Researchers found that riluzole reversed key genetic changes associated with Alzheimer's and cognitive decline in rats. The drug restored expression of glutamate-clearing molecules and genes critical for neural communication and plasticity.
Researchers created knockout mice that lack a gene involved in DNA repair, shedding light on how cells fix broken DNA. The mice developed kidney and liver dysfunction due to impaired detoxification, highlighting the importance of FAN1 protein.
A new study reveals that glial cells play a dynamic role in shaping nerve endings, controlling neuron connections and functions. Glial cells use specific molecular mechanisms to regulate the shapes of different neuronal cell types, including those expressing temperature- or odor-sensing proteins.
Scientists at Rockefeller University have identified a new way for cells to die in the linker cell of Caenorhabditis elegans, resembling neuronal death in humans. The discovery suggests that this process might be involved in neurodegenerative disorders and could serve as a target for future drugs.
Researchers at Rockefeller University have identified a set of neurons in the fly brain that are activated only when flies eat sweet solutions, especially when hungry. These neurons connect to taste neurons in the pharynx, allowing flies to directly taste and monitor food while swallowing it.
A new study at Rockefeller University uses magnetic forces to control neurons in mice, finding the brain plays a vital role in glucose metabolism. By targeting specific cells, researchers can activate or inhibit neural activity, offering potential therapeutic applications for metabolic and neurologic diseases.
A research team has mapped the structure of a unique nuclear pore complex found in trypanosomes, an ancient parasite species diverged from yeast and humans. The study reveals that the architecture of the inner ring is similar across different eukaryotes, while the outer ring exhibits distinct features, suggesting an ancient origin.
Researchers have found that the RNA virus bovine viral diarrhea virus relies on host miRNAs, specifically miR-17 and let-7, to replicate. Inhibiting this interaction may provide an effective target for developing new drugs to control BVDV.
Researchers found that the average number of tornadoes per outbreak increased by 50% from 1954 to 2014, while the total number of tornadoes remained largely unchanged. This suggests that tornadoes are increasingly clustered in outbreaks, making extreme events more likely.
Scientists have identified a crucial gene that regulates the activation of hair follicle stem cells, leading to increased hair growth but also wear and tear. In mice lacking this gene, hair follicles enter an overactive state, resulting in premature greying and balding.
Researchers from Rockefeller University have identified a hormone called amylin as a critical component of the system responsible for regulating food intake. Amylin acts in the brain to help control consumption, working in concert with another hormone leptin to control body weight.
Researchers at Rockefeller University found that the cell body actively controls axon degeneration in embryos. The study reveals that a lack of NGF triggers a message within the cell that ultimately instructs the axon to die.
Researchers have discovered that young worms can form lasting memories of toxic bacteria smells, using a different set of neurons than adult worms. The study, published in Cell, sheds light on the neural circuits that drive early learning and memory formation.
Researchers discovered a bacterial immune system that waits until viruses replicate before attacking them, allowing for more efficient defense. This new strategy, called type III CRISPR-Cas, takes up to nine hours to clear infections and has potential applications in biotechnology and medicine.
Researchers at Rockefeller University have captured atomic images of the herpes simplex 1 virus revealing how it inserts itself into another protein to evade detection by immune cells. The study provides a mechanistic explanation for the virus's ability to escape immune system recognition.
New research reveals that neurons in the gut play a crucial role in regulating inflammation and protecting intestinal tissue from over-reacting. The study, published in Cell, found that specific types of macrophages are activated by signals from neurons to prevent excessive inflammation.
A new study from Rockefeller University found no overall differences in DNA methylation between worker and queen ants, challenging the popular explanation for their social roles. The research suggests that methylation may contribute to stable expression of household genes, but further studies are needed to confirm this.
Researchers at Rockefeller University discover a new signaling mechanism that instructs cells to become stem cells during embryonic development. The finding suggests that stem cells may exist before the niche is formed and has implications for understanding skin cancer treatments.
Researchers at Rockefeller University have identified pivotal changes in epigenetic pathway genes required for forming the cerebellum's circuitry. The study reveals that specific epigenetic regulators are crucial for neuronal connections and ion channel expression.
Researchers discovered brief opportunities for recovery from chronic stress by altering gene expression, enabling neural circuitry changes. The brain retains the ability to change and adapt, even under repeated stress.
Researchers have discovered a new mechanism behind chromothripsis, a phenomenon where cells undergo multiple mutations due to telomere crisis. This chain of events can create chromothripsis, leading to cancer, and may inform early diagnosis methods.
Researchers at Rockefeller University discover how dopamine alters connections between neurons in fly brain to change odor responses. This study parallels the action of dopamine in human brain, suggesting a coordinated mechanism for flexible behavior.
Researchers at Rockefeller University found that mRNA components are expressed unevenly, with some regions carrying coding sequences and others not. This skewed expression may regulate protein production, particularly during embryonic development, and could provide new insights into gene function.
Scientists at Rockefeller University identified a new regulator of RNA polymerase II, a critical process for gene expression. The discovery could lead to more specific cancer therapies by targeting this form of gene regulation.
Researchers have discovered a way to manipulate the parasite that causes African sleeping sickness, making it easier for the host immune system to eliminate. By inhibiting specific proteins, they can 'trick' the parasite into a different stage of its lifecycle.
Scientists have discovered that the length of a living organism's 24-hour internal clock remains constant despite temperature fluctuations. The study found that external pathways sensitive to temperature cue the clock to skip ahead or backward, while the core mechanisms within the clock itself remain insensitive to temperature.
Researchers at Rockefeller University discovered a new signaling molecule, NELL2, that guides axons during critical brain development. The molecule directs commissural axons to the midline using Robo3 receptors, shedding light on axon guidance and potential treatments for horizontal gaze palsy with progressive scoliosis.
Researchers have identified mutations in the STAT3 protein that can block its ability to act as a transcription factor, suggesting a basis for new cancer treatments. The discovery reinforces the importance of targeting transcription factors like STAT3 in fighting cancer.
Research by Rockefeller University scientists shows DNA strands increase mobility during repair, which may serve as a 'fail-safe mechanism'. This process is linked to chemotherapy and cancer treatment, and understanding its mechanisms could lead to new therapies.
A team of researchers has revealed the molecular architecture of the replisome, a complex responsible for unwinding and replicating DNA in eukaryotic organisms. The findings show that the replisome has a unique structure, with one polymerase sitting above the helicase, challenging decades-old textbook drawings.
A brain imaging study found that certain facial patches prefer both faces and bodies to process an individual. This suggests the brain combines facial and body information to represent a whole person. The findings have relevance for understanding human social processing.
Researchers at Rockefeller University have identified two genes vital for hair cell production in young mice. Altering these proteins' expression can induce new hair cells in matured utricles, providing a potential target for regenerating lost sensors in humans.
Acute myeloid leukemia cells are addicted to the presence of JMJD1C, a protein that plays a key role in cancer-promoting effects. The team identified JMJD1C as a potential therapeutic target for multiple types of leukemia.
Scientists have developed finches with a genetic mutation linked to Huntington's disease, enabling them to study the disorder's effects on speech. The transgenic birds display behavior disorders associated with the condition, providing valuable insights into its neurological basis.
Researchers at Rockefeller University have detailed the structure of the ion channel Slo2.2, which helps regulate potassium ions and prevent overstimulation in neurons. The discovery sheds new light on how neurons reset after intense activity and could potentially inform treatments for epilepsy and intellectual disabilities.
Scientists at Rockefeller University uncover new insights into mechanical forces governing mitotic spindle formation. They describe how kinesin-5 acts as a molecular motor to organize the spindle, generating forces that tune its balance. This research has medical implications for cancer therapies and understanding cell division.
A new class of antidepressants has been found to work by targeting the brain's ability to respond to glutamate. The experimental therapies have been shown to produce an antidepressant effect in mice by altering brain signaling in particular neurons.
Researchers at Rockefeller University have made new discoveries about the DNA repair process, uncovering previously unknown functions of histone H2AX. They found that a specific portion of the protein interacts with phosphorylated H2AX, facilitating the repair of double-stranded breaks in DNA.
Researchers at Rockefeller University identified a protein that recognizes a chemical instruction tag on RNA molecules. This 'reader' molecule determines the fate of RNA by recognizing m6A tags, influencing gene expression and splicing processes.
Researchers discovered that a promising class of cancer drugs can lead to memory loss in mice due to molecular changes in the brain. The findings suggest the potential risks of these therapies and highlight the need for further investigation into their brain effects.
Researchers at Rockefeller University have discovered a single gene, SEC14L2, that allows the easy replication of hepatitis C virus in human liver cancer cell lines. This breakthrough enables scientists to study naturally occurring forms of the virus and develop new effective treatments.
Researchers at Rockefeller University identified a molecular pathway that can dampen amyloid-β production, a hallmark of Alzheimer's disease. By targeting this pathway, it may be possible to develop drugs to reduce amyloid-β and potentially treat or prevent the disease.
Male flies precisely assess potential partner suitability through complex neural integration, weighing taste and smell signals to make a decision. The study reveals P1 neurons play a crucial role in integrating sensory information, enabling the male fly to choose the right partner.
A recent study by Rockefeller University researchers has uncovered the connection between malaria and a deadly blood cancer called Burkitt's lymphoma, which predominantly affects children in equatorial Africa. The research found that the malaria parasite causes DNA damage in B lymphocytes, leading to cancer-promoting changes.
Researchers at Rockefeller University have identified two proteins, SATB1 and ZDHHC2, that appear to protect neurons from degeneration in Parkinson's disease. These proteins were found to be more abundant in dopamine-producing neurons in the substantia nigra pars compacta region, which is less affected by the disease.
Researchers identified two new genes, RAD51 and UBE2T, linked to Fanconi anemia, a rare genetic disorder. The study sheds light on the critical DNA repair pathway and its role in preventing cancer, maintaining tissues, and fertility.
Researchers at Rockefeller University have identified a similar process in flies that ignores visual input caused by their own flight turns. This finding can help understand how ongoing behavior influences visual perception and may provide insights into sensory processing disorders such as schizophrenia.
Researchers have determined the structure of a simple bacterial cell membrane pump that controls protein passage, offering new insight into bacterial manipulation. The PCAT pump, a single-protein machine, recognizes and processes cargo before pumping it out of the cell.
Researchers at Rockefeller University discovered that high affinity B cells divide faster during the antibody selection process, giving them an advantage. This discovery builds on earlier work and may have important implications for improving vaccines and understanding lymphomas.
Researchers at Rockefeller University have identified a genetic error that makes children susceptible to two unrelated diseases: aggravating fungal infections and invasive, potentially fatal bacterial disease. The mutation affects the RORC gene, which controls the production of cytokines crucial for fighting off mycobacteria.