The Endocrine Society provides guidelines for treating gender-dysphoric individuals, emphasizing the importance of multidisciplinary teams and informed consent. The recommended treatment includes hormone therapy to suppress sex hormone secretion and maintain normal levels for the person's affirmed gender.
A nationwide study found that women with PCOS have a four times greater risk of developing type 2 diabetes and are diagnosed at an average age of 31, compared to those without PCOS.
A comprehensive review highlights the importance of lifestyle modifications and emerging approaches to manage menopausal symptoms after breast cancer. Non-pharmacologic therapies and several promising emerging agents show promise for symptom relief with reduced breast cancer risk.
A new study highlights the need to improve testosterone prescribing practices in the VA, with variations found in age, experience, specialty, and region. Providers under 40 were more likely to prescribe testosterone, while those over 60 were less likely.
A new Israeli study found that higher BMI and even normal-weight adolescents are at increased risk of death from non-coronary cardiovascular diseases. Researchers analyzed data from over 2 million adolescents, showing a significant association between adolescent obesity and mid-life cardiovascular mortality.
The Endocrine Society issued a Scientific Statement on obesity's causes, emphasizing the need to understand underlying mechanisms that make it difficult to maintain weight loss. The statement highlights the complex interplay between genetics, developmental influences, and the environment in contributing to obesity.
A comprehensive review highlights the most effective treatment options for co-managing type 2 diabetes and osteoporosis. Researchers suggest using medications like Metformin and DPP-4 inhibitors to protect bone health. Meanwhile, insulin therapy is recommended for achieving glycemic control in patients with T2D and fractures.
Researchers analyzed DNA samples from over 95,000 participants to examine the association between Alzheimer's disease and low BMI. The study found no causal relationship, suggesting that individuals with Alzheimer's disease are more likely to have low BMIs due to weight loss in the early stages of the disease.
A large-scale UK study has found that children with obesity face four times the risk of developing type 2 diabetes compared to those in the normal BMI range. The study examined data from over 369,000 children and found no association between obesity and increased incidence of type 1 diabetes.
The Endocrine Society has issued a statement advising healthcare providers on how to spot hormonal causes of high blood pressure that can be cured with surgery or treated effectively with medication. Screening for underlying conditions is crucial to prevent cardiovascular disease, renal disease, and even death.
A new study presents evidence that vitamin D deficiency is associated with increased markers of cardiovascular disease in overweight and obese children. The research found a significant link between low vitamin D levels and higher levels of atherogenic lipids, triglycerides, and non-HDL cholesterol.
Researchers found that inhaled corticosteroid use is associated with a higher body mass index (BMI) and an increased prevalence of the metabolic syndrome in women. Corticosteroid users had a 1.4-fold elevated likelihood of having the metabolic syndrome, with nearly a point higher BMI.
A recent study found that high-calorie diets cause similar levels of bone loss in mice regardless of fat content. Glucocorticoid signaling in the skeleton plays a crucial role in diet-induced metabolic disturbances. Disrupting this signaling pathway may protect against obesity and related health issues.
A study found that individuals with obesity who participated in a structured weight loss program reported fewer hours missed from work after six months. On average, participants worked 6.4 hours more than expected, while their overall work performance did not change significantly.
Children at high risk of developing type 2 diabetes may benefit from screening using both hemoglobin A1C and oral glucose tolerance tests, according to new research. The study found that the optimal cutoff points for diagnosing prediabetes and diabetes in youth were 40 mmol/mol (5.8%) and 44 mmol/mol (6.2%), respectively.
Researchers have discovered a unique metabolic signature in the urine of diabetic, obese black teenagers that may become a way to predict the development of type 2 diabetes. Levels of serotonin metabolites were found to be lower in those with diabetes, while other metabolites were higher.
Researchers found that treating polycystic ovary syndrome (PCOS) early can restore ovulation and normalize symptoms, potentially preventing future subfertility. The study suggests a new approach to treating PCOS, using SPIOMET to reduce visceral fat and insulin levels.
A new study found that a videoconferencing educational program equips rural primary care providers with the confidence to manage patients with complex diabetes. The program, called Endo ECHO, improves access to specialized care for large numbers of patients through weekly virtual clinics.
A new study finds that an artificial pancreas system improves blood glucose control better than usual home management for children aged 5 to 8 years with type 1 diabetes. The wearable device uses computer algorithms to track blood sugar levels and adjust insulin dosing, resulting in a longer time in the target range.
A study has identified hormones as the cause of inguinal hernias in older men, finding that increased estrogen action and decreased testosterone levels lead to muscle tissue weakness and scarring. The researchers propose using aromatase inhibitors as a potential treatment to prevent recurrence or even surgery.
Researchers found that traumatic brain injuries disrupt the stress axis differently in female and male mice, leading to increased anxiety and depression in women. The study provides a missing link between mild blast injuries and neuropsychiatric disorders.
A study of 260 individuals with type 2 diabetes found that night shift workers had poorer glycemic control, despite adjusting for factors like diet and sleep duration. The research highlights the need for special attention to managing diabetes in this population through healthy habits and medication use.
Lindsey Konkel received the Endocrine Society's Award for Excellence in Science and Medical Journalism for her coverage of endocrine-disrupting chemicals' impact on placenta development. The article highlights how exposure to EDCs can increase an individual's risk of developing diseases later in life.
Preliminary research suggests that low-calorie sweeteners promote metabolic dysfunction and increase glucose transport into cells. Studies found increased expression of genes markers of fat production and inflammation in human stem cells exposed to sucralose.
A new study finds that deep transcranial magnetic stimulation (dTMS) causes weight loss in obese individuals by improving their intestinal bacteria composition. After five weeks of treatment, dTMS-treated subjects lost more than 3 percent of their body weight and 4 percent of their fat compared to the control group.
Research found disparities in type 1 diabetes care among US military children, with white and officers' kids more likely to use insulin pumps and continuous glucose monitors. These technologies led to better glycemic control, but hospitalizations remained similar between pump users and those using multiple daily injections.
Patients undergoing bariatric surgery who have higher levels of the thyroid hormone triiodothyronine (T3) lose significantly more excess weight than those with normal T3 levels. This finding underscores the potential for thyroid hormone treatment after bariatric surgery.
A new study found that higher levels of vitamin D, insulin-like growth factor-1, and dehydroepiandrosterone sulfate are associated with a lower risk of worsening frailty in men. These findings suggest that targeting these hormones may help prevent frailty development in aging men.
A new study found that brain signals associated with fullness are dulled in obese children, leading them to overeat and gain weight. Obese children's brains responded more strongly to high-calorie foods after eating, suggesting a blunted satiety response.
A phase 3 trial found that a natural combined estradiol-progesterone capsule significantly decreased moderate to severe hot flashes in postmenopausal women. The treatment was well-tolerated with minimal side effects, presenting an alternative to unregulated hormone therapies.
A new simple tool can help identify individuals with a higher risk of developing prediabetes. The tool is based on the time it takes to reach a maximal sugar level during an oral glucose tolerance test, indicating poorer pancreatic function and increased risk for diabetes.
The study found that E4 lowered testosterone levels in healthy male volunteers, with decreasing total and free testosterone, FSH, and estradiol levels. The hormone was well-tolerated, with only libido decrease and nipple tenderness reported.
A new study conducted in rats found that mothers' alcohol use before conception can harm their offspring's glucose function, increasing the risk of developing diabetes. The research suggests that pre-pregnancy alcohol exposure may be passed on to the child, leading to lifelong effects on glucose homeostasis.
Research published in ENDO 2017 found that patients with more severe heart failure are associated with higher TSH and T4 levels, lower T3 levels, and increased risk of needing mechanical assistance or death. Subclinical hypothyroidism is also linked to worse survival outcomes.
A new survey finds that nearly a quarter of transgender individuals in Toronto regard their fertility as important, yet most lack knowledge about reproductive options. Early discussions with healthcare professionals may improve awareness and access to these options.
A new measurement technique has reanalyzed vitamin D levels and lowered the estimated Recommended Dietary Allowance (RDA) from 800 to 400 International Units (IU) per day. This change may have significant public health implications, with easier-to-achieve daily intake of 400 IU recommended.
A study of 9,231 individuals found that those with higher free thyroxine (FT4) levels had an elevated risk of atherosclerotic morbidity and mortality independent of cardiovascular risk factors. Higher FT4 levels were also associated with greater risk of subclinical atherosclerosis.
Thyroid cancer incidence has increased in the US, with higher rates among Hispanics and African Americans compared to non-Hispanic Whites. The study found a significant rise in incidence among young people, particularly Hispanic females between 20-49 years old.
A study by the Endocrine Society found that higher exposure to certain flame retardants may be associated with an increased risk of papillary thyroid cancer. The researchers collected dust samples from homes and analyzed participants' blood samples to assess long-term exposure to these environmental chemicals.
Research reveals that consuming cow's milk with levothyroxine supplement can lead to reduced absorption of the medication, potentially resulting in inadequate thyroid hormone levels. The study advises patients on managing hypothyroidism or taking levothyroxine to avoid consuming dairy products simultaneously.
Research suggests that early-life BPA exposure can lead to fatty liver disease by reprogramming gene expression. The study found that BPA creates new activating epigenomic marks on genes driving the progression of NAFLD in rats.
Researchers developed a decision-tree tool to screen women with gestational diabetes for obstructive sleep apnea. The study found that neck circumference was significantly larger in the OSA group, and having a neck circumference greater than 35.5 cm was associated with higher risk for sleep apnea.
A study found that prolonged sleep disturbance can lead to reduced bone formation and increased osteoporosis risk. After three weeks of cumulative sleep restriction, healthy men had lower levels of a bone formation marker, indicating a potential bone loss window.
Researchers have developed selective androgen receptor degraders (SARDs) that can degrade all forms of the androgen receptor, potentially providing advanced treatment options for men with castration-resistant prostate cancer. These molecules inhibit the growth of aggressive prostate cancers that are unresponsive to other treatments.
Exposure to BPS multiplies breast cancer cells, exhibiting estrogen-mimicking behavior, and may cause breast cancer to become more aggressive. The study confirms BPS as a potent endocrine disruptor.
Research suggests that exposure to common pesticides like pyrethroids may cause boys to reach sexual maturity earlier. A study of Chinese boys found a strong association between increased levels of the pesticide metabolite 3-PBA and accelerated puberty, including higher levels of testosterone.
A study of people with type 2 diabetes found that those with a later sleep-wake time preference reported more depression symptoms, regardless of sleep quality. The findings support an association between circadian regulation and psychological functioning in patients with type 2 diabetes.
The partnership brings together the Endocrine Society's expertise and Medscape's innovative digital platforms to equip physicians with timely and useful guidance on diagnosing and treating endocrine disorders. Experts will produce original features and share case studies on Medscape Consult, leveraging its crowdsourcing platform.
Hypothalamic amenorrhea affects adolescent girls and women with low body weight, causing halted menstruation. The Endocrine Society's Clinical Practice Guideline provides recommendations for diagnosis and treatment, emphasizing behavioral modifications and specialized dietary instructions.
A new study found that intensive medical treatment using oral medications, insulin, and lifestyle therapies can reverse type 2 diabetes in up to 40% of participants. The study's findings support the notion that type 2 diabetes can be reversed, at least in the short term, with medical approaches.