Two studies by OHSU scientists found that elderly men taking SSRIs have lower bone mineral density, while elderly women taking the drugs experience a higher rate of yearly bone loss. The researchers caution against drawing conclusions about causality but suggest screening and extra protection may be needed.
Researchers found that female teen steroid users were more likely to engage in other high-risk behaviors, including substance abuse, sexual activity before age 13, and mental health issues. The study suggests that anabolic steroid use is a marker for high-risk girls who need targeted interventions.
A new study developed a simple marker that allows urologists to identify men at risk for high-grade prostate cancer, even after a negative initial biopsy. This finding could reduce overtreatment and unnecessary biopsies while improving patient outcomes.
The OHSU Cancer Institute study found that sipuleucel-T vaccine slowed the rate of rise of serum PSA in exploratory analyses, but did not significantly delay cancer progression. The treatment also showed a favorable safety profile with common side effects like fatigue and chills.
Researchers have identified C-reactive protein (CRP) as a strong indicator of survival for men with advanced prostate cancer. The study found that higher levels of CRP are associated with shorter survival and lower response to chemotherapy.
A recent study published in Nicotine & Tobacco Research found that many smokers are receptive to using their own spiritual resources when attempting to quit. The research, conducted by Oregon Health & Science University, discovered that women were more likely to report a spiritual practice or belief compared to men, and smokers who smo...
A study published in PNAS reveals that deactivating the protein cyclophilin D can protect nerve fibers in a mouse model of multiple sclerosis. Researchers hope to develop drugs that target this protein to treat the progressive form of MS, which affects half of all patients.
Researchers at OHSU have identified a G protein-coupled receptor called TAAR1 as a key player in the brain's response to methamphetamine. The discovery offers new hope for developing therapies to reverse meth's adverse health effects and reduce addiction, by targeting this newly found receptor.
Researchers found that patients who received Gleevec after surgery were significantly less likely to have cancer recurrence compared to those who didn't receive it. The study showed a 97% survival rate for patients on Gleevec, with only mild side effects reported.
A $2.5 million grant will expand Care Management Plus, a technology-intensive primary care model that reduces hospitalizations and improves health outcomes for older adults with chronic illnesses. The program has shown promising results in initial studies, including better blood sugar control and reduced mortality rates.
Researchers at OHSU discovered a gene cluster in a marine bacterium that produces a bioactive molecule with anti-cancer properties, including activity against pancreatic and renal cancer. The team aims to engineer the production of bryostatins, promising compounds for cancer treatment.
The study reveals that leptin resistance causes the breakdown of the brain's appetite regulation system. Researchers found that a key gene called SOCS-3 plays a critical role in this process and may be targeted to aid in weight loss. The research provides new insights into obesity and potential therapeutic strategies.
OHSU research reveals calcium ions modulate auditory nerve cells' recharging after bursting signals. High levels of calcium can be toxic, but regulating sodium pump activity conserves energy and prevents cell death.
A VA researcher has developed a method to identify men at risk for high-grade prostate cancer, reducing the need for unnecessary biopsies. The study found that a high PSA adjusted for prostate size and Gleason scores above 7 indicate a higher risk of life-threatening prostate cancer.
The Oregon Health & Science University (OHSU) has received a $1 million grant from Intel to develop and test new technologies for monitoring cognitive function and mobility in older adults. The project aims to create innovative devices that can help prevent the loss of independence among seniors.
A five-year study published in the New England Journal of Medicine shows that Gleevec has a nearly 90% overall survival rate for patients with CML, significantly improving patient outcomes compared to previous estimates of five years.
A study by OHSU researchers has found that using a 'skinny scope' in an office setting is as accurate, less expensive and less risky than the gold standard -- sedated upper endoscopy. The procedure was well-tolerated and more immediately informative for patients.
Researchers at OHSU School of Dentistry identify interaction between two proteins in nerve cells carrying pain information from the head and neck to the brain. This finding may help develop therapies for migraines and other craniofacial pain conditions.
A study by Oregon Health & Science University researchers found that stress triggers a relapse of methamphetamine abuse in mice, validating human studies. The researchers used a compound to mimic metabolic changes during stress and found it was effective in reinstating drug-seeking behavior.
A study by Oregon Health & Science University found that women on hormone therapy are more sensitive to negative events and can process emotions similarly to younger women. However, hormone therapy does not improve memory for negative events, suggesting that the brain's arousal system is modified with age.
A study by OHSU eye doctor William Mathers found a higher risk of suffering vision loss from contact lenses compared to laser vision correction surgery. This contradicts traditional assumptions that contact lenses are safer than laser surgery, highlighting the importance of proper care and cleaning.
OHSU researchers show that CD8+ T-cells can literally eat virus-infected cells, providing insight into the human immune system and potential new way to gauge vaccine effectiveness. The discovery may help determine vaccine efficacy by measuring T-cell response to and consumption of a candidate vaccine.
The Methamphetamine Abuse Research Center (MARC) will investigate the genetic basis of addiction and develop targeted therapies. The center aims to create educational programs for school-age children and provide clinical treatments for rural patients affected by meth use.
Research from Oregon Health & Science University reveals that children born to overeating mothers are at risk for liver and pancreas damage, contributing to early-onset obesity and diabetes. Brain changes in the hypothalamus also occur, predisposing them to weight problems.
Researchers at OHSU discovered that the over-expression of Smad7 causes epidermal stem cells to shift from producing hair follicles to sebaceous glands in aged skin. This finding provides a potential therapeutic approach for treating hair loss, oily skin, and certain cancers.
Researchers developed an unobtrusive activity assessment system to track daily activity patterns of elderly individuals, detecting subtle changes that may indicate early signs of dementia. The study found significant differences in walking times and variability between healthy elders and those with mild cognitive impairment.
A computer card game called FreeCell has been adapted to detect early signs of dementia by assessing players' planning and efficiency. Researchers found that the game can distinguish between cognitively healthy elders and those with mild cognitive impairment, suggesting potential for early treatment strategies.
Using mass spectrometry, researchers identified three activating mutations of the tyrosine kinase JAK3 in AML cells, leading to a potential new treatment target. The study's fast and affordable approach could help analyze cancer cells for mutations in just weeks.
Researchers at OHSU are testing a new device called the U-plate to aid in repairing broken ribs. The study aims to identify individuals who benefit most from surgical repair versus nonsurgical therapy.
A recent study discovered the PLA2G6 gene, linked to neuroaxonal dystrophies, may shed light on nerve cell degeneration in Parkinson's and Alzheimer's. The discovery has implications for understanding brain iron accumulation and potential treatments.
OHSU researchers found that interleukin-15 (IL-15) restores tissue CD4+ T cells when given with antiretroviral drugs in SIV-infected monkeys. This discovery offers hope for effective therapies to boost HIV patients' immune systems.
Researchers at OHSU Cancer Institute analyzed data from 5,587 colon cancer subjects to determine five-year conditional survival rates. The study found that as time elapsed since diagnosis, most subjects experienced an improvement in their subsequent five-year conditional survival following the initial disease-free period.
A study by OHSU Cancer Institute physicians validates the reclassification of breast cancer stages, improving disease-free survival rates for patients previously diagnosed with Stage II and III. The revised classification system has been shown to increase 10-year survival rates for these patients, from 30-36%.
Researchers found a new predictor of disease for overweight men using PSA density calculation, helping to accurately diagnose prostate cancer in this high-risk group. The study analyzed 647 men with elevated PSA levels and identified a lower PSAD calculation needed for accurate diagnosis, beating prior predictors.
A five-year study confirms Gleevec's effectiveness in treating Gastrointestinal Stromal Tumor (GIST), with 84% of participants showing clinical improvement. The treatment has durable benefits, with two patients experiencing complete remission, despite some developing resistance.
Researchers found that when treatment was restarted after a chemotherapy holiday, roughly three-quarters of study subjects responded again or experienced stabilized PSA levels. The median duration of the first chemotherapy holiday was 16 weeks, providing a clinically meaningful break for most patients.
A five-year update from the IRIS Study Group shows excellent results for people with Chronic Myelogenous Leukemia (CML) treated with Gleevec, a targeted cancer therapy. Overall survival rates reach 89% at five years, with fewer than 1% of patients progressing to accelerated or blast crisis phases.
A study led by Michael C. Heinrich, M.D., found that patients with gastrointestinal stromal tumor (GIST) responded differently to Sunitinib depending on their tumor's genetic abnormality. The research highlights the importance of personalized medicine in cancer treatment.
Researchers found that men with the same hemoglobin levels before treatment experienced significantly different overall and progression-free survival depending on whether they were black or white. Anemic blacks fare worse than anemic whites, while blacks with high baseline hemoglobin fare better.
Researchers found 322 genes in the adrenal gland with rhythmic functions, separate from the master body clock. This discovery may impact therapies for diseases and improve treatment outcomes.
A groundbreaking study by OHSU researcher has created the world's first animal model that mimics human head and neck cancer at both pathological and molecular levels. This model enables researchers to screen for novel therapeutic approaches, potentially leading to improved treatment options for this often deadly disease.
Scientists at OHSU School of Medicine found that bone marrow-derived cells fuse with intestinal stem cells in both normal and diseased tissue, promoting tumor growth and cancer development. This discovery has implications for understanding the balance between rapid regeneration and cancer risk.
OHSU researchers found that beta amyloid can be found both inside and outside of brain cell mitochondria in Alzheimer's mice, suggesting a key role in the disease. Mitochondrial oxidative damage may contribute to the progression of Alzheimer's by producing hydrogen peroxide.
A study by Oregon Health & Science University reveals that low-dose melatonin taken in the afternoon can help most people with winter depression whose bodily rhythms are out of sync. The treatment was found to be effective for those who were naturally 'night owls', while morning larks responded better to taking melatonin in the morning.
A study at Oregon Health & Science University found that stroke patients who received electrical stimulation therapy showed significant improvement in hand mobility and strength compared to those receiving rehabilitation alone. The therapy, which induces neural plasticity, helps patients regain lost functions.
Researchers are testing LY450139, a gamma secretase inhibitor, to prevent amyloid plaque build-up and stop Alzheimer's disease progression. The study aims to determine the safety, efficacy, and optimal dosage of the drug in 45 participants.
Researchers found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density in men with advanced prostate cancer. The study supports guidelines for monitoring bone density and initiating treatment to prevent fractures.
A new study found that androgen deprivation therapy is ineffective in preventing the spread of localized prostate cancer, despite its increasing use among men with non-spreading disease. Researchers suggest that men may endure significant side effects for uncertain benefits.
Scientists discovered that mice lacking the DNA repair enzyme NEIL1 develop severe obesity and metabolic syndrome, with enlarged livers and insulin resistance. The study suggests an important role for NEIL1 in preventing metabolic disorders.
Scientists studied mice lacking POMC gene to understand obesity and fat distribution. The research shows that cortisol levels are not the sole factor, but rather part of a chain of hormonal signals associated with obesity. Glucocorticoids were found to accelerate weight gain and diabetes in treated mice.