A team of scientists at Yale and Harvard has set a new benchmark for the electron's roundness, contradicting some Supersymmetry theories. The research used a unique method to detect particles, showing that the electron is more spherical than predicted by these extensions.
A single dose of oxytocin has been shown to temporarily normalize brain regions responsible for social deficits in children with autism. The hormone facilitates social attunement, allowing brain regions involved in social behavior and cognition to activate more for social stimuli.
A Yale-led team identified common neural circuits affected by autism-risk genes and when they exert their effects on the developing human brain. The findings suggest new targeted treatments for autism may be possible, focusing on specific neural circuits at specific times.
A recent study published in the British Medical Journal found that top-performing hospitals had fewer readmissions from all diagnoses and time periods after discharge. The researchers concluded that preventing complications is key to reducing readmissions, suggesting a more holistic approach to patient care.
A Yale University study reveals that a person's social network is a key predictor of becoming a victim of gun homicide, even more so than race, age, gender, or poverty. The research found that individuals within the same social network are more likely to engage in similar risky behaviors.
A new study finds that 65% of Americans agree clinicians should be involved in explaining DTC genetic test results. This concern is shared by physician groups and medical journals, highlighting the importance of doctor guidance on interpreting genetic risks.
A new study published in SAGE Open found that people with psychotic disorders such as schizophrenia are more likely to be left-handed. The research team studied 107 individuals from a public outpatient psychiatric clinic and found that 40% of those with schizophrenia were left-handed, compared to 11% of those with mood disorders.
A recent study found that African-American women and non-white women have lower knowledge about urinary incontinence and pelvic organ prolapse compared to white women. The study suggests that culturally sensitive educational interventions are urgently needed to address these disparities.
A Yale School of Medicine study found that immune sensor Nlrp3 inflammasome triggers age-related inflammation, leading to loss of function and frailty. Reducing Nlrp3 activation may help delay or prevent chronic diseases.
Researchers from Yale and Harvard successfully recoded the E. coli genome, enabling it to resist viral infection by limiting natural protein production. The new genetic code also allows for the creation of potent proteins with novel functions.
A study by Yale researchers found that Medicare spent $447 million annually on PSA-based screenings for prostate cancer, with most of it going to men over 75. The cost variation was mainly due to follow-up tests, not the use of the PSA itself.
A massive data analysis has implicated dozens of mutations in breast and prostate cancer development, focusing on non-coding DNA elements. The study provides new insights into the causes and treatment of cancer.
The introduction of the HPV vaccine was introduced in a manner that generated cultural conflict, leading to low vaccination rates. In contrast, the Hepatitis B vaccine was introduced with less controversy and higher completion rates. The article highlights the importance of using evidence-based strategies to anticipate and avoid recurr...
A Yale-led study has identified 52 genes that significantly correlate with outcome in patients with IPF, predicting shorter survival time and guiding treatment decisions. The discovery of these biomarkers may lead to better prediction of disease presence and severity.
The incidence of baby bed-sharing has more than doubled since 1993, with black and Hispanic infants at higher risk of SIDS. Healthcare provider advice plays a key role in educating caregivers about safe sleep practices.
A new study by Yale University researchers found that older adults are more risk-averse than their midlife counterparts when choosing between possible gains, but more risk-seeking when choosing between losses. The study suggests important policy implications for decision-making across the lifespan.
A new study by Yale researchers found that the body's energy-producing mitochondria play a crucial role in regulating appetite and obesity risk. Dynamic changes in mitochondria can either spur or stop obesity, highlighting the importance of mitochondrial plasticity in maintaining healthy energy levels.
Hospitalizations for endocarditis have declined in recent years, but a disparity in outcomes persists among black patients. The study suggests that a reduction in antibiotic use may be contributing to the decline, and clinicians should consider individual risks and benefits on a case-by-case basis.
Researchers at Yale University have identified a protein that serves as the missing link in the chain of events leading to Alzheimer's disease. Blocking this protein with an existing drug has been shown to restore memory and synaptic density in mouse models of the disease. The findings offer strong hope for developing new treatments.
A study by Yale School of Medicine researchers found a significant increase in preoperative breast MRI use among older women with breast cancer, leading to more aggressive surgical treatment. Women who received an MRI were more likely to undergo bilateral mastectomy and contralateral prophylactic mastectomy.
A recent study by Yale University researchers found that former prisoners are more likely to be hospitalized for acute preventable conditions, with a rate 30-65% higher than the general population. The study's results highlight the need for improved healthcare before and after release.
A Yale University study reveals that nearly 50,000 unnecessary deaths among women aged 50-69 with hysterectomies could have been avoided if they used estrogen-only therapy instead of combined hormone therapy. The decline in estrogen usage was linked to the 2002 WHI study's findings on women with a uterus, but not those without one.
The study reveals that Salmonella typhi's powerful typhoid toxin is responsible for the devastating symptoms of typhoid fever. The discovery could lead to the development of effective vaccines and therapeutics targeting this toxin, offering hope for saving millions of lives.
A comparative genomics study led by Yale School of Medicine researchers has identified thousands of sequences controlling genes in the developing human limb. These regulatory sequences are active in humans but not in other primates or mice, suggesting they evolved since the human-monkey divergence.
Women who give birth vaginally are at increased risk of developing pelvic organ prolapse during the year after delivery. Pelvic organ prolapse occurs when connective tissue, muscles, nerves, and blood vessels are damaged, leading to complications such as urinary incontinence and bowel control.
Researchers at Yale University found that a human metastatic tumor can arise when a leukocyte and a cancer cell fuse to form a genetic hybrid, potentially explaining how cancer cells travel to distant organs. The study's findings provide the first evidence of such a phenomenon in humans and could lead to new therapy targets.
A Yale team identified a key molecular mechanism underlying higher-order thinking, which is impaired in schizophrenia. The discovery of the alpha7 nicotinic receptor's role in cognitive function may lead to new treatments for cognitive disorders.
A Yale project has made all of Medtronic's clinical trial research data for a bone growth product available for independent reanalysis. The project, known as the Yale University Open Data Access Project (YODA), aims to address the problem of unpublished and selectively published clinical evidence.
A new study has identified genetic variants that can predispose children to dyslexia and language impairment, allowing for earlier diagnoses and more successful interventions. The research found specific parts of the DCDC2 gene, including READ1, to be associated with reading and verbal language difficulties.
Eve Marder's groundbreaking discoveries have fundamentally changed our understanding of how neural circuits operate and produce behavior. Her research on the stomatogastric ganglion has broad implications for studying neurological diseases like schizophrenia, depression, and chronic pain.
A massive genomics study by Yale researchers found hundreds of mutations causing congenital heart disease, often affecting histone-modifying genes. The study's findings suggest a wide range of common congenital diseases share common pathways.
Researchers discovered that VEGF-driven artery formation requires the binding of VEGFR2 and NRP1. Mice lacking a part of NRP1 molecule had poorly constructed arteries and failed to repair blood vessel blockages. This study opens new therapeutic opportunities for cardiovascular and anti-cancer therapies.
Researchers at Yale University have discovered a key marker to identify newborns at risk for autism: abnormal placental folds and cell growths called trophoblast inclusions. This breakthrough allows for earlier diagnosis and treatment, potentially improving outcomes.
Researchers at Yale University found that even though one of three approved loop diuretics offers more benefits, it is rarely prescribed due to cost concerns. The study compared the effectiveness of toresemide, furosemide, and bumetanide in treating heart failure.
Researchers at Yale University have found that AgRP neurons, which regulate appetite, also impact immune cell function. Suppressing these neurons can lead to increased inflammation and vulnerability to autoimmune diseases like multiple sclerosis.
A Yale University study found that hyperoxia can activate stress pathways in developing lungs, leading to conditions like bronchopulmonary dysplasia. Blocking Cox2 with a pain drug reversed BPD in mice, suggesting it as a potential treatment target.
Experts at Yale University and the American Academy of Neurology call for limiting or ending the use of memory-enhancing drugs in healthy children. They cite concerns over long-term health safety, incomplete decision-making capacity, and risks of over-medication and dependency.
A new study by researchers at Yale University found that infants as young as nine months old prefer individuals who punish those who are not like themselves. Babies tend to dislike those whose tastes differ from their own and want them to be treated badly, but also prefer someone who is nice to an individual similar to themselves.
Yale researchers have identified a key genetic switch that facilitates brain maturation and plasticity. By blocking this gene, they were able to reset the old brain to adolescent levels of plasticity, allowing adult mice to recover from injuries and master new motor tasks more quickly.
Researchers at Yale School of Medicine found that dietary salt can induce and worsen pathogenic immune system responses in mice, leading to a more severe form of multiple sclerosis. They discovered the key molecular pathway involved in this response and proposed regulatory networks that govern autoimmune disease.
Researchers identified a critical fictive temperature (CFT) that determines glass ductility, suggesting any glass can be made ductile or brittle by adjusting cooling rates. The study applies to all glasses, not just metallic glasses, and has implications for designing ductile glasses.
A recent study published in Developmental Cell identifies piRNAs as the primary guides for epigenetic factors, controlling gene expression patterns in Drosophila. This breakthrough discovery has significant implications for understanding cancer development and may lead to new therapeutic opportunities.
Påebo is being honored with the prestigious award for his groundbreaking work on extracting DNA from ancient human remains and sequencing Neandertal's nuclear DNA. The prize recognizes his discovery that Neandertals contributed up to 4% of modern humans' genetic material.
A new study reveals that slow-firing neurons are essential for higher-order thinking and mental representations, which are compromised in diseases like schizophrenia and Alzheimer's. The research identifies NMDA-NR2B receptors as key regulators of neuronal firing.
A new approach by Yale University scientists offers greater control over the three-dimensional structure of molecular compounds, enabling more effective drugs. This breakthrough can lead to the creation of novel piperidine derivatives with improved binding properties.
Yale researchers identified social attention deficits in six-month-old infants with autism spectrum disorders, suggesting an early warning sign. The study's findings may pave the way for earlier interventions and treatment strategies.
Researchers at Yale University have defined the genetic landscape of uterine serous carcinoma (USC), a chemo-resistant form of endometrial cancer. The study identifies three previously unknown genes that play a role in tumor growth and development, offering new avenues for personalized therapy.
A team of researchers at Yale University has identified four new genetic suspects linked to the origins and treatment of meningiomas. The study found that tumors mutated with these genes tend to be located in different areas of the brain, indicating their likelihood of becoming malignant.
Research at Yale School of Medicine shows that patients are at high risk of readmission for a broad spectrum of medical conditions within the first month after hospital discharge. The study found that readmissions were frequent and resulted from different medical conditions than the initial hospitalization.
A new study found nearly 18% of hospitalized patients returned to the emergency room or were readmitted within 30 days of discharge, with mental health and prostate issues having the highest rates. The study suggests that many more patients require acute medical care after hospitalization than previously recognized.