Researchers at OHSU Cancer Institute have determined that the prostate moves up and down by up to 2 millimeters during the breathing cycle, affecting radiation treatment accuracy. This new information will help doctors determine suitable margins for treatment, reducing side effects and improving patient outcomes.
Researchers at OHSU discovered males from a strain of mice called MRL/MpJ have the innate ability to repair their own knee cartilage. Cartilage injuries heal poorly in humans, leading to osteoarthritis, which affects one quarter of the adult population by 2020.
Researchers at OHSU have devised an ultrasound imaging technique that picks up subtle early evidence of PAD, which current conventional tests miss. The test could lead to early treatments that head off serious complications like gangrene and death.
Researchers at OHSU Cancer Institute found that Ipilimumab effectively stimulates the immune system to fight prostate cancer, particularly in patients with resistant tumors. The drug works by blocking CTLA-4, releasing the safety brake and allowing the immune response to have a stronger anti-tumor effect.
Researchers at OHSU Cancer Institute found that Sagopilone, a novel chemo drug, significantly reduced PSA levels and showed positive results in some cases of advanced prostate cancer. The study involved men with androgen-independent prostate cancer that has metastasized.
Researchers found DNA abnormalities in the KIT gene linked to highly malignant skin cancers, offering hope for effective treatments. The study could lead to targeted therapies within 18 months.
A study by OHSU Cancer Institute researchers found that nearly 67% of stomach cancer patients are not getting the best therapy, despite compelling clinical data available since 2001. The study also showed a five-month survival advantage for patients who received chemotherapy and radiation therapy.
Researchers at OHSU have developed new antibodies that can recognize pancreatic cancer and gastrointestinal cancers. These antibodies show promise in early detection and treatment of pancreatic cancer, which is the fourth-leading cause of cancer death in the US.
Researchers pinpointed the protein FANCD2 as slowed production leads to genetic changes triggering lung cancer. Low levels of FANCD2 cause DNA damage and faulty cells committing suicide.
Dr. Jerald Block's research on the 1999 Columbine high school shootings suggests that virtual worlds played a significant role in the tragedy, blurring boundaries between reality and fantasy. The presentation will also discuss other school shootings, including Red Lake and Virginia Tech.
A study by OHSU Cancer Institute researcher Tomasz Beer found that a protein called C-reactive protein can predict the survival rate of men with advanced prostate cancer. The discovery could lead to a simple blood test to help patients and doctors understand the disease's progression.
A report by Oregon Health & Science University expert William Hersh predicts a 40% increase in health IT workforce needed to control healthcare costs and reduce medical errors. The US would need 40,784 additional full-time equivalents (FTE) of IT staff to advance to higher levels of HIT adoption.
OHSU Cancer Institute researchers discovered the gene ASPP2 is necessary in eliminating cancer cells. This protein activates pathways that tell cancer cells to die, protecting them from one of the steps leading to cancer. The study may lead to better therapies and cancer care for patients.
Researchers found that a tumor protein present in aggressive breast cancers correlates with poor prognosis and growth/spread of disease. GRB-7 protein is related to HER-2/Neu gene, influencing treatment response and potentially informing clinical predictions and new therapies.
OHSU Cancer Institute researchers found that SGX393 is effective against Gleevec-resistant chronic myeloid leukemia (CML) by inhibiting T315I mutant and most, but not all, other Gleevec-resistant mutants. The combination of SGX393 with Sprycel or Tasigna completely suppressed resistance in a pre-clinical study.
Researchers at OHSU and Washington University have identified the mechanism of a bioengineered enzyme that functions efficiently as a potent clot busting agent, retaining minimal power to cause clot building. The breakthrough could lead to a safe alternative for treating heart attacks and strokes with a $20 billion market potential.
The survey found that no state is providing all of the recommended care to the majority of their children with special health care needs. State-by-state comparisons show vast differences in the quality of care, with some states performing well in specific areas but failing overall.
A new study using neurophysiology technology will track pelvic floor damage in women before, during, and after pregnancy. The goal is to determine if vaginal birth affects pelvic floor strength and coordination, or if other factors like pregnancy itself play a role.
Researchers found a biomarker that identifies men with a five-fold increased risk of prostate cancer recurrence if their tumors show silencing of the CDH13 gene. The study, which examined DNA methylation changes in 151 research subjects, suggests a potential tool to improve prediction accuracy and inform clinical practice.
A study found that selective publication in antidepressant trials significantly overstates their effectiveness, with nearly all positive studies being published and most negative ones not. However, when combining all studies using meta-analysis, each drug was superior to a placebo, but less effective than reported.
Researchers found that 77% of methadone users with low levels had no significant cardiac abnormalities, while 60% of non-methadone users had identifiable evidence of cardiac disease. The study suggests a link between methadone and sudden cardiac death, potentially necessitating additional safeguards before therapy.
Researchers at OHSU Neurological Sciences Institute have discovered the brain's wiring system that determines when to perform shivering as a defense against cold. The study reveals that this process involves parallel but distinct sensory pathways for conscious and subconscious cold detection.
Researchers at Oregon Health & Science University have discovered a way to jumpstart the production of new naïve T-cells, which are vital for fighting infections. This approach could provide long-term protection against diseases such as the flu for aging Americans.
Researchers found that a specific hormone, TNF-alpha, drives the JAK2 enzyme to cause an often deadly red blood cell cancer called polycythemia vera. The study showed mice with normal TNF-alpha production developed severe bone marrow fibrosis within weeks.
Researchers at Oregon Health & Science University Cancer Institute have discovered a new drug candidate, SGX393, effective against highly resistant mutations in CML. Combining SGX393 with existing drugs Sprycel and Tasigna suppresses resistant growth, raising the possibility of 'cocktail' therapies to prevent drug resistance.
A new test, called RAPID, has been developed to identify proteins that drive cancer growth in acute myeloid leukemia. This breakthrough technology enables researchers to quickly compile a database of mutant genes and potentially match targeted drugs with patients.
Abnormal stem cells with deletions of chromosome 7 or duplications of chromosome 8 have been found in some CML patients, suggesting new targets for therapy. The discovery opens a new window into understanding the roots of chronic myeloid leukemia.
Researchers announced new data showing Gleevec improves outcomes for children with Ph+ ALL, reversing the poor prognosis, and prevents disease progression in adults with CML. Continuous treatment with Gleevec has shown a declining rate of relapse over time, with no patients progressing to advanced phase in CML.
A recent study by Oregon Health & Science University finds that low-income families face three major barriers to healthcare: lack of insurance coverage, poor access to services, and unaffordable costs. Families with public health insurance often reported feeling unwelcome and having difficulty accessing care due to long travel distances.
Researchers at Oregon Health & Science University have discovered that a cough suppressant, dextromethorphan, reduces dyskinesias in rats. Additionally, a drug tested as a schizophrenia therapy, BMY-14802, has been shown to effectively curb the involuntary movements more so than dextromethorphan.
Researchers found that antibody responses to viruses like measles and mumps remain protective for several decades, even for life. This means people may not need booster shots as frequently as previously thought, potentially reducing unnecessary vaccinations.
A study found that prazosin, an alpha-1 receptor antagonist, can block the increase of steroid hormones in the brain, which are associated with brain damage and cognitive impairment. This may provide a neuroprotective effect against post-traumatic stress disorder, Alzheimer's disease, depression, and schizophrenia.
A new study by OHSU researchers has found that children carrying the apoE4 gene already exhibit reduced cognitive function. They used a virtual reality test to assess spatial learning and memory in 7- to 10-year-olds with and without the gene.
Researchers at OHSU have identified the WNK kinase protein complex as a master switch that regulates blood pressure. The study reveals how this complex modulates salt and potassium balance in the kidney, raising or lowering blood pressure depending on its functioning.
A Portland researcher argues that overly restrictive intellectual property laws slow the availability of existing medications as life-saving treatments. Berger suggests that 'use' patents involving new uses for old medications need to be reformed to encourage pharmaceutical companies to develop these drugs.
Researchers at Oregon Health & Science University have found that highly targeted radiation therapy can prevent long-term rectal damage in prostate cancer patients. The combination of intensity-modulated radiation and seed marker-based image-guided radiation therapies resulted in nearly 98% of participants having no rectal damage.
Researchers at Oregon Health & Science University found that positioning pelvic cancer patients on their stomachs rather than their backs improves the delivery of radiation therapy, reducing toxicity and improving precision. This method allows for more accurate targeting of tumors while sparing healthy tissues.
OHSU researchers found that combining surgery and radiation therapy increases early survival rates in patients with locoregional extrahepatic cholangiocarcinoma. The study analyzed 2,591 cases of bile duct cancer diagnosed between 1973 and 1998.
A new study published in Journal of Adolescent Health found that random drug and alcohol testing among high school athletes did not reduce past month or year use. In fact, students at schools with regular testing reported feeling less athletically competent and believed less in the benefits of drug testing.
A recent study published by Oregon Health & Science University discovered a strong correlation between the size and shape of a woman's hips and her daughter's risk of breast cancer. Women with wider, rounder hips were found to be more than three times as likely to have daughters with breast cancer.
The new guideline recommends clinicians rely on evidence-based therapies, limit X-rays, and consider non-pharmacologic options like exercise therapy, chiropractic care, and massage. The guidelines aim to reduce unnecessary radiation exposure and improve patient outcomes for low-back pain treatment.
The Oregon Health & Science University School of Medicine is part of a national team researching ways to preserve or restore fertility in women with cancer. Researchers are studying methods to freeze and store ovary tissue and grow follicles in culture, aiming to help young cancer patients have children.
Researchers at OHSU demonstrate a new technique using contrast-enhanced ultrasound and targeted microbubbles to detect inflammatory processes leading to atherosclerosis. This could enable early detection and prevention of coronary heart disease and stroke, two of the nation's most lethal diseases.
Stephen A. Back, a pediatric neurology expert at Doernbecher Children's Hospital, has received the prestigious Javits Neuroscience Investigator Award for his research on white matter brain injury in premature infants. His work aims to develop therapies that can reverse brain damage and slow cognitive decline in aging adults.
Researchers at OHSU have created a technique to produce human liver cells in mice, which can be used to test how pharmaceuticals are metabolized. This innovation has the potential to change the way drugs are tested and could lead to breakthroughs in treating diseases such as hepatitis C and malaria.
A recent survey of 176 hospitals by OHSU researchers reveals common adverse unintended consequences of adopting CPOE systems, including workflow shifts. Despite these challenges, the study finds that such systems can still reduce medical errors and increase cost efficiency.
A recent study by OHSU and VAMC researchers found that female mice are more susceptible to brain cell death after alcohol withdrawal than male mice. The study suggests that women may be more vulnerable to the neurotoxic consequences of alcohol consumption, which could contribute to debilitating cognitive dysfunction and motor deficits ...
A $2 million federal grant will help the OHSU Cardiac Arrhythmia Center pinpoint those at greatest risk of sudden cardiac arrest due to left ventricular hypertrophy. The study aims to improve identification and prediction methods, potentially averting disaster before it happens.
Five Oregon Health & Science University faculty members have been honored with the 2007 OHSU Faculty Senate Awards. The winners include Michael Danilchik for groundbreaking research on early morphogenesis, William Hersh for developing a respected academic program in biomedical informatics, Carol Christlieb for exceptional service to nu...
Researchers have developed a new tool that uses patient characteristics such as age, gender, race, and tumor site to estimate conditional survival. This will enable personalized predictions of prognosis for head and neck cancer patients.