Developing neurons use the receptors DCC and neogenin to detect Netrin-1, guiding their growth towards anatomical boundaries. This understanding may lead to the development of drugs for spinal cord or brain injuries.
Researchers estimate that humans can distinguish between more than 1 trillion odor mixtures, far exceeding the previously accepted number of 10,000. The study suggests that humans' sense of smell is more sensitive than previously thought, but often underutilized.
Researchers discovered an unusual genetic mutation in patients with fibrolamellar hepatocellular carcinoma, a rare and aggressive form of liver cancer. The mutated gene, called a chimera, is constantly active and drives the growth of tumor cells.
Researchers at Rockefeller University have identified a new regulator of the proteasome's activity, tankyrase, which uses ADP-ribosylation to modify PI31. This discovery has significant implications for treating multiple myeloma and other diseases, offering a potential therapeutic target.
Researchers identified a defective gene responsible for isolated congenital asplenia (ICA), a rare disorder characterized by the absence of the spleen. The RPSA gene mutation affects approximately 50% of patients with ICA, leading to a lack of splenic tissue.
Researchers developed Epimorex to target bacterial weaknesses exploited by viruses that attack them. In mice, Epimorex protected against anthrax and killed MRSA with no evidence of resistance.
Mutated histone H3 causes aberrant gene silencing in childhood brain cancer DIPG, leading to tumor growth. Researchers identify potential tool for inhibiting enzymes, developing pharmaceuticals targeting specific SET-domain methyltransferases.
A team of researchers has created a map of gene 'shortcuts' between all human genes, simplifying the search for disease-causing mutations. This tool, called the human gene connectome, uses GPS-like principles to predict the distance and route between any two genes.
Vitamin D supplements did not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. Researchers found that correcting vitamin D deficiencies with high doses of oral vitamin D supplements had no effect on cholesterol levels in the short term.
Researchers at Rockefeller University discovered that the influenza A virus's NS1 protein hijacks key regulators of antiviral gene function by mimicking a core component of gene regulating machinery. This finding suggests a possible target for new antiviral and anti-inflammatory drugs.
A study published in the Nature journal Scientific Reports found that many tea and herbal products contain unlisted ingredients, including weeds and plants from various families. The research used DNA barcoding technology to identify unknown species in 70 tea products and 60 herbal products, revealing a total of 25 unexpected ingredients.
A recent study by Joel E. Cohen and colleagues found that childbearing impeded education more than education reduced childbearing among Norwegian women. The researchers followed all women born in Norway in 1964 through the end of their childbearing, using year-by-year data on education, enrollment, and reproduction.
Researchers have developed a genetically humanized mouse model for hepatitis C, enabling the testing of molecules that block the virus's entry into cells. The new model has the potential to serve as a critical role in prioritizing drug and vaccine candidates.
A new report by US and European researchers found that world forests are becoming larger carbon sinks due to increased density, with no significant expansion of forest area. This increase in density helped maintain regional carbon levels despite deforestation, offering a way to mitigate carbon emissions through managed forestry.
Researchers at Rockefeller University found that anti-inflammatory drugs decrease the efficacy of selective serotonin reuptake inhibitors (SSRIs) in treating depression and obsessive-compulsive disorder. The study suggests that this may be due to the overlap between depression, inflammation, and Alzheimer's disease.
Rockefeller scientists have developed a new polarized microscopy technique that can help deduce the orientation of specific proteins within cells. By harnessing the unique properties of polarized light, researchers have filled in the gaps left by other techniques and made important new discoveries about protein complexes.
A team of researchers from Rockefeller University has carried out a comprehensive evaluation of the antiviral activity of interferon-induced factors, revealing unique subsets of genes that inhibit various viruses. The study found that specific combinations of genes can be more potent than individual ones in suppressing viral replication.
Researchers identify SMER28 molecule that increases autophagy to clear amyloid-beta protein aggregates. Increasing autophagy may improve treatment outcomes for neurodegenerative diseases like Alzheimer's and Parkinson's.
A new study has identified the precise steps in the molecular evolution of Streptococcus pneumoniae, a major threat to global health. The research reveals that the bacterium's genetic makeup has undergone significant changes, with a likely birthplace in Europe and widespread spread across the globe.
Scientists at Rockefeller University have discovered a new class of dendritic cells, called monocyte-derived dendritic cells, that can be derived from blood monocytes. These cells have been shown to have the same functional properties as classical dendritic cells and are promising for therapeutic uses in humans.
Researchers found that the Reaper protein triggers apoptosis by interfering with inhibitor of apoptosis proteins and delivering its death sentence to the mitochondria. By targeting the protein to the mitochondrial membrane, it can be made more effective at killing cells, providing a potential new approach for cancer treatments.
Researchers at Rockefeller University identified a gene called Sept4 that regulates programmed cell death in precursor cells, which can increase the risk of developing cancer. The study found that mice lacking the Sept4 gene had twice as many hematopoietic stem cells and were more susceptible to tumors.
Researchers at Rockefeller University have made two fundamental discoveries about broadly neutralizing anti-HIV antibodies, which effectively keep the virus at bay. They found that most antibodies bind to their target in a polyreactive manner, enhancing overall affinity by binding non-specifically to the virion.
Researchers have identified gamma-secretase activating protein (GSAP) as a key player in the formation of Alzheimer's disease-plaque beta-amyloid. Gleevec, a cancer drug, shows promise in targeting GSAP and reducing plaque production.
Researchers at Rockefeller University have identified two compounds emitted by mosquito predators that deter female mosquitoes from laying eggs in pools of water. These natural insect repellents could provide an environmentally friendly alternative to controlling disease-carrying insects.
Researcher Bruce S. McEwen explores how daily life experiences contribute to overall wear and tear, known as allostatic load, which can lead to lifelong health problems. He emphasizes the importance of improving early childhood development through supportive home environments and parental aid.
Researchers identified a gene variant that affects mice's response to natural hormone fluctuations, leading to increased anxiety and impaired memory. The study suggests the gene may play a role in premenstrual dysphoric disorder (PMDD) and other menstrual cycle-related disorders.
Researchers tracked a virulent strain of MRSA using genome sequencing, shedding light on its spread between South America, Europe, and Southeast Asia. The study reveals the bacteria's evolutionary history and patient-to-patient transmission within a single hospital.
Two NYC high school students used DNA barcoding techniques to discover a zoo of 95 animal species in their homes, including invasive insects and fish. They also found evidence of food fraud, with 11 out of 66 food products mislabeled, posing health risks to consumers.
Mother and daughter cells differ in gene expression and regulation, leading to varying cell cycles. Researchers found that proteins Ace2 and Ash1 control the commitment to divide, with daughters receiving these proteins at birth.
Researchers have developed transgenic songbirds to study the molecular secrets of vocal learning and neuronal replacement. The birds, which can be manipulated genetically, will enable scientists to explore these complex processes at the molecular level.
Researchers at Rockefeller University discovered that Bacillus anthracis forms a symbiotic relationship with viruses to survive and thrive. The viruses alter the lifestyle of the bacteria, influencing its ability to produce spores and form communities.
Researchers at Rockefeller University discovered that telomeres resemble fragile sites in DNA, where replication can stall. A protein called TRF1 helps prevent this by removing unusual structures from telomeric DNA, allowing smooth progression of DNA replication.
New research reveals that cells employ similar molecules for importing and exporting cargo, blurring the line between endocytosis and exocytosis. This challenges traditional biological assumptions about dedicated molecules for specific processes.
Researchers have for the first time visualized the three-dimensional structure of a crucial subcomplex of the nuclear pore complex (NPC), a fundamental innovation in multicellular life. The findings support a common architecture between NPCs and coated vesicles, revealing an ancient evolutionary connection.
Researchers identify three key findings: toxic stress disrupts brain architecture, major risk factors include poverty and abuse, and relieving this stress can improve individual well-being and societal health. The report proposes promising applications in health policy and clinical practice to address these disparities.
A $10 million Simons Foundation gift supports a joint initiative between Rockefeller University and the Institute for Advanced Study in Princeton, NJ. The initiative brings together biologists, mathematicians, physicists, and computer scientists to explore quantitative approaches to biological problems.
A new nucleotide, 5-hydroxymethylcytosine, has been discovered in the mouse brain, opening a new front in epigenetic research. This discovery may challenge existing approaches to investigating DNA methylation and could have significant implications for understanding gene regulation.
Researchers discover that Trypanosoma brucei breaks its DNA to change its surface coat, a key strategy for avoiding immune cells. This finding suggests a common mechanism for DNA rearrangement in parasites and humans.
Researchers used microscopy to study neuron growth in Caenorhabditis elegans and found that certain neurons work backward from their destination. The discovery suggests that the brain is wired based on connectivity rather than absolute distance, providing an explanation for how the brain grows in proportion to the organism.
Scientists at Rockefeller University have uncovered a gene control mechanism that guides epidermal skin stem cells in mouse embryos, tempering the development of the skin barrier. The findings provide insights into therapeutic advances for prematurely born infants with underdeveloped skin.
Researchers at Rockefeller University have identified a diverse team of antibodies in slow-progressing HIV patients whose coordinated pack hunting knocks down the virus. These natural antibodies, produced by six people infected with HIV, show limited neutralizing ability when alone but become effective when combined.
Researchers have successfully infected pig-tailed macaques with a human version of HIV, creating an animal model for studying prevention methods. The new strain, simian-tropic HIV-1 (stHIV-1), can spread almost as quickly as in humans and persists for several months.
Researchers discovered that the locust brain encodes turbulent plumes of odor molecules using surprisingly little neural machinery. The findings suggest a new theory on how animals smell, proposing that individual neurons preserve almost full information about precise temporal dynamics of odors.
Researchers at Rockefeller University identified a human protein, occludin, that makes mouse cells susceptible to the hepatitis C virus. This discovery provides a clear foundation for developing an animal model and tailored treatments for the disease.
A new neuroimaging study shows that stressed humans experience impaired attention-shifting abilities, similar to rats under stress. However, the brain's resilience allows for quick recovery from stress, returning to normal function within a month.
Rockefeller University scientists have discovered a new family of ionotropic glutamate receptors in the fly nose, which explains how cells in coeloconic sensilla detect odors. The finding fills a missing piece in the organizational logic of the insect olfactory system and raises questions about their evolutionary origin.
The Rockefeller University Center for Clinical and Translational Science has awarded grants to university investigators to conduct early studies in translational science. These studies may lead to improvements in human health if successful.
Researchers find AID causes genetic malfunctions leading to Burkitt's lymphoma and potentially other cancers. The enzyme, responsible for immune system adaptation, also targets a cancer-promoting gene.
Researchers at Rockefeller University have developed a new method for identifying proteins that give a cell type its unique identity, offering a breakthrough in cellular analysis. This technique, translating ribosome affinity purification (TRAP), can distinguish between any type of cell in any tissue, with applications for research int...