Articles tagged with Allografts
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A recent study by UCLA Health found that a key genetic variant in the C3 gene increases the risk of chronic lung allograft dysfunction (CLAD) after lung transplantation. CLAD is the primary cause of mortality after lung transplantation, and the study suggests that impaired complement regulation drives this process.
A new study from the University of Missouri School of Medicine found that pre-surgical behavioral evaluations can improve patient outcomes after orthopedic surgery. By identifying and addressing potential barriers to recovery, patients are more likely to follow post-operative plans and achieve successful outcomes.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
A new study from the University of Cincinnati College of Medicine examines pregnancy outcomes in women with kidney transplants who use assisted reproductive technology. The research found increased rates of hypertension and preterm birth, but no significant difference in live birth rates or two-year kidney transplant survival.
A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation. Researchers mapped how human immune cells interact with pig kidney tissue, revealing critical early markers of rejection and potential intervention strategies.
An international team of scientists has molecularly decoded blood stem cell differentiation pathways using state-of-the-art sequencing methods. They identified a crucial surface protein, PD-L2, which suppresses the immune response by preventing T cell activation and release of inflammatory substances.
A new study highlights the link between socioeconomic disadvantage and poorer survival rates after heart transplantation in Medicaid-insured patients. The research found that these patients had a higher likelihood of developing cardiac allograft vasculopathy (CAV), a condition affecting transplanted hearts and limiting long-term survival.
Researchers aim to advance eye transplantation through cutting-edge technologies and techniques, including cell-based therapies and device development. The six-year project, led by Kia Washington at the University of Colorado Anschutz Medical Campus, seeks to overcome current limitations in whole-eye transplant success rates.
The world's first combined whole eye and face transplant has demonstrated allograft survival, including rejection-free graft survival. The transplanted eye has maintained normal pressure, good blood flow, and some remaining structure and functions in the retina. Researchers are now focused on understanding how to restore sight.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
Researchers found that specific microbes in the gut reduce graft versus host disease after stem cell transplantation. Patients with low microbial metabolite risk index had better survival rates, fewer graft vs. host reactions, and reduced relapses.
A study by researchers from the University of Chicago reveals that bacteria in donated organs complicate the immune response after transplantation. The findings show that immune responses against commensal bacteria add to the rejection of the organ, reducing the effectiveness of immunosuppressive drugs and causing damage to the graft.
Researchers propose reinstating waiting time for recipients experiencing early post-transplant allograft failure within an expanded timeframe to boost transplant numbers. This policy change could potentially reduce the perceived patient-level risk of transplanting marginal organs and improve organ utilization.
A new electronic 'nose' has been developed to detect when a lung transplant is beginning to fail, with 86% accuracy. The device uses machine learning algorithms to analyze exhaled breath patterns and identify lung diseases, offering new hope for patients diagnosed with chronic allograft dysfunction.
A single-center retrospective study found that 1-year kidney transplant outcomes are similar for HCV-negative recipients from HCV-positive or negative donors. The results suggest that transplantation of kidneys from HCV-infected donors to HCV-negative recipients is a viable option.
Researchers at UAB have developed a biocompatible coating that delays allograft and autoimmune-mediated rejection in mouse models of T1D. The coating, consisting of multiple layers of tannic acid, protects transplanted islets from immune cells and oxidative stress.
A recent study proposes a quality control framework for umbilical cord blood-sourced allografts, outlining future safety and potency benchmarks. The study identifies a unique liaison among the UCB-sourced allograft, host mesenchymal stem cells, and their secreted exosomes that influences tissue regeneration in vivo.
Researchers found that older patients (over 40) with knee pain can benefit from osteochondral allograft transplantation, showing significant improvement in knee function and daily activities. This novel approach offers an alternative to traditional treatments for cartilage disorders in active individuals.
Researchers at the University of Konstanz have successfully prevented chronic antibody-mediated organ rejection in a rat model using immunoproteasome inhibition with the selective inhibitor ONX 0914. This approach reduces activated plasma cells producing allo-antibodies and leads to improved renal function.
Researchers found that bilirubin supplementation significantly decreased islet cell death after isolation and nutrient deprivation. The study also showed that bilirubin suppressed the release of damage-associated molecular patterns (DAMPs), which are foreign cell-fighting immune cells.
Research on 14,105 ACL reconstruction cases found that soft tissue allografts processed with high radiation or chemicals increased revision rates by 2-4 times compared to BPTB autografts. The study suggests that surgeons should consider the processing methods of allografts when making surgical decisions.
A new therapeutic approach using autograft followed by allograft resulted in a record-breaking 41% cure rate and 60% relapse-free survival rate in patients with multiple myeloma. The study showed promising results with low mortality rates and high efficacy in subsequent treatments.
A UK study compared a new nerve repair technique, called a nerve allograft, to existing methods. The study found that the new technique produced more consistent results and better outcomes, while avoiding donor site morbidity.
A study of 99 patients found that autografts had a lower failure rate than allografts after ACL reconstruction. The study suggests that using an autograft may increase the lifespan of these procedures and minimize future surgeries.
Researchers found that blood vessels in face transplant recipients reorganize themselves, creating new networks to ensure healthy circulation. This understanding could improve surgical planning and assessment of potential complications, potentially shortening operation time and reducing procedure-associated complications.
A study published in Neural Regeneration Research found that a nanofibrous PHBV conduit can repair long-segment sciatic nerve defects with similar functional recovery rates to autologous nerve grafting. The conduit's flexible and porous structure allows for optimal nutrient transport, making it suitable for long-term use.
Researchers have developed a nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit for the repair of long-segment sciatic nerve defects. The study found that regenerated nerves were macroscopically observed and histologically assessed, with restoration of nerve continuity and formation of myelinated nerve fibers.
Researchers developed tissue-engineered nerves using acellular nerve allografts and bone marrow mesenchymal stem cells to repair long-segment sciatic nerve defects. The study showed improved hind limb motor function and similar conduction velocities to autologous nerve grafting.
Researchers found that non-self-donated stem cells survive better when injected into the striatum of the brain, accumulating along a 'pocket' between natural bordering regions. This discovery has important ramifications for designing cell therapies for neurological disorders.
A new study reveals that secondhand smoke results in graft rejection in transplant patients, with a specific enzyme's expression being key to the process. Researchers found that SHS suppressed an enzyme produced by innate immune cells, hindering long-term islet allograft survival.
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
A study found that female recipients of male donor kidneys have a higher risk of transplant failure in the first year after transplantation. However, this increased risk is reversed after ten years. The study suggests that H-Y antigens on male cells may elicit an immune response in female kidney transplant recipients.
Researchers at the University of Rochester Medical Center have developed a new graft technique using freeze-dried tendon grafts loaded with gene therapy, showing significantly fewer adhesions than traditional autografts. The study demonstrates promising results in restoring range of motion and accelerating healing after hard-to-treat i...
A study published in the Journal of Clinical Investigation shows that reinfusing anergic T cells into rhesus monkeys after kidney transplantation leads to prolonged and potentially indefinite graft survival without additional immunosuppressive agents. This approach has shown promise for improving organ transplantation outcomes in humans.
A new Georgia Tech micro-CT imaging technique helps tissue engineers develop better bone grafts by analyzing vascularization and mineralization. The technique provides high-resolution 3D images of bone repair, enabling researchers to optimize implant design and improve bone healing.
A 24-month study found that everolimus reduced intimal thickening and cardiovascular events, while sirolimus showed plaque regression. The results suggest that intravascular ultrasound measurements can be used as a valid surrogate for therapeutic intervention.
Researchers found that patients with kidney transplants from donors aged 55-79 had comparable allograft survival rates as those from younger donors. The study also revealed that older recipient patients may benefit from receiving kidneys from older deceased or living donors, particularly those facing prolonged waiting times on dialysis.
A study published in the New England Journal of Medicine found that everolimus significantly reduced the incidence of acute rejection and cardiac allograft vasculopathy in heart transplant patients. The medication also lowered rates of cytomegalovirus infection, a major risk factor for these complications.
Certican has been shown to target underlying causes of chronic allograft dysfunction and late graft loss, including acute rejection and vascular remodelling. The drug demonstrated superiority over azathioprine in reducing acute rejection episodes and pulmonary function decline.