Researchers have developed a comprehensive catalog of the Aedes aegypti genome, which could lead to novel strategies for reducing mosquito-borne illnesses. The new tool has revealed genes coding for ionotropic receptors that detect odors, and enzymes neutralizing toxic effects of insecticides.
Researchers discover that embryonic cells retain a memory of chemical signals they encounter during development. Exposure to WNT and Activin signaling is necessary for differentiation, and cells can remember previous exposure to these signals, even if the signal is absent at the time of treatment.
Researchers found kanglemycins, a group of natural antibiotics similar to rifamycin, which can target mutated RNAPs. These antibiotics may have emerged as a result of evolutionary pressures in nature, providing a potential solution to the rising problem of antibiotic resistance.
A new study suggests that our brains can rewire and change in response to new experiences, even when we're not consciously forming new memories. This process of plasticity enables us to better perceive and interpret the world, with potential implications for brain disorders such as autism and schizophrenia.
Scientists have found spiking neurons in the tiny roundworm C. elegans, which could help understand fundamental principles of brain computation. The discovery overturns decades of dogma and reveals a unique coding mechanism that allows the worm's olfactory neurons to encode information in two ways.
Scientists find DEET confuses critters by messing with neurons that help sense surroundings. Researchers also discover genetic and cellular mechanisms underlying response to the chemical.
Researchers have developed a novel immunotherapy that can suppress HIV for months at a time, using a combination of two anti-HIV antibodies. The treatment, called broadly neutralizing antibodies (bNAbs), has shown promising results in clinical trials, with some patients experiencing sustained viral suppression for over four months.
ASTN2 helps move proteins away from the membrane, supporting neuronal connections; defects lead to neurodevelopmental disorders like autism and intellectual disabilities. The cerebellum's complex roles in cognition and language may be linked to ASTN2 dysfunction.
A recent study published in Nature found that even small groups of genetically identical ants exhibit greater stability and division of labor when compared to solitary individuals. This research challenges the long-held assumption that competition is more attractive than collaboration when resources are scarce.
A new study describes the structure of an ion channel responsible for detecting odors in insects, revealing how millions of receptor varieties evolved to accommodate diverse habitats. The discovery offers insights into insect olfaction and evolution, potentially leading to innovations for disease prevention and human benefit.
Researchers found that people with the rare disease have genetic mutations in CIB1, EVER1, or EVER2, which compromises their immune response to ß-HPVs. The study revealed that ß-HPVs can replicate and cause skin lesions and cancer when this defense mechanism is disrupted.
Researchers found that patients with severe depression have decreased levels of acetyl-L-carnitine in their blood, which may indicate a specific subtype of depression. The study suggests that LAC screening could be used as an effective biomarker for diagnosing treatment-resistant depression.
A new study sheds light on the evolution of workers and queens in ants by identifying a key gene involved in regulating reproduction. Researchers found that a gene coding for an insulin-like peptide, ILP2, promotes and suppresses reproduction in ants.
Research from Rockefeller University reveals that giant neurons in the brainstem, called nucleus gigantocellularis, express genes linked to nitric oxide production and blood vessel relaxation. This discovery supports their role in initiating behavior and potentially understanding psychiatric disorders like bipolar disorder and ADHD.
Researchers at Rockefeller University have discovered the molecular means by which some cancers caused by BRCA1 mutations evade treatment by PARP inhibitors. The study challenges previous assumptions about the mechanics of these drugs and provides a foundation for advancements in PARP inhibitor therapy.
Researchers found that evolutionary changes occur deep in the fly brain, in a small cluster of neurons controlling mating behavior. The study overturned long-held beliefs about how evolution ensures animals perpetuate their species.
Researchers discovered that oxygen-starved tumor cells struggle to produce aspartate, a crucial amino acid. By targeting this Achilles' heel, doctors may develop new treatments to block aspartate uptake or production.
Researchers find subplate neurons don't die but become part of the adult cerebral cortex, influencing brain disorders. They identify a connection between subplate neurons and certain brain conditions and outline innovative stem cell techniques for treatment.
Researchers at Rockefeller University have devised an improved method for isolating and identifying tiny fragments of RNA in human blood products, establishing extracellular RNA as a potentially reliable class of biomarkers. The new approach has been successfully tested on 312 blood samples from healthy subjects, confirming the stabili...
Researchers at Rockefeller University discovered that glial cells play a crucial role in regulating sleep and movement in worms, offering new insights into the neuroscience of sleep. The study found that glial cells help counteract the inhibitory effect of a specific neuron on movement.
A team of Rockefeller scientists has discovered the molecular signals that direct cell differentiation in human embryos, shedding light on the earliest stages of development. The findings have implications for regenerative medicine and could lead to new treatments for diseases such as cancer and diabetes.
New technology tracks brain cell interactions in mice, shedding light on neuronal activity and potential insights into brain disorders such as autism and schizophrenia. The device captures three-dimensional images of neurons flashing on and off as they communicate with each other.
Researchers at Rockefeller University discover a molecular doorstop antibiotic that kills Mycobacterium tuberculosis, but not suitable for clinical use. By understanding its mechanism of action, medicinal chemists can design new antibiotics that target specific enzymes, offering hope for a more targeted treatment against the disease.
Researchers discover an unusual cell-death process in microscopic worms, where the dying cell breaks apart and is gradually removed by other cells. The study sheds new light on how phagocytes, the body's vacuum cleaners, work.
Scientists recommend regular brain scans for children with rare liver cancer due to its potential to metastasize. Early detection could increase surgical removal success and inform treatment choices.
Researchers at Rockefeller University have mapped the architecture of the nuclear pore complex in yeast cells, revealing a massive cylindrical configuration with flexible components. The study provides insights into cell transport and may aid efforts to understand and treat diseases linked to defects in the pore complex.
Researchers identified a single gene mutation that makes some people more susceptible to viral brain infections like encephalitis. The DBR1 gene affects mRNA splicing, impairing immunity in the brain stem and leading to virus invasion.
Researchers discovered patterns of behavior across different stages of life in C. elegans worms, showing that genetic differences and neuromodulators contribute to individuality. The team found that removing serotonin reduced unique foraging behaviors, highlighting the importance of diversity in species survival.
Scientists at Rockefeller University have identified a molecule called Daple that helps construct and align the sensory hair bundles in the inner ear. These bundles are crucial for detecting sound, motion, and spatial orientation.
Researchers developed a new method to track cell-to-cell interactions, dubbed LIPSTIC, which allows for the identification and counting of specific cells involved in immune responses. This breakthrough enables scientists to better understand how the immune system functions in live animals.
Scientists at Rockefeller University discovered early abnormalities in human embryonic stem cells with Huntington's disease, suggesting the disorder originates much earlier than previously thought. The study implies that existing treatments may do more harm than good and necessitates a new approach to treating the disease.
Research suggests that different bacterial strains can provoke varied immune responses in humans, contradicting previous studies that used a single strain. This variability is contributed by viruses infecting the bacteria, and may help predict disease outcomes and tailor treatment.
New research uses 3D imaging to visualize the inner workings of fat tissue in mice, identifying potential targets for new drugs to treat and prevent obesity and diabetes. The study reveals that beige fat, which can be induced to burn energy, has high potential for treatment.
Researchers discovered a chemical, HP-I, that regulates female mosquito sexual proclivities, helping females avoid multiple mates and reducing disease transmission. The protein's role in inter-species sex also holds promise for understanding complex reproductive patterns between different mosquito species.
A new study identifies a chimeric gene as the driver of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare and usually lethal liver cancer. The research offers prime targets for drugs to treat the disease, including kinases and cellular signaling systems. Researchers are now working to design therapeutics targeting these pathways.
Researchers find that certain spellings in HIV and other viruses' genetic codes are critical for replication and infection. The discovery highlights a potential avenue for vaccine development by exploiting this variation.
Researchers at Rockefeller University have discovered a potential new treatment for Fragile X Syndrome by targeting chromatin remodeling proteins, which play a key role in the disease's symptoms. The study found that inhibiting these proteins can alleviate symptoms and improve neuronal function.
Research reveals that wounds heal more than twice as fast in skin with prior inflammatory experience, thanks to sensitized stem cells. These cells remain active long after the initial inflammation has subsided and are better equipped to migrate into the wound.
Researchers at Rockefeller University have developed new smell tests that can detect olfactory disorders more reliably than conventional options. The tests aim to identify underlying causes of neurological disorders like Alzheimer's and Parkinson's diseases early on, potentially improving treatment outcomes.
Michael W. Young, a Rockefeller University biologist, has been awarded the Nobel Prize in Physiology or Medicine for his groundbreaking work on circadian rhythm. His research revealed the molecular mechanisms that govern biological clocks, which regulate sleep, eating behavior, and metabolism.
Researchers have engineered gut bacteria to produce molecules that mimic human ligands, binding to receptors involved in glucose and appetite regulation. This breakthrough may lead to novel therapeutic approaches for diseases such as diabetes and obesity.
Researchers discovered two previously unknown brain areas involved in face recognition, which integrate visual perception with memory and social knowledge. The brain's response to familiar faces is distinct from visually familiar ones, with a sudden 'aha' moment when recognizing a long-known acquaintance.
Researchers at Rockefeller University created genetically altered ants to explore the evolutionary roots of ant social behavior. The study found that a gene essential for sensing pheromones is crucial for pheromone detection and social organization, leading to behavioral abnormalities in mutant ants.
Researchers at Rockefeller University have discovered two brain cell populations that regulate appetite and may offer a new path to treating obesity. The study found that activating specific neurons in the dorsal raphe nucleus can suppress hunger and promote weight loss, opening up new avenues for developing effective obesity drugs.
A team of Rockefeller scientists has identified a specific type of nerve cell, called cholecystokinin (CCK)-expressing neurons, as the site where selective serotonin reuptake inhibitors (SSRIs) initiate their action. This discovery may pave the way for new antidepressants that act more quickly and produce fewer side effects.
Researchers at Rockefeller University have developed a new animal model for hepatitis C using a virus closely related to the human disease, allowing for study of disease progression and immune system response. This breakthrough could accelerate hepatitis C vaccine development and lead to the eradication of the disease.
Researchers developed an algorithm to capture neural activity within mouse brain tissue, enabling them to track hundreds of individual neurons in a single recording. The technique, combined with light field microscopy, allows for real-time monitoring and alteration of stimuli based on brain activity.
A team of scientists from Rockefeller University and Hunter College has developed an interactive underwater touchscreen to investigate dolphin intelligence and communication. The system allows dolphins to choose activities and make decisions, providing insights into their cognitive abilities and potential for symbolic communication.
Researchers have identified a neural circuit in flies that updates its internal compass based on the insect's own movements, allowing it to track turns and navigate in the dark. This mechanism is similar to what has been suggested to exist in larger mammalian brains, including humans.
Researchers at Rockefeller University have identified a brain network exclusively dedicated to analyzing social interactions in rhesus macaques. This network may represent an evolutionary precursor to the neural circuitry that supports theory of mind in humans, potentially blurring the lines between human and primate cognition.