The EPIC atlas provides a comprehensive immune cell database to study the mechanisms of immunity and develop more effective treatments. It enables researchers to stratify and analyze data sets using artificial intelligence, accelerating vaccine development and identifying new therapeutic targets.
A study of pregnant women found that those who ate at night and consumed lower-quality diets were more likely to retain five kilogrammes or more after giving birth. Practising night eating along with low diet quality demonstrated the greatest likelihood of substantial postpartum weight gain and retention.
A new study found that early screen exposure, sleep disruption, and emotional behavioral difficulties (EBD) are associated in preschool children with neurodevelopmental disorders. The study suggests that the presence of multiple screen devices in the bedroom and excessive daily screen time are key factors contributing to these issues.
Researchers from SingHealth Duke-NUS Institute of Precision Medicine linked chronic sleep deprivation to increased cardiovascular disease risk markers and accelerated biological aging. Volunteers who slept less than five hours a night had shorter telomeres, which are thought to represent cellular age.
A new study published in Nature Medicine found that fetal gene therapy can prevent and cure neonatal lethal neurodegenerative diseases in humans in utero. The therapy was tested on mice with Gaucher disease and showed promising results, including improved brain degeneration and increased survival time. Researchers believe this approach...
Researchers from SingHealth, Duke-NUS Medical School, and NCCS have sequenced the complete genetic blueprint of durian, a tropical fruit known for its unique smell. The study reveals that durian has approximately 46,000 genes, nearly double those found in humans.
Researchers identified a group of regulatory T cells linked to inflammation in JIA, which can be used as a diagnostic marker and predict treatment responsiveness. The team also found that patients' DNA features affect treatment outcomes, enabling personalized medicine for improved care.
Scientists discovered fetal immune system establishment as early as 2nd trimester, allowing independent responses and immune tolerance. Dendritic cells expressing Arginase-2 regulate TNFα production, preventing unwanted inflammatory responses.
Assoc Prof Lim Soon Thye has received a S$2.5 million Tanoto Foundation Professorship to advance research on Non-Hodgkin's Lymphoma, a cancer prevalent in Asia with limited treatment options. The funding will focus on improving diagnostic and clinical outcomes for patients.
A Singapore-led team, with support from the Swiss Rising Tide Foundation, is conducting a Phase III clinical trial to evaluate Aspirin as secondary prevention therapy for patients with established colorectal cancer. The study aims to determine the effectiveness of Aspirin in reducing cancer recurrence and mortality.
A team of Singaporean scientists has identified the genetic landscape of fibroepithelial breast tumors, revealing how they progress from benign to cancerous types. The study's findings may improve diagnostic accuracy and enhance clinical intervention for patients with these tumors.
A study by Singapore researchers established that gene p73 has both promotional and suppressive functions in tumor growth. The findings suggest that p73 is stabilized and activated under hypoxic conditions, promoting efficient blood vessel formation that supports tumor development.
A multi-disciplinary team from Singapore has characterised genetic changes associated with liver metastasis in colorectal cancer, enabling the development of personalised diagnostic tests. The research could lead to improved treatment and cure rates for patients.
A study by NCCS reveals a new attenuated-dose regimen of sunitinib improves patient quality of life and reduces treatment costs for Asian patients with metastatic renal cell carcinoma. The median overall survival rate increased to 27.4 months, reducing toxicities by 30% compared to the conventional dosing.
Researchers identified a strong association between an East-Asian specific mutation and increased risk of wet AMD, highlighting the importance of HDL metabolism in the disease's pathogenesis. The study also uncovered three new genes linked to AMD for the first time.
A phase II clinical trial combining Sorafenib and Selective Internal Radiation Therapy (SIRT) achieved improved patient survival, with median overall survival of 20.3 months for intermediate stage HCC patients. The treatment also showed promise in downstaging locally advanced HCC to potentially curative treatment.
A study conducted by National Cancer Centre Singapore found that breast cancer surgery can be safely performed on women aged 80 and above. Most patients recovered without complications, while only 3% developed major complications. The results dispel the misconception that surgery is unsafe for elderly patients.
A phase I clinical trial for MicroVAX's cancer vaccine has begun in Singapore, assessing safety and immune response against breast, prostate, colon, ovary, and lung cancers. The vaccine targets a common protein on many types of cancer.
A new study has shown that Celgosivir, a naturally occurring compound, is generally safe and well-tolerated in patients with dengue virus. The treatment regimen will be tested in the next phase to evaluate its therapeutic effect.
A multi-disciplinary team of scientists has discovered that a gene called MED12 is altered in nearly 60% of fibroadenomas, the most common benign breast tumours diagnosed in women. The study's findings have potential applications in distinguishing fibroadenomas from breast cancer and developing targeted therapies.
A research team led by Dr. Zeng Li has discovered a novel function of the Amyloid Precursor Protein (APP), which controls the growth and maturation of newborn brain cells. This finding may help researchers understand how APP goes awry in Alzheimer's disease and potentially lead to innovative therapeutics.
A randomized controlled double-blinded trial involving 213 healthy women showed that the DIVA System provided better systolic blood pressure control and reduced nausea incidence compared to manual vasopressor administration. The system's enhanced speed and accuracy deliver a safer and better birth experience for patients.
Researchers found that ANP32E strips histone H2A.Z from DNA, altering gene expression and leading to improper chromatin structure in cells lacking the protein. This discovery could reveal novel therapeutic strategies for diseases and cancers.
A team of Singapore scientists has made a breakthrough in understanding the molecular basis of bile duct cancer by mapping human genes disrupted in cholangiocarcinoma. The study identified several genes that were repeatedly disrupted in CCA development, suggesting new potential avenues for treatment.
Researchers at NHCS successfully reversed effects of hERG mutation in patient-specific heart cells, scoring a world's first. The discovery could revolutionize drug development and lead to a potential cure for the life-threatening condition within 5-8 years.
A team of Singaporean and Taiwanese scientists have discovered that Aristolochic Acid (AA), a natural compound found in traditional Asian herbal remedies, is the most potent carcinogen identified to date, causing extensive DNA mutations. The study also reveals AA's possible link to liver cancer and calls for increased public awareness ...
A new type of deadly intestinal lymphoma has been identified in Asian patients, with a novel biomarker and diagnostic test developed to accurately diagnose the disease. The study's findings impact the 2008 WHO classification and offer improved treatment strategies.
Researchers at the National Cancer Centre Singapore have discovered a crucial link between mutant p53 genes and reduced treatment response in cancer patients. The dominant-negative effect of these mutations inhibits tumor suppressor activity, leading to poor responses or earlier relapse after treatment.
Researchers at NHCS have developed a novel human heart cell model of ARVC, allowing for safer study of genetic cardiovascular diseases and risk stratification. The model replicates key characteristics of the disease, including abnormal fatty changes and altered desmosomal proteins.
The SingHealth Duke-NUS Scientific Congress recognized outstanding research in basic, translational, clinical, and health services and systems fields. The event honored researchers who presented breakthrough studies on post-surgical scarring, pre-eclampsia, virtual reality rehabilitation for stroke patients, and more.
A new treatment method has been developed to reduce post-surgical scarring in glaucoma patients. The treatment uses a gel containing the anti-scarring drug 5-Fluorouracil, which is time-released over several days, resulting in fewer injections and less hospital visits.