Researchers tracked infant monkeys separated from mothers at different stages of infancy to find varying behavioral impacts on social skills and adult behaviors. Timing of separation significantly influenced the development of social comfort, dominance, and playfulness in adulthood.
Researchers have identified a key gene called TTF-1 that delays female puberty. The study found that mice lacking this gene exhibited delayed puberty and reproductive issues, suggesting a potential link to the nation's rising obesity rates.
Researchers at OHSU have determined the structural basis underlying a crucial mechanism that allows gram-positive bacteria to adapt to available energy sources. This finding could lead to the development of new antibiotics that disrupt this mechanism, making bacteria more susceptible to counter-attacks by the human body.
A review of herbal and nutritional supplements found eight products associated with clinically significant ocular side effects, including ginkgo biloba, Echinacea purpurea, chamomile, licorice, canthaxanthine, Datura, niacin, and vitamin A. The side effects range from dry eye to retinal hemorrhages and transient visual loss.
A pilot study dubbed STAND UP! aims to monitor food intake and physical activity in schools to reduce risk factors for type 2 diabetes among sixth-graders. The program's results will be used to improve the intervention before expanding it to middle schools nationwide.
The POLST program has been widely adopted in Oregon nursing homes, with most residents receiving aggressive treatment despite 'do not resuscitate' orders. EMTs also report increased clarity on treatment options after using the form.
Researchers at OHSU-VAMC found that estrogen increases regulatory cells and FoxP3 protein, key for fighting autoimmune diseases like MS. The study provides a new mechanism for understanding how pregnancy reduces MS symptoms.
The Oregon Health & Science University has launched a new Bioanalytical Shared Resource (BSR) lab, supported by the $500 million Oregon Opportunity initiative. The BSR provides advanced analytical services for drugs and molecules, enabling researchers to quickly move from laboratory to patient testing.
Researchers at OHSU have discovered a possible method for early detection and prevention of premature birth by identifying biomarkers associated with intra-amniotic infections in both animal and human studies. The breakthrough technology has the potential to save young lives and may lead to significant health benefits.
Researchers have discovered that N-acetylcysteine (NAC) can prevent cisplatin-induced ototoxicity, a type of progressive and irreversible hearing loss in patients undergoing chemotherapy for head and neck cancer. The study found that NAC was most effective when given 15 minutes before chemotherapy.
A study published in the Journal of Gerontology: Medical Sciences confirms that dementia is often misdiagnosed or left undiagnosed in clinical settings. Researchers found that nearly 60% of patients with mild cognitive impairment and over 70% of those with moderate-to-severe impairment experienced adverse events, yet only a small perce...
Researchers at Vollum Institute found that dopamine molecules are released from midbrain nerve cells in a targeted manner, traveling to receptors within milliseconds. The study's findings suggest new therapeutic targets for Parkinson's disease and substance abuse.
OHSU researchers are studying vaccination methods for seniors and children, with a focus on developing protection against infectious diseases. The study aims to understand immune system changes that occur with aging and develop methods to manipulate the system for better protection.
Researchers identified Mpdz gene as key player in physical dependence and withdrawal from sedative-hypnotic drugs. The study found that higher expression of Mpdz correlated with reduced susceptibility to drug withdrawal seizures.
Researchers at OHSU's Oregon Stem Cell Center have discovered that macrophages, not stem cells, can fuse with diseased liver cells to correct genetic liver disease in mice. This finding suggests that transplantation of macrophages alone may be a more targeted and effective treatment approach than traditional stem cell therapy.
Researchers at OHSU found LGD5552 prevented rats from developing a MS-like disease, showing reduced side effects compared to current treatments. The compound's tissue-selective properties may offer a novel avenue for prolonged use in humans.
A randomized controlled trial found that yoga is as effective as aerobic exercise in improving measures of fatigue in multiple sclerosis patients. The study also showed improvements in physical health and quality of life among participants.
A new study shows that estrogen skin patches can counteract high cholesterol associated with hormone therapy for prostate cancer. The patches decreased overall cholesterol levels by 10 percent and increased good cholesterol (HDL), while also improving lipid profiles.
Researchers found that clinicians missed about half of symptoms reported by patients, and patients also missed about half of the symptoms recorded by physicians. The study suggests that new patient reporting tools should be developed for use in chemotherapy clinical trials to improve accuracy.
A new study finds that estrogen therapy significantly improves verbal memory performance in men with advanced prostate cancer, while hormone deprivation impairs it. Estrogen also reduces depression and confusion in these patients.
A new study suggests that men who take statins, common cholesterol-lowering drugs, have a significantly reduced risk of prostate cancer. Statin use was associated with a 58% lower risk of prostate cancer and a 55% lower risk of elevated PSA levels.
Researchers found four distinct risk groups and seven independent risk factors for prostate cancer detection, including abnormal exam findings, age, family history, and PSA density. Men with high-risk features remain at risk despite multiple negative biopsies, emphasizing the need for vigilant follow-up.
Researchers have discovered a new clinical treatment, SU11248, that overcomes resistance to Gleevec in patients with gastrointestinal stromal tumors (GIST). The drug has shown striking clinical benefits, stabilizing the disease in 65% of patients and inducing partial responses in 13%.
A new study found that hormone deprivation therapy is less effective for younger men with higher grade tumors, suggesting it needs further investigation as an alternative treatment for localized prostate cancer. The study also revealed a higher risk of bone fractures in men on hormone therapy due to osteoporosis.
A study found that 18% of early-onset Parkinson's disease patients have a single parkin gene mutation, raising questions about the clinical implications of this finding. The study's results challenge the long-held assumption that two mutations are required to develop Parkinson's disease.
A recent OHSU study found that Parkinson's caregivers experience dramatic declines in physical and mental health over 10 years, with increased strain and depression. The study identified predictors of caregiver risk, highlighting the importance of supporting family caregivers to improve patient outcomes.
Researchers have developed an iron oxide nanoparticle that can outline brain tumors and other lesions for up to five days under MRI, providing a new imaging marker. This contrast agent has the potential to assist in image-guided brain surgery and improve diagnosis of neurological disorders.
Researchers at OHSU are developing a new class of viral vaccine vectors, based on cytomegalovirus (CMV), to serve as the basis of an HIV vaccine. The approach aims to generate a superior and more durable anti-HIV immune response that can persist over subsequent years.
Researchers discovered a new compound, T1 amine, that rapidly induces hypothermia, slows heart rate, and drops blood pressure in mice. This effect may provide a valuable tool to manage patients with acute hypermetabolic states, including hyperthyroidism.
A study by OHSU found that methylphenidate, Ritalin, increases the effects of levodopa on dopamine levels, improving symptoms such as tapping and walking speeds. In contrast, paroxetine had no effect on physical symptoms but increased walking speed in Parkinson's patients.
A study by OHSU researchers has identified genetic defects in five genes as responsible for a minority of unexplained sudden cardiac deaths. The findings provide hope that gene defects may also have caused remaining deaths and bring closer to predicting who is vulnerable to sudden death.
Researchers found that the rate of total brain volume loss can predict which mildly cognitively impaired individuals are at high risk of developing dementia. Combining this with hippocampus volume measurements provides a strong model for predicting cognitive outcomes.
A new grant from NIH will help create a diagnostic tool for childhood apraxia of speech, a neurologically based speech motor disorder affecting about one-tenth of 1 percent of US children. The tool will automate existing measurements and develop new ones to reduce human variability in diagnosis.
Researchers identified a series of genes related to mitochondrial metabolism in brain cells that were more active in mice with Alzheimer's disease. These genes are thought to provide new insights into the disease's early cellular changes and may lead to the development of novel interventions.
The Proteomics Shared Resource at OHSU enables faster and more precise protein identification, processing up to 180 samples in six hours. The lab's advanced technology, including a robotic arm and mass spectrometer, helps researchers analyze proteins and identify their composition.
A study examining health care benefits and disadvantages when physicians treat themselves found that even doctors who disapprove of self-doctoring may do so due to lack of thought. Benefits include convenience and control, but also risks such as delayed care and ignoring medical instincts.
Researchers at OHSU discovered a possible connection between infant hormone exposure and obesity risk. The study found that early-life leptin surge affects brain development, particularly in the arcuate nucleus of the hypothalamus.
The Oregon Stem Cell Center aims to develop therapies using adult stem cells for human diseases through a rapid approach from basic research to animal trials and human studies. The center's focus will be on the liver and pancreas, building on OHSU's existing expertise in cell therapy.
OHSU scientists successfully transplanted ovarian tissue into monkeys, allowing the return of hormone cycles and egg production. The procedure may lead to new methods for preserving fertility in young cancer survivors.
Researchers at OHSU will explore the use of evolutionary computing to analyze images and classify abnormalities in the prostate. The goal is to create a more accurate and less invasive method for detecting prostate cancer.
Researchers found an irregularly shaped cluster of nerve cells in the hypothalamus of the sheep brain associated with female mate preference. The study provides clues to the processes involved in development and regulation of heterosexual and homosexual behavior.
Patients with massive skin cancers can now experience significant improvement in function, appearance, and quality of life after undergoing free tissue transfer surgery. This innovative technique, pioneered by OHSU researchers, has revolutionized the care of patients with this condition.
A recent study published in the Pediatrics journal found that the United States may have a surplus of pediatricians for the next 20 years. Despite fears of a shortage, researchers used a novel approach to projecting the work force and found that the experience in pediatrics differs greatly from other primary care specialties.
Researchers at OGI School of Science & Technology have successfully grown silicon nanowires in a precise location and direction using electrical fields. This breakthrough technology has the potential to revolutionize the microelectronic industry by enabling the fabrication of high-performance electronic devices.
ATLAS reduces anabolic steroid use among male adolescent athletes in schools nationwide. ATHENA aims to reduce eating disorders and drug use among young female sport teams. Both programs have been designated national models and are easy to implement.
Researchers at OHSU are conducting a study to investigate whether early treatment with the eczema drug Elidel can prevent asthma in children with a family history of allergic disease. The study aims to enroll 200 infants with eczema and assess whether early intervention reduces the incidence of asthma.
A research team led by OHSU scientists is studying metal homeostasis and its disruption in human cells, focusing on copper and iron concentrations. The project aims to understand the regulation of metals in cells and their impact on disease progression.
A study published in Science has identified the Alox15 gene as a potential human therapeutic target for osteoporosis risk. The gene's over-activity leads to reduced bone density and increased risk of osteoporosis, but inhibitors of the gene's enzyme can improve bone mass and strength.
Researchers at OHSU discovered a novel compound called STX that activates a rapid signaling pathway in nerve cells, providing an alternative to estrogen replacement therapy. The new compound shows promise in alleviating menopause symptoms and may be more effective than existing treatments.
A new study found that three months is too soon to judge a patient's response to Gleevec, a common CML treatment. Researchers discovered that achieving a complete cytogenetic response had a significant impact on long-term outcome and survival rates.