Researchers discovered significant structural changes and impaired left-ventricular function in the hearts of SMA mice, along with lower heart rates. Gene therapy approach showed promise in restoring heart rates and preventing dilated cardiomyopathy.
A new national study found that fractures in US high school athletes resulted in significantly more time lost from competition than other injuries. Fractures also led to substantial medical costs and imposed significant restrictions on participation.
A new study published in the American Journal of Industrial Medicine reveals that there was no significant difference in injury prevalence between ethnic minority and majority groups of Chinese farmers. The US-China Agricultural Injury Research Training Project successfully trained Chinese scholars, expanding collaborative research act...
A new study aims to investigate whether delaying the clamping of a newborn's umbilical cord for two minutes after birth can improve their recovery from corrective heart surgery. The study hopes to determine if this practice can decrease the need for blood transfusions in critically ill babies.
A Nationwide Children's Hospital study shows that one-third of sickle cell disease patients receiving narcotics were not prescribed laxatives, highlighting the need for increased attention to constipation prophylaxis. The study found that older children and patients with medical admissions were more likely to receive laxatives.
A recent study by Nationwide Children's Hospital sheds light on the deadly bowel disease necrotizing enterocolitis (NEC) in infants born with complex congenital heart disease. The research reveals that neonates undergoing the hybrid procedure have a lower risk of NEC compared to those receiving the Norwood procedure.
A modified measles virus has been shown to effectively kill medulloblastoma cells in laboratory studies and mouse models, suggesting its potential as a new treatment option for childhood brain tumors. The vaccine strain targets the CD46 receptor, which is highly expressed in multiple tumor types.
A new national study found that more than 63,000 pediatric mobility aid-related injuries were treated in US emergency departments from 1991-2008. The majority of these injuries occurred at home and varied by the type of mobility aid used.
Researchers at Nationwide Children's Hospital developed a mouse model of vesicoureteral reflux, a condition that can lead to chronic kidney disease. The study found that these models lacked the protein fibroblast growth factor receptor 2 (Fgfr2), which is involved in tissue and organ development.
A study by Nationwide Children's Hospital found that immigrants with disabilities were more likely to be employed than US-born individuals with disabilities. The median income for foreign-born persons with disabilities was $20,000, compared to $22,000 for U.S.-born individuals.
A new study by Nationwide Children's Hospital found that sexual minority youth are bullied two to three times more often than heterosexual youth. This increased vulnerability to bullying is associated with a range of physical and mental health issues, including suicidal thoughts and behaviors.
According to a new study published in Injury Prevention, the risk of serious injury at resident summer camps is relatively low compared to other popular youth activities. The study found that less than 3% of camp injuries required hospital admission, with nearly 75% of injuries sustained by campers.
A recent study defines feeding milestones for premature infants, helping to improve their quality of life. Infants born before 28 weeks gestational age faced significant feeding delays and prolonged hospital stays.
A unified approach to caring for extremely premature infants in the first week of life resulted in improved patient outcomes, including a decrease in hospital stay duration. Infants treated using small baby guidelines showed higher survival rates without complications like bronchopulmonary dysplasia and severe intraventricular hemorrhage.
A new national study found that over half of US cheerleading injuries are caused by stunts, with nearly all concussions occurring during stunt performance. The majority of injuries also occurred during practice.
A study demonstrates the effectiveness of a gene delivery strategy producing follistatin, which inhibits myostatin, in non-human primates, showing pronounced increases in muscle size and strength. The treatment is well-tolerated and has long-term effects, paving the way for potential clinical trials.
A recent nationwide study found that hot tub-related injuries have more than doubled over the last 18 years, with slips and falls being the most common cause. The study also highlights the need for special attention to be given to the pediatric population due to the severity of hot tub-related injuries.
A recent study found that burn injuries in children have decreased by 31% since 1990, but children under six are still at high risk of injury. The majority of injuries occurred in the home and resulted from thermal burns.
Severe injuries accounted for 15% of all high school sport-related injuries, with males experiencing a higher rate in football and wrestling. Commonly injured body sites included the knee, ankle, and shoulder.
A recent study published in Research in Sports Medicine found that football injuries sustained during the beginning and middle of a game are more severe than those occurring at the end or in overtime. The majority of severe injuries, including concussions, occurred during kickoff and punting phases.
A recent nationwide study found a 150% increase in PE class-related injuries to elementary, middle and high school students in the United States between 1997 and 2007. The most common injuries were lower-extremity sprains and strains, with middle school-aged children accounting for the majority of cases.
A nationwide study found a significant rise in rock climbing-related injuries, with over 40,000 patients treated between 1990 and 2007. The majority of injuries were falls from heights above 20 feet, which increased the risk of hospitalization by 10 times.
A nationwide study reveals that slips, trips, and falls are the leading cause of bathtub- and shower-related injuries in children. Most injuries occur to young children under 4 years old, with facial lacerations being the most common diagnosis.
Researchers discovered that delivering a small molecule that is highly expressed in normal tissues but lost in diseased cells can result in tumor suppression. The study employed a novel strategy to treat hepatocellular (liver) cancer, using microRNAs (miRNA) gene delivery via a recombinant adeno-associated virus (AAV).
A nationwide study found a significant decrease in baseball-related injuries among children and adolescents, with emergency department treatments dropping by 25%. The most common injuries were soft tissue injuries, followed by facial and upper extremity injuries, highlighting the importance of injury prevention efforts.
A recent study found that an average of nearly 15,000 children younger than 18 years old visited emergency departments annually for furniture tip-over injuries from 1990-2007. The majority of injuries occurred among children younger than 7 years of age and resulted from televisions tipping over.
Researchers successfully transferred a gene to produce a protein necessary for healthy muscle fiber growth, increasing muscle-fiber size and producing the needed protein for at least six months. The findings demonstrate the feasibility of gene therapy for treating limb-girdle muscular dystrophy and other muscle disorders.
A recent study published in Pediatrics found that one out of every four children with concussions experience significant post-concussive symptoms, which may last longer for those with more severe injuries. Classifying concussions as high-risk or low-risk could help physicians provide targeted treatment and intervene earlier to improve ...
Shoulder injuries accounted for 8% of all injuries in high school athletes, with boys experiencing higher rates than girls. Player-to-player contact was associated with nearly 60% of shoulder injuries across sports.
A new strategy developed at Nationwide Children's Hospital is helping premature infants and newborns with severe swallowing difficulties learn to feed on their own. The approach involves individualized, crib-side studies that use advanced sensors to capture the rhythm of muscular contractions throughout the aero-digestive tract.
The study found that rare injuries accounted for 3.5 percent of high school athletes' injuries between 2005 and 2007, including eye injuries, neck and cervical injuries, dehydration, and heat illness. Football was the most common sport associated with these rare injuries.
A new study reveals childhood constipation can lead to serious health issues, pain, and low self-esteem, with treatment costs equivalent to those of asthma or ADHD. Simple changes in diet and behavior, such as regular bowel movements and high-fiber foods, can help prevent or correct constipation.
After a decade-long decline, US youth suicide rates surged by 18% in 2003-2004, with the trend persisting into 2005. Researchers suspect prescription antidepressant medication may be a contributing factor, as concerns over side effects led to a 20% drop in prescriptions.
A nationwide study found that approximately 6,500 children are treated for diving-related injuries annually, with most common injuries occurring at heights under 1 meter. The largest age group affected was 10- to 14-year-olds, who were twice as likely to experience head or neck injuries.
A new national study examines the rising number of golf cart-related injuries, finding a 132% increase over 17 years. The majority of these injuries occurred at sports and recreational facilities, but those on the street were more likely to result in concussions and hospitalizations.
A new study found that high school baseball-related injuries have increased in severity over the past decade, with many resulting in head/face and teeth injuries, fractures, or concussions. The study recommends the use of helmets with face shields or mouth guards to reduce these types of injuries.
Researchers at Nationwide Children's Hospital developed a computerized behavioral screening system called Health eTouch, which found that adolescents who received immediate results were more likely to be identified as having problems by their pediatrician, with 68% vs. 52% for delayed results
A new study published in Pediatrics found that 80% of pediatric patients with low bone density had vitamin D insufficiency. Vitamin D deficiency can contribute to low bone mass and worsen underlying metabolic bone disease if left untreated, according to the study's lead author.
A nationwide study found an estimated 572,580 bunk bed-related injuries during a 16-year period, resulting in nearly 36,000 cases annually. The majority of injuries occurred among males and children younger than 6 years old, with fractures being the third most common injury.
A study of 76 children and adolescents found that obesity negatively impacts vascular endothelial function, a key indicator of cardiac health. The findings suggest that early signs of cardiovascular disease may begin in childhood, highlighting the need for intervention.
A nationwide study published in Pediatrics reveals that over 600,000 American children participate in gymnastics each year, despite the high risk of injury. The study found nearly 27,000 injuries annually, with fractures and dislocations most common among younger children.
Researchers identified a protein called follistatin that could lead to new clinical treatments for musculoskeletal diseases, including Duchenne muscular dystrophy. Gene-delivery therapy involving FS treated hind leg muscles of mice, resulting in increased muscle mass and strength, well-tolerated for over two years.
A study by Nationwide Children's Hospital found that more than 98,000 high school sports-related injuries were directly linked to illegal activities, with the highest rates in girls' soccer and volleyball. The research suggests that reducing illegal activity through rule enforcement and education may reduce sports-related injuries.
A new national study finds that burn-related injuries among children and adolescents in the US may be a more significant public health concern than previously estimated. The study found that young children are most at risk of burns, with those under 2 years old accounting for half of all pediatric burn hospitalizations.
A new national study found that bicycle-related injuries among children and adolescents result in nearly $200 million in hospital inpatient charges annually. The study also estimates that approximately 10,700 children are hospitalized annually for a bicycle-related injury, with an average length of stay of three days.
A study by Nationwide Children's Hospital found that 12 out of 17 adolescents were misdiagnosed with asthma due to vocal cord dysfunction, which can cause breathing difficulties. The use of spirometry tests in emergency departments may help differentiate VCD from asthma attacks and reduce misdiagnosis.
A new study has found that over 2.1 million individuals were treated in US emergency departments for ladder-related injuries between 1990 and 2005, with an average of 136,000 cases annually.
A new study found that antidepressants are effective in treating pediatric major depressive disorder and anxiety disorders, with a lower risk of suicidal thoughts compared to FDA estimates. The study suggests antidepressants should be considered as first-line treatment options for children under 19.
A nationwide study found that motor vehicle crashes and rider behavior are the leading causes of nonfatal school bus-related injuries in the US. Children aged 10-14 suffered the most injuries, accounting for 42% of total incidents.
A new study found that an in-store safety intervention significantly increased the use of child safety-restraints in shopping carts. The intervention, which included greeters and a cash incentive coupon, led to a 34% increase in correct restraint use.