Researchers at Rockefeller University discovered a new mechanism to create more effective and efficient vaccines against the flu virus. By harnessing modified antibodies, they were able to elicit broad protection against multiple strains of the virus.
Research at Rockefeller University discovered that the recycling of a specific type of histone, H3.3, is essential for forming connections among neurons and facilitating learning throughout life. The study found that increased turnover of H3.3 is linked to neural activity and gene expression changes necessary for synapse formation.
Researchers suggest that a sequence of tailored immunizations could guide the immune response to develop special antibodies that can neutralize HIV. The approach targets the virus's binding site, which remains unchanged despite mutations.
Rockefeller University scientists have uncovered crucial steps in the nuclear pore complex's dilation and constriction mechanism. Transport factor karyopherin initiates ring dilation by stabilizing Nup58, allowing larger molecules to pass through.
Researchers at Rockefeller University have discovered two antibody-binding receptors on immune cells that work together to kill tumors and create a memory of them. The study found that targeting specific antigens with antibodies can lead to the formation of immunological memory, which can suppress future tumor growth.
Researchers at Rockefeller University have cracked the code of a fundamental process bacteria use to defend themselves against invaders. The type III CRISPR-Cas system targets both viral DNA and RNA, preventing viruses from copying themselves and infecting more bacteria.
Researchers at Rockefeller University found that short stretches of genetic material called tRNA fragments can reduce the growth and spread of breast cancer cells. These fragments bind to a key player in the life cycle of cancer cells, known as an oncogene, reducing its ability to promote cell division and metastasis.
A new purpose for histone variant H3.3 has been discovered, preventing genetic mutations by keeping retrotransposons in place. This study reveals a basic mechanism of epigenetics in stem cells, which helps maintain the stability of the genome.
Researchers analyzed genomic data from 16,000 individuals to understand the impact of mutations in two genes associated with a blood disorder. They found that about 1.3% carry a mutation in at least one gene, and algorithms predicted varying levels of harm from these mutations.
Researchers found a potent antibody, 3BNC117, can dramatically reduce viral loads in HIV-infected individuals by catching the virus off guard. The treatment was well-tolerated and effective, with some individuals experiencing sustained reductions in viral loads.
Researchers at Rockefeller University discovered that fast-swimming bacteria can form two-dimensional crystals by clustering together in a lattice structure. The crystals are held together by the rotating motion of individual cells, which creates a unique pattern similar to atoms in mineral crystals.
Researchers tracked protein coats on sleeping sickness parasite, finding up to 80 distinct disguises present at any time. This challenges conventional understanding of antigenic variation and its role in parasite survival.
Researchers discovered a rare genetic mutation that prevents certain children from producing a protein necessary to fight off the flu. This mutation can lead to life-threatening symptoms and has been found in only one case, but clinicians now have a potential treatment option for children with severe flu cases.
Scientists at Rockefeller University successfully adapted CRISPR-Cas9 gene editing to the Aedes aegypti mosquito, which transmits hundreds of millions of people annually with deadly diseases. The researchers aim to understand how different genes help the species operate as a disease vector and create new ways to control its spread.
Cells sort out hairpin-loop structures meant to encode small RNAs, known as microRNAs, using a specific chemical tag. The discovery has wide-ranging implications for development, health and disease, including cancer.
Researchers at Rockefeller University identified Sox9 as a key molecule controlling stem cell plasticity in hair follicles. Sox9 enables hair follicle stem cells to regain their ability to produce new tissue and heal wounds by amplifying genes associated with stemness.
Researchers studied a simple three-cell network within the roundworm brain and found that the collective state of the neurons determines the likelihood of movement towards an odor. The study suggests that nervous systems have internal patterns of activity that are as important as external signals in generating behaviors.
Researchers report significant recovery after a single dose of an experimental treatment targeting interleukin-23, a key immune signaling protein in psoriasis. The study found nearly all patients experienced dramatic improvement in their symptoms, with an average 80% reduction in skin lesions.
Researchers at Rockefeller University found that the Hepatitis C virus binds to miRNA-122, altering gene activity in infected liver cells. This interaction may contribute to liver damage and cancer progression.
Researchers at Rockefeller University found that exposure to TGF-beta prompts changes in mouse tumor stem cells, making them more vulnerable to drugs. The study suggests that this environmental factor contributes to the unpredictable behavior of cancer cells and may lead to better treatment strategies for life-threatening cancers.
Researchers have discovered a new role for the Cas9 enzyme in bacterial immune systems, revealing how bacteria form memories of past viral threats. By analyzing the interactions between Cas9 and other enzymes, scientists have gained insight into the mysterious process by which bacteria encode viral DNA in their genomes.
Researchers discovered that the immune system can turn off cellular enzymes needed by the Influenza A virus, which could lead to new treatments for flu. The study found that PAI-1 protein plays a key role in this process, and its inhibitors may be used to combat viral infections.
High school students Anya Dunaif and Nell Kirchberger collected bacteria from NYC subway stations that resisted two common antibiotics. The samples are part of a city-scale environmental DNA sampling effort to profile the microbiome and assess biological threats.
Researchers found that latent HIV likely resides in long-lived memory cells that help the immune system remember pathogens. The study suggests these cells are the source of the virus's hidden reserves, which could lead to a possible cure for HIV.
Long-acting cabotegravir injections have been shown to be highly protective against vaginal transmission of a virus similar to HIV in two studies involving female monkeys. The drug's potential to improve adherence and offer an additional option for HIV prevention has sparked hope among researchers.
Scientists confirm that face-processing areas in macaque brains respond selectively to facial motion, while reacting less to other types of motion. A new 'middle dorsal patch' is also identified, appearing reliably in response to moving faces, suggesting a potential equivalent in humans.
Researchers found that riluzole treatment boosted spatial memory and communication between neurons in aging rats. The drug promoted the growth of thin spines, which are rapidly adaptable, and increased synaptic clustering.
Researchers at Rockefeller University have successfully used electromagnetic waves to remotely control insulin production in diabetic mice, opening up new possibilities for treating diseases. The system, dubbed radiogenetics, uses a natural iron storage particle and heat-activated ion channel to trigger gene expression in cells.
Researchers find that embryonic stem cells can modify their metabolism to keep their entire genome accessible, allowing them to renew themselves. This discovery could lead to breakthroughs in regenerative medicine and a better understanding of cancer.
Researchers at Rockefeller University have discovered how tiny channels in neurons translate mechanical force into electrical signals. The TRAAK channel uses a novel mechanism involving potassium ion flow and lipid molecules to balance pain sensations.
Researchers found that mosquitoes acquired a love for human body odor and key genes drive this preference. The study suggests that humans provide an ideal lifestyle for mosquitoes, with access to water and large groups, contributing to their evolution as disease vectors.
Research at Rockefeller University resolves the long-standing debate on Rap1's role at telomeres, revealing that human Rap1 plays a minor role in protecting telomeres. The study contradicts previous findings and sheds light on the protein's potential unrelated function.
Researchers developed a system to identify high-affinity nanobodies, which can precisely target specific molecules. This allows scientists to select the best nanobodies, eliminate cross-reactive ones, and generate super-high-affinity dimers for therapeutic or diagnostic applications.
Researchers have gained new insight into the complex molecular process of cholesterol production by mapping the structure of a key enzyme involved in the process. The study revealed two pockets within the enzyme's architecture that help spark the synthesis of cholesterol, with potential implications for the treatment of high cholesterol.
Researchers discovered a paradoxical immune protein that both helps and hinders the immune system response, leading to increased susceptibility to rare bacterial infections and predisposition to autoimmune diseases. The protein ISG15 plays a crucial role in resolving inflammation and preventing autoinflammatory disorders.
Researchers at Rockefeller University have identified a newly discovered class of brain cells that respond to oxytocin in female mice. These oxytocin receptor interneurons (OxtrINs) play a key role in influencing social behavior, particularly in females during their reproductive cycle, and may also contribute to human social interactions.
Researchers develop a novel antibiotic technique that uses the CRISPR enzyme to target specific DNA sequences in drug-resistant microbes, while leaving harmless bacteria intact. This approach shows promise in reducing the risk of secondary infections and preventing the spread of antibiotic resistance.
Researchers at Rockefeller University identified the molecular mechanisms of the stress gap in mice with similar genetic backgrounds. The findings suggest potential new markers for stress-related disorders and a promising route to developing new treatments.
Scientists have discovered that the bacterial immune system can distinguish between harmful and helpful viruses by watching for a specific transcription cue. This adaptation allows bacteria to harness viral genes for their own benefit, offering new insights into the complex relationships between microbes and viruses.
New research at Rockefeller University reveals how IELs develop to protect the intestinal epithelium, a critical interface between the gut and body. Understanding this pathway may lead to new insights into inflammatory diseases of the gut and cancer.
Broadly neutralizing antibodies, combined with viral inducers, have been found to control HIV in mice by targeting latent reservoirs of infected cells. The approach, called "shock and kill," resulted in a 57% success rate in preventing viral rebound.
New research from Rockefeller University suggests that the speed of a signal plays a crucial role in determining an embryonic cell's fate. The study found that cells respond better to signals with pulses rather than continuous ones, and that slower increases in signal strength can lead to weaker responses.
Researchers at Rockefeller University have identified a protein called TARBP2 that triggers breast cancer's spread by blocking other proteins linked to neurodegeneration. This finding suggests new cancer therapies targeting this 'master regulator' could be effective.
Researchers at Rockefeller University developed the first model system to understand the DNA 'replication fork' process in eukaryotic cells. This breakthrough enables scientists to study the molecular tools involved in cell division and may have significant implications for human disease research, particularly cancer.
In a study published in Current Biology, researchers found that the Abdominal-B gene controls a set of neurons responsible for a major part of female fly receptivity. This discovery provides insight into the neural circuitry that drives courtship behavior on the female side.
Scientists have successfully replicated the process of human embryonic stem cells differentiating into separate populations with a reproducible spatial order. By confining cells in tiny circular patterns on glass plates, researchers were able to induce endoderm, mesoderm and ectoderm formation, mirroring natural conditions.
A potential Alzheimer's drug has been identified that prevents abnormal blood clots in the brain, which contribute to memory loss and cognitive decline. The compound, RU-505, targets amyloid-β's role in forming clots and shows promise in both test tube experiments and mouse models.
Researchers have developed a way to identify isolated pieces of DNA floating outside the bacterial chromosome, which can play important roles in virulence and antibiotic resistance. Extrachromosomal DNA elements, such as phages and plasmids, were found widespread among medically important strains of Staphylococci.
Researchers have developed a new monkey model for AIDS using pigtailed macaques, which can cause full-blown AIDS in primates. The model allows for the study of HIV-1's interaction with host antiviral defenses and has the potential to improve prevention and treatment research.
New research reveals that brain activity transitions through dynamic 'way stations' before returning to full consciousness after anesthesia. The study's findings have implications for understanding how brain injury or neurological disease disrupts consciousness, and may provide new insights into coma recovery.