1 protein helps fruit fly cells sprout 'fingers' to build the intricate network of the trachea. The protein's presence is crucial for cell migration and elongation, with too much or too little resulting in abnormal development.
Health experts argue that pharmaceutical companies abuse the Orphan Drug Act by marketing drugs for common conditions, generating billions in profits. The law was designed to encourage rare disease treatments but has instead led to high medication costs and monopolies.
Researchers found that mice exercising on a wheel increased SIRT3 levels, protecting against neurodegeneration and degeneration. Bolstering mitochondrial function with gene therapy technology also offered protection against stress and age-related cognitive decline.
Children with neuromuscular disorders such as cerebral palsy and muscular dystrophy are three times more likely to experience cardiac arrest during spine surgeries. The study found that the absolute risk of cardiac arrest is minuscule, but knowing who's at highest risk can improve preparedness and response time.
A new study developed a potential test to sort out precancerous pancreatic cysts from harmless ones, with an accuracy rate of up to 98 percent. The test combines genetic markers and clinical evaluation, potentially helping patients avoid unnecessary surgery.
Researchers have found ranibizumab to be an effective alternative to laser therapy for treating proliferative diabetic retinopathy, a disease that causes extensive harm to the blood vessels in the retina. The drug carries fewer side effects and improves vision by about half a line on an eye chart compared to the laser group.
A 2-year-old girl was diagnosed and treated for XDR TB, the first detailed account of a young child in the US. The successful treatment highlights the need for better understanding and creative approaches to pediatric tuberculosis.
Scientists at Johns Hopkins Medicine have identified a crucial enzyme in maintaining telomere length. The discovery was made using a novel method called ADDIT, which found that ATM kinase plays a vital role in lengthening telomeres.
A new study has revealed reasons why lab-grown stem cells fail to mature in the laboratory and provided a possible solution to overcome these 'developmental arrest'. The researchers analyzed over 200 heart cell samples from mice embryos and animals, identifying biochemical pathways that are out of sync with adult cells.
A study by Johns Hopkins Medicine found that nearly one-third of knee and hip arthroplasty surgeries had excessive door openings, potentially defeating the safety effects of positive pressure systems. The researchers suggest planning better to prevent unnecessary door openings and exploring reasons behind frequent door opening.
A new study suggests that rare 'missense' mutations in the HER2 gene may not cause breast cancer growth or spread on their own. The research team found that such mutations may also fail to predict response to anti-cancer drugs targeting the HER2 gene, unlike common amplification alterations.
Researchers found that type II afferent neurons in the inner ear respond to tissue damage similar to pain-sensing nerve cells. This discovery may lead to new treatments for hyperacusis, a condition characterized by increased sensitivity to loud noises.
Researchers found that sleep fragmentation is especially detrimental to positive mood, leading to a 31% decline in positive mood after the second night. Interrupted sleep also affected different domains of positive mood, including energy levels and feelings of sympathy and friendliness.
A computer model developed by Johns Hopkins predicts that strengthening HIV care, including retention in care and increased testing, can avert 752,000 new infections and 276,000 AIDS deaths over 20 years. Enhanced interventions could reduce incidence by 54% and mortality by 64% at a cost-effectiveness ratio of $45,300 per QALY.
A head-to-head comparison study by Johns Hopkins researchers shows that non-invasive CT scans are better at spotting clogged heart vessels than stress tests. CT angiograms detected blockages in nine out of ten people, while stress tests picked up blockages in six out of ten.
A study of nearly 3,000 adults found significant differences in how male and female hearts change over time. The research suggests that men's and women's hearts may develop age-related heart failure for different reasons, highlighting the need for gender-tailored treatments.
Garden-variety staph infections are just as deadly for newborns as drug-resistant strains, according to a study by Johns Hopkins Medicine. Nonresistant bacterial infections affect more than twice as many babies and have the same high mortality rate as their drug-resistant cousins.
Researchers found a link between MMF and an increased risk of CNS lymphoma in solid organ transplant patients. However, combining MMF with calcineurin inhibitors (CNIs) appears to protect against this rare form of lymphoma, according to the study published in Oncotarget.
Researchers found that effective HIV therapy can lower the risk of HBV infection, and vaccination against HBV protects individuals from acquiring a new HBV infection regardless of HIV status. However, vaccination rates remain low among high-risk groups.
Male fruit flies release a specific pheromone, 9-tricosene, that attracts females to lay eggs near food sources. This discovery sheds light on how flies navigate complex environments using odorants, and its potential application in controlling mosquito-borne diseases like malaria.