Researchers dispelled the myth that eating late at night causes weight gain. Female rhesus monkeys on a high-fat diet gained 5% more weight after having their ovaries removed, showing ovarian hormones play a role in weight balance. The study found no correlation between late-night eating and weight gain.
Scientists have developed a new method to study Fanconi anemia proteins using Xenopus eggs, allowing them to study the proteins' function in DNA replication and repair. The research found that Fanconi proteins play a crucial role in preventing DNA breaks during replication, even if the DNA is damaged.
Researchers at OHSU have discovered a protein fragment, p95HER-2, which closely correlates with lymph node metastasis and earlier recurrence of breast cancer. The study suggests that p95HER-2 is a marker for metastasis and may help identify patients with longer disease-free survival.
Researchers found that male Asian elephants release different enantiomer ratios of frontalin, a pheromone, depending on their age and stage of musth. These ratios elicit varying responses in female elephants and other males, allowing them to distinguish maturity and reproductive phase.
Researchers at Oregon Health & Science University (OHSU) have identified a critical gene, Brg-1, that regulates the differentiation of stem cells into neurons and glial cells in the brain. This discovery could lead to new therapies for brain injuries, Parkinson's disease, and other conditions affecting brain function.
Researchers are developing intelligent systems to monitor seniors' daily lives and detect changes in health. The ORCATECH center is creating technologies for in-home monitoring of mobility, cognition, and medication management.
A new study found that hearing loss from chemotherapy is common in children treated with platinum agents, with 61% of patients experiencing some form of hearing loss. The study highlights the need for improved reporting and awareness of ototoxicity to prevent long-term development issues.
A new study challenges traditional beliefs about morphine's impact on breathing difficulties in dying patients. Contrary to the long-held notion that morphine hinders breathing, researchers found that controlled doses of morphine can actually prolong life by slowing down breathing and reducing panic. This shift in understanding is bein...
Research reveals a likely connection between early-life stress and teenage mental health problems, including behavioral and emotional disorders. Monkeys studied showed similar responses to early-life stresses as human children, providing a clearer developmental picture.
Researchers at OHSU found that mice consuming fewer calories experienced a boost in essential neurochemical glutamate, which reversed a Parkinson's-induced drop. The study suggests dietary restriction may be beneficial in early-stage Parkinson's disease.
A study of rhesus macaque monkeys found that individual activity levels are highly variable, regardless of living space, and tend to remain consistent over time. The research suggests that changing one's activity level is difficult due to genetic factors.
A new study found that a vitamin D pill combination extended the lives of men with advanced prostate cancer by about eight months compared to those receiving chemotherapy and placebo. The pill, DN-101, also protected against major side effects of chemotherapy.
Researchers found that the hormone PYY inhibits eating in the morning but not in the evening, resulting in mild weight loss. High doses of PYY are required for weight loss, and further studies are needed to understand its potential as a weight loss treatment.
A retrospective study found that Finnish children who had coronary heart disease as adults were born small, thin at age 2, and gained weight rapidly. These growth patterns were linked to insulin resistance later in life, a known risk factor for coronary heart disease.
VGTI researchers will investigate West Nile virus susceptibility in older adults, aiming to develop new treatments and a vaccine. The studies will focus on immune system responses and identify factors that increase susceptibility to the disease.
The study aims to assess the extent of use of the program in three states, compare it to traditional end-of-life care planning, and examine its impact on symptom management. Researchers will gather data through phone surveys and medical chart reviews to inform strategies for improving end-of-life programs nationwide.
A study by John Scott found that the mAKAP signaling system is perturbed in cases of heart disease, leading to cardiomyocyte hypertrophy. Researchers have identified a potential therapeutic target for treating this condition by suppressing the enzyme phosphodiesterase with drugs such as growth hormone.
OHSU neurologists offer reliable strategies for diagnosing and managing Parkinson's disease. The article highlights the importance of non-pharmacological therapies such as exercise, nutrition, and emotional health in addition to pharmacological care.
A new study at VGTI developed more accurate testing methods for monkeypox, which could be useful in a future outbreak. The researchers found that their test could detect the virus years after infection and even identify vaccinated individuals who were not showing symptoms.
Researchers identify signal in damaged brain that prevents cells from restoring lost myelin; HA accumulation linked to CD44 protein. Oligodendrocyte progenitors can be prevented from maturing into myelin-producing cells, while injection of HA into damaged myelin prevents reforming.
Researchers at OHSU developed a portable device that uses audio cues to assist individuals with balance disorders, such as those caused by vestibular loss or Parkinson's disease. The device has shown significant improvement in reducing sway area and increasing time spent within the safe zone during early testing.
A new study published in the New England Journal of Medicine found that daclizumab can reduce organ rejection in heart transplant patients by 25%. The treatment also showed a lower rate of bacterial infections compared to placebo. Researchers believe this incremental step will help improve outcomes for heart transplant patients.
A study published in the Journal of Neuroscience Research found that patients with multiple sclerosis (MS) have lower expression of the FOXP3 gene, leading to reduced immune suppression. A new drug called NeuroVax was shown to increase FOXP3 levels and restore immune regulation in some patients.
Researchers enrolled 200 patients who had suffered from recent episodes of ventricular tachycardia or fibrillation and found that fish oil supplements increased the risk of life-threatening heart rhythms. The study suggests that patients with implanted defibrillators should avoid fish oil supplements.
Researchers at Oregon Health & Science University found elevated levels of leptin may be the cause of cachexia, a common complication of CKD. Blocking the MC4-R pathway in the brain may provide a novel therapeutic strategy to combat this life-threatening complication.
A new technique called laparoscopic inversion esophagectomy (LIE) has been developed to improve the removal of diseased tissue from the esophagus. LIE eliminates technical obstacles that plagued the original procedure, allowing for faster recovery and fewer complications.
Researchers found that the drop in estrogen levels during menopause is linked to increased cortisol levels and abdominal fat. Estrogen replacement therapy may help prevent this rise in cortisol and delay or prevent weight issues.
A study published in Pediatrics recommends new guidelines for air bag safety in children. The research found that children under 14 are at high risk of serious injury from air bags when sitting in the front passenger seat, while older children benefit from air bag protection.
A recent study found that homemade gene expression technology is less reliable than commercial microarray platforms. The research, led by OHSU scientist Peter Spencer, used standardized protocols to compare lab-built and commercially produced microarrays, showing improved reproducibility with commercial platforms.
The retina's neural connections can reorganize and adapt in response to sudden changes in ambient light, allowing it to process visual information more efficiently. This finding has implications for the development of prosthetic retinal devices and may help researchers better understand the underlying mechanisms of vision.
Researchers at Oregon Health & Science University developed a nomogram to identify men with high-grade prostate cancer and those who can be closely monitored. The chart uses clinical variables such as age, digital rectal exam findings, and PSA density to predict tumor grade, reducing the need for biopsies.
Researchers found that the combination of DN-101 and docetaxel extended overall survival by 7.1 months without increasing toxicity, outperforming docetaxel alone. Additionally, the treatment resulted in a strong PSA response, with 63% of patients experiencing a reduction in prostate-specific antigen.
A new study demonstrates high rates of tumor death in patients receiving a preoperative chemotherapy and radiation regimen, suggesting a promising approach for treating high-grade soft tissue sarcomas. The regimen has been associated with significant but manageable toxicity and modest wound complication rates.
Researchers analyzed tumor DNA from 324 GIST patients and found that those with a KIT exon 11 mutation responded better to Gleevec. The study confirms the need for new drugs for patients whose GIST genotype is less responsive to Gleevec.
The OHSU study found that ThinkFirst significantly improves knowledge of injury prevention among program participants, leading to a decline in traffic-related fatalities and injuries. The program has educated over 250,000 children on injury prevention since its inception in Oregon.
Research shows that vitamin C can help prevent smoking-related lung development problems in unborn babies. The study found that vitamin C dosed during pregnancy may improve lung air flow and reduce adverse outcomes.
A recent OHSU study suggests that ginkgo biloba may improve attention in MS patients with cognitive impairment, with minimal side effects. The study found that patients taking ginkgo performed better on a test measuring attention and executive functions compared to those receiving a placebo.
A study by OHSU scientist David Grandy found a strong correlation between dopamine supersensitivity and high-affinity D2 receptors in individuals with schizophrenia. This discovery could lead to improved treatments for schizophrenics and amphetamine abusers.
A study published in Health Services Research found that patients with head injuries transferred from rural trauma centers to Level I trauma centers in Oregon and Washington had a 10% lower mortality risk. This improvement is attributed to the comprehensive care and training programs available at Level I centers.
Researchers at OHSU have developed a medication that blocks the MC4 receptor to reverse the effects of cachexia, increasing appetite and weight while decreasing metabolic rate. The study demonstrates a potential new treatment for this serious disorder, providing hope for patients affected by AIDS and cancer.
Researchers analyze prosody and communication in autism, finding children with autism understand social-emotional information better with enhanced prosody. They aim to create a sharper understanding of core issues and differences between children with different forms of communication disorders.
Researchers have developed an MRI approach using shutter speed analysis, which provides more accurate information on breast cancer detection. This method distinguishes between malignant and benign tumors, improving diagnosis and treatment outcomes.
A study published in Clinical Cancer Research shows that Herstatin blocks the growth of brain tumors by inhibiting signaling inside tumor cells. The treatment has shown promise as a viable alternative to traditional brain tumor treatment methods, particularly for glioblastoma, the most deadly form of brain cancer.
A new study by OHSU researchers suggests that two types of iron nanoparticles can effectively degrade carbon tetrachloride, a toxic contaminant in groundwater. The study found that one type of nanoparticle quickly and effectively broke down carbon tetrachloride into harmless products.
OHSU researcher recommends increasing public access to FDA's clinical trials registry and results database. This would provide a comprehensive view of drug efficacy and safety, benefiting healthcare providers, researchers, and the public. The FDA could make its reviews more user-friendly with minimal staffing increases.
Scientists at the Vollum Institute have developed a technique to understand gene regulation, uncovering 6,300 regulatory regions that map to distinct sites on the genome. This breakthrough may help unravel the genomic instruction set governing gene expression in different cell types.
Researchers at VGTI found that aging mice have greater T cell clonal expansions, which are less effective in fighting disease. This leads to a reduced ability to fight off pathogens, making the immune system less diverse and capable.
A four-year project aims to understand how androgen influences the skeleton, with potential implications for stress fracture prevention and treating osteoporosis. The study examines the effects of androgen therapy on bone health in both men and women.
The Oregon Health & Science University will focus on tuberculosis research, using cells from TB patients with successful immune responses to create vaccines. The goal is to provide protection to others while over 2 million people die worldwide each year of TB.
A study found that word retention drops sharply after two minutes among men undergoing testosterone deprivation therapy, despite initial encoding being similar to healthy men. The lack of testosterone affects the function of the hippocampus, a curved ridge in the brain controlling learning and memory.