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PNAS Nexus


A ubiquitous architectural pattern in nature

Researchers have identified and classified 100 biological tilings across various taxonomic groups, providing insights into their functions and dominance. These findings could lead to novel manufacturing design challenges and bio-inspired innovations.

SourcePNAS Nexus·JournalPNAS Nexus·DateNov 11, 2025

Seeing persuasion in the brain

A mega-analysis of 16 neuroimaging studies found that brain activity in reward and social processing regions can predict which messages are well-received by both scanned individuals and broader audiences. Effective messages activate brain responses related to mentalizing, anticipating rewards, and evoking emotions.

SourcePNAS Nexus·JournalPNAS Nexus·DateNov 4, 2025

AI produces shallower knowledge than web search

Learning with AI chatbots versus traditional web search produces shallower knowledge, as evidenced by experiments with thousands of online participants. Participants who used AI chatbots developed less original advice and were less willing to adopt it compared to those using web links.

SourcePNAS Nexus·JournalPNAS Nexus·DateOct 28, 2025

Algorithmic outreach leads to information inequality

A study using the independent cascade model on diverse social networks found that algorithmic outreach creates information gaps, leaving vulnerable nodes without important information. A proposed multi-objective algorithm aims to minimize this effect, resulting in a 6-10% reduction in vulnerable nodes with negligible impact on reach.

SourcePNAS Nexus·JournalPNAS Nexus·DateOct 21, 2025

Yeast survives Martian conditions

Researchers found that yeast can survive Martian-like conditions by assembling ribonucleoprotein condensates, which protect RNA and affect mRNA fates. The study suggests the importance of understanding RNP condensates in predicting the effects of Martian conditions on life.

SourcePNAS Nexus·JournalPNAS Nexus·DateOct 14, 2025

Air pollution and childhood myopia

A study of nearly 30,000 Chinese children found that air pollution, particularly nitrogen dioxide and fine particles, is a significant risk factor for childhood myopia. Exposure to poor air quality can cause oxidative stress and inflammation of the eye, potentially harming vision.

SourcePNAS Nexus·JournalPNAS Nexus·DateSep 23, 2025

Meditation to treat depression and gaming addiction

A study found that mindfulness meditation training significantly decreased depressive symptoms, Internet Addiction Test scores, and video game cravings in individuals with depression and gaming disorder. Brain imaging revealed a decrease in brain responses to gaming cues and increased activity in the lentiform nucleus.

SourcePNAS Nexus·JournalPNAS Nexus·DateSep 23, 2025

AI-based satellite count of migrating wildebeest

A recent study using AI and satellite images estimates that fewer than 600,000 wildebeest migrate across the Serengeti-Mara ecosystem annually, contradicting previous aerial surveys. The findings highlight the potential of satellite-based population counts for terrestrial mammals.

SourcePNAS Nexus·JournalPNAS Nexus·DateSep 9, 2025

Farming strategies to protect biodiversity

Empirical evidence shows that land sharing and land sparing strategies alone are insufficient for balancing agricultural production with biodiversity conservation. Context-specific combinations of both approaches yield the best results, according to a meta-analysis published in PNAS Nexus.

SourcePNAS Nexus·JournalPNAS Nexus·DateSep 2, 2025

The irresistibility of extrapolating from past performance

A large-scale study found that people who made successful guesses in a sequence of fair coin tosses rated their chances of further success higher and were more willing to bet on it. In contrast, unlucky guesses led to pessimistic predictions about future performance, with a stronger negative effect than the positive one.

SourcePNAS Nexus·JournalPNAS Nexus·DateAug 26, 2025

Predicting nationality from beliefs and values

A neural network trained on the World Values Survey predicts an individual's country of origin with 90% accuracy from their attitudes and values. The top predictors include political attitudes, environmental attitudes, family values, and interpersonal relationships.

SourcePNAS Nexus·JournalPNAS Nexus·DateAug 26, 2025

Mapping West Nile virus risk

Researchers developed a machine learning model to predict WNV risk based on weather, land cover, and demographic data. The model shows highest risk in urban areas with high temperature and precipitation during summer months.

SourcePNAS Nexus·JournalPNAS Nexus·DateAug 19, 2025

Extinction in Macaronesia

The study chronicles 220 extinctions in Macaronesia, with half linked to human arrival and a post-human extinction rate exceeding 12 times higher than pre-human periods. Conservation efforts are crucial to mitigate the extinction crisis in these unique island ecosystems.

SourcePNAS Nexus·JournalPNAS Nexus·DateAug 5, 2025

How to survive the explosion of AI slop

The article highlights the risks of deepfakes and manipulated media, with expert Hany Farid advocating for legal requirements, imperceptible watermarks, and digital media literacy to mitigate these harms. He also explores policy landscape and authentication techniques to sort real from synthetic content.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 29, 2025

Social steps to mitigate mental illness

A study analyzed social determinants' impact on mental health, identifying variables that predict problems, such as physical health, loneliness, and satisfaction. Implementing policies like financial stability, local community engagement, and volunteering may reduce mental illness rates by up to 3 percentage points.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 22, 2025

Genes for surviving plague in prairie dogs

A study of the genetic basis of plague immunity in prairie dogs has identified key genes linked to survival. The research provides insights into rapid adaptation to a globally introduced virulent pathogen in a keystone species.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 8, 2025

Consequences of low Antarctic sea ice

Research on record-low years of Antarctic sea ice reveals warming of the Southern Ocean, increased ice-shelf calving, and stronger phytoplankton blooms. Low sea-ice area negatively affects krill and fish populations, ultimately impacting their predators and humans operating in Antarctica.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 1, 2025

Fentanyl detection through packaging

Researchers developed a magnetic resonance technique to detect fentanyl hydrochloride in sealed packages, offering a non-invasive solution. The technique uses Nuclear Quadrupole Resonance (NQR) spectroscopy, which can identify key target nuclei in the drug, allowing for effective detection and potential diversion of large quantities.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 1, 2025

Creativity across disciplines

Combinative and transformative creativity are recognized by Julio M. Ottino as essential components of creative breakthroughs. Historical figures such as Filippo Brunelleschi and Niels Bohr demonstrate creative fluidity, while AI's limitations in transformationally creative tasks are discussed.

SourcePNAS Nexus·JournalPNAS Nexus·DateJul 1, 2025

Predicting cognitive abilities from brain scans

A new study predicts cognitive abilities from brain scans by integrating multiple MRI modalities through a technique called stacking. The method achieves substantial predictive accuracy and improved test-retest reliability, suggesting a more reliable neural marker of cognitive function.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 24, 2025

The urge to delay a return to pleasure

A study on Americans' behavior after the COVID-19 shutdowns found that people often delay returning to lost pleasures. Participants reported waiting longer to satisfy their first time back, indicating a desire for a special experience.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 24, 2025

Mapping barriers to natural climate solutions

Natural climate solutions like wetland restoration and reforestation face various barriers, including lack of funding, insufficient information, and ineffective policies. The study highlights the need for collaborations across sectors and disciplines to unlock their full potential.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 24, 2025

Is it immoral to be too rich?

Global survey of 4,351 participants reveals that people in more equal and wealthy societies are more likely to condemn excessive wealth. Moral condemnation is linked to values related to equality, purity, and younger age, suggesting concerns about the corrupting influence of wealth.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 24, 2025

Instant AI-assisted test for viral infection

A non-DNA based test using a nanopore device and AI model can identify live viruses in patients within minutes. The system showed 100% sensitivity and 71.4% specificity for detecting herpesvirus, with improved accuracy when conditions were adjusted.

SourcePNAS Nexus·JournalPNAS Nexus·DateJun 10, 2025

Can AI analogize?

A recent study evaluates GPT-4's performance in solving letter-string analogies, a task requiring basic counting and relational understanding. The model excels at this task, demonstrating emergent analogical reasoning capabilities that may be supported by structured operations and relational representations.

SourcePNAS Nexus·JournalPNAS Nexus·DateMay 27, 2025

AI aversion in social interactions

An experimental study found that humans are less likely to exhibit fairness, trust, and cooperation when interacting with a large language model (LLM) compared to another human. Participants in online games played with either a human or an LLM acting on behalf of another person showed reduced social behavior.

SourcePNAS Nexus·JournalPNAS Nexus·DateMay 27, 2025

Public opinion on who should do content moderation

A survey of 3,000 US residents found that Americans prefer domain experts over non-experts or algorithms for content moderation. Small juries of independent experts were viewed as the most legitimate, while large, diverse juries with minimal qualifications were also seen as acceptable.

SourcePNAS Nexus·JournalPNAS Nexus·DateMay 20, 2025

Moral insights from Reddit’s “AITA?” board

The study analyzes 369,161 posts from Reddit's 'AITA?' board, finding that dilemmas concerning relational obligations were the most common type. Violations of trust, such as lying and cheating, were evaluated more negatively than acts of harm, highlighting the importance of trust in moral cognition.

SourcePNAS Nexus·JournalPNAS Nexus·DateMay 13, 2025

5G is safe

A recent study published in PNAS Nexus has found that 5G exposure does not alter gene expression and methylation profiles in human skin cells. The researchers used advanced equipment to control for temperature, which was previously cited as a potential cause of adverse effects.

SourcePNAS Nexus·JournalPNAS Nexus·DateMay 13, 2025

Biodiversity and ecosystem stability

A recent study suggests that highly diverse microbial ecosystems may actually decrease stability under stress conditions. In contrast, low-diversity ecosystems often exhibit increased growth rates and community stability when faced with starvation or high salinity.

SourcePNAS Nexus·JournalPNAS Nexus·DateApr 29, 2025