Researchers at OHSU Doernbecher Children's Hospital report that low blood flow to the premature brain does not cause irreversible loss of brain cells, but rather disrupts their ability to mature. This discovery opens up new avenues for potential therapies to promote regeneration and repair of the premature brain.
A study by Oregon Health & Science University found significant health care shortcomings among autistic adults, including lower rates of preventive services and higher emergency department use. The research highlighted the need for better primary care services for this population.
Researchers at OHSU School of Dentistry discovered a direct role of BDNF in regulating blood pressure, which may help prevent or treat high blood pressure. The study found that BDNF levels increase dramatically in nerve cells during hypertension.
Researchers at OHSU have discovered that blocking a specific enzyme can promote myelin-forming cell differentiation and remyelination in MS patients, potentially leading to improved nerve cell function. The discovery could be a 'life-changer' for millions with MS and other demyelinating diseases.
Researchers at OHSU have successfully demonstrated a new gene therapy method that can replace mutated mitochondrial DNA with healthy copies in human cells. This breakthrough has the potential to prevent devastating diseases passed from mother to infant.
Researchers at Oregon Health & Science University have demonstrated that banked human neural stem cells can survive and make functional myelin in mice with severe symptoms of myelin loss. The study provides proof of principle for treating a wide variety of disorders that affect myelin, including cerebral palsy and multiple sclerosis.
A recent study found that nearly 20 percent of people who underwent low back fusion surgery developed post-traumatic stress disorder symptoms. The strongest factor in determining whether a patient suffered PTSD symptoms was a pre-surgery psychiatric disturbance, but some patients without such diagnoses also experienced symptoms.
A new study published in Neurology says Gingko biloba does not improve cognitive performance in people with multiple sclerosis. The research followed up on earlier findings that suggested there may be some benefit, but found no cognitive benefits to using the supplement.
Researchers have developed a novel human liver-chimeric mouse model that enables the study of human malaria's lethal forms. The FRGTM KO mouse model will be used to study new drug interventions, parasite attenuation, and innate immune responses to Plasmodium falciparum liver stage infection.
Researchers at OHSU's Vaccine and Gene Therapy Institute studied the mechanism behind protection offered by slightly weakened monkey AIDS virus versions that were too risky for human use. The study reveals that anti-viral T cells in lymphoid tissue are responsible for this protection, which is lost when the virus is further weakened.
Researchers at OHSU School of Dentistry discovered that TDP-43, linked to ALS and other neurodegenerative diseases, activates multiple molecular pathways when genetically manipulated. The study found that the loss of TDP-43 results in widespread gene activation and altered splicing, which can be reversed by restoring TDP-43 expression.
Researchers at Oregon Health & Science University's ONPRC have discovered a new method for creating vaccines that is thought to be safer and more effective than current approaches. The approach uses hydrogen peroxide to inactivate viruses for use as vaccines, showing protective vaccine-induced immunity against three diseases: West Nile...
A new study at Oregon Health & Science University finds that daily Vitamin C supplementation improves pulmonary function tests in newborns born to pregnant smoking women, potentially altering the fetal origins of respiratory disease. The treatment may block some effects of smoking on lung development.
A Phase III clinical trial found lenalidomide treatment decreased the risk of progressive myeloma or death in stem cell transplant patients, with a 63 percent reduction in disease progression risk. The study's results support the use of lenalidomide maintenance therapy after stem cell transplantation to improve patient outcomes.
A recent OHSU study found that multiple sclerosis specialists have seen over 600 patients misdiagnosed with MS, resulting in unnecessary treatment costing $11 million per year. The study highlights the importance of clinical expertise in recognizing and correcting diagnostic errors.
Researchers at OHSU and ONPRC have created a new animal model for attention deficit hyperactivity disorder (ADHD), which displays human-like symptoms in mice. The model uses a mutated form of the SynCAM1 gene, found in glial cells, to mimic the condition.
A recent OHSU study sheds light on the process of passing mitochondrial genes from mother to child, revealing a narrow window of early embryonic development where these genes are transferred. The research challenges existing genetic testing methods, which may not accurately diagnose certain genetic disorders.
Researchers identified unique subgroups among children with ADHD, highlighting individual variability. The study suggests new methods for characterizing individuals and tailoring treatments to address specific deficits and strengths.
A study found that four premarketing trials for second-generation antipsychotics remained unpublished and yielded unflattering results. The researchers suggest that publication bias can blur distinctions between effective and ineffective drugs, potentially obscuring the true efficacy of these medications.
Researchers are studying specially bred mice to better understand flu outbreaks and develop safer vaccines. The mice's varying immune response to the flu helps identify genetic factors influencing disease severity.
Researchers at OHSU discovered glial cells, previously thought to support growth, actually regulate the growth of brainstem neurons responsible for cardiorespiratory control. This finding has profound implications for the prevention and treatment of SIDS, with potential applications in high blood pressure and other disorders.
A new stent procedure has shown remarkably positive results in how patients recover from strokes, with 56% of participants experiencing an excellent neurological outcome compared to 33% with traditional methods. The study also found a significant reduction in mortality rates among those who underwent the new procedure.
Researchers at OHSU have discovered a critical link between brain-derived neurotrophic factor (BDNF) and Rett syndrome, a neurological disorder affecting one in 10,000 baby girls. The study found that mutant neurons in the brainstem fail to produce BDNF, leading to breathing difficulties and other symptoms.
A study by OHSU Knight Cancer Institute suggests that faulty proteins may be key to identifying new treatments for ovarian cancer. Researchers found that 41% of patients with early disease recurrence had abnormal levels of other proteins, opening up a new direction in treatment.
Scientists at OHSU successfully produced the world's first primate chimeric offspring, three baby rhesus macaques, shedding light on stem cell functions and abilities in primates compared to rodents. The research has significant implications for regenerative medicine, particularly in treating diseases like Parkinson's.
The Oregon Health & Science University's Physician Orders for Life Sustaining Treatment (POLST) program has expanded to 34 states and improved end-of-life care outcomes. The program provides a comprehensive set of medical orders based on patient preferences, ensuring accurate treatment with a high degree of accuracy.
A new study by OHSU researcher Peter Steyger sheds light on why certain antibiotics harm the inner ear, providing hope for a potential solution to block their effects and save thousands of lives. The discovery is the result of Steyger's personal experience with antibiotic-induced deafness as a child.
Scientists at Oregon Health & Science University have identified a definitive role for the brain in regulating involuntary muscle mass loss associated with chronic illnesses. The process is driven by a signaling system that controls stress responses and cortisol release.
A new study uses high-field MRI to detect tiny white matter lesions in developing brains, revealing previously undetectable injuries. This breakthrough has the potential to prevent delays in therapy and improve diagnosis and prognosis of white matter injury in preterm infants.
Researchers at Oregon Health & Science University discovered that calcineurin inhibitors spurs the production of a natural protein in the kidney, leading to hypertension. A thiazide diuretic drug blocks this protein, reducing hypertension in mice and showing promise for transplant patients with similar issues.
A new study published in American Journal of Physiology and Endocrinology Metabolism found that mice born to mothers on a high-fat diet before and during pregnancy have higher fat mass and smaller livers. Switching to low-fat diet reduces risk, according to researchers at Oregon Health & Science University.
Researchers at OHSU's ONPRC have developed a new contraceptive that directly targets the key enzymes responsible for releasing an egg from the ovary. This approach aims to prevent pregnancy while minimizing systemic effects and improving effectiveness compared to existing hormonal birth control methods.
Abnormalities in breast cancer stem cells found in some cancers can lead to tumor development and recurrence, according to a recent study published by OHSU Knight Cancer Institute researchers. The study suggests that these mutated cells are resistant to chemotherapy and radiation, allowing the disease to recur.
Researchers at Oregon Health & Science University have identified the orexin system as responsible for inducing lethargy during illness. The study suggests that targeting this system with existing narcolepsy drugs could be an effective way to treat sickness-induced lethargy and improve quality of life for chronically ill patients.
Researchers mapped out the order of DNA changes in advanced skin and ovarian tumors using a statistical approach, finding that key gene TP53 mutations occurred earlier than previously believed. This discovery could help identify personalized therapies for cancer patients by targeting early mutations.
A team of researchers has discovered a naturally occurring disease in monkeys that shares similarities with multiple sclerosis, providing new insights into the cause of the disease. The discovery is associated with a herpes virus and could lead to significant advancements in MS research and treatment.
A new study at Oregon Health & Science University found that immediate IUD insertion after abortion significantly reduces unintended pregnancies compared to delayed insertion. The study also highlighted the challenges of accessing IUDs due to federal policy restrictions.
A new study reveals that a high-fat diet during pregnancy can decrease blood flow from the mother to the placenta and increase the risk of stillbirth. Researchers found this effect regardless of whether the mother was obese or slender, and in monkeys with hyper-insulinemia.
Researchers at OHSU Knight Cancer Institute discovered a gene called Src that plays a key role in kidney cancer growth. This finding could lead to more effective treatments for patients who don't respond to current therapies. The study's authors are now initiating clinical trials to test how these tumors respond to existing FDA-approve...
A comprehensive report found that fewer than half of US children receive comprehensive, quality health care, with significant variations across states. The study highlights the need for improvement in all states, particularly in accessing mental health and specialist care.
Researchers at Oregon Health & Science University have developed a vaccine candidate that programs the immune system to respond swiftly to HIV, with over half of monkeys showing control over virus replication. The vaccine candidate has been shown to maintain control for over a year, outperforming antiretroviral therapy in clearing the ...
Researchers discovered that sirolimus stabilizes lung function and improves quality of life in women with lymphangioleiomyomatosis (LAM), a rare lung disease. OHSU expert Alan Barker co-authored the study, which could also inform cancer treatment.
Researchers at Oregon Health & Science University discovered a new approach to prevent ovarian cancer in high-risk women while maintaining fertility. The treatment involves removing the ovarian surface epithelium layer, which has no known function, without affecting ovary function or overall animal health.
Researchers have identified a promising new approach to treating alveolar rhabdomyosarcoma by targeting the Igf1r and Her2 pathways. This method has shown promise in preventing resistance to current treatments, with significant increases in tumor cell killing when combining inhibitors.
A study funded by a $700,000 grant from the National Trauma Institute aims to improve blood-clot prevention medication dosing for critically ill or obese trauma patients. TEG technology will be used to guide physicians in determining the optimal dose of Lovenox.
Researchers have defined the cell of origin for sarcoma, a type of childhood and adult cancer. The study may lead to targeted therapies that convert cancer cells into normal ones.
New research at OHSU finds that the brain responds differently to fructose and glucose, with fructose inhibiting activity in cortical brain control areas. This study supports animal research and links fructose to obesity, suggesting a potential explanation for the nation's growing obesity epidemic.
A study of rhesus macaque monkeys found that oral contraceptives did not lead to significant weight gain or changes in food intake. In fact, obese monkeys lost weight and reduced body fat due to increased basal metabolic rate.
A recent study published in Psychiatric Services reveals that young women veterans are at significantly higher risk of suicide than civilian women. According to the data, female veterans aged 18-34 are at the highest risk, with nearly triple the rate of suicides compared to their non-veteran counterparts.
Researchers at OHSU are exploring the safety and effectiveness of a non-surgical female sterilization method that uses polidocanol foam to close fallopian tubes, potentially reducing unintended pregnancy rates. The study aims to provide a game-changing family planning strategy for women in low-resource settings.