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PNAS Nexus


Predicting long-term psychedelic side-effects

Researchers surveyed 654 people who planned to take psychedelics, finding a weak correlation between lifetime psychedelic use and delusional ideation. The study suggests that schizotypal traits may not be caused by taking psychedelics, with only 1/3 of participants experiencing lingering hallucinatory sensory experiences after four weeks.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 22, 2025

Antibiotic pollution in rivers

Human consumption of antibiotics has increased by 65% since 2000, resulting in estimated 8,500 tonnes reaching river systems globally. Chronic environmental exposure can reduce microbial diversity and increase antibiotic-resistant genes, impacting fish and algae health.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 22, 2025

Coastal heritage threatened by climate change

The article highlights the vulnerability of US Gulf coast archaeological sites to climate change-induced sea level rise and extreme weather. The study calls for an integrated approach combining coastal ecosystem management with archaeological and historical resource preservation using Indigenous traditional ecological knowledge.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 15, 2025

A tale of two hummingbird bills

Researchers found that a narrow island separating the two species suggests recent speciation or extensive gene flow. The study proposes sexual selection as a key driver of species differentiation.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 15, 2025

Urinals without splashback

Researchers designed urinals using physics and differential equations to minimize splashback, improving hygiene and accessibility. The Nautilus design fits various urination heights, making it accessible for children and people with wheelchairs.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 8, 2025

AI propaganda: prolific and persuasive

A study reveals that AI-powered content on a Russian-backed outlet increased publication rate by over 100% and broadened topics, while maintaining persuasive power. The research warns of the urgent need to mitigate AI-assisted propaganda campaigns.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 1, 2025

Plastic-degrading enzymes from landfills

Researchers discovered plastic-degrading enzymes in landfills worldwide, suggesting a promising method for plastic recycling. The study identified 31,989 possible enzymes and predicted protein functions using machine learning and tertiary structure modeling.

SourcePNAS Nexus·JournalPNAS Nexus·DateMar 18, 2025

AI in engineering

The article explores the role of AI in engineering, highlighting benefits such as improved transportation and manufacturing, but also raises concerns about safety, privacy, bias, and governance. The authors discuss weaknesses in data-driven models and call for research into regulatory frameworks to address these issues.

SourcePNAS Nexus·JournalPNAS Nexus·DateMar 11, 2025

Mapping consensus locations for offshore wind

The study identifies suitable areas for offshore wind installations, with 18% of sites acceptable from a socio-environmental perspective. Smaller projects may offer less uncertainty in their impacts, making them more robust for development.

SourcePNAS Nexus·JournalPNAS Nexus·DateMar 4, 2025

Merging schools to reduce segregation

Researchers explore merging public elementary schools to reduce racial segregation, finding a median reduction of 20% in some districts. The approach also slightly increases commute times, but can halve district-wide segregation with careful planning.

SourcePNAS Nexus·JournalPNAS Nexus·DateMar 4, 2025

Ending pandemics with smartwatches

Recent studies demonstrate that smartwatches can detect infections early through subtle physiological changes, prompting timely action to slow disease spread. By identifying infections sooner and reducing social contacts, wearable technology may help contain future outbreaks and prevent pandemics.

SourcePNAS Nexus·JournalPNAS Nexus·DateMar 4, 2025

Using brain scans to forecast human choice at scale

Researchers used fMRI data to predict choices made by thousands of people on crowdfunding websites, finding consistent associations in the NAcc region. This neuroforecasting technique has potential for scaling up predictions of human behavior across diverse populations.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 25, 2025

AI’s emotional blunting effect

Large language models (LLMs) can alter sentiment in research summaries, making it difficult to accurately assess public opinion on climate change. LLMs tend to display a more neutral tone than original texts, regardless of prompts or model sophistication.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 25, 2025

Submersible robot surfs water currents

Researchers developed a submersible robot that leverages vortices to boost efficiency in autonomous underwater vehicles. By 'surfing' vortex rings, CARL reduces energy consumption by one-fifth compared to traditional methods.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 25, 2025

Peptides to clean up microplastics

Scientists have identified peptides that can capture and hold microplastics, providing a potential solution for removing these tiny plastic particles from environments. The method combines biophysical modeling, molecular dynamics, quantum computing, and reinforcement learning to optimize the binding of plastics to the peptides.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 18, 2025

Purity and environmental concern

The study found that counties with strong emphasis on fairness norms had higher odds of favoring green practices, while those emphasizing purity norms had stronger influence on household carbon footprint. Counties with high education levels also showed increased support for green attitudes.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 11, 2025

Branch patterns in trees and art

Researchers found branch patterns in art to mirror those in nature, with values of α ranging from 1.5 to 2.8, corresponding to natural trees. Abstract artworks can be visually identified as trees using realistic α values, while works deviating from scaling exhibit reduced recognition.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 11, 2025

A gender gap in using AI for research

A significant gender gap was found in the use of AI for research, with male researchers experiencing a notable increase in productivity after ChatGPT's release. Female researchers spent less time using AI and perceived it as less efficient, exacerbating existing productivity disparities.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 11, 2025

Financial comfort and prosociality

A study of 80,337 people across 76 countries found that those with higher incomes and financial well-being reported greater prosocial actions and attitudes. Higher income individuals were more likely to donate, volunteer, and trust others, although they also showed lower trust in others.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 4, 2025

Big cities fuel inequality

A study reveals that large cities have ceased to be centers of upward social and economic mobility, with population density and connectedness associated with reduced intergenerational mobility. Urban expansion has also led to decreased average social capital, contributing to growing inequality within and across generations.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 4, 2025

Painted lady butterflies migrations and genetics

A study on painted lady butterfly migrations found that environmental conditions, rather than genetic coding, drive their migratory patterns. The research revealed that butterflies can travel vast distances, crossing the Sahara Desert, without showing significant genomic differences between short and long-distance migrants.

SourcePNAS Nexus·JournalPNAS Nexus·DateFeb 4, 2025

Pancreas cells secrete neuroprotective factor

Researchers discovered that pancreatic β cells produce a neuroprotective agent called Fibroblast Growth Factor 23 (FGF23), which can stop amyloid-β-induced neuronal cell death. FGF23 may increase ribosomal proteins, helping to maintain homeostasis in neurons.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 28, 2025

The oral microbiome and dementia

A study found a link between oral microbiome and dementia risk, with certain bacteria associated with better executive function. A nitrate-rich diet may favor beneficial oral bacteria, potentially delaying cognitive decline.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 28, 2025

Paywalls shape newspaper coverage

Adopting paywalls leads to a strategic shift in newspaper coverage, with a 5.1% decrease in local news and modest declines in soft news, according to a study of US newspapers between 2006-2022. Smaller cities and urban areas experiencing demographic changes exhibit notable declines in local news and increases in popular content.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 28, 2025

Mass shootings increase alcohol sales

A study analyzing data from 35,000 retailers found that public mass shootings lead to a 3.5-5.5% increase in weekly alcohol sales for at least two years. The authors suggest whole-community approaches to address the trauma of mass shootings and its impact on alcohol consumption.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 21, 2025

Roman urbanites followed medical recommendations for weaning babies

A study of ancient Roman teeth reveals that urban dwellers weaned their babies earlier than rural communities, following medical recommendations similar to those in modern cities. The findings support the idea that cities act as information hubs and offer more medical resources, leading to closer adherence to expert health guidelines.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 14, 2025

Crop switching for climate change in China

A study recommends planting alternative crops in areas currently growing maize and rapeseed to increase productivity by 14.1% while minimizing leached nitrogen and water use. The optimal crop distributions also promote future food security with coordinated actions at the national scale.

SourcePNAS Nexus·JournalPNAS Nexus·DateJan 7, 2025

Simulating natural selection in assisted reproduction

Researchers highlight the risks of bypassing natural selection in assisted reproductive technologies (ART), which can lead to deleterious epigenetic changes and increased health problems. They propose applying evolutionary principles to ART protocols to improve outcomes for human ART and animal production.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 17, 2024

Machine learning prediction of human intelligence

Researchers used machine learning to predict multiple types of intelligence from brain connections, with general intelligence performing best. The model's accuracy improved when trained on theory-driven connections, suggesting there are still unknown aspects of intelligence to discover.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 10, 2024

High-speed rail and regional environmental inequality

The introduction of high-speed rail between 1998 and 2010 spread green technologies and reduced industrial pollution across lagging regions, particularly in central inland provinces and northeastern areas. This led to a 0.49%–1.70% reduction in national industrial pollution and increased patent filings for green technology patents.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 10, 2024

The biomechanics of the rose prickle

The rose prickle's curved tapering shape and microstructural density enable supreme damage resistance capabilities. Researchers propose that these features could be used to develop ultra-small anchoring tools for diverse applications.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 10, 2024

COVID infection and age-related blindness

An experimental study in mice found that SARS-CoV-2 infection can damage the retinas, leading to long-term implications for vision. The virus caused widespread inflammation across the retinal pigment epithelium, including complement activation and increased production of inflammatory cytokines.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 3, 2024

Parasite-inspired medical devices

Researchers designed a millimeter-scale mechanism inspired by tapeworms to anchor small medical devices to soft tissues. The device, made of stainless steel and polyimide film, can be used in various medical applications and has potential for affixing sensors to marine organisms.

SourcePNAS Nexus·JournalPNAS Nexus·DateDec 3, 2024

Engineering hypoallergenic cats

A team of scientists used CRISPR technology to investigate the role of Fel d 1, a gene that triggers cat allergies. By analyzing genetic diversity and expression levels, they found that cats genetically modified to lack CH2 were healthy, suggesting that the allergen may not be essential for feline health.

SourcePNAS Nexus·JournalPNAS Nexus·DateNov 26, 2024