Researchers at UT Southwestern Medical Center found that Klotho, an anti-aging hormone, suppresses renal fibrosis and cancer growth in mice. This discovery offers a potential new treatment for patients with chronic kidney disease and acute kidney injury.
The study will investigate environmental and genetic factors affecting child health, development, and quality of life. Researchers aim to understand the impact of various factors on chronic illness in children.
Dr. Mala S. Mahendroo will investigate biological mechanisms and causes of premature birth with a new $600,000 Burroughs Wellcome Fund grant. She aims to develop an imaging tool to assess collagen changes that precede preterm birth.
UT Southwestern researchers have identified a specific type of blood pressure medication that minimizes the effect of decreased blood flow and oxygen levels in muscles during exercise. This finding has implications for people with high blood pressure who may stop exercising due to fear of heart attack or stroke.
Researchers at UT Southwestern Medical Center found that neural stem cells in the brain's memory area become activated after injury and remodel the area with newly generated nerve cells, but this process may be limited by a finite pool of stem cells.
Researchers at UT Southwestern Medical Center have discovered genetic pathways that selectively starve kidney cancer cells. The study found that inactivating the von Hippel-Lindau gene can block cells from using oxygen to generate energy, forcing them to use alternative methods such as glycolysis.
A study of pregnant women using intrauterine devices found that over half had malpositioned devices, which may increase pregnancy complications. Regular sonograms after IUD placement can help confirm proper positioning and reduce risks.
Researchers at UT Southwestern Medical Center discovered a hormone pathway that could lead to new ways of treating type 1 diabetes independent of insulin. Fibroblast growth factor 19 (FGF19) has insulin-like characteristics and may offer an alternative treatment for diabetes.
A new anti-asthma medication has been found to nearly eliminate seasonal asthma attacks in children and young adults with allergic asthma. Researchers found that the treatment improved asthma control, reduced symptoms by 25%, and decreased asthma attacks by 30%.
Researchers at UT Southwestern Medical Center identified a chemical compound that may lead to a drug to combat cancers dependent on the anti-viral enzyme TBK-1. The compound, 6-aminopyrazolopyrimidine, was tested in mice and showed effectiveness in reducing cancer growth.
A retrospective study found three-year catheter survival rates of over 91% for patients with end-stage renal disease who underwent peritoneal dialysis. Non-infectious complications, such as obstruction and trauma, were significantly associated with catheter failure.
Researchers at UT Southwestern Medical Center discovered a brain signaling pathway that induces leptin resistance, leading to decreased satiety and increased visceral fat. Activating this pathway, known as cAMP-EPAC, can induce leptin resistance in hypothalamic neurons, a critical site of leptin action.
A study found that patrons of black-owned barbershops who received regular blood pressure measurements and encouragement from barbers were nearly nine times more likely to see a physician than those who only received hypertension literature. The intervention led to a significant increase in men controlling their hypertension, with rate...
A UT Southwestern study found that children placed with relatives have better outcomes in some areas, but may be at higher risk of substance use and teenage pregnancy. Kinship caregivers receive fewer support services than foster parents.
Researchers at UT Southwestern Medical Center discovered that newborn hearts can heal themselves completely. Within three weeks of removing a portion of the heart, it was able to grow back the lost tissue and function like a normal heart. This breakthrough offers new possibilities for treating heart disease.
Researchers found that Klotho hormone levels are low in patients with chronic kidney disease, which can lead to serious side effects. Restoring adequate Klotho levels improved renal function and reduced vascular calcification in mice with CKD.
Researchers have developed a novel technology to diagnose Alzheimer's disease from blood samples before symptoms appear, identifying two potential biomarkers with 90% accuracy. This breakthrough could lead to earlier intervention and improved outcomes for patients.
A new study reveals that standardized medication dosages for children with tuberculosis are too low and may not be effective due to individual variations in response. The researchers used computer simulations to determine how a child's body handles the medication, highlighting the need for personalized treatment plans.
Researchers found that dutasteride is impractical due to high costs and marginal impact on survival and quality of life for at-risk groups. The medication's annual cost of $1,400 outweighs its benefits, making it less effective as a preventive measure.
UT Southwestern researchers found that eliminating glucagon action can restore glucose tolerance to normal in mice with type 1 diabetes. This suggests a potential 'cure' for the disease, as insulin would no longer be necessary.
Patients with diabetes, kidney disease, and anemia who don't respond to treatment with darbepoetin alpha have a higher risk of cardiovascular disease or death. The study suggests customizing treatment based on initial response to the drug could reduce risk.
Researchers at UT Southwestern Medical Center have discovered a key mechanism by which the 'starvation hormone' adiponectin functions, promoting cell survival and inhibiting cell death in both pancreatic beta cells and cardiomyocytes. This finding has implications for treating conditions like diabetes, heart disease, and cancer.
Researchers pinpointed the ventral premammillary nucleus as a key site in the brain where leptin acts to trigger puberty in females. This finding sheds light on the potential impact of childhood obesity on the onset of puberty, particularly in girls.
Researchers at UT Southwestern Medical Center discovered gene expressions in lung tumors and normal tissue that predict patient survival time and guide effective treatments. The study found specific nuclear receptors associated with good prognosis and identified potential drug targets for personalized therapy.
Researchers developed a clinical risk prediction rule using factors such as sex, race, and health history to assess the danger of carotid surgery. The CEA-8 rule found that one-fourth of asymptomatic patients were at higher risk than recommended national guidelines, highlighting the importance of weighing individual benefits and risks.
A new blood test can detect cardiac troponin T levels in 25% of seemingly healthy individuals, indicating an increased risk of dying from heart disease. The test's results showed that those with elevated troponin T levels were nearly seven times more likely to die within six years.
Researchers at UT Southwestern Medical Center have identified the molecular mechanisms underlying antiphospholipid syndrome (APS), a potentially life-threatening condition that causes blood clots. The study's findings suggest that targeting specific proteins may lead to new therapies for APS and its associated pregnancy complications.
UT Southwestern researchers have identified a gene responsible for JMP syndrome, an extremely rare disorder characterized by severe joint stiffness, muscle loss, and panniculitis-induced lipodystrophy. The proteasome subunit beta-type 8 (PSMB8) gene mutation affects immune cell function, leading to inflammation and fat loss.
Researchers at UT Southwestern Medical Center have discovered a feedback cycle involving microRNAs, proteins called ZEB1 and ZEB2, and pregnancy-maintaining hormone progesterone. MicroRNA levels increase before labor, enabling uterine contractions.
A circuit in the brain regulating serotonin-receptor signaling may explain anti-diabetic actions independent of body weight and feeding. Reactivating this receptor in specific neurons protects mice from insulin resistance and metabolic problems.
A study by UT Southwestern Medical Center found that the adrenal gland hormone aldosterone increases activity in the nervous system that raises blood pressure. The research suggests that treating hypertension requires targeting not just the kidneys but also the sympathetic nervous system.
Researchers at UT Southwestern Medical Center found that infusing leptin into the brain of mice with type 1 diabetes reversed lethal consequences and improved metabolism. The study suggests a novel role for the brain in mediating beneficial actions of leptin, potentially leading to new therapies for individuals with type 1 diabetes.
Temperature fluctuations have a profound impact on the human body's internal clock. By regulating body temperature, these cyclic changes set the timing of cellular activity, influencing metabolism and sleep patterns. This discovery suggests an ancient mechanism that may have evolved in other organisms to control daily biological cycles.
A study published in Archives of Internal Medicine found that hormone therapy after menopause increases the risk of developing kidney stones by approximately 20 percent. The research calls into question the long-held belief that estrogen protects women from the disease, and clinicians need to consider the risks and benefits of hormone ...
Researchers at UT Southwestern Medical Center have created an experimental vaccine that stimulates more than 10 times as many antibodies against beta-amyloid as similar DNA vaccines. The new approach shows promise in generating enough antibodies to be useful clinically in treating patients.
A national study found that keeping blood pressure at 130/80 mm Hg reduced the risk of disease progression by 27 percent for patients with proteinuria. However, intensive lowering of blood pressure in all African-Americans did not slow disease progression.
UT Southwestern researchers have found a set of proteins in blood serum that shows promise as a sensitive and accurate way to diagnose Alzheimer's disease. The analysis proved 94 percent accurate in detecting suspected Alzheimer's and 84 percent accurate in ruling it out in people without the disease.
Researchers aim to determine if vigorous exercise can help people abstain from stimulant abuse and improve their health. The study, STRIDE, will monitor participants' drug abstinence and relapse rates, as well as physical and mental health outcomes.
A recent analysis by UT Southwestern Medical Center found that more people are consuming alcohol now than in the early 1990s. The study, which gathered data from over 85,000 respondents, suggests that a range of factors, including social, economic and ethnic influences, contribute to the increase.
Researchers found that traditional programs may not be effective for all teens, but targeted approaches may help curb aggression. Factors such as poverty, academic troubles, and depression can increase the risk of fighting among certain groups.
Researchers at UT Southwestern Medical Center have found that overexpressing microRNA-21 promotes the formation, growth and survival of new tumors in mice with non-small-cell lung cancer. The study suggests that inhibiting miR-21 could be a therapeutic approach to treating the disease.
Researchers have discovered unique metabolic properties of bone-marrow stem cells that allow them to survive and replicate in low-oxygen environments. This finding may lead to new strategies for enriching stem cells by selecting those with specific metabolic characteristics.
Researchers have uncovered a critical mechanism by which Vibrio parahaemolyticus kills cells and causes food poisoning. The study reveals that the bacterium uses a molecule called VPA0450 to remove a phosphate from host-cell membranes, leading to cell destruction.
Researchers at UT Southwestern Medical Center have found that amphetamine abuse increases the risk of aortic dissection in young adults. The study, published in American Heart Journal, analyzed medical records from nearly 31 million people and found a threefold increase in odds of aortic dissection among those who abused amphetamines.
Researchers discovered a distinct cholinergic system in cocaine-addicted brains, affecting blood flow and regions involved in emotions and behavior. This finding may lead to new treatment options for addiction by targeting this specific system.
The Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center has attained NCI designation, recognizing its innovative research and excellent patient care. The center will receive a $7.5 million support grant over five years to advance cancer research and provide patients access to promising new treatments.
Researchers at UT Southwestern Medical Center discovered a tiny RNA fragment, miR-451, that regulates red blood cell production. By inhibiting this process, they hope to develop new treatments for cancers and anemia.
Researchers compared two treatments for preventing strokes due to carotid artery disease, but found no clear winner. While surgery may be beneficial for patients who have had a stroke or temporary stroke in the past 12 months, stenting offers similar benefits for asymptomatic patients.
A study published in Nature found that high doses of corticosteroids given repeatedly over several weeks may help individuals with lupus by killing off the cells producing interferon alpha. This approach is more effective than standard treatment, which can lead to long-term side effects.
Researchers at UT Southwestern Medical Center discovered a link between anti-TPO antibodies and placental abruption in pregnant women. The study of over 17,000 women found that antibody-positive women were three times as likely to experience placental separation during labor.