Researchers find a mathematical signature of disintegration from order to chaos in swirling bacterial patterns. This discovery links turbulence in biology and physics, shedding light on the dynamics of active fluids.
A research team at Rockefeller University has identified a potent new weapon against the Zika virus: Z004, an antibody that neutralizes the virus and could be used to create a vaccine. The discovery was made by analyzing blood samples from people who had been infected with the virus.
Researchers at Rockefeller University have created lysibodies, human-germ hybrid molecules that target specific carbohydrate molecules on bacterial cell surfaces, helping the immune system fight off microbial pathogens. The approach shows promise for treating life-threatening infections caused by drug-resistant bacteria like MRSA.
Researchers at Rockefeller University discovered that our primate ancestors evolved a defense mechanism against an ancient virus by manipulating its gene function, leading to its extinction. This study provides valuable insights into the genetic material used by animals to combat viruses, sometimes resulting in viral extinction.
Scientists have successfully tracked fish migration by analyzing DNA in seawater, revealing the presence or absence of several key species. This new technique allows for cheap and non-invasive sampling, potentially improving our understanding of environmental impact on local fish populations.
Researchers at Rockefeller University discovered a genetic mutation in the CRY1 gene that slows the internal biological clock, causing delayed sleep phase disorder. The mutation affects up to 1 in 75 people and can be present in families, with relatives sharing similar signs of persistent sleep problems.
Researchers discovered that microbes activate CRISPR systems early on in viral infections, capturing snippets of viral DNA to create a powerful defense. This early response enables microbes to recognize and attack subsequent viral infections more effectively.
Researchers have determined the three-dimensional structure of the human protein responsible for cystic fibrosis. The study reveals similarities with its zebrafish counterpart, allowing for a deeper understanding of how the protein functions normally and leads to the disease.
Researchers at Rockefeller University have discovered that changes in the vascular system and a plasma component called Factor XII may trigger Alzheimer's disease. The study suggests that targeting this process could lead to early diagnosis and new treatments for the condition.
Researchers found that early intervention with two anti-HIV antibodies can induce potent immunity to HIV, allowing the immune system to effectively control the virus. In a study using macaque monkeys, treatment suppressed the virus levels for up to six months and enabled some animals to spontaneously regain control of the virus.
Sanford Simon at Rockefeller University has received a $600,000 grant from the Fibrolamellar Cancer Foundation to develop a therapy for fibrolamellar hepatocellular carcinoma. The disease typically affects adolescents and young adults with no history of liver disease, and there is currently no standard treatment regimen.
A recent study found that a combination of genetic predisposition, early stress, and male sex increases the risk of social avoidance in individuals with autism. The researchers tested this theory using mice and found evidence supporting the idea that these three factors build on each other to produce the social avoidance characteristic...
Researchers have identified a new class of reader proteins linked to cancer, including leukemia. Disrupting these proteins may lead to effective combination therapies.
Researchers have shed new light on the molecular pump MRP1, which expels cancer drugs from cells. The pump's unique structure features two-part pocket allowing it to accommodate various substances.
Researchers found that a genetic immunodeficiency and delayed acquired immunity combine to produce life-threatening infection. The study identified a critical protein TIRAP that plays a key role in immune defense against invading bacteria.
A crowdsourcing effort helped researchers develop a mathematical model that can forecast the scent a molecule will evoke. The study used over 1 million data points from human volunteers to link perceptual information to chemical features, achieving a perfect score of 0.83 in smell prediction.
Researchers discovered how a protein called WAVE1 regulates brain response to cocaine, providing fundamental insights into the brain's inner workings. The study suggests new potential treatments for cocaine addiction and highlights the importance of understanding dopamine signaling.
Researchers at Rockefeller University found that peroxisome positioning plays a crucial role in controlling the balance between stem cell renewal and differentiation. Disrupted peroxisome distribution led to slower cell division, reduced skin cell differentiation, and tissue formation issues in mouse embryos.
A new biologic agent, 10-1074, has shown early promise as part of a potential new strategy for treating HIV. The drug demonstrated rapid decline in viral load in infected individuals and may be effective in preventing infection in high-risk populations.
Scientists at Rockefeller University have developed a detailed analysis of RNA polymerase, crucial to all cells, which is targeted by the antibiotic rifampicin. The study identifies potential strategies for new drugs that can effectively combat resistant TB strains.
A team at Rockefeller University has discovered an antibody signature that may increase the risk of severe secondary dengue infections. The study found that patients with more serious disease have high levels of antibodies whose Fc regions lack a particular sugar, which strongly activate immune cells and lead to bleeding disorders.
A new study reveals that changes in translation play a crucial role in the development of skin cancer. The researchers found that eIF2A, a protein involved in translating genetic instructions, is overexpressed in certain types of cancer and can serve as a potential therapeutic target for treating the disease.
A study using antibodies from an elite controller has shown that a combination of three broadly neutralizing antibodies can completely suppress HIV in infected mice. The finding validates the approach of using multiple antibodies to control HIV infection, pointing towards a potential new treatment for people infected with HIV.
The MacKinnon lab has reconstructed the three-dimensional architecture of three molecular channels using cryo-electron microscopy. The findings reveal intricate details about how these channels function, with implications for understanding muscle contraction, heart rhythm, and other physiological processes.
The brain can distinguish between expected and unexpected visual motion by selectively silencing neurons sensitive to yaw during intentional turns. This allows flies to stabilize their flight path and shift their gaze without interference. The study provides insights into how the brain processes visual information to control behavior
Researchers at Rockefeller University have identified a single mutation that enables bacteria to acquire genetic memories of viruses 100 times more frequently than naturally. This breakthrough could facilitate the creation of CRISPR-based recording systems for various applications, including data storage and cancer research.
Researchers identify opposing signaling pathways that determine the formation of hair follicles and sweat glands in humans, similar to mice but separated by time. This discovery has potential to improve methods for culturing human skin tissue used in grafting procedures.
Researchers created the first three-dimensional map of the cystic fibrosis protein, revealing a vulnerable spot in the protein responsible for many cases of the disease. The map shows that one half of the channel bears more disease-causing mutations, including one responsible for 70% of disease cases.
Researchers at Rockefeller University found genetic evidence of bacteria capable of producing compounds with potent effects as medicines in urban soil. The study identified a wide range of natural products with potential therapeutic applications, including antibiotics and antifungal agents.
New research clarifies why wounds heal more slowly with age by examining molecular changes in aging mouse skin. The results show that disruptions in communication between skin cells and immune cells slow down the healing process.
Researchers at Rockefeller University have discovered two promising new antibiotics, humimycin A and humimycin B, produced by bacteria in the human body. The compounds work by inhibiting an enzyme that builds bacterial cell walls, offering a potential solution to antibiotic resistance.
Researchers at Rockefeller University used Caenorhabditis elegans worms to study the impact of genetic variations on social behavior. They found that certain genetic variants affect sensitivity to pheromones, leading to changes in foraging strategies, and suggest a link between population density and behavioral adaptations.
Researchers have developed a new method to record brain activity in living mice, capturing the dynamic activity of thousands of neurons in three dimensions. The technique, known as 'light sculpting,' uses laser pulses to illuminate and analyze the activity of neurons within specific layers of the brain.
Researchers discovered that Kinesin-14 protein helps cells bundle growing microtubules into organized structures by guiding their growth in parallel. This mechanism is conserved throughout evolution and found in various animal cells, including humans and flies.
Researchers used genomic testing and data analysis to predict patient response to psoriasis treatment. The approach identified gene-expression profiles that can be used to forecast treatment success with over 95% accuracy.
Researchers at Rockefeller University discovered a protein called CRHBP that reduces anxiety in male mice by halting the activity of a stress-inducing hormone. In contrast, the same protein has no effect on female mice.
Scientists discovered that a common intestinal microbe produces an enzyme called SagA, which protects worms and mammals from harmful bacteria like Salmonella typhimurium. The findings could lead to the development of probiotics against Clostridium difficile, a leading cause of hospital-acquired infections.
A research team has identified mutations responsible for midline craniosynostosis, a type of skull-fusion disorder that affects the top of the skull. The study found that rare genetic variants in one gene interact with common changes near another gene to cause the disorder.
Researchers at Rockefeller University and La Jolla Institute for Allergy and Immunology found that Zika virus can infect adult brain cells, specifically neural progenitor cells, leading to cell death and reduced neuron generation. This may have implications for cognitive decline and conditions such as depression and Alzheimer's disease.
Researchers at Rockefeller University have determined the structure of Eag1, a cancer-linked potassium channel, using cryo-electron microscopy. The study reveals key differences between Eag1 and other potassium channels, shedding light on its molecular mechanisms and potential role in cancer.
Scientists discovered that regulatory T cells, which calm inflammatory responses, migrate into the gut lining and convert into anti-inflammatory CD4+ cells. The presence of microbes is necessary for this conversion.
Researchers have created a new mouse model to evaluate CD40-antibody drugs with improved accuracy, advancing those more likely to be effective in patients. The study found that engagement of the human Fc receptor FcRIIB is essential for therapeutic activity, while FcRIIA compromises it.
New research suggests that fluctuations in tRNA levels can have a dramatic impact on cellular function, driving metastatic breast cancer. The study found that two specific tRNAs were associated with increased metastasis, leading to changes in gene expression and protein production.
A study published in Nature Communications reveals that replacing a protein complex involved in muscle development may alleviate symptoms of muscular dystrophy. The researchers identified a genetic switch that drives pericytes and PICs to become muscle cells, providing a potential target for drug development.
Chronic stress alters the architecture of the brain's amygdala, leading to anxiety and depressive disorders. An experimental new drug may prevent this damage by increasing resilience in mice at risk for developing these conditions.
Researchers at Rockefeller University have developed a new technique that captures the activity of an entire mouse brain in a single snapshot. This comprehensive view allows for robust and unbiased comparisons between active neuronal populations, enabling hypothesis generation about brain function.
Researchers developed a new approach to map HIV's interactome, revealing the complex interactions between viral proteins and host cell machinery. The study provides insights into how viruses like HIV infect and replicate in host cells, shedding light on potential anti-HIV therapies.
Researchers at Rockefeller University discover a rare form of cancer caused by a mutation in histone proteins that package DNA. The mutation triggers a proliferative state, leading to tumor development without other DNA mutations present.
A Phase 1 clinical trial shows that an antibody-based drug can stimulate patients' immune response, enabling them to make new or better antibodies against HIV. The researchers also found that the antibody was able to engage immune cells and accelerate their clearance of HIV-infected cells.
Scientists have developed a novel technique to study human embryo implantation, allowing for the first time to observe molecular and cellular processes up to day 14 after fertilization. This breakthrough expands understanding of human development and may shed light on early miscarriages and infertility causes.