An analysis of FDA advisory committee meetings found that over 90% of public speakers supported marketing approval for new cancer drugs, with many having financial ties to the companies. However, the study also highlights the importance of considering these ties when evaluating patient testimonies.
A new study found that out-of-hospital births in Oregon were associated with a higher risk of perinatal death, while in-hospital births were linked to increased cesarean deliveries and other obstetric interventions. However, the overall risk for perinatal death was low in all settings.
Scientists uncover network of genes controlling puberty onset, discovering repressors that delay puberty. The study may help develop new treatments for precocious puberty and understand the impact of environmental factors on early puberty onset.
The Beat AML collaboration has identified over 10 cell signaling pathways and mutations that may contribute to disease progression in acute myeloid leukemia. Researchers have also found promising therapeutic approaches, including disrupting the cancer cell microenvironment and targeting key inflammatory pathways.
A new study by Oregon Health & Science University found that regular face-to-face social interactions with family and friends significantly lower the risk of depression, while phone calls and digital communications have less impact. Study participants who met up frequently had the lowest level of depressive symptoms.
A national survey of EMS providers identified airway management skills and personal anxiety as key factors contributing to pediatric safety events in out-of-hospital care. The study supports the American Academy of Pediatrics' recommendation for pediatric physician involvement in EMS training and policy development.
Researchers at Oregon Health & Science University found that aminoglycoside antibiotics increase susceptibility to hearing impairment due to inflammation from bacterial infections. The study suggests that targeted alternatives are needed to treat life-threatening infections without sacrificing patients' ability to hear.
Researchers found that breast cancer survivors who used liquid lidocaine on the vulvar vestibule experienced reduced pain and improved sexual function. The study's results suggest that this non-invasive treatment could alleviate physical and emotional pain associated with sex, making it more enjoyable for both individuals.
A new treatment method using magnetic pulses has shown promise in reducing tinnitus symptoms for more than half of study participants. The treatment, known as transcranial magnetic stimulation, targets the auditory cortex in the brain and has been approved only for depression treatment.
Researchers at OHSU develop breakthrough technique to replace diseased tissue in patients with mitochondrial disease, paving the way for regenerative medicine treatments. The study uses mitochondrial replacement to create healthy mitochondria from patient skin cells, opening doors to a world of cure options.
Researchers discovered that chromosomal abnormalities in human embryos can be predicted within the first 30 hours of development. This finding could improve IVF success rates, which have hovered around 30-35 percent worldwide. By analyzing a single cell level, they identified 12 genes that are activated prior to the first cell division.
A recent study has provided a more complete picture of how proteins move, laying the foundation for understanding molecular causes of human disease and developing potent drug treatments.
The study reveals how addictive drugs interfere with dopamine signaling, leading to addiction. New treatments may be developed to block interference with dopamine transporters.
A new study reveals a sharp increase in MS drug costs over the past 20 years, with long-standing drugs like Betaseron and Copaxone seeing average annual price hikes of 21-36%. The study highlights the need for reform to address unsustainable pricing and ensure life-changing treatments remain accessible to patients.
A new non-invasive OCT technology has been developed that can improve the clinical management of macular degeneration, diabetic eye disease and glaucoma, the leading causes of blindness in the United States. The technology allows for earlier diagnosis and treatment, enabling more timely intervention to prevent irreversible loss of vision.
The OHSU Knight Cancer Institute awarded $462,656 to 17 projects statewide to address community-identified needs and decrease the impact of cancer on Oregonians. The funded projects focus on preventing tobacco use among youth, increasing colorectal cancer screening, and developing skin cancer prevention programs.
Research reveals that high-fat diets and maternal obesity during pregnancy compromise the blood-forming stem cell system in the developing fetus. This may contribute to the rise in immune diseases and allergic dispositions in children. The study provides a model for testing whether dietary interventions can repair the damage.
A large international group of scientists has published the results of a first-ever look at the genome of dozens of common birds, revealing how modern birds evolved after the mass extinction that wiped out dinosaurs. The research also provides insight into how songbirds learn to sing and brain connection with human speech.
Researchers will screen tens of thousands of chemical molecules to identify effective adjuvants for vaccines against infectious diseases. The project aims to develop novel applications for enhancing the immune response against Ebola virus, HIV, and other virus infections.
The Kay Yow Cancer Fund has awarded a $100,000 young women's breast cancer research grant to the Knight Cancer Institute at Oregon Health & Science University. The grant will support research on non-steroidal anti-inflammatory drugs (NSAIDs) and their potential effectiveness in preventing metastasis of breast cancer in young women.
The gibbon genome sequencing project provides new insights into chromosomal rearrangements, evolutionary history, and genetic factors in human health. The study sheds light on the complex evolution of gibbons and their role in understanding human diseases.
Scientists at OHSU have found that nuclear transfer is superior to iPS method in reprogramming human skin cells into embryonic stem cells, with the former producing stem cells almost identical to those from in vitro fertilized eggs. The study's findings hold major implications for developing better embryonic stem cells and therapies.
Researchers have gained unprecedented insight into the NMDA receptor, a key player in learning and memory. The new 3D model provides vital clues for developing drugs to combat neurological diseases such as Alzheimer
A study published in the FASEB Journal found that resveratrol supplements caused significant developmental abnormalities in the pancreas of offspring from pregnant monkeys, raising concerns about their safety during pregnancy. Researchers recommend that pregnant women and those planning to become pregnant avoid taking the supplement.
A Phase III clinical trial found that enzalutamide significantly reduced the risk of prostate cancer progression by 81 percent and improved overall survival by 29 percent. The treatment also helped prevent cancer spread to bones and delayed chemotherapy needs.
The Gordon Sondland and Katherine Durant Foundation has donated $1 million to the Oregon Health & Science University's Knight Cancer Institute to establish an annual research conference, drawing top thought leaders in cancer treatment. The conference aims to accelerate breakthroughs in early detection and treatment.
A low-fat diet may help alleviate fatigue in people with multiple sclerosis (MS). The study found that participants who followed a plant-based diet very low in saturated fat had significantly less fatigue at the end of the year compared to those who didn't follow the diet.
A recent study found that clinical trials often report adverse events less frequently on government websites compared to peer-reviewed medical journals. Inconsistent reporting of primary outcomes and deaths also occurred, highlighting the need for more comprehensive information on ClinicalTrials.gov.
A study published in the Journal of Neuroscience found that monkeys fed a diet high in omega-3 fatty acids had brains with highly connected and well-organized neural networks. This similarity is remarkable, especially when compared to human brains using the same imaging techniques.
Researchers at Oregon Health & Science University have discovered that an antioxidant called MitoQ can significantly reverse a multiple sclerosis-like disease in mice. The treatment reduced inflammation, demyelination, and neurological disabilities, showing promise for treating MS.
Researchers found that moderate drinking boosted the immune system of rhesus macaques, leading to enhanced responses to vaccines. In contrast, heavy drinkers showed diminished vaccine responses. The study suggests a potential link between moderate alcohol consumption and improved immune function.
A study found that branched chain amino acids improved wakefulness and restored orexin neurons in mice with mild TBI, suggesting a potential dietary supplement to address sleep disturbances and cognitive problems
Researchers at OHSU discovered a way to use small molecules to fix misfolded proteins, allowing them to function normally again. This technique has the potential to treat diseases such as cystic fibrosis, cataracts, and Alzheimer's disease.
Researchers at OHSU's Vollum Institute published two papers on neurotransmission in Nature, revealing a detailed view of the structural biology of the dopamine transporter. This breakthrough could lead to the development of better antidepressants with few or no side effects.
A new study published in Pediatrics reveals that childhood gunshot injuries are a leading cause of death and injury in children and adolescents in the US. The research found that gunshot injuries result in higher proportions of serious injuries, major surgery, and hospital deaths compared to other injury sources.
Researchers at Oregon Health & Science University have developed an HIV/AIDS vaccine candidate that appears to completely clear the AIDS-causing virus from the body. The vaccine uses a modified form of cytomegalovirus to generate T-cells capable of targeting and eliminating infected cells.
A study published in Health Affairs found that over 85,000 minimally injured patients were sent to major trauma hospitals despite not needing them, resulting in excessive costs. The study suggests that early decisions in the healthcare process can lead to higher costs downstream.
Researchers found that interactions between tau and amyloid-beta proteins in the brain may worsen Alzheimer's disease progression. The study identified the presence of these protein complexes in human brain tissue and mouse brains with Alzheimer's, suggesting a potential key to understanding the disease.
A recent review conducted by Oregon Health & Science University found that a bone growth product used in spinal surgeries offers no real benefit over traditional bone grafts and comes with potential harms. The review also identified reporting bias in studies funded by the product's manufacturer, Medtronic.
A new surgical technique for deep brain stimulation (DBS) has been developed, allowing for more accurate placement of brain electrodes and reducing complications. The procedure is safer and faster than traditional DBS surgery, making it a promising treatment option for various medical conditions beyond Parkinson's disease.
Researchers at OHSU's Vollum Institute have discovered a new NMDA receptor subtype that is the most common at synapses, contradicting previous drug development efforts. The study suggests that this subtype may be a new target for developing effective therapies for neurological disorders.
Researchers at OHSU have discovered a strategy to increase the number of viral peptides that T cells recognize, allowing them to more effectively respond to HIV. The method uses cytomegalovirus (CMV) to generate SIV-specific T cells that can target multiple viral peptides, providing a better targeting system for the immune system.
A breakthrough study led by Shoukhrat Mitalipov converts human skin cells into embryonic stem cells using a variation of somatic cell nuclear transfer. The reprogrammed cells can transform into various cell types, including nerve cells, liver cells, and heart cells, without the risk of transplant rejection.
Researchers at Oregon Health & Science University have isolated a molecular mutation causing two rare forms of leukemia. The study suggests that patients with these conditions could be helped by existing FDA-approved drugs, paving the way for potential treatment breakthroughs.
A study published in Obesity found that the body's internal clock regulates hunger, increasing appetite for sweet, starchy and salty foods in the evenings. This natural tendency can lead to weight gain due to impaired sugar tolerance and energy storage in the evening, rather than expending energy after a morning meal.
Researchers at Oregon Health & Science University have developed a new drug called ELQ-300 that shows great promise in treating and preventing malaria. The drug targets the parasite earlier than existing treatments, making it potentially more effective and requiring fewer doses.
Researchers at Oregon Health & Science University found that hospitals adopting Lean methodologies from Toyota and similar manufacturing approaches improved heart attack process of care measures, leading to lower 30-day mortality rates. However, no significant association with reduced readmission rates was observed.
OHSU scientists have made a breakthrough by growing human liver stem cells in culture, demonstrating their therapeutic potential. The study's findings suggest that these cells can be infinitely expanded and converted into functional liver cells, offering new hope for treating chronic liver diseases.
Researchers at OHSU found that epigenetic control, specifically DNA methylation and histone changes, play a crucial role in regulating puberty. By delaying puberty in female rats using targeted gene therapy, the study provides new insights into the complex protein/gene interactions involved.
Researchers have identified a new source of powerful antibiotics in shipworms, which could combat antibiotic resistance. Additionally, bacteria carried by cone snails produce neuroactive chemicals with promise for pain treatment. The discovery was made through the Philippine Mollusk Symbiont International Cooperative Biodiversity Group.