A Yale University study found that new national guidelines can accurately prescribe statins to patients at risk for cardiovascular disease. The research shows the new guidelines produce a modest increase in patient treatment, with only 92% of those with heavy plaque being assigned to statin therapy under the new method.
Yale physicists have successfully cooled strontium monofluoride to near absolute zero using magneto-optical trapping, enabling new research in quantum chemistry and particle physics. The discovery opens doors for experimentation in precision measurement, quantum simulation, ultracold chemistry, and tests of the standard model.
Scientists at Yale University have successfully changed the color of butterfly wings using evolutionary principles, producing the first structural color change in an animal. The research has implications for the design of new materials and devices, and may help physicists and engineers develop more efficient designs.
Researchers at Yale University have discovered a new drug compound, TC-2153, that inhibits the negative effects of STEP protein and reverses cognitive deficits in Alzheimer's disease. The compound was found to improve cognitive function in mice, suggesting a potential therapeutic avenue for treating the disease.
A new study by Yale researchers found that blocking the effects of PPARgamma in brain cells can prevent weight gain and resistance to high-fat diets. This discovery has key implications for treating type 2 diabetes, where weight gain is a common side effect of medication.
A study by Yale researchers has identified a crucial role for prolyl endopeptidase enzyme in regulating glucose sensing in the brain. The findings suggest that this enzyme plays a key role in controlling blood sugar levels, and could eventually lead to new treatments for diabetes.
Researchers at Yale University developed a diagnostic test to detect PD-L1 expression in early-stage breast cancers, with 60% showing high levels of PD-L1 and tumor-infiltrating lymphocytes. High levels predicted better survival rates for patients, suggesting an immune system's role in controlling these cancers.
LUX-Zeplin (LZ) will boost the size and effectiveness of the original LUX technology with a larger xenon detector, aiming to spot Weakly Interacting Massive Particles (WIMPs) as they move through liquid xenon.
A study by Yale University researchers found that obese women were impaired in learning associations between food cues and rewards, but normal-weight individuals and men did not show the same impairment. This suggests a specific behavioral intervention targeting food-specific learning impairments may be effective in treating obesity.
Researchers from Yale University analyzed the eye structure of an extinct sea scorpion, finding that it had a basic visual acuity level but worsened with size. The study suggests the creature was not a top predator but may have been a scavenger hunting at night.
Researchers at Yale University and Fermilab successfully relocated a 30-ton MicroBooNE particle detector to its new building, marking a major step towards studying neutrino behavior. The experiment aims to examine how neutrinos interact and change within a distance of 500 meters.
Astronomers at Yale University have discovered seven previously unseen dwarf galaxies using a novel telescope that can detect low-surface-brightness objects. The finding suggests the possibility of a new class of galaxies in space, with potential implications for dark matter and galaxy evolution.
A study by Yale University researchers found that Medicare spending on breast cancer screening increased significantly between 2001 and 2009, despite no corresponding decrease in new breast cancer cases. The use of digital mammography technology, which is more expensive than standard film technology, contributed to the increase.
In experiments by Yale and Harvard psychologists, more than two-thirds of people were willing to take a sustainable 'fair share' of resources, while selfish individuals consistently destroyed them. Democratic principles led to group consensus on resource allocation, ensuring the next generation's survival.
A 25-year-old patient with alopecia universalis has successfully regrown a full head of hair, including eyebrows and facial hair, after receiving the novel treatment. The patient's condition was previously untreatable, but the new treatment using FDA-approved drug tofacitinib citrate reversed his disease.
A Yale University study found a 50% drop in obstetric malpractice liability claims and payments after implementing patient safety measures, including standardized care and teamwork training. The hospital's efforts reduced liability claims by 95%, saving over $47 million.
A study found that colorectal cancer rates declined significantly after increasing cancer screening tests. The incidence of late-stage and early-stage cancers decreased, resulting in a reduction of 550,000 cancers during the period.
Jessell's seminal research revealed how naïve neural cells develop into distinct motor neuron subtypes to form the spinal cord circuitry. His work has helped create a blueprint for treating neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).
A phase 1b immunotherapy trial combining nivolumab and ipilimumab has shown high one-year and two-year overall survival rates of 94% and 88%, respectively, in advanced melanoma patients. The treatment regimen has demonstrated long-lasting benefits for these patients.
According to a Yale University study, nearly 12% of American children experience confirmed maltreatment by age 18, affecting over 5.6 million children between 2004 and 2011. Black and Native American children are disproportionately affected, with one in five and one in seven experiencing maltreatment respectively.
Researchers at Yale School of Medicine discovered that leptin affects not only brain cells called neurons but also other types of cells involved in appetite regulation. This finding could lead to the development of new treatments for metabolic disorders such as obesity and diabetes.
Researchers report promising results from a phase I study on MPDL3280A, an investigational drug for treating advanced bladder cancer. The trial showed improved response rates among patients with PD-L1-positive tumors, with 7% achieving complete responses.
A daily 20-minute walk can significantly reduce the risk of mobility disability in older adults, with a 18% reduction observed in participants who engaged in physical activity. The Lifestyle Interventions and Independence for Elders (LIFE) Study found that maintaining mobility is key to functioning independently.
Researchers at Yale Cancer Center presented findings from the 50th Annual Meeting of ASCO, highlighting the effectiveness of nivolumab and ipilimumab in treating advanced melanoma. Additionally, studies showed that lifestyle changes such as healthy eating and regular exercise can decrease biomarkers related to breast cancer recurrence ...
A new measure ranks US hospitals based on complications following hip and knee replacements, revealing a significant four-fold difference in risk-adjusted complication rates. The study found no disparities in outcomes between hospitals caring for higher proportions of Medicaid-eligible or black patients.
A recent study by Yale University researchers found that black male incarceration has compromised research studies on health outcomes, leading to a significant loss of follow-up data. The study estimated that high incarceration rates among black men may have accounted for up to 65% of the loss of follow-up among this group.
Despite recommendations for safer sleeping, infant deaths continue to occur due to bed sharing and prone sleeping. A study found that 18% of parents share a bed with their infants, with black families at higher risk.
Researchers identified a previously unknown neurodegenerative disorder caused by a single mutation in the CLP1 gene, found in individuals born during the Ottoman Empire. The study suggests that consanguineous marriages in Turkey contribute to the high prevalence of rare genetic disorders.
The genetic blueprint of the tsetse fly provides researchers with codes for its proteins, enabling functional research and improved control methods. Access to the genome data could lead to new strategies to combat African sleeping sickness.
Parts of ancient Antarctica reached temperatures similar to today's California coast and Florida heat due to high CO2 levels. The study used a new method to measure past temperatures, providing insights into the sensitivity of the climate system to greenhouse gases.
Researchers confirmed a genetic variant linked to significantly increased risk of aortic dissection or full rupture. Patients with the mutation may benefit from earlier surgical therapy before an aortic dissection occurs.
Scientists at Yale have confirmed a long-held theoretical prediction in physics, improving the energy storage time of a quantum switch. The breakthrough opens new frontiers for quantum information processing and measurement systems.
A new study recommends sweeping changes to policy and clinical practice to reduce the odds of multiple births after fertility treatments. By expanding insurance coverage for IVF, improving doctor-patient communications, and investing in research, fertility experts aim to minimize health risks and long-term costs associated with multiples.
Scientists at Yale University have developed a faster way to identify and characterize complex alloys known as bulk metallic glasses (BMGs), which are stronger than steel. The new method allows researchers to screen about 3,000 alloys per day, significantly reducing the time needed for discovery.
A Yale-led research team developed a new approach to species conservation that prioritizes genetic and geographic rarity. The method was applied to all 9,993 known bird species, revealing areas where maximum conservation of bird diversity can be achieved with minimal investment.
New research sheds light on how environmental stressors affect the cells of the developing brain, leading to conditions like schizophrenia and post-traumatic stress disorder. Yale scientists discovered a single molecular trigger, HSF1, that activates in brain cells exposed to toxins, making them susceptible to neuropsychiatric disorders.
A new species of ancient porpoise has been identified with an unprecedentedly long symphysis, a structure analogous to the human chin, measuring 85 cm. This unique feature suggests that the animal used its chin to probe the seabed for food, contradicting modern porpoises' feeding habits.
A Yale University analysis found nearly all clinical trials had discrepancies between reported results and published articles. The study suggests errors in reporting or intentional changes may have occurred. Accurate reporting is crucial for maintaining trial integrity.
A new study by Yale University researchers found that a faster and less expensive form of radiotherapy for treating prostate cancer may come with a higher rate of urinary complications. Stereotactic body radiotherapy (SBRT) is a newer treatment option that can be completed in one to two weeks, compared to seven to nine weeks for intens...
The American Academy of Child and Adolescent Psychiatry has revised key parameters for evaluating and treating autism, emphasizing early diagnosis and a team approach to care. Researchers led by Fred Volkmar recommend a coordinated medical, psychological, and communication evaluation to differentiate between autism and other disorders.
A single molecular switch governs production of protective mucus lining intestinal walls, which can be breached by failure of immune system, leading to diseases like inflammatory bowel disorders and metabolic conditions.
Researchers at Yale University have made a breakthrough in understanding the cellular mechanisms behind pulmonary hypertension, a life-threatening condition that affects millions. The study identified specific cells responsible for the disease's progression and suggests potential targets for therapy.
A new study by Yale School of Medicine researchers found that blood pressure medication use is associated with a higher risk of serious fall injuries, similar to the impact of strokes and heart attacks. The study suggests that clinicians should weigh the potential harms and benefits of prescribing medications for older adults.
Yale researchers discovered that accelerating cell cycle speed reduces barriers to changing a cell's fate, allowing for pluripotent cells to be created more efficiently. The study found that cells with faster cycles can become multiple cell types, whereas slower cycles remain in their original state.
About 20 children per day are hospitalized due to firearm injuries in the US, resulting in 453 deaths annually among those under 20. The most common types of firearm injuries include open wounds, fractures, and internal injuries.
A Yale University study found that 50% of women of reproductive age have never discussed their reproductive health with a provider, while 30% visit providers less than once a year or not at all. The study also revealed knowledge gaps on fertility concerns and optimal conception methods.
A new study published in Cell found that mice offspring of mothers consuming a high-fat diet during lactation had abnormal neuronal circuits and altered insulin signaling, leading to lifelong obesity. The study suggests that proper nutrition during critical developmental periods can impact long-term metabolic health.
Researchers at Yale University found that a combination of hydroxychloroquine may partially reverse the detrimental effects of antiphospholipid antibodies on human placental cell function, potentially benefiting pregnant women with lupus and/or antiphospholipid syndrome. This could lead to improved pregnancy outcomes for these patients.
A study published in JAMA found that more than one-third of FDA-approved drugs were approved based on a single clinical trial, without replication. The study analyzed the strength of clinical trial evidence supporting drug approvals from 2005 to 2012 and found significant variability in trial design and duration.
A Yale study estimates that 8 million lives have been saved in the US as a result of anti-smoking measures introduced 50 years ago. The study found that these efforts have significantly reshaped public attitudes and behaviors concerning cigarettes, resulting in an estimated 157 million years of life being saved.